LOCUS       NM_032683               1578 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MPV17 mitochondrial inner membrane protein like 2
            (MPV17L2), mRNA.
ACCESSION   NM_032683
VERSION     NM_032683.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Yi,W.R., Tu,M.J., Yu,A.X., Lin,J. and Yu,A.M.
  TITLE     Bioengineered miR-34a modulates mitochondrial inner membrane
            protein 17 like 2 (MPV17L2) expression toward the control of cancer
            cell mitochondrial functions
  JOURNAL   Bioengineered 13 (5), 12489-12503 (2022)
   PUBMED   35579419
  REMARK    GeneRIF: Bioengineered miR-34a modulates mitochondrial inner
            membrane protein 17 like 2 (MPV17L2) expression toward the control
            of cancer cell mitochondrial functions.
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Dalla Rosa,I., Durigon,R., Pearce,S.F., Rorbach,J., Hirst,E.M.,
            Vidoni,S., Reyes,A., Brea-Calvo,G., Minczuk,M., Woellhaf,M.W.,
            Herrmann,J.M., Huynen,M.A., Holt,I.J. and Spinazzola,A.
  TITLE     MPV17L2 is required for ribosome assembly in mitochondria
  JOURNAL   Nucleic Acids Res 42 (13), 8500-8515 (2014)
   PUBMED   24948607
  REMARK    GeneRIF: The findings suggest MPV17L2 contributes to the biogenesis
            of the mitochondrial ribosome, uniting the two subunits to create
            the translationally competent monosome.
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Sawcer,S., Hellenthal,G., Pirinen,M., Spencer,C.C.,
            Patsopoulos,N.A., Moutsianas,L., Dilthey,A., Su,Z., Freeman,C.,
            Hunt,S.E., Edkins,S., Gray,E., Booth,D.R., Potter,S.C., Goris,A.,
            Band,G., Oturai,A.B., Strange,A., Saarela,J., Bellenguez,C.,
            Fontaine,B., Gillman,M., Hemmer,B., Gwilliam,R., Zipp,F.,
            Jayakumar,A., Martin,R., Leslie,S., Hawkins,S., Giannoulatou,E.,
            D'alfonso,S., Blackburn,H., Martinelli Boneschi,F., Liddle,J.,
            Harbo,H.F., Perez,M.L., Spurkland,A., Waller,M.J., Mycko,M.P.,
            Ricketts,M., Comabella,M., Hammond,N., Kockum,I., McCann,O.T.,
            Ban,M., Whittaker,P., Kemppinen,A., Weston,P., Hawkins,C.,
            Widaa,S., Zajicek,J., Dronov,S., Robertson,N., Bumpstead,S.J.,
            Barcellos,L.F., Ravindrarajah,R., Abraham,R., Alfredsson,L.,
            Ardlie,K., Aubin,C., Baker,A., Baker,K., Baranzini,S.E.,
            Bergamaschi,L., Bergamaschi,R., Bernstein,A., Berthele,A.,
            Boggild,M., Bradfield,J.P., Brassat,D., Broadley,S.A., Buck,D.,
            Butzkueven,H., Capra,R., Carroll,W.M., Cavalla,P., Celius,E.G.,
            Cepok,S., Chiavacci,R., Clerget-Darpoux,F., Clysters,K., Comi,G.,
            Cossburn,M., Cournu-Rebeix,I., Cox,M.B., Cozen,W., Cree,B.A.,
            Cross,A.H., Cusi,D., Daly,M.J., Davis,E., de Bakker,P.I.,
            Debouverie,M., D'hooghe,M.B., Dixon,K., Dobosi,R., Dubois,B.,
            Ellinghaus,D., Elovaara,I., Esposito,F., Fontenille,C., Foote,S.,
            Franke,A., Galimberti,D., Ghezzi,A., Glessner,J., Gomez,R.,
            Gout,O., Graham,C., Grant,S.F., Guerini,F.R., Hakonarson,H.,
            Hall,P., Hamsten,A., Hartung,H.P., Heard,R.N., Heath,S., Hobart,J.,
            Hoshi,M., Infante-Duarte,C., Ingram,G., Ingram,W., Islam,T.,
            Jagodic,M., Kabesch,M., Kermode,A.G., Kilpatrick,T.J., Kim,C.,
            Klopp,N., Koivisto,K., Larsson,M., Lathrop,M., Lechner-Scott,J.S.,
            Leone,M.A., Leppa,V., Liljedahl,U., Bomfim,I.L., Lincoln,R.R.,
            Link,J., Liu,J., Lorentzen,A.R., Lupoli,S., Macciardi,F., Mack,T.,
            Marriott,M., Martinelli,V., Mason,D., McCauley,J.L., Mentch,F.,
            Mero,I.L., Mihalova,T., Montalban,X., Mottershead,J., Myhr,K.M.,
            Naldi,P., Ollier,W., Page,A., Palotie,A., Pelletier,J., Piccio,L.,
            Pickersgill,T., Piehl,F., Pobywajlo,S., Quach,H.L., Ramsay,P.P.,
            Reunanen,M., Reynolds,R., Rioux,J.D., Rodegher,M., Roesner,S.,
            Rubio,J.P., Ruckert,I.M., Salvetti,M., Salvi,E., Santaniello,A.,
            Schaefer,C.A., Schreiber,S., Schulze,C., Scott,R.J., Sellebjerg,F.,
            Selmaj,K.W., Sexton,D., Shen,L., Simms-Acuna,B., Skidmore,S.,
            Sleiman,P.M., Smestad,C., Sorensen,P.S., Sondergaard,H.B.,
            Stankovich,J., Strange,R.C., Sulonen,A.M., Sundqvist,E.,
            Syvanen,A.C., Taddeo,F., Taylor,B., Blackwell,J.M., Tienari,P.,
            Bramon,E., Tourbah,A., Brown,M.A., Tronczynska,E., Casas,J.P.,
            Tubridy,N., Corvin,A., Vickery,J., Jankowski,J., Villoslada,P.,
            Markus,H.S., Wang,K., Mathew,C.G., Wason,J., Palmer,C.N.,
            Wichmann,H.E., Plomin,R., Willoughby,E., Rautanen,A.,
            Winkelmann,J., Wittig,M., Trembath,R.C., Yaouanq,J.,
            Viswanathan,A.C., Zhang,H., Wood,N.W., Zuvich,R., Deloukas,P.,
            Langford,C., Duncanson,A., Oksenberg,J.R., Pericak-Vance,M.A.,
            Haines,J.L., Olsson,T., Hillert,J., Ivinson,A.J., De Jager,P.L.,
            Peltonen,L., Stewart,G.J., Hafler,D.A., Hauser,S.L., McVean,G.,
            Donnelly,P. and Compston,A.
  CONSRTM   International Multiple Sclerosis Genetics Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     Genetic risk and a primary role for cell-mediated immune mechanisms
            in multiple sclerosis
  JOURNAL   Nature 476 (7359), 214-219 (2011)
   PUBMED   21833088
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068499.1, BC093008.1, BG740168.1 and BC005064.1.
            
            On May 17, 2019 this sequence version replaced NM_032683.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093008.1, SRR1163657.346282.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000599612.3/
                                                  ENSP00000469836.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC068499.1         18036-18047
            13-13               BC093008.1         1-1
            14-638              BG740168.1         2-626
            639-665             BC093008.1         627-653
            666-711             BG740168.1         652-697
            712-809             BC093008.1         700-797
            810-1372            BC005064.1         713-1275
            1373-1578           AC068499.1         21561-21766
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1578
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /note="MPV17 mitochondrial inner membrane protein like 2"
                     /db_xref="GeneID:84769"
                     /db_xref="HGNC:HGNC:28177"
                     /db_xref="MIM:616133"
     exon            1..251
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..685
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /note="mpv17-like protein 2; MPV17 mitochondrial membrane
                     protein-like 2"
                     /codon_start=1
                     /product="mpv17-like protein 2 precursor"
                     /protein_id="NP_116072.2"
                     /db_xref="CCDS:CCDS42522.1"
                     /db_xref="GeneID:84769"
                     /db_xref="HGNC:HGNC:28177"
                     /db_xref="MIM:616133"
                     /translation="MARGGWRRLRRLLSAGQLLFQGRALLVTNTLGCGALMAAGDGVR
                     QSWEIRARPGQVFDPRRSASMFAVGCSMGPFLHYWYLSLDRLFPASGLRGFPNVLKKV
                     LVDQLVASPLLGVWYFLGLGCLEGQTVGESCQELREKFWEFYKADWCVWPAAQFVNFL
                     FVPPQFRVTYINGLTLGWDTYLSYLKYRSPVPLTPPGCVALDTRAD"
     exon            252..422
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /inference="alignment:Splign:2.1.0"
     exon            423..499
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /inference="alignment:Splign:2.1.0"
     exon            500..628
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1578
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /note="hexamer: AATAAA"
     polyA_site      1372
                     /gene="MPV17L2"
                     /gene_synonym="FKSG24"
                     /note="major polyA site"
ORIGIN      
        1 gactcgcgac tggtcggcgc ggcgaaagca gagcggcgcg ccggttcctt ggttcctgag
       61 ggcgatggcg cggggtggct ggcgccggct acgccgcctg ttatccgcgg ggcagcttct
      121 attccagggc cgcgcgctgc tcgtcactaa cacgctgggc tgcggcgcgc tcatggcggc
      181 cggtgatggc gtgcgccagt cctgggagat ccgcgcccgg cccggccagg ttttcgaccc
      241 acggcgctcc gcgagcatgt ttgcggtggg ctgcagcatg ggtcccttcc tgcactactg
      301 gtacttgtcg ctggaccgcc tattccctgc gtctggcctc cgaggcttcc caaatgtcct
      361 caagaaggtc ctcgtggatc agctggtagc ctctccattg ctgggcgtct ggtacttctt
      421 gggccttggc tgcctggagg gtcagacagt gggtgagagc tgccaggagc tgcgggagaa
      481 gttctgggaa ttctacaagg cagactggtg cgtgtggcct gctgcgcagt tcgtgaactt
      541 cctcttcgtg cccccccaat ttcgagtcac ctacatcaac ggcctgacgc tgggctggga
      601 cacgtacctg tcctacttga agtaccggag cccagttcct ctgacacccc caggctgtgt
      661 ggccctggac acccgagcag actgaactgt ctgcttcctg gaccagatgc aagactgtct
      721 cctggcggac caccccctct gacagaaggg gaatgggctc ctgcagcaag ctcgggtctt
      781 gagccacgtc ccagcaccac ttcagctccg gagcattggg ctgagccgcc ctttccaagc
      841 tcacttctgg gactgagttt cctcaaccgg aacacaccca tgaagatgga tgatcatccc
      901 ctagcccttc tcagcaggaa cctcatgcga cctgtgacca agatgtccca tcctcagcac
      961 agggcccact ctgccaacca gtctcaagca ccagcccctc aacactgcca tccacctggc
     1021 tctgggccaa gccaccaatc cagagctccc tcaggtcctg ggactaaggc ggggacatga
     1081 ctgatcccct cagagcaggc tcaggcctgg agtcggcccc caaaagtttc acatagggcc
     1141 aggcagcctc tgtgtttctt tccctggtcc tgaactgtgg aaatgccatt aaactctctc
     1201 tataatgtaa ctgaaactgc tggctgggcg cagtggctcc cacctgtaat ctcagccctt
     1261 cccgaggctg aggtggaagg attgctcgag gccaggtgtt cgagaccagc ctgggcaaca
     1321 tagcaagacc ctgtctctat ttatattgaa aaataaaaat aacaaaagaa aatgctgtgg
     1381 atgatcaaaa ccagggtggg caggacccgg tgctcacagg gacacacatg gatggtccat
     1441 tcgctttatt gggtgcgtgt agtgttgtca tgacatctcc taaggaactg gggggcacgt
     1501 ttgacactca tgaggtcaga acaggtctgg tgggcggggg gggggggggt cccagggtgg
     1561 tgaataccca cagcacac
//
