LOCUS       NM_138409               2137 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens melanocortin 2 receptor accessory protein 2 (MRAP2),
            transcript variant 1, mRNA.
ACCESSION   NM_138409
VERSION     NM_138409.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   da Fonseca,A.C.P., Abreu,G.M., Zembrzuski,V.M., Campos Junior,M.,
            Carneiro,J.R.I., Nogueira Neto,J.F., Magno,F.C.C.M., Rosado,E.L.,
            Bozza,P.T., de Cabello,G.M.K. and Cabello,P.H.
  TITLE     Study of LEP, MRAP2 and POMC genes as potential causes of severe
            obesity in Brazilian patients
  JOURNAL   Eat Weight Disord 26 (5), 1399-1408 (2021)
   PUBMED   32578125
  REMARK    GeneRIF: Study of LEP, MRAP2 and POMC genes as potential causes of
            severe obesity in Brazilian patients.
REFERENCE   2  (bases 1 to 2137)
  AUTHORS   Chen,V., Bruno,A.E., Britt,L.L., Hernandez,C.C., Gimenez,L.E.,
            Peisley,A., Cone,R.D. and Millhauser,G.L.
  TITLE     Membrane orientation and oligomerization of the melanocortin
            receptor accessory protein 2
  JOURNAL   J Biol Chem 295 (48), 16370-16379 (2020)
   PUBMED   32943551
  REMARK    GeneRIF: Membrane orientation and oligomerization of the
            melanocortin receptor accessory protein 2.
REFERENCE   3  (bases 1 to 2137)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2137)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2137)
  AUTHORS   Rouault,A.A.J., Rosselli-Murai,L.K., Hernandez,C.C., Gimenez,L.E.,
            Tall,G.G. and Sebag,J.A.
  TITLE     The GPCR accessory protein MRAP2 regulates both biased signaling
            and constitutive activity of the ghrelin receptor GHSR1a
  JOURNAL   Sci Signal 13 (613) (2020)
   PUBMED   31911434
  REMARK    GeneRIF: The GPCR accessory protein MRAP2 regulates both biased
            signaling and constitutive activity of the ghrelin receptor GHSR1a.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2137)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    GeneRIF: MRAP2 is an endogenous inhibitor that competes with MRAP
            for binding to MC2R and decreases the potency of
            adrenocorticotropic hormone (ACTH).
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2137)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
  REMARK    GeneRIF: identify MRAP and MRAP2 as unique bidirectional regulators
            of the melanocortin receptor family
REFERENCE   8  (bases 1 to 2137)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regions of melanocortin 2 (MC2) receptor accessory protein
            necessary for dual topology and MC2 receptor trafficking and
            signaling
  JOURNAL   J Biol Chem 284 (1), 610-618 (2009)
   PUBMED   18981183
REFERENCE   9  (bases 1 to 2137)
  AUTHORS   Metherell,L.A., Chapple,J.P., Cooray,S., David,A., Becker,C.,
            Ruschendorf,F., Naville,D., Begeot,M., Khoo,B., Nurnberg,P.,
            Huebner,A., Cheetham,M.E. and Clark,A.J.
  TITLE     Mutations in MRAP, encoding a new interacting partner of the ACTH
            receptor, cause familial glucocorticoid deficiency type 2
  JOURNAL   Nat Genet 37 (2), 166-170 (2005)
   PUBMED   15654338
REFERENCE   10 (bases 1 to 2137)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010003.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138409.3.
            
            Summary: This gene encodes a protein that modulates melanocortin
            receptor signaling. The encoded protein has been shown to interact
            with all known melanocortin receptors and may regulate both
            receptor trafficking and activation in response to ligands. Mice
            lacking a functional copy of this gene exhibit severe obesity and a
            mutation in this gene may be associated with severe obesity in
            human patients. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010003.2, SRR1660803.215804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257776.5/ ENSP00000257776.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2137              BC010003.2         17-2153
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.2"
     gene            1..2137
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:112609"
                     /db_xref="HGNC:HGNC:21232"
                     /db_xref="MIM:615410"
     exon            1..112
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /inference="alignment:Splign:2.1.0"
     exon            113..246
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..737
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /note="isoform 1 is encoded by transcript variant 1; MC2R
                     accessory protein 2"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2
                     isoform 1"
                     /protein_id="NP_612418.2"
                     /db_xref="CCDS:CCDS5001.1"
                     /db_xref="GeneID:112609"
                     /db_xref="HGNC:HGNC:21232"
                     /db_xref="MIM:615410"
                     /translation="MSAQRLISNRTSQQSASNSDYTWEYEYYEIGPVSFEGLKAHKYS
                     IVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDK
                     VFSRQGNEESRSLFHCYINEVERLDRAKACHQTTALDSDVQLQEAIRSSGQPEEELNR
                     LMKFDIPNFVNTDQNYFGEDDLLISEPPIVLETKPLSQTSHKDLD"
     exon            247..346
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /inference="alignment:Splign:2.1.0"
     exon            347..2137
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /note="hexamer: AATAAA"
     polyA_site      2137
                     /gene="MRAP2"
                     /gene_synonym="bA51G5.2; C6orf117"
                     /note="major polyA site"
ORIGIN      
        1 actcgcccgg ccctgggcgg tgggaggcgg cggcggcggc ggcgctcgcg cacctcggag
       61 gagccaggag ccggaaccag ggccgagccc gcgggccggg gctagccagc cggtcggaga
      121 tgtccgccca gaggttaatt tctaacagaa cctcccagca atcggcatct aattctgatt
      181 acacctggga atatgaatat tatgagattg gaccagtttc ctttgaagga ctgaaggctc
      241 ataaatattc cattgtgatt ggattttggg ttggtcttgc agtcttcgtg atttttatgt
      301 tttttgtgct gaccttgctg accaagacag gagccccaca ccaagacaat gcagagtcct
      361 cagagaagag attcagaatg aacagctttg tgtcagactt tggaagacct ctggagccag
      421 ataaagtatt ttctcgccaa ggcaacgagg agtccaggtc tctctttcac tgctacatca
      481 atgaggtgga acgcttggac agagccaaag cttgtcacca gaccacagcc cttgacagtg
      541 acgtccaact ccaggaagcc atcagaagca gtgggcagcc agaggaggag ctgaacaggc
      601 tcatgaagtt tgacatcccc aactttgtga acacagacca gaactacttt ggggaggatg
      661 atcttctgat ttctgaacca cctattgttc tggaaactaa gccactttcc cagacctcac
      721 acaaagacct ggattgagaa acatgctctg taaagggtct tcctgaagat gtggattcta
      781 tctttatgta gcaagaaatc tacatccacc aaaattgtgt gtgtttgggg gagagagaga
      841 catagagata gagacagaga ggcagagaag agaccccttt agaagagagc tgagctgatt
      901 aagctgagtg gttttttgtt ttgttttgtt tttgcttttt aatacatttg gagctttggg
      961 agtattaaag tatttacacc aagcttgtcc aacccgtggc atgtgtccca ggacagcttt
     1021 gaatgtggcc caatacaaat tttaaacttt attaaaacat gagttttgtt tttttttttg
     1081 ctattttttt taaagctcgt cagctatcgt tagtgttagt gtactttatg tgtggcccaa
     1141 gacaactctt cttccagtgt ggcacaggga agctaaaaga ttggacacct ctgatttata
     1201 ctagctcgtt ttgcttgttg aaaaatttgg ccaaatacct attgtcagca ttcttgggtg
     1261 aggattagcc taccatgttc taatctggcc ctgccactac tatgctctac ctttggtgag
     1321 ttgctttacc tctctgggct gccccatttt taactgtagg ttgacaggtc tagagtgatc
     1381 catcccacct ctaatatttt gtgaatttat gactttgcct tcagatgagg ctgagctata
     1441 cataaaacag tataaactag ggtactgcct cgtatctctt gtaggctctc tcaaatctct
     1501 gtaccttcca cttaacccta attgagccaa gctttagtca ggggatctgg ttgtctacca
     1561 gaatgtcagg agactcatct tacacagtca tggtggccaa tgtttctggt gggttgtgct
     1621 gaaacagctc ttctgagaac ttccaaccac ccatgctcta acctggagac agccatcccc
     1681 tgcctcagaa taagtaccaa ttcgtagtac atgtatggta ctcttgtccc caagaaatgt
     1741 taggaagctt gtcagctgaa tgagaggagg tgccttctgg gtatctctgt gttggtgtat
     1801 ctgtgccatt ggctacagaa caagaaaaat actatttgcc atgctattac cttggcagat
     1861 gtgtaggtga tagtcatctg gctttgagct gagatggtca gtgggttgta aattccccac
     1921 tagcagatat tcagggtggc ctgagttatg taaacaagtg agcaacacag ctttaatttc
     1981 atggaggaat caaagctgca cactggtatt aaaacaactt gattttgcgc acacagttgc
     2041 atgcatggca agctgttaac ctctgggtgg cattttcatt atgaatttgt tcaccacctg
     2101 tcttgcttaa gctacaaaat aaatgcattt gactgca
//
