LOCUS       NM_198275               3983 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myelin protein zero like 3 (MPZL3), transcript variant
            1, mRNA.
ACCESSION   NM_198275 XM_113683
VERSION     NM_198275.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Ramani,S.R., Tom,I., Lewin-Koh,N., Wranik,B., Depalatis,L.,
            Zhang,J., Eaton,D. and Gonzalez,L.C.
  TITLE     A secreted protein microarray platform for extracellular protein
            interaction discovery
  JOURNAL   Anal Biochem 420 (2), 127-138 (2012)
   PUBMED   21982860
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Racz,P., Mink,M., Ordas,A., Cao,T., Szalma,S., Szauter,K.M. and
            Csiszar,K.
  TITLE     The human orthologue of murine Mpzl3 with predicted adhesive and
            immune functions is a potential candidate gene for immune-related
            hereditary hair loss
  JOURNAL   Exp Dermatol 18 (3), 261-263 (2009)
   PUBMED   19054061
  REMARK    GeneRIF: Homozygous or compound heterozygous mutations of MPZL3
            might be involved in immune-mediated human hereditary disorders
            with hair loss.
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Cao,T., Racz,P., Szauter,K.M., Groma,G., Nakamatsu,G.Y.,
            Fogelgren,B., Pankotai,E., He,Q.P. and Csiszar,K.
  TITLE     Mutation in Mpzl3, a novel [corrected] gene encoding a predicted
            [corrected] adhesion protein, in the rough coat (rc) mice with
            severe skin and hair abnormalities
  JOURNAL   J Invest Dermatol 127 (6), 1375-1386 (2007)
   PUBMED   17273165
  REMARK    Erratum:[J Invest Dermatol. 2007 Nov;127(11):2678]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC417020.1, BC113586.1 and AP002800.4.
            
            On Nov 23, 2018 this sequence version replaced NM_198275.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.52329.1,
                                           SRR1660807.112298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278949.9/ ENSP00000278949.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DC417020.1         4-48
            46-876              BC113586.1         31-861
            877-3983            AP002800.4         149290-152396       c
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3983
                     /gene="MPZL3"
                     /note="myelin protein zero like 3"
                     /db_xref="GeneID:196264"
                     /db_xref="HGNC:HGNC:27279"
                     /db_xref="MIM:611707"
     exon            1..144
                     /gene="MPZL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..779
                     /gene="MPZL3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; myelin protein zero-like protein 3"
                     /codon_start=1
                     /product="myelin protein zero-like protein 3 isoform a
                     precursor"
                     /protein_id="NP_938016.1"
                     /db_xref="CCDS:CCDS8392.1"
                     /db_xref="GeneID:196264"
                     /db_xref="HGNC:HGNC:27279"
                     /db_xref="MIM:611707"
                     /translation="MQQRGAAGSRGCALFPLLGVLFFQGVYIVFSLEIRADAHVRGYV
                     GEKIKLKCTFKSTSDVTDKLTIDWTYRPPSSSHTVSIFHYQSFQYPTTAGTFRDRISW
                     VGNVYKGDASISISNPTIKDNGTFSCAVKNPPDVHHNIPMTELTVTERGFGTMLSSVA
                     LLSILVFVPSAVVVALLLVRMGRKAAGLKKRSRSGYKKSSIEVSDDTDQEEEEACMAR
                     LCVRCAECLDSDYEETY"
     exon            145..311
                     /gene="MPZL3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..522
                     /gene="MPZL3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..688
                     /gene="MPZL3"
                     /inference="alignment:Splign:2.1.0"
     exon            689..752
                     /gene="MPZL3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..3983
                     /gene="MPZL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3957..3962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPZL3"
                     /note="hexamer: AATAAA"
     polyA_site      3983
                     /gene="MPZL3"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtg ttacctgtgt cgttaccggg agctgtaaac aaggtgtgca agcatctgaa
       61 gagctgccgg gatgcagcag agaggagcag ctggaagccg tggctgcgct ctcttccctc
      121 tgctgggcgt cctgttcttc cagggtgttt atatcgtctt ttccttggag attcgtgcag
      181 atgcccatgt ccgaggttat gttggagaaa agatcaagtt gaaatgcact ttcaagtcaa
      241 cttcagatgt cactgacaaa cttactatag actggacata tcgccctccc agcagcagcc
      301 acacagtatc aatatttcat tatcagtctt tccagtaccc aaccacagca ggcacatttc
      361 gggatcggat ttcctgggtt ggaaatgtat acaaagggga tgcatctata agtataagca
      421 accctaccat aaaggacaat gggacattca gctgtgctgt gaagaatccc ccagatgtgc
      481 atcataatat tcccatgaca gagctaacag tcacagaaag gggttttggc accatgcttt
      541 cctctgtggc ccttctttcc atccttgtct ttgtgccctc agccgtggtg gttgctctgc
      601 tgctggtgag aatggggagg aaggctgctg ggctgaagaa gaggagcagg tctggctata
      661 agaagtcatc tattgaggtt tccgatgaca ctgatcagga ggaggaagag gcgtgtatgg
      721 cgaggctttg tgtccgttgc gctgagtgcc tggattcaga ctatgaagag acatattgat
      781 gaaagtctgt atgacacaag aagagtcacc taaagacagg aaacatccca ttccactggc
      841 agctaaagcc tgtcagagaa agtggagctg gcctggacca tagcgatgga caatcctgga
      901 gatcatcagt aaagacttta ggaaccactt atttattgaa taaatgttct tgttgtattt
      961 ataaactgtt caggaactct cataagagac tcatgacttc ccctttcaat gaattatgct
     1021 gtaattgaat gaagaaattc ttttcctgag caaaaagata ctttttgatt catctttgct
     1081 ctggaatgta ttacatgttt tcttccaact gtttgaagga gaattttgaa tgtttgccac
     1141 accgctgata cccaaataat tttttaaatg aagtggagct tgtggcttcc tgatgtgtca
     1201 ccagacaaaa tattcgcttg ggatatgtat tctttgtttt ttgctccatg tacactttca
     1261 gctgtgagtt agtatagggc gtatacttac cggtttaatg acctcaacct cagttgtgtt
     1321 tggataactt agggtgtata cccttagttt ccttagagtt ggtaggatca agtcattggt
     1381 ttgctttgac tgggttttta aagtattaag tacagtgtca tcaatttaca gttaaggaaa
     1441 ggaatcgtga agtagaaaaa ttattttctt tagtcttgct ggtacaattt gggctaagga
     1501 gtctttgtta ttttctgtct tgcttttttt tttttttttt tttttttgag gcagagtctc
     1561 actctgtcgc caggctggag tgcagtggtg tgatcttggc tcactgcaac ctctgcctcc
     1621 tgggttcaag cgattcttgt gcctcagcct ctcgagtagc tgggattaca ggcatgcgcc
     1681 accacaccca gctaattttt gtgtttttag tagagacggg gtttcaccat tttggccagg
     1741 atggtctcaa tcccctgacc tcgtgatcca cctgcctcgg cctcccaaag tgttgggatt
     1801 acaggcatga gccactgtgc ttggcctgtt attttatttt cttataacta caacttttct
     1861 tcttgaattt tcaggtcaga ggcaagaaaa actctttaca ggtttttagt ggggggctta
     1921 tggagtattt caggagttct ttgcaaatta aatcatcttt tcacttgtat tgtttttcaa
     1981 aactttgttg atttctaaaa tgtgccaact gtgagtaaac tatggtattt gcaagtggtt
     2041 tttacataat atttgagatg aggaagtgag attgtgcatg acatacttct cctttgtatt
     2101 ctctcagtgc cttacagcag gttactccat tctgctatga caacttgttt caaatgttaa
     2161 tttacatagg attttttata agccattaag gcatatgtat agtatatcag taaagatgga
     2221 tggtgcatat ataaatagtc ttctgtaata gtgattggat ttacttctca attatgagag
     2281 acaaaaatta tcccctcacc tgtctctatt ctttcaacag gttgatccct tttcatgatt
     2341 tttcattagg tggttcagga agtttccata ttacagcgct tcagactgta tatgttagtt
     2401 taaaaatcac ttttctctct ctcaacttct ttcttttttt tttgaagact taatttaaaa
     2461 aatttgggtt gttagatccg tatcatagat ttggcctagc ctcttctgtt aacctagtcc
     2521 acagatgagc gaatctggtt agttgaagga cattgtgatt tgactctggt cacgcgagga
     2581 agtagaaggg caaagacagg accggcagtt tacatttcca gtggttaaac ctcacggtac
     2641 tttgggactg cttgttaact tttgtggttg tctgaggcca atctaacgtg accatttctg
     2701 acacctcaac agagagagga aagcaacttg agcaatgaga gtaaataact tgggctctca
     2761 gagatttgaa gatagagatc tcattgtgag ggggactatt ttgcaggtcc tcatttctcc
     2821 aagaaagaga tggtgttaca ggaacccact gaaagccata tcccattaaa tgaggaacta
     2881 attttggctg ggccttcttg taatgtcctc gcaggtgtgt tgtgaagatt aatgcagggt
     2941 agtatgtttg tagattgaca cctagtctaa acttgaggta attggtgctc tgtgaatact
     3001 cagtcgtgtt cttttatagc cttaatcatg atttgaacta gtcccttgct ttttaaatga
     3061 ctgaatgaag tccttcgtgg taagggagta cgttgataac ttagtttact atatgggttt
     3121 gtggtcgcat cccagtcatc agctgctatc attttccttc ttcatccctt atactgagat
     3181 ttgggttaca gctttttatt cttcgaagga tcacaaagca gtgtacagac acctgccttc
     3241 tttaaggatg aaaggaagat aaagtggtct ttttttgttt acttatttgt ttcacctctt
     3301 gtttgagtaa cttctaaggt gctattctct ctctcttttt gctacctcat gagctcttgt
     3361 cacagccatg gaaaccagcc tcgtttagaa agggaactta gttcagaagg ggttaaaagc
     3421 cttccagaat ttttctttag ctgctgaagt ttttacatgt ggttacatga ctttaagttt
     3481 tatgcattac gctcttaatt ctattacaaa atgtggactc accaattgct ttgtgttttc
     3541 catgtgacct gttacttcag gctacttggg gaacatctta gtcctctgta gctcctgaac
     3601 ccagcactgg tgcttcaaga gagaaggtag cacgtctttg ttcaaaacaa aacaaaacga
     3661 cacttctgga ggccacatcc tgaatatgaa tgttctacta agtcactcag ttatggttct
     3721 aaagggaaac tgtaagaaga cccacaagga gtggaccaag actattattt aattgcacaa
     3781 cttgaaactt tgctgccaga agaggcagct ccattccttt gactccagtg ttgggctgtt
     3841 aactgctgca cctcattgcc tttttttgtt tttgtttttg ttttgtagga gggtaggcac
     3901 tgttgggcca tatgcacaaa tattgtaact cttggtatct ttactgcatc atagtcaata
     3961 aacttctttg taccctttgg cta
//
