LOCUS       NM_003953               4978 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant
            1, mRNA.
ACCESSION   NM_003953
VERSION     NM_003953.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4978)
  AUTHORS   Wang,A., Fan,F., Zang,C., Li,C., Hong,H., Wang,Z., Gao,Y., Chen,L.,
            Yu,X., Zhou,C. and Zhao,C.
  TITLE     MPZL1 Promotes Lung Adenocarcinoma Progression by Enhancing Tumor
            Proliferation, Invasion, Migration, and Suppressing Immune Function
            via Transforming Growth Factor-beta1
  JOURNAL   Hum Gene Ther 34 (11-12), 540-553 (2023)
   PUBMED   37183407
  REMARK    GeneRIF: MPZL1 Promotes Lung Adenocarcinoma Progression by
            Enhancing Tumor Proliferation, Invasion, Migration, and Suppressing
            Immune Function via Transforming Growth Factor-beta1.
REFERENCE   2  (bases 1 to 4978)
  AUTHORS   Feng,J., Ouyang,H., Wang,J., Pan,D., Sheng,L., Xu,C., Lin,W.,
            Hu,D., Chang,C. and Jia,D.
  TITLE     MPZL1 upregulation promotes tumor metastasis and correlates with
            unfavorable prognosis in non-small cell lung cancer
  JOURNAL   Carcinogenesis 43 (10), 919-929 (2022)
   PUBMED   35727197
  REMARK    GeneRIF: MPZL1 upregulation promotes tumor metastasis and
            correlates with unfavorable prognosis in non-small cell lung
            cancer.
REFERENCE   3  (bases 1 to 4978)
  AUTHORS   Sun,D., Gou,H., Wang,D., Li,C., Li,Y., Su,H., Wang,X., Zhang,X. and
            Yu,J.
  TITLE     LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to
            oncogenic MPZL1 and is associated with patient outcome
  JOURNAL   Int J Biol Sci 18 (8), 3156-3166 (2022)
   PUBMED   35637954
  REMARK    GeneRIF: LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly
            binding to oncogenic MPZL1 and is associated with patient outcome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4978)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4978)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4978)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4978)
  AUTHORS   Zhao,R., Guerrah,A., Tang,H. and Zhao,Z.J.
  TITLE     Cell surface glycoprotein PZR is a major mediator of concanavalin
            A-induced cell signaling
  JOURNAL   J Biol Chem 277 (10), 7882-7888 (2002)
   PUBMED   11751924
  REMARK    GeneRIF: PZR is a major receptor of ConA and has an important role
            in cell signaling via c-Src. Considering the various biological
            activities of ConA, the study of PZR may have major therapeutic
            implications
REFERENCE   8  (bases 1 to 4978)
  AUTHORS   Zhao,R. and Zhao,Z.J.
  TITLE     Dissecting the interaction of SHP-2 with PZR, an immunoglobulin
            family protein containing immunoreceptor tyrosine-based inhibitory
            motifs
  JOURNAL   J Biol Chem 275 (8), 5453-5459 (2000)
   PUBMED   10681522
REFERENCE   9  (bases 1 to 4978)
  AUTHORS   Tang,D.S., Yu,K.P., Tang,X.X., Zhang,H.L., Pan,Q., Dai,H.P. and
            Xia,J.H.
  TITLE     Cloning of Human Myelin Protein Zero-like Genes by Bioinformatics
            Strategy
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32 (4),
            364-368 (2000)
   PUBMED   12075424
REFERENCE   10 (bases 1 to 4978)
  AUTHORS   Zhao,Z.J. and Zhao,R.
  TITLE     Purification and cloning of PZR, a binding protein and putative
            physiological substrate of tyrosine phosphatase SHP-2
  JOURNAL   J Biol Chem 273 (45), 29367-29372 (1998)
   PUBMED   9792637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA725074.1, AY359019.1, Z99943.1 and AW292498.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003953.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075334.1, SRR1660805.14382.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359523.7/ ENSP00000352513.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DA725074.1         33-40
            9-1785              AY359019.1         1-1777
            1786-4687           Z99943.1           65024-67925
            4688-4978           AW292498.1         17-307              c
FEATURES             Location/Qualifiers
     source          1..4978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..4978
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /note="myelin protein zero like 1"
                     /db_xref="GeneID:9019"
                     /db_xref="HGNC:HGNC:7226"
                     /db_xref="MIM:604376"
     exon            1..261
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..980
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein zero related; myelin protein zero-like
                     protein 1; immunoglobulin family transmembrane protein"
                     /codon_start=1
                     /product="myelin protein zero-like protein 1 isoform a
                     precursor"
                     /protein_id="NP_003944.1"
                     /db_xref="CCDS:CCDS1264.1"
                     /db_xref="GeneID:9019"
                     /db_xref="HGNC:HGNC:7226"
                     /db_xref="MIM:604376"
                     /translation="MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPK
                     EIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPP
                     FKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENL
                     PVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRK
                     SPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN"
     exon            262..428
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /inference="alignment:Splign:2.1.0"
     exon            429..642
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /inference="alignment:Splign:2.1.0"
     exon            643..775
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /inference="alignment:Splign:2.1.0"
     exon            776..878
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /inference="alignment:Splign:2.1.0"
     exon            879..4978
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3859..3864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /note="hexamer: AATACA"
     polyA_site      3882
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /note="major polyA site"
     regulatory      4957..4962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
                     /note="hexamer: AATAAA"
     polyA_site      4978
                     /gene="MPZL1"
                     /gene_synonym="MPZL1b; PZR; PZR1b; PZRa; PZRb"
ORIGIN      
        1 gcagagctgg agagccgcgg ctgggaccgg agtggggagc gcggcgtgga ggtgccaccc
       61 ggcgcgggtg gcggagagat cagaagcctc ttccccaagc cgagccaacc tcagcgggga
      121 cccgggctca gggacgcggc ggcggcggcg gcgactgcag tggctggacg atggcagcgt
      181 ccgccggagc cggggcggtg attgcagccc cagacagccg gcgctggctg tggtcggtgc
      241 tggcggcggc gcttgggctc ttgacagctg gagtatcagc cttggaagta tatacgccaa
      301 aagaaatctt cgtggcaaat ggtacacaag ggaagctgac ctgcaagttc aagtctacta
      361 gtacgactgg cgggttgacc tcagtctcct ggagcttcca gccagagggg gccgacacta
      421 ctgtgtcgtt tttccactac tcccaagggc aagtgtacct tgggaattat ccaccattta
      481 aagacagaat cagctgggct ggagaccttg acaagaaaga tgcatcaatc aacatagaaa
      541 atatgcagtt tatacacaat ggcacctata tctgtgatgt caaaaaccct cctgacatcg
      601 ttgtccagcc tggacacatt aggctctatg tcgtagaaaa agagaatttg cctgtgtttc
      661 cagtttgggt agtggtgggc atagttactg ctgtggtcct aggtctcact ctgctcatca
      721 gcatgattct ggctgtcctc tatagaagga aaaactctaa acgggattac actggctgca
      781 gtacatcaga gagtttgtca ccagttaagc aggctcctcg gaagtccccc tccgacactg
      841 agggtcttgt aaagagtctg ccttctggat ctcaccaggg cccagtcata tatgcacagt
      901 tagaccactc cggcggacat cacagtgaca agattaacaa gtcagagtct gtggtgtatg
      961 cggatatccg aaagaattaa gagaatacct agaacatatc ctcagcaaga aacaaaacca
     1021 aactggactc tcgtgcagaa aatgtagccc attaccacat gtagccttgg agacccaggc
     1081 aaggacaagt acacgtgtac tcacagaggg agagaaagat gtgtacaaag gatatgtata
     1141 aatattctat ttagtcatcc tgatatgagg agccagtgtt gcatgatgaa aagatggtat
     1201 gattctacat atgtacccat tgtcttgctg tttttgtact ttcttttcag gtcatttaca
     1261 attgggagat ttcagaaaca ttcctttcac catcatttag aaatggtttg ccttaatgga
     1321 gacaatagca gatcctgtag tatttccagt agacatggcc ttttaatcta agggcttaag
     1381 actgattagt cttagcattt actgtagttg gaggatggag atgctatgat ggaagcatac
     1441 ccagggtggc ctttagcaca gtatcagtac catttatttg tctgccgctt ttaaaaaata
     1501 cccattggct atgccacttg aaaacaattt gagaagtttt tttgaagttt ttctcactaa
     1561 aatatggggc aattgttagc cttacatgtt gtgtagactt actttaagtt tgcacccttg
     1621 aaatgtgtca tatcaatttc tggattcata atagcaagat tagcaaagga taaatgccga
     1681 aggtcacttc attctggaca cagttggatc aatactgatt aagtagaaaa tccaagcttt
     1741 gcttgagaac ttttgtaacg tggagagtaa aaagtatcgg ttttattctt tgctgatgtc
     1801 ctttctgctt gaaataacag tcaccataca gctaaaggag aggagtttct ttccttctaa
     1861 gtaggcagaa atggtatcat tatgttgccg ctctccaatc tcccagagct cgctctctag
     1921 agaatcacct tctttcgctt tttttttttt ttttgaggta gagtctcact atgttgccca
     1981 gactagcctt gaactcttgg gctcaagtga ttctccctcc tcagcctccc gagtagctgg
     2041 aacgaactat agttgcacca ctgcagctgg caagaatcac cttctttata aagcgtcagt
     2101 catgcttcca gcaagaggca gcatcagtca tggctttata acagcttcat ggtgcctcaa
     2161 agactgttga ggttaatgag agcctagatt agacagtttg gctgtccttc cctaaaactt
     2221 gttttctcct attcactact ccccaccgca cttaaaatct atgagttttt actttttact
     2281 gggaatggaa agtgtggtga agatcattca acacttatgt tgtcatttct cccattttct
     2341 gaattttttt ttaaatttcc ccccttttaa aattgttcga aagcccacag ttatggaaag
     2401 aattactgtc tagatggtct gcagaacgtg tttggggtga gtgggagtga ggggcaatgt
     2461 tactttttct ccctgtagtt tggagtccat tatgagctgc tgctttttct tctcatcttg
     2521 tcatcttctg gggatgtttg aaggctgagt tccaacagaa ttcacaaagg gaataaaaca
     2581 ggattgagat tttgaggtgt gcacaaggtg gtaagataaa gggcatatga gcttcaaaac
     2641 taatgctgtt gcatacatga agccttttgt tttttgagga gctatttttg ttattcttgt
     2701 aacgctccac cttacatgcc acatctgtgt gagtcaacag ggatcaggtt tggtcaccac
     2761 acatgtctga agctgggcag cgtctgctct gtgttctgtg tggaatggag aaaaaaacgc
     2821 ctgccctgct gccttccatg ttcataggcc cagcccaaga gagtgacaca cagtgctggc
     2881 cctgagacat ttccacaaag tggtcaactc tgccttgcat cctaaaactt tttgggcatc
     2941 tattttgaaa actataggag cctttggaag gcctcttatg tttggagggg aagggtgttg
     3001 agattgtcac catccttcaa gctgagactc ctggtgagcc tttgccacca tgaaaaccac
     3061 atagctgacc agggctgtgc ttgaggtaca gaggacacac attgtagaca ggcctgtgtc
     3121 atgtttcctt acagtcgttt tttacagaga aaaggggcat tgttttttca ctgctttctc
     3181 aacagttcct gtgaataaat gaaacatttc ggagctccct gagagcaaga gccttcactt
     3241 cttcttgcgg tgccgggacc atgtgttggt gaagctggtg ctgtgggggc cactcactcg
     3301 aatgacacct ggaggcctgt tcctccctta ccactccctt ccccagcccg acttcttggc
     3361 ctcctgccca accagacacc tcaaactctg tcagtgccct ggcattctgg cagagaatcc
     3421 tcaccagttc tcaccaacct tccccccagg caagggcagc tgccagcatg gtgctctgcc
     3481 aggacaggtt tccctgaagg aagctgctca cactgagatg agcctctcag ggcaggacct
     3541 cttcccaagc cctgcacacc cacccctgca gcccttttgg ctcccctttt ccctgtgcct
     3601 cagcactcct ttcctggttg cagataacga actaaggttg cctaaagggc agatctgccc
     3661 tctccatgtc ttcgtcctgg caaacagggt cgtcttaaaa ttatgcgcta attctgtatg
     3721 ggagcactca aaaggcatta cttagagatt gaaatttcaa actatctcta gtttttcaat
     3781 ggaaatatat cagctaggga aaaaccatca agctcattat tattttttga tcttcagttg
     3841 tatttttgtg aatattttaa tacatctttt tcaatttctg aattgtgttg tgtgctcatt
     3901 ttgaccagaa tagaaaaaga gatatgcctt tcactcatat cattccagct acacctgcct
     3961 tcttttcttc aaaaatgccg tccgtgtgcc tgcttctggg cctttgcaca tgctgttccc
     4021 tgggcctgaa gcatgccttc tgccaatatt cctgtggttt gctctctgac ttcctttaag
     4081 cctctgctca aatgttacct cctcagggag accttctgtg atatataaaa gagcaagccc
     4141 cccaccccac cgcctcagcc ttcctggccc cctcagttct gctctagtta ctctatttct
     4201 ctccctcttt cccagtacac acttgtctgt tctcccgcat tagaacatag ttaacaagag
     4261 accagaacct tgctgttttg ttcactgctc cgtctgcagt aaagggaaca gcacctggca
     4321 cttagctgct caatacatgt tacgtggatg gatgagtagg tggaagcatt catccattca
     4381 gcaacctaca ctgagaacaa tcctgtgcca agcactgtgc taagcataag gaaacaaaac
     4441 aagacaaagc tcctcaagga gcttgccaca gggtggaggt gacaggtgac atgaatggaa
     4501 gtaactagta gttaccaaat acttggtgtg agccaggcac tttgcatttc tttctctatt
     4561 atttctgtga gttaacagta attgtactaa tcttaatccc attgtttgaa agattatatg
     4621 gcttacccag ggccacttag ctaataaagg aacagagaag aggggctggg cctggggccg
     4681 ctgtttgatc cacagccttg ttcctaacca ctatgccctg tggcctctca caccaaaagg
     4741 aagtaccaaa ctgcttcctt actcaaataa atgtgctgaa atgcagttgc agttttctcc
     4801 cagtccctta ggagctggtt agagagtccc ttaggaactt gagagggtag tgtagtctag
     4861 gtggtaggca cagatgtctg agagctttaa cctcagtctg gaagacaatg tggtgactta
     4921 atttgttgag aactatgtta caaataatgt gttactaata aaacattgag gcttcgca
//
