LOCUS       NM_001385161            7724 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens major histocompatibility complex, class I-related
            (MR1), transcript variant 6, mRNA.
ACCESSION   NM_001385161
VERSION     NM_001385161.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7724)
  AUTHORS   McWilliam,H.E.G. and Villadangos,J.A.
  TITLE     MR1 antigen presentation to MAIT cells and other MR1-restricted T
            cells
  JOURNAL   Nat Rev Immunol 24 (3), 178-192 (2024)
   PUBMED   37773272
  REMARK    GeneRIF: MR1 antigen presentation to MAIT cells and other
            MR1-restricted T cells.
            Review article
REFERENCE   2  (bases 1 to 7724)
  AUTHORS   Shrinivasan,R., Wyatt-Johnson,S.K. and Brutkiewicz,R.R.
  TITLE     The MR1/MAIT cell axis in CNS diseases
  JOURNAL   Brain Behav Immun 116, 321-328 (2024)
   PUBMED   38157945
  REMARK    GeneRIF: The MR1/MAIT cell axis in CNS diseases.
            Review article
REFERENCE   3  (bases 1 to 7724)
  AUTHORS   Jirous Drulak,M., Grgic,Z., Pluzaric,V., Sola,M.,
            Opacak-Bernardi,T., Viljetic,B., Glavas,K., Tolusic-Levak,M.,
            Perisa,V., Mihalj,M., Stefanic,M. and Tokic,S.
  TITLE     Characterization of the TCRbeta repertoire of peripheral
            MR1-restricted MAIT cells in psoriasis vulgaris patients
  JOURNAL   Sci Rep 13 (1), 20990 (2023)
   PUBMED   38017021
  REMARK    GeneRIF: Characterization of the TCRbeta repertoire of peripheral
            MR1-restricted MAIT cells in psoriasis vulgaris patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7724)
  AUTHORS   Wyatt-Johnson,S.K., Kersey,H.N., Codocedo,J.F., Newell,K.L.,
            Landreth,G.E., Lamb,B.T., Oblak,A.L. and Brutkiewicz,R.R.
  TITLE     Control of the temporal development of Alzheimer's disease
            pathology by the MR1/MAIT cell axis
  JOURNAL   J Neuroinflammation 20 (1), 78 (2023)
   PUBMED   36944969
  REMARK    GeneRIF: Control of the temporal development of Alzheimer's disease
            pathology by the MR1/MAIT cell axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7724)
  AUTHORS   Ashley,C.L., McSharry,B.P., McWilliam,H.E.G., Stanton,R.J.,
            Fielding,C.A., Mathias,R.A., Fairlie,D.P., McCluskey,J.,
            Villadangos,J.A., Rossjohn,J., Abendroth,A. and Slobedman,B.
  TITLE     Suppression of MR1 by human cytomegalovirus inhibits MAIT cell
            activation
  JOURNAL   Front Immunol 14, 1107497 (2023)
   PUBMED   36845106
  REMARK    GeneRIF: Suppression of MR1 by human cytomegalovirus inhibits MAIT
            cell activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7724)
  AUTHORS   Parra-Cuadrado,J.F., Navarro,P., Mirones,I., Setien,F., Oteo,M. and
            Martinez-Naves,E.
  TITLE     A study on the polymorphism of human MHC class I-related MR1 gene
            and identification of an MR1-like pseudogene
  JOURNAL   Tissue Antigens 56 (2), 170-172 (2000)
   PUBMED   11019920
REFERENCE   7  (bases 1 to 7724)
  AUTHORS   Riegert,P., Wanner,V. and Bahram,S.
  TITLE     Genomics, isoforms, expression, and phylogeny of the MHC class
            I-related MR1 gene
  JOURNAL   J Immunol 161 (8), 4066-4077 (1998)
   PUBMED   9780177
REFERENCE   8  (bases 1 to 7724)
  AUTHORS   Yamaguchi,H., Kurosawa,Y. and Hashimoto,K.
  TITLE     Expanded genomic organization of conserved mammalian MHC class
            I-related genes, human MR1 and its murine ortholog
  JOURNAL   Biochem Biophys Res Commun 250 (3), 558-564 (1998)
   PUBMED   9784382
REFERENCE   9  (bases 1 to 7724)
  AUTHORS   Yamaguchi,H., Hirai,M., Kurosawa,Y. and Hashimoto,K.
  TITLE     A highly conserved major histocompatibility complex class I-related
            gene in mammals
  JOURNAL   Biochem Biophys Res Commun 238 (3), 697-702 (1997)
   PUBMED   9325151
REFERENCE   10 (bases 1 to 7724)
  AUTHORS   Hashimoto,K., Hirai,M. and Kurosawa,Y.
  TITLE     A gene outside the human MHC related to classical HLA class I genes
  JOURNAL   Science 269 (5224), 693-695 (1995)
   PUBMED   7624800
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356267.27.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: MAIT (mucosal-associated invariant T-cells) lymphocytes
            represent a small population of T-cells primarily found in the gut.
            The protein encoded by this gene is an antigen-presenting molecule
            that presents metabolites of microbial vitamin B to MAITs. This
            presentation may activate the MAITs to regulate the amounts of
            specific types of bacteria in the gut. Several transcript variants
            encoding different isoforms have been found for this gene, and a
            pseudogene of it has been detected about 36 kbp upstream on the
            same chromosome. [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.121084.1, U22963.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367580.6/ ENSP00000356552.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL356267.27        37183-37274
            93-353              AL356267.27        52252-52512
            354-629             AL356267.27        53211-53486
            630-905             AL356267.27        55435-55710
            906-1010            AL356267.27        56773-56877
            1011-7724           AL356267.27        58425-65138
FEATURES             Location/Qualifiers
     source          1..7724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..7724
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="major histocompatibility complex, class I-related"
                     /db_xref="GeneID:3140"
                     /db_xref="HGNC:HGNC:4975"
                     /db_xref="MIM:600764"
     exon            1..92
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1051
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 6; major histocompatibility complex, class I-like
                     sequence; major histocompatibility complex class I-related
                     gene protein; MHC class I-like antigen MR-1; MHC class-I
                     related-gene protein; MHC class I-related protein"
                     /codon_start=1
                     /product="major histocompatibility complex class I-related
                     gene protein isoform 1 precursor"
                     /protein_id="NP_001372090.1"
                     /db_xref="CCDS:CCDS1342.1"
                     /db_xref="GeneID:3140"
                     /db_xref="HGNC:HGNC:4975"
                     /db_xref="MIM:600764"
                     /translation="MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEF
                     ISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRL
                     QRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHT
                     IKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVT
                     ALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLY
                     SCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAI
                     YLPTPDR"
     exon            93..353
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /inference="alignment:Splign:2.1.0"
     exon            354..629
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /inference="alignment:Splign:2.1.0"
     exon            630..905
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1010
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..7724
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2315..2320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="hexamer: AATAAA"
     polyA_site      2339
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="major polyA site"
     regulatory      3984..3989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="hexamer: ATTAAA"
     polyA_site      4014
                     /gene="MR1"
                     /gene_synonym="HLALS"
     regulatory      7701..7706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="hexamer: AATAAA"
     polyA_site      7724
                     /gene="MR1"
                     /gene_synonym="HLALS"
                     /note="major polyA site"
ORIGIN      
        1 aaaagaaccc ggaaagagaa ggactatggg ggaactgatg gcgttcctgt tacctctcat
       61 cattgtgtta atggtgaagc acagcgattc ccggacgcac tctctgagat attttcgcct
      121 gggcgtttcg gatcccatcc atggggtccc tgaatttatt tcggttgggt acgtggactc
      181 gcaccctatc accacatatg acagtgtcac tcggcagaag gagccacggg ccccatggat
      241 ggcagagaac ctcgcgcctg atcactggga gaggtacact cagctgctga ggggctggca
      301 gcagatgttc aaggtggaac tgaagcgcct acagaggcac tacaatcact cagggtctca
      361 cacttaccag agaatgattg gctgtgagct gctggaggat ggaagcacca caggatttct
      421 gcagtatgca tatgacgggc aggatttcct gatcttcaat aaagacaccc tctcctggct
      481 ggctgtagat aatgtggctc acaccatcaa gcaggcatgg gaggccaatc agcatgagtt
      541 gctgtatcaa aagaattggc tggaagaaga atgtattgcc tggctaaaga gattcctgga
      601 gtatgggaaa gacaccctac aaagaacaga gcccccactg gtcagagtaa atcgcaaaga
      661 aacttttcca ggggttacag ctctcttctg caaagctcat ggcttttacc ccccagaaat
      721 ttacatgaca tggatgaaaa acggggaaga aattgtccaa gaaattgatt atggagacat
      781 tcttcccagt ggggatggaa cctatcaggc gtgggcatca attgagcttg atcctcagag
      841 cagcaacctt tactcctgtc atgtggagca ctgcggtgtc cacatggttc ttcaggtccc
      901 ccaggaatca gaaactatcc ctcttgtgat gaaagctgtc tctgggtcca ttgtccttgt
      961 cattgtgctg gctggagttg gtgttctagt ctggagaaga aggccccgag agcaaaatgg
     1021 agccatctac cttccaacac cagatcgatg attgcagatc cctcttttcc agttctcctt
     1081 cctctaggag ccatgttatc ctctgtcccc catagagtca agcctagtgc ttgaaggtcc
     1141 tgacgacacc cacaacatac atgagagtaa tgggattgag catttatggc agcaacagag
     1201 gagccacaaa atgttctttg ttctttggct ccaaaaagac tgtcagcttt cagtctcttt
     1261 tgatggactg ttttatcaga gttgacttta aatacagctt gtctcatgac acaacgcttc
     1321 cctacattct atttgtcaat gatgatttgc aactagttgg agattctcag agcaggaagg
     1381 aatcttttca accagagcag gaactgtctt ctgcaatgcc ttggacttga gcctccagcc
     1441 tccacttgaa caccatgtga agggaacctc agtacttcat aaaatggcct ttctcattca
     1501 tctttcatgg gaacatttat tgtacaagcg ctttgaatat catgggcacc atgactgtga
     1561 ccctacaggt aggattggat cactccatga gagtagccgg caggtttcta caatggcctg
     1621 ggaatggact gattattttt atacattttc tggcctgaga gaaagccaaa gtcccctgct
     1681 gttcacagca accctgcctg ggagcttgga atcttggtaa tctgcccggt tggatctatg
     1741 gaggtagtct cacccttttt gtcttttgtg ggaaattaag agaaataatt atcagacata
     1801 tcatcacctc cagtggaact acagagacct ggacccagct gcactatttt aatgtaaaaa
     1861 taacagtatg gccaggtgca gtggctcacg cctgtaatcc catcactttg agcagccaag
     1921 gcgggcggat cacgaggtca ggagattaag accatcctgg ccaatatggt gaaaccctgt
     1981 ctctactaaa atacaaaaaa ttagctgggc atggtgttgc gtgcctgtag tcccagctac
     2041 ttgggaggct gagacagggg aattgcttga acccgggagg cagagattgc agtgagccga
     2101 gatcacgcca ctgcactcca gcctggcgac agagtgagac tctatctcaa aataataata
     2161 ataataataa taataataat aataataata acagtatatt tggtgtcagg agagggctca
     2221 attctcattt ctgcctttcc tgtgctggct catggtagct gggcatgact tgccttccta
     2281 cataggttgt cttcatacat atgcactggg aatcaataaa agcccatggt gagaatgaac
     2341 atccccttaa tgttccttac tatccccaac ccctgaggcc tcacctactg ccctgccatg
     2401 tggagctact tgccctgggg ctgccagtca cacattcctc ggtcctactt ctctgacccc
     2461 gtttgactct gcacctgagc cctaatgctt acttcagtga cctgaacttt gacaagtggc
     2521 ttttgtcctg cacctcaggt ttgacctctg ctctcccttg accttgactg tgacatttga
     2581 cctttggctt taatcattac agcctcagat aaaggtacct tcagcccggg cacagtggct
     2641 cacgcctgta atcctagcac tttgggaggc tgaggcaggc ggattccctg agctcaggag
     2701 ttcaagacca gcctgggcaa cacggtgaaa ccctgtctct actaaaatac aaataattag
     2761 ctgggcatgg tggcatgtgc ctatagtccc agctacttgg gaggctaagg caggagaatc
     2821 acttgaatct ataaggcaga ggtggcagtg agccgagatc acaccactgc actccagcct
     2881 gggcaacgga gcaagactct gtctccaaaa aaaaaaagaa agataccctc agtgtgccag
     2941 gcctctaaga gctcacctgc caggcttcct ccttgctcca ctgtcccatg taattccata
     3001 tatgaagcta ccactgtaca tctctctttt ccggtgcctg ttgagttgca tagaagcaca
     3061 gttgtgttta ttttgttttt agggttgcca tgggcaattt ccgtgccact tttaagcagt
     3121 gttgcactgt gaagagaatg taggcaagtt tatttctgga atggtttctt cttacaatca
     3181 gaatagttag gatgtaatat atttttgggt gggcatttaa agtgaaaagg tacatattta
     3241 catagacaca ggtgataatg tatctatgta aatgcctttt gattctgcaa ctgcaggata
     3301 ctctcatcaa agacacagat aaaaagcctc tgtgtttcca aggccttgcc ctacacctaa
     3361 cacataatat gtccaaatgg atgaagagga ggcaaggaca aggatgtgat gacaaaacat
     3421 tctgttatgc acttgtagca tttatgtttc ttcctggggg attttataat actaaaagaa
     3481 tcataatata aagagatgat taaaaaaaaa atactgccgg gcacggtggc tcatgcctgt
     3541 aatcccagca ttttgggagg ccgaggtggg cagatcacct gaggtcggga gttcgagacc
     3601 agcctgacca acatggagaa accctgtctc taccaaacat acaaaattag ccggggatgg
     3661 tggcgcatgc ctataatccc agctactcgg gagtctgagg cagaagaacc gcttgaaccc
     3721 gggaggcaga ggttgtggtg agccgagatc gcgccatcgc actctagcct gggcaacaag
     3781 agtgaaactc catctcaaaa aaataaaaat aaaataagta agtaatacct aaaattctgc
     3841 aaccttcatt ttactataga tggttgaaga ttatattact tcttaattgt tttagccttg
     3901 ttattgcttc attacttcat ggttgttgag tacagatgct cagtaatcat aacctatgaa
     3961 atatttgaca ccatgatcta aacattaaaa acaaataact gtgctattgc cacagctatg
     4021 ttttggcttt gaattttctt tactgaatat tttggatcaa gaacactaga tgagaaacct
     4081 gttcaactct gttctttttt ttttttttaa ctccactgta tttattacct gtttttgttt
     4141 tttttgtttg tttgtttttg atgtgcatat agaccaagat gtggtaaatt taaatggcag
     4201 atgtttttga tgtggtacat ttaagggaga gaaagcagtt taaagagcag ggtgaaaaat
     4261 ccaacaagac tccatcgaga gtttctgagc tctcccatca ggggccagtc ctcctttcct
     4321 ctctcctctt actcccatga tttccaagtt gtgatccttt ccttatttct gaggaatgac
     4381 ttggtttctc ctcttctttt tttggcctga gagaagatgt ttttgcactt gtagctatga
     4441 ggaacagatt gtccactagg gaggccagct gatcattttc tgccagagtc acacagagca
     4501 gtcacacctt attttgaaaa ccactgtctg gggtctttgt cctcacatat gcaggtctag
     4561 tgtccccaca aagtgatcag atggatatat aaagtggagt gccaatgtat taatttactg
     4621 tgagaaacac aattgctaag tgggtcagat atctgtctca gctggtcagt acaccttcca
     4681 gcaggaaaat ctacataaga acaactaaat cacaatctgt agagtgcttg atgaccccag
     4741 aattggtgca aggggacaca ttcttgcttg ttagcacctg ctctctggag tttgctattt
     4801 tctcacacac agtgtattag ttcacagaat gttctccaag gaggacaggg ggctttgccc
     4861 atagccatgt gctgtgggca gcagagctag gaagaagcac aggcatctcc cagcccaggt
     4921 gtttcccact taactgcatt gcccttttca tctttttttt ttccccaata gcttcaggac
     4981 attcagtaca ttgtgctttt tagaggttga tgattccact gcctgagctg ccttcacctc
     5041 tctttctttg gaaattgcca tctttgagca ttgtatgtct ctgtaacatc tctgcatctc
     5101 cttttcactc tggcctccct ttctccattg tccttctagc ttctggttgc cccaaacccc
     5161 acagactgtg taacaaaacc caaaacctat tggtttaaaa caatacccat tttattttct
     5221 ttcatagttt ctatgggtca ggaatttgga tatggcttgg gtaagcagtt ctggcttctc
     5281 atggagttgg aggcaagtgg tggctggaac agaaatgggg cagccagggg tggtggccag
     5341 gcatcagcta catctcctcc atgtagtctc aggaactctc catgtaatct ctctgtgtgg
     5401 gttgggcttc ctcacaacat ggtggcctca gggcagtcac tgcttacatg gcagctagct
     5461 tccctcagag tgagtatccc aagagatcac agtcaaagtg catagcattt atataatcta
     5521 atcttggaag tcacaaaatg tcattcttgt gatactctca ttggtgaaga agtcataaaa
     5581 tcctgctcag gttcaaaaag agggtgtata gaacccaaca ctcaatagga agattgtcag
     5641 agttacattg taagaagagc atgtagttgg gagatatcat tgtggccatt ttgggaaaga
     5701 tgcaacatgt cacaatgtca tgttctccat cgtctccccg ttccaccttg tactggtttc
     5761 caagggtagt cgtttaaaag taccacaaaa actgggtggc ttggaacaac agaaatttat
     5821 tgtttcacag ttctggaggc cagaagttca aaatgaagtg ttggcagaaa catgctgcct
     5881 ctaaagggac tgggaaagga tctgttccag gcttccctcc tatcttctgg ttgttccttg
     5941 ccttctggct gcgtaactct agtcttcatt tggtgttctc cctgcatgca tggctttgtg
     6001 tccaaatttc cttttttcat gaggccatca gtcatactgg attagggacc cactctacta
     6061 ctgcaggatg acctcacctt cccaaattac atctgcaaca accctatttc caaagaaggc
     6121 cacattctga ggtactgggg gttataactt caacatgaat tttttggagg aaacaattca
     6181 actcctaaca catctctacc caacctctgt aggttccctc aatccaccaa aattttttgg
     6241 ctccactgga ttatctagca gttaggaaac caagatcatt aaatgaattc accgcaacta
     6301 cagtgagact gactacctta gcttacctct gtgaaaggag ttaagccaaa ggaatctgtg
     6361 gaattttgga gagtttggga gcatttgggg gcaggaggca aatgttcttc ctttaaatca
     6421 caacacttag ttctcttcca tttataagac tcacccctcc atcccaaccc ctgcaccaca
     6481 ggacaaggaa gtgttcttgg tcttcaactt tcatccctga tggtgaaagc agttgctcct
     6541 gacctatttg cccaccagct tctcctctgg agcctgaggc ttctgatgcc tgcctggctg
     6601 gttctcagta agaaggtcaa gttcaaccag aggggagatg ctgatgcctt tcagtactta
     6661 aatatgagtt cagaccctgg ggcctggaca taagatttgg ggtcccctgg atataagatt
     6721 tctgaaaaca ctcagactgt ggagacccct gctgagggag aagccccaaa ctgtggcttc
     6781 aggggaatgc accaaggctc tcattgaggc caccttctcc aacaagctcc cctcctgctt
     6841 ccccatggct ggcatggctg aggaaaaagg acactgagca cagcccgtgc atgagcggct
     6901 tgccatgcaa caggataaaa cccataatgc cactcagcaa gccttggttg taaatctagt
     6961 ttgattacat ttgtaatcaa atgatggcca tttgttctgt ttctggtttg tgaaccaact
     7021 gaagacataa gcagggcctc agctaaccca caaatagcac atgtgtgcaa actggaaaaa
     7081 tgaacccttc ttctgggagg acgccagccc aggccaggtc acccggcttg gccagcagaa
     7141 cacagagtag attttggtcc cgtttgttcc ccagtggggt atctatcctt gtgcagggca
     7201 caagcctaca tggtggctct ggtcatatca ttagaaaata gacagaaatg ggctgcacac
     7261 cagaatgaat gaattgaatt gaaagggagg agtgatggtg gaaaaaaaaa caagtcaatt
     7321 catttagact ggtagaacca gaaccactgt gtagtacatc caaacggtta aaattccctg
     7381 gaagatgtta cataatccta tcatggtgtt tatttatgga aatctatttt aaaaatttta
     7441 tgtaatactg cacagtctgt ttgcatgatg ccttgtacgt agtagcaact cagtaaatac
     7501 tttttgaatg aactagtata gtattttaat tagctagtct tcatgtactg gtacaaaaga
     7561 acagtgtcat cttacagctg aagtcataga ggggaaatat cccactcaag atcatataac
     7621 attccaggta ctcaggatga atggtttgag gactggtctg aattcttcaa aggtttcagc
     7681 tgtattaaca ttctccatct aataaacttt atcttgtcat tgca
//
