LOCUS       NM_001128423            5894 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens MPV17 mitochondrial inner membrane protein like
            (MPV17L), transcript variant 1, mRNA.
ACCESSION   NM_001128423
VERSION     NM_001128423.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5894)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Human Mpv17-like protein with a mitigating effect on mtDNA damage
            is involved in cAMP/PKA signaling in the mitochondrial matrix
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (10), 118792 (2020)
   PUBMED   32621840
  REMARK    GeneRIF: Human Mpv17-like protein with a mitigating effect on mtDNA
            damage is involved in cAMP/PKA signaling in the mitochondrial
            matrix.
REFERENCE   2  (bases 1 to 5894)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Identification of interacting partners of Human Mpv17-like protein
            with a mitigating effect of mitochondrial dysfunction through mtDNA
            damage
  JOURNAL   Free Radic Biol Med 87, 336-345 (2015)
   PUBMED   26165189
  REMARK    GeneRIF: these observations suggest that M-LPH is involved in the
            maintenance of mtDNA and protects cells from mitochondrial
            dysfunction.
REFERENCE   3  (bases 1 to 5894)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Identification of Rhit as a novel transcriptional repressor of
            human Mpv17-like protein with a mitigating effect on mitochondrial
            dysfunction, and its transcriptional regulation by FOXD3 and GABP
  JOURNAL   Free Radic Biol Med 52 (8), 1413-1422 (2012)
   PUBMED   22306510
REFERENCE   4  (bases 1 to 5894)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   5  (bases 1 to 5894)
  AUTHORS   Iida,R., Yasuda,T., Tsubota,E., Takatsuka,H., Matsuki,T. and
            Kishi,K.
  TITLE     Human Mpv17-like protein is localized in peroxisomes and regulates
            expression of antioxidant enzymes
  JOURNAL   Biochem Biophys Res Commun 344 (3), 948-954 (2006)
   PUBMED   16631601
REFERENCE   6  (bases 1 to 5894)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM838624.1, DQ004255.1 and AC140504.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001128423.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ004255.1, SRR3476690.331198.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000396385.4/
                                                  ENSP00000379669.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BM838624.1         1-93
            94-1719             DQ004255.1         94-1719
            1720-2309           AC140504.2         102894-103483
            2310-5894           AC140504.2         103484-107068
FEATURES             Location/Qualifiers
     source          1..5894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..5894
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /note="MPV17 mitochondrial inner membrane protein like"
                     /db_xref="GeneID:255027"
                     /db_xref="HGNC:HGNC:26827"
                     /db_xref="MIM:618100"
     exon            1..454
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..735
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Mpv17-like protein type 1; Mpv17-like protein type 2; M-LP
                     homolog; MPV17 mitochondrial membrane protein-like; Human
                     Mpv17-like protein"
                     /codon_start=1
                     /product="mpv17-like protein isoform 1"
                     /protein_id="NP_001121895.1"
                     /db_xref="CCDS:CCDS45421.1"
                     /db_xref="GeneID:255027"
                     /db_xref="HGNC:HGNC:26827"
                     /db_xref="MIM:618100"
                     /translation="MAGWWPALSRAARRHPWPTNVLLYGSLVSAGDALQQRLQGREAN
                     WRQTRRVATLVVTFHANFNYVWLRLLERALPGRAPHALLAKLLCDQVVGAPIAVSAFY
                     VGMSILQGKDDIFLDLKQKFWNTYLSGLMYWPFVQLTNFSLVPVQWRTAYAGVCGFLW
                     ATFICFSQQSGDGTFKSAFTILYTKGTSATEGYPKK"
     exon            455..525
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..555
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..5894
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4623..4628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4647
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /note="major polyA site"
     regulatory      5769..5774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /note="hexamer: ATTAAA"
     polyA_site      5799
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
     regulatory      5865..5870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
                     /note="hexamer: ATTAAA"
     polyA_site      5894
                     /gene="MPV17L"
                     /gene_synonym="M-LPH; M-LPH1; M-LPH2; MLPH1; MLPH2;
                     MPV17L1"
ORIGIN      
        1 aatcgctccg gagcttctgg agggggcaga tgcaggtgcc ggctgctgca gtgcagtagc
       61 tgctggaggc tggggaggcc cggacccggt gcaggaagac gccgaccacg cgggctcctg
      121 atcgcgggcg cccacagcgc ggacatggcg ggctggtggc cggcgttgtc gcgcgcggcc
      181 cggcgccacc cgtggcccac caacgtgctg ctttacggct cgctcgtctc ggccggggac
      241 gcgctgcaac agcggctgca gggccgcgag gccaactggc gccagacgcg gcgcgtggcc
      301 acgttggtgg tgaccttcca cgccaacttc aactacgtgt ggctgcgcct gctggagcgc
      361 gcgctcccgg gccgagcgcc gcacgccctg ctggccaagt tgctgtgcga ccaggtggtc
      421 ggtgcgccca tcgcggtctc ggccttctat gtcggtatga gcattctcca aggaaaggat
      481 gacatatttt tggacctgaa acagaaattc tggaatacct atctgagtgg actgatgtac
      541 tggccctttg tacagctgac caacttcagc cttgttcctg ttcaatggag aacagcttac
      601 gctggagtct gtggttttct ctgggccacc ttcatctgtt tttcccagca gagtggtgac
      661 ggcacattca agtcagcttt caccatttta tatacaaagg ggaccagtgc cacagaaggg
      721 tacccgaaga aatgagaagt caaggactct cttaaaggga ccacattttt tacctaaaat
      781 gcacagaatt gcctgcagac aaaatatttg atgtgccaat tatgcacttc attttgagga
      841 attactacta tttatagacc cactttttaa aaaattatca atgattattt ttgaattgta
      901 ttcagacttt tttcctgttc tagtctgaaa tattacttct ctaatatttt ggttaatatg
      961 aataatagtg gcaaaatggc attttagaat tattaatatt tctaatattt taacacaagt
     1021 ttcaggaaac ttggttttga ttgttcacat ttctattcta aaatctcagg ttatctcctg
     1081 aacacttttg ggcagatgaa gttttatacc aaaaaatagt tcttagagtg aattttaatt
     1141 tacatagaac tcaatcgaaa tgaagattta ataaccagat ttctttctcc aaaacataca
     1201 caatttgtta ttttagtaaa tacctttttt tttttttttt tttttgtggt ggagtcttgc
     1261 tgtctccccg gctggagcgc agtggcacga tcgcggctca ctgcagcctc catcctctgg
     1321 gttcaagcaa ttctcctgcc tcaggctcct gagtagctgg gattacaggc acgtgacacc
     1381 aggcccagct gatttttgta tttttgttca tttgcttttg tttttgacac agagtctcgc
     1441 tctgtcgccc aggctggaat gcagttgtga gatctcggct cactgcaagc tccgcctccc
     1501 gggttcacgc cattctgcgt cagcctccca agtagctggg actacaggca cctgccacga
     1561 tgcctagcta attttttgta tttttagtag agatgaagtt tcaccgtgtt ggccaggatg
     1621 gtcttgatct cctgaccgca taatccaccc acctcggcct cccaaagtgc tgggattaca
     1681 ggcgtgagcc accacaaccg actttttttt tttttttttt ttgagacaga gactcgctct
     1741 gtcacccagg ctggagtgca gtggcatgat ttcggctcac tgcaacctct gtctcctggg
     1801 ttcaaacgat cctactgcct catccttcgg agtagctggg attacaggca ggtgccacca
     1861 tgcctggctc atttttgtat ttttagtaga gagggcgttt tgccatgttg gctaggctgg
     1921 tctctgtccg tcctctgagc tcaagctaag ccatcatatc ccagtgacct gcacatatac
     1981 atccagatgg cctgaagtta ctgaagatcc acagaagtga aaatagcctt aactgatgac
     2041 attgcaccat tgtgatatgt tactgcccca ccctaactga tcaatgtact ttgtaatcct
     2101 cccaccctta agaaggttct ttttaattct ccccaccctt gagaatgtac tttgtgagat
     2161 ccacccctgc ccgcaaaaca ttgctccaaa ctccaccacc tatccccaaa cctgtaagaa
     2221 ctaatgataa tccaccaccc tttgctgact ccttttttgg actcagcccg cctgcactca
     2281 ggtgaaataa acagccatgt tgctcataca aagcctgttt ggtggcctct tcacacggac
     2341 acgtgagaca gtctccaact cctggcctca actgatccac tctcattggc ctcccaaggt
     2401 gctgggatta taggcatgag ccaccgcacc tggctcagta agtacatttt ttattatcaa
     2461 aaacagagta gtgtatgatt ggcgtattct gtgtagaatg tattttattg atgtcttcta
     2521 tttttataat ttttaatgaa tgctttttag ttttgggcag attcagttga ctaaagcacc
     2581 tcatttccca gatacatgaa ataaaatact tggtttcttt tccaatttca cactgatgtt
     2641 attttgtgaa aatcagtgct ttaagataaa tatttatact ttaaggtaaa catgagaaac
     2701 ttgatctaat atttaatatt tattcagttc tacactttat taacttctac accagcagat
     2761 ttaaaaatta tgtaactatc tcaagaagtt tcacttggac gtagtggttc acgcttgtaa
     2821 tcccagcact ttgggaggct gaggtgggag gattgcttaa ggcaaggagt ttgagaccag
     2881 cctgggcaat acagcaagat cccatctcta ttttaaagaa aagtttcact ttgggaggcc
     2941 aaggcggttg gatcacaagg tcaggagatc gagaccatcc tggctaacat ggtaaaaccc
     3001 catctctact aaaaatacaa aaaattagcc aggcgtggtg gtgggcgcct gtagtcccag
     3061 ctactcggga ggctgaggca gacgaatggc atgaacccgg gaggcagaga ttgcagtgag
     3121 ctgagattgt gccactgcac tccagcctgg gtgacagagt gagactccgt ctcaaaaaaa
     3181 aaaagtttca gtaaattcca cctaagaatt ccaccagagt tctgtcatct ccaatgtcat
     3241 gttccacaga tttcaagttg tgaagccctg aactgttaat ttatcctgag aatgtatatt
     3301 taagcttaat ttaagactat atacctaaaa attgagcata taatttgtat aatttgttta
     3361 tgtaagtttc tgtaagtcat aaatatgtag tttccaagtg gataatttac ctgaatgtaa
     3421 aaggcattaa tatattttac attattggga ccatagtaca gaaatttcta aatggtttgt
     3481 aaaataactt gttatttgct ttgttgtaaa agtagttaat acaatggaaa aatggtttcg
     3541 taataagaag atacatttta acatcaaaac gtaggccggg cacagtggct tacgcctgta
     3601 atcccagcac tttgggaggc cgaggcgggc agatcacgag gtcaggagat cgagaccatc
     3661 ctggctaaca tggtgaaacg ccatctctac taaaaataca aaaaattagc tgggcatggt
     3721 ggcgggcgcc tgtagtccca gctgctctgg aggctgaggc aggagaattg catgaacccg
     3781 ggaggcggag cttgcagtga gcagagatca ggccactgca ctccagccta ggcgacagag
     3841 cgagaatctg tctcaaaaca aacaaacaaa caaaaaactg tacccaagtt aattataagt
     3901 actacctggt gcaaaacttt acagaagctg tggtatcact tttatgatag aagaatagtg
     3961 tttgcatttt gtataaaagt acttggggct gggcatgatc gcttatgtct ataatccaag
     4021 tgctttggga ggcgaaggca ggtggatcat ctgagcccag gagtttgaga ccagcctagg
     4081 caacatggca agagcctgtc tctccaaaac ctacaaaaat tagccaagca tggtggtgtg
     4141 agcctgtagt cccagctact tggaagactc atgcaggagg atctctcgag ctcaggaggc
     4201 agaagatgaa taaataaatg gatgcaactg aatgagatga ggtctctctt gaaggagaga
     4261 gcaaaagaga tttaaataat aacaattata agaaggctgg gcgcggtggc tcatgcttgt
     4321 aatcccagca ctttgggagg ccaaggcagg tggatcggtt gaggtcagga gttcaagacc
     4381 agcatggcca acacagtgaa accccgtctc tattaaaaat acaaaattaa ccggacatgg
     4441 tagtgcgtcc tgtagtctca gctactcagg tggctgagac aggagaatcg cttgaacctg
     4501 ggaggcatag gttgtagtga gccgataaat ataaaaagta ttaaagtact aacagaagaa
     4561 aatttccact gatcaccctt tagctttaaa taatgcagaa gcatatgccc agtttacttg
     4621 taattaaaaa tcatgcatca ttcacaattt atcagtcttt tttgtttgta caaaaactaa
     4681 tataagttat tctcttttat ttgtattgtg attggtttga tgagagggaa ttaggccact
     4741 tgagagtttg tgcgtgttta taattttctg gctgggcccg gtggctcatg cctgtaatcc
     4801 cagcactttg ggaggccaag gcgggcggat cacttgagct caggagtttg agaccaactt
     4861 gggcaatgtg gtgaaaccct atccctacca aaaatacaaa aattagccgg gtgtggtggc
     4921 ttgcacctgt cctcccagct acttgggggt gctgaggcag gaggatcact caagcccagg
     4981 aggtggaggt tgcagtgagc cgagatcacg ccactgcact ccaggaaggg caacagagca
     5041 agactgtgtc tataaaaaaa aaaaaaaaga aagaaaagta aattaacttt ggtatttcag
     5101 gttgtattta tatggggact tcacatcaac tatgttcact acaattgacc aagttaagtg
     5161 tagacagtct ctttaataga gagattatct ggaactgcaa tttttttttt ttttttgaga
     5221 cagagtttcg ctttgtagcc caggttggag tgcagtgtcg cgatctcgcc tcactgcaac
     5281 ctctgtctcc cgggttcacg ccattctcct gcctcagccc aagtagcagg gactaaaggc
     5341 gcccgccacc atgacccact aatttttttt ttttttggat ttttagtaga gtcggggttt
     5401 cactgtgtta gccaggatgg tctcaacctc ctgacctcgt gatctgcctg cctctgcctc
     5461 ccagagtgct gggattacag gtgtgagcca ccgcgcccgg cctggaactg caatttctaa
     5521 ctcatacatc attgctataa accttatttg tttactgttt ctcttccaag gacggtcagt
     5581 catcctttaa aattcatttg aagttatgaa aagatagttt ttgttacatg ggaaatttac
     5641 ttttagtaca gtaaaatgtt atgtgaattt ctacagaatg tttgctagaa tgaattatat
     5701 ctaggatatg cttaacaata tattctggag gcagctttca tttgaaatta ggttcatctt
     5761 ctgagagtat taaaaagtta atgggttttt gtgcctgaag attttgatgt tgcatttggc
     5821 tacatttaat ccactttcac ccataaggtt tagcatctaa aaaaattaaa tcactgctaa
     5881 tgcaattaaa atga
//
