LOCUS       NM_001044370            3436 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens metallophosphoesterase domain containing 1 (MPPED1),
            transcript variant 1, mRNA.
ACCESSION   NM_001044370 NM_001585 XM_936442
VERSION     NM_001044370.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Schwartz,F. and Ota,T.
  TITLE     The 239AB gene on chromosome 22: a novel member of an ancient gene
            family
  JOURNAL   Gene 194 (1), 57-62 (1997)
   PUBMED   9266672
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Schwartz,F., Eisenman,R., Knoll,J., Gessler,M. and Bruns,G.
  TITLE     cDNA sequence, genomic organization, and evolutionary conservation
            of a novel gene from the WAGR region
  JOURNAL   Genomics 29 (2), 526-532 (1995)
   PUBMED   8666403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA773758.1, BC028035.1, U84894.1 and BX546033.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001044370.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290541.1, SRR1803613.216925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465404
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443721.2/ ENSP00000400686.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               DA773758.1         1-136
            137-220             BC028035.1         1-84
            221-282             U84894.1           47-108
            283-2328            BC028035.1         147-2192
            2329-2483           U84894.1           2155-2309
            2484-2508           BC028035.1         2348-2372
            2509-3436           BX546033.2         4712-5639
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3436
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="metallophosphoesterase domain containing 1"
                     /db_xref="GeneID:758"
                     /db_xref="HGNC:HGNC:1306"
                     /db_xref="MIM:602112"
     exon            1..145
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            146..447
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1204
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="adult brain protein 239; metallophosphoesterase
                     domain-containing protein 1"
                     /codon_start=1
                     /product="metallophosphoesterase domain-containing protein
                     1 precursor"
                     /protein_id="NP_001037835.1"
                     /db_xref="CCDS:CCDS46723.1"
                     /db_xref="GeneID:758"
                     /db_xref="HGNC:HGNC:1306"
                     /db_xref="MIM:602112"
                     /translation="MWRSRWDASVLKAEALALLPCGLGMAFSQSHVMAARRHQHSRLI
                     IEVDEYSSNPTQAFTFYNINQGRFQPPHVQMVDPVPHDAPKPPGYTRFVCVSDTHSRT
                     DPIQMPYGDVLIHAGDFTELGLPSEVKKFNEWLGSLPYEYKIVIAGNHELTFDQEFMA
                     DLIKQDFYYFPSVSKLKPENYENVQSLLTNCIYLQDSEVTVRGFRIYGSPWQPWFYGW
                     GFNLPRGQALLEKWNLIPEGVDILITHGPPLGFLDWVPKKMQRVGCVELLNTVQRRVQ
                     PRLHVFGHIHEGYGVMADGTTTYVNASVCTVNYQPVNPPIVIDLPTPRNS"
     exon            448..629
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            630..855
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            856..971
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1085
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..3436
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2484..2489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2508
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="major polyA site"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="hexamer: ATTAAA"
     polyA_site      3328
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
     regulatory      3413..3418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="MPPED1"
                     /gene_synonym="239AB; C22orf1; FAM1A"
                     /note="major polyA site"
ORIGIN      
        1 acttgcagcc tcggacgcgc ggcgaggcgg ccgccgccgg aggagccccc gcccctgcgc
       61 gcctccctcc cgggagcccc tgcctccctc ggtgcgcgct gctgctcgca gccgccgcgg
      121 ccgccgaaga ggagcccggg gccagtctgt ttccaggtct ggcggggggc cgggctgcgg
      181 tggcggcagc ggtgggagat gccggggcgg ccggcggagg tccatgtggc gctctaggtg
      241 ggatgccagc gtcctgaagg cggaggccct ggccctcctc ccctgcggcc tgggcatggc
      301 attctcccag tcccacgtga tggccgctcg gcggcaccag cacagccggc tcatcatcga
      361 ggtggacgag tacagctcca accccaccca ggccttcacc ttctacaaca tcaaccaggg
      421 ccgcttccag ccaccgcatg tgcagatggt ggacccggtg cctcacgatg cccccaaacc
      481 tccaggctac acccgcttcg tctgcgtctc tgatacccac tcgaggacgg accccatcca
      541 gatgccgtac ggcgacgtgc tgatccacgc tggggacttc actgagctgg ggctcccgag
      601 cgaggtgaag aagttcaacg agtggctggg cagcctgccc tacgagtaca agatcgtgat
      661 cgcaggcaac cacgagctga cctttgacca ggagttcatg gccgacctca tcaagcagga
      721 cttttactac ttcccatctg tgtcgaagct gaagccggag aactatgaga atgtgcagtc
      781 gctgctgacc aactgcatct accttcagga ctcggaggtc accgtgcggg gcttccggat
      841 ctatggctcc ccatggcagc cctggttcta cggctggggc ttcaacctcc cgcgaggcca
      901 agccctgctg gagaaatgga acctcattcc cgaaggcgta gacatcctga taacccatgg
      961 accaccactg ggcttcctgg actgggtccc caagaagatg cagcgggtgg gctgtgtgga
     1021 gctgctcaac acggtgcaga ggcgcgtcca gccgcggtta catgtctttg gccacatcca
     1081 cgaagggtat ggtgtcatgg cagatgggac gaccacctat gtgaatgcgt ccgtatgcac
     1141 tgtgaactac cagcccgtga acccgcccat agtcatcgac ctccccacac cccggaactc
     1201 ctgactgctc cccactgccc ctgccctgcc cgcccgtgtc agctccacag gcctggcccg
     1261 gccactgttc cttccatgct gagttgcctg gacgacccat ctggctgcgg ggactggcct
     1321 agcaggcagg tcagggcctt ggaacgactc tttagccttc tgtcacctgg agttgggacc
     1381 ctgcgcatcc ccatcagggg ttctgtgctc atttactttt tctgcgtgta catcctgcgt
     1441 gtacctcgtt aaaggaccta ctaagctcat ggccctgtca tgtttgggaa atgactaaat
     1501 cttcattctt ctcccttgga cgccctcctg gtttgggaag ctgctgctct tgaatgggtt
     1561 ttggaagtta cacaaaatct ccctctaacc acgggtctgt gtggcggcat gcccctgggt
     1621 tggggtgggt gggaggattc gtgagctgca cacagacagt ccctttctct cctcccaagt
     1681 gagggaggag acaggcccaa ggcggaggcc ctccgaggga gcatttaggg acatctcagg
     1741 aattcagacc gcacctggcc aggcccacag ctgtttgcct ggcattgttc cccccttttt
     1801 cttcccatag gcatttttgt ttacttgaac aatgacctga gtgtcctagg cattcactcg
     1861 gagcctggat gatgggggct ggttctacag aatgagccac tggcattcgt gcccaggacc
     1921 agtgagagcg ttcccagtca tggggggatg acccttggtc ccacggggaa cacactgctc
     1981 tgtagaatgc ggtagcctgg atggagggtc tgcaggctta ggctgcagca ggcctgccat
     2041 gggtgtgaac ccatgtccag gcacgcaccg acacacatgc acgcacgcac ccctcttaat
     2101 tgaaccaagt gggtcctgtg tttctctttt ctgccccgta gtgaggttct gttccttggt
     2161 gcggcttccc ttgcaccgtt aggattctgt ctggcatgcc tgcagccgag gaagcccagg
     2221 accagccggc cctgtgaatt ggagggtggc acagggaccg agcgggcccc aggctccagc
     2281 agccccacct tggacagctt ctttttcttc tttgaattag gactggaggg ggtggggcca
     2341 gggcggtggt gggaaccggt agggcctaga tgaggggcag gcagtcaggc agaaatgggc
     2401 aagttcaggg tcagattctg tcgttattta atattttgtt catcatggac tttttctgca
     2461 tttattttga tttttaacgt tgcattaaag tagtattatt tgtcctgatt ggtgactttt
     2521 tttgcacccc tttccgttgt acatctgaga gaagggtgtc actccctcac ccaggtccca
     2581 gccctgggaa ccagcctacc gtgagccctt ttgcagatat agactcattt catcctcaga
     2641 tggtccttca aggtaggtac tttagtccca ttttagagat gagacgattg aggccagagg
     2701 ggtgtggtaa cttgcctggg ggctcacagc acaaaaggag ccgaggcagg atctgaccct
     2761 tgttctctgg cctcactgcc ctcactttgc catgacccga agttatgtcc ctacaaagca
     2821 atgcatggtc caaggctctt tttattgtat ttttattttt aagggtcctg ttcaaaactg
     2881 gtgtgagctc tgaggagtcc tgaaccctgg gtgcagcatc ctagcatcct gggagtcctt
     2941 ttctgcccac actgagctgg gctcctcgag gggtggggct gctgtccctg gaagcctggc
     3001 agcagcactg tatcgggttg gctgaagctg agcgccgtgg ggtgcagggc tccaggaatc
     3061 ccgtttggct gaaggggttc ctgtagccag ggatgtttat gaggtctctc tgatgcccca
     3121 ggcgcaggac atgtgtgcgg gtggagaaaa gcaggccctt tcagtgccag ctccactcaa
     3181 tttctatgtg gaccaagaac gataaactta aaaaaatttt tttcctaagg tatcttcaga
     3241 atatggtgta tttttatgtg gaaaagaaaa gttatgaagg cagctgttac tttaagagaa
     3301 aattcattaa aagtcctcga ggtatgaaga tgacggcgtg cttctcaatc attttggcat
     3361 aacttgattg tggctgtaat tttttttttt ttttttgtca agcatgtcag acaataaagt
     3421 ctttgtaaaa agagaa
//
