LOCUS       NM_023075               3330 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens metallophosphoesterase 1 (MPPE1), transcript variant
            1, mRNA.
ACCESSION   NM_023075
VERSION     NM_023075.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3330)
  AUTHORS   Chen,X., Xu,J., Wang,P., Shang,L., Guo,J., Huang,L., Jiang,Y.A.,
            Chen,J., Chen,H., Shang,Y. and Zhang,Q.
  TITLE     Metallophosphoesterase 1, a novel candidate gene in hepatocellular
            carcinoma malignancy and recurrence
  JOURNAL   Cancer Biol Ther 21 (11), 1005-1013 (2020)
   PUBMED   33054568
  REMARK    GeneRIF: Metallophosphoesterase 1, a novel candidate gene in
            hepatocellular carcinoma malignancy and recurrence.
REFERENCE   2  (bases 1 to 3330)
  AUTHORS   Hirata,T., Mishra,S.K., Nakamura,S., Saito,K., Motooka,D.,
            Takada,Y., Kanzawa,N., Murakami,Y., Maeda,Y., Fujita,M.,
            Yamaguchi,Y. and Kinoshita,T.
  TITLE     Identification of a Golgi GPI-N-acetylgalactosamine transferase
            with tandem transmembrane regions in the catalytic domain
  JOURNAL   Nat Commun 9 (1), 405 (2018)
   PUBMED   29374258
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3330)
  AUTHORS   Lohoff,F.W., Ferraro,T.N., Brodkin,E.S., Weller,A.E. and Bloch,P.J.
  TITLE     Association between polymorphisms in the metallophosphoesterase
            (MPPE1) gene and bipolar disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (3), 830-836 (2010)
   PUBMED   19859903
  REMARK    GeneRIF: These results provide evidence of an association between a
            polymorphism in the MPPE1 gene and bipolar disorder.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3330)
  AUTHORS   Fujita,M., Maeda,Y., Ra,M., Yamaguchi,Y., Taguchi,R. and
            Kinoshita,T.
  TITLE     GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored
            proteins from the ER to the Golgi
  JOURNAL   Cell 139 (2), 352-365 (2009)
   PUBMED   19837036
  REMARK    GeneRIF: Data demonstrate that glycosylphosphatidylinositol(GPI)
            glycan acts as an endoplasmic reticulum-exit signal and suggest
            that glycan remodeling mediated by PGAP5 regulates GPI-anchored
            proteins transport in the early secretory pathway.
REFERENCE   5  (bases 1 to 3330)
  AUTHORS   Yosifova,A., Mushiroda,T., Stoianov,D., Vazharova,R., Dimova,I.,
            Karachanak,S., Zaharieva,I., Milanova,V., Madjirova,N.,
            Gerdjikov,I., Tolev,T., Velkova,S., Kirov,G., Owen,M.J.,
            O'Donovan,M.C., Toncheva,D. and Nakamura,Y.
  TITLE     Case-control association study of 65 candidate genes revealed a
            possible association of a SNP of HTR5A to be a factor susceptible
            to bipolar disease in Bulgarian population
  JOURNAL   J Affect Disord 117 (1-2), 87-97 (2009)
   PUBMED   19328558
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3330)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
REFERENCE   7  (bases 1 to 3330)
  AUTHORS   Vuoristo,J.T. and Ala-Kokko,L.
  TITLE     cDNA cloning, genomic organization and expression of the novel
            human metallophosphoesterase gene MPPE1 on chromosome 18p11.2
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 60-63 (2001)
   PUBMED   11978971
  REMARK    GeneRIF: cDNA cloning, genomic organization and expression of the
            novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB035278.1, AF363484.1, BC002877.2, AL833636.1, AW663162.1 and
            AP001269.4.
            
            On May 17, 2019 this sequence version replaced NM_023075.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.58912.1,
                                           SRR1660803.89480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588072.6/ ENSP00000465894.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                DB035278.1         481-549
            70-1406             AF363484.1         552-1888
            1407-1899           BC002877.2         1078-1570
            1900-2193           AL833636.1         1743-2036
            2194-2354           AW663162.1         114-274
            2355-2481           AL833636.1         2199-2325
            2482-3330           AP001269.4         17917-18765         c
FEATURES             Location/Qualifiers
     source          1..3330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..3330
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="metallophosphoesterase 1"
                     /db_xref="GeneID:65258"
                     /db_xref="HGNC:HGNC:15988"
                     /db_xref="MIM:611900"
     exon            1..117
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            118..224
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            225..597
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1507
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metallo phosphoesterase; post-GPI attachment to proteins
                     factor 5; post-GPI attachment to proteins 5"
                     /codon_start=1
                     /product="metallophosphoesterase 1 isoform 1"
                     /protein_id="NP_075563.3"
                     /db_xref="CCDS:CCDS11853.1"
                     /db_xref="GeneID:65258"
                     /db_xref="HGNC:HGNC:15988"
                     /db_xref="MIM:611900"
                     /translation="MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYL
                     AIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAF
                     QTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDI
                     GFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVS
                     HRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFK
                     ENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSF
                     IMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGK
                     RKTR"
     exon            598..706
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            707..810
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            811..885
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            886..994
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1060
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1183
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1324
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..3330
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1874..1879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="hexamer: AATAAA"
     polyA_site      1907
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="major polyA site"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="hexamer: AATAAA"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="hexamer: AATAAT"
     polyA_site      2476
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
     polyA_site      2481
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2545
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="hexamer: GATAAA"
     polyA_site      2776
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2894
                     /gene="MPPE1"
                     /gene_synonym="Cdc1; PGAP5"
ORIGIN      
        1 gcagttcccg ggtccctcgg ccaccgaagc caccctgccc tggtgaaagg gctcccgcac
       61 cgcccggtgc tccccatctg cctggcgttg tgcgcagagc tggaaagcat ggctgttata
      121 aatgaattct gattttgggg agcagatgcc aacttagagc ctcgtaccaa tctctctgtc
      181 tttaaaagat gaggtgactt ggtgattttc ctggaaaatt ataggtgccc agctaagacc
      241 tgaatgccat caccctcccc agggctctgc agttttctcg tggtgaaccc ttgatggatt
      301 tgttgttgct tgagaaatgg cgatgatcga attggggttt ggaagacaga attttcatcc
      361 attaaagagg aagagttcat tgctgttgaa actcatagct gttgtctttg ctgtgcttct
      421 attttgtgaa tttttaatct attacttagc gatctttcag tgtaattggc ctgaagtgaa
      481 aaccacagcc tctgatggtg aacagaccac acgtgagcct gtgctcaaag ccatgttttt
      541 ggctgacacc catttgcttg gggaattcct aggccactgg ctggacaaat tacgaaggga
      601 atggcagatg gagagagcgt tccagacagc tctgtggttg ctgcagccgg aagtcgtctt
      661 catcctgggg gatatctttg atgaagggaa gtggagcacc cctgaggcct gggcggatga
      721 tgtggagcgg tttcagaaaa tgttcagaca cccaagtcat gtacagctga aggtagttgc
      781 tggaaaccat gacattggct tccattatga gatgaacaca tacaaagtag aacgctttga
      841 gaaagtgttc agctctgaaa gactgttttc ttggaaaggc attaactttg tgatggtcaa
      901 cagcgtggcg ctgaacgggg atggctgtgg catctgctct gaaacagaag cagagctcat
      961 tgaagtttct cacagactga actgctcccg agaggcacgt ggctccagcc ggtgtggacc
     1021 tgggcctctg ctgcccacgt ctgcccctgt cctcctgcag cattatcctc tgtatcggag
     1081 aagtgatgct aactgttctg gggaagacgc tgctcctgca gaggaaaggg acatcccatt
     1141 taaggagaac tatgacgtgc tttcacggga ggcatcacaa aagctgctgt ggtggctcca
     1201 gccgcgcctg gttctcagtg gccacacgca cagcgcctgc gaggtgcacc acgggggccg
     1261 agtccccgag ctcagcgtcc catctttcag ttggaggaac agaaacaacc ccagtttcat
     1321 catgggtagc atcacgccca cagactacac cctctccaag tgctacctcc cacgtgagga
     1381 tgtggttttg atcatctact gtggagtggt gggcttcctt gtggtcctca cactcactca
     1441 ctttgggctt ctagcctcac cttttctttc tggtttgaac ttgctcggaa agcgtaagac
     1501 aagatgaaga gcaggcgcca ttataaatat caaagcccaa gaaatggaac tttgggcaga
     1561 gatcatgtta gaatcaagtg gatgatgaga ccaattacag gccgtctctc tgcacagcac
     1621 agaaattctc aatcactgaa atgagtaact gcaaaataaa tagttgattg tactgttctc
     1681 atgctataaa agtggacagg tactctacaa caaatctgtt ttctcatttt tatcaaatat
     1741 atgtatcatc aaaggttgca tctgtacagt atgtaaatgc tattaatgtc gtcactcaca
     1801 tgcacgacag tccttgttcc cccaggaagg gcctggtggc cccagcacac acttgggatt
     1861 atgtgtatac ataaataaat attgggctgt ttccctcttc ctgtgaagtg gttctcaaat
     1921 tcctatgtac tgtaaagctg tacccttaaa agtacagatg tggccgggca cagtggctca
     1981 cacctgtaat cccagcactt tgggaggctg aggcgggtgg atcacttgag gtcaggagtt
     2041 caagaccagc ctggccaaca tggtgaaacc tcgtctccgc tagaaataca aaaattagcc
     2101 aagcatggta gcaagtgcct ataataccag ctgaggctga ggcaggagaa tcccttgagc
     2161 ccgggaggcg gaggttgcag tgagccaaga tcatgccact gcactccagc ctgggcaaca
     2221 gagtgagact ccgtctcaaa aaatatattt aaaaaaaaaa aagtacagat gtgatgtgca
     2281 gaacatattg ttttcgtaga tttttatact tgatcaatta atggaatcag atttttagat
     2341 aagtgtaatt ttctctatag gagaccacgt tgctacatct gttaatgcct gtcagtgatc
     2401 aaaagaaact taaaaagtgg aatgggatat ggcttttggt acctgaaaat aaatgcttta
     2461 ataattgtaa gccagataaa agttattctt tttgtttttt ttcttaacag tctggctgtt
     2521 gtttgaatta aactcttaaa caggatgttt agttagaggg taattgttga gtaatgatgc
     2581 atacaacagc atacttccct ttcttgctgg gggtgcagct tttcagtttt cttgttttac
     2641 tttgacagtg caaggggaac tgaaaataat ttccattgta ttatttatct tagttcagct
     2701 gagggcttta tgagacagtg gatggggagg cagtaagacg gtgatgagat aaaatgtgtg
     2761 tgttgcactg actgtctata aagttatcct ttcttcatga aaaagtagca tttaaatctg
     2821 gatgagttta taaaggatta caaaatgctg atttatagag taaactttaa aatattaaag
     2881 actaaagact aaaagaagag taataatgaa gtaatgtagg ctgtcacttc tctagatttg
     2941 tattgttgaa aatttaactt tggacatctt tatagattat tattttagac ctacaaaaac
     3001 taccctcaac tctgtggcta cagctagaat atgaagcatc attgctacac cagttcttac
     3061 tttctagata ttgttggtgt gtcataatgt ttgaggctgt atttgtaagt cttgcaagtg
     3121 tgagaaagag ccgtatcttt tgactttata cttcagatta aggttttgta atgtttcttc
     3181 ttcaaaaggc aagtgaagct gtcatcctca ttctcctagg ccagacacaa acattgacac
     3241 gtcaaggttt tttttttttt tttttttggc ctgagtctca ctttgatgtc caggctggag
     3301 tgcgatggca cgacctcggc tcactgcaat
//
