LOCUS       NM_001318170            5138 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAGUK p55 scaffold protein 7 (MPP7), transcript
            variant 1, mRNA.
ACCESSION   NM_001318170 XM_005252367
VERSION     NM_001318170.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5138)
  AUTHORS   Li,R., Zhang,W., Shi,B., Ma,L., Jiang,F., Wang,X. and Li,J.
  TITLE     A common variant SNP rs1937810 in the MPP7 gene contributes to the
            susceptibility of breast cancer in the Chinese Han population
  JOURNAL   Mol Genet Genomic Med 11 (9), e2198 (2023)
   PUBMED   37194388
  REMARK    GeneRIF: A common variant SNP rs1937810 in the MPP7 gene
            contributes to the susceptibility of breast cancer in the Chinese
            Han population.
REFERENCE   2  (bases 1 to 5138)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5138)
  AUTHORS   Liao,W., Fan,L., Li,M., Deng,H., Yang,A. and Liu,F.
  TITLE     MPP7 promotes the migration and invasion of breast cancer cells via
            EGFR/AKT signaling
  JOURNAL   Cell Biol Int 45 (5), 948-956 (2021)
   PUBMED   33377561
  REMARK    GeneRIF: MPP7 promotes the migration and invasion of breast cancer
            cells via EGFR/AKT signaling.
REFERENCE   4  (bases 1 to 5138)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5138)
  AUTHORS   Hamanoue,H., Megarbane,A., Tohma,T., Nishimura,A., Mizuguchi,T.,
            Saitsu,H., Sakai,H., Miura,S., Toda,T., Miyake,N., Niikawa,N.,
            Yoshiura,K., Hirahara,F. and Matsumoto,N.
  TITLE     A locus for ophthalmo-acromelic syndrome mapped to 10p11.23
  JOURNAL   Am J Med Genet A 149A (3), 336-342 (2009)
   PUBMED   19208380
REFERENCE   6  (bases 1 to 5138)
  AUTHORS   Bhoj,E.J., Romeo,S., Baroni,M.G., Bartov,G., Schultz,R.A. and
            Zinn,A.R.
  TITLE     MODY-like diabetes associated with an apparently balanced
            translocation: possible involvement of MPP7 gene and cell polarity
            in the pathogenesis of diabetes
  JOURNAL   Mol Cytogenet 2, 5 (2009)
   PUBMED   19216786
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5138)
  AUTHORS   Ngai,H.H., Sit,W.H., Jiang,P.P., Thongboonkerd,V. and Wan,J.M.
  TITLE     Markedly increased urinary preprohaptoglobin and haptoglobin in
            passive Heymann nephritis: a differential proteomics approach
  JOURNAL   J Proteome Res 6 (8), 3313-3320 (2007)
   PUBMED   17616219
REFERENCE   8  (bases 1 to 5138)
  AUTHORS   Stucke,V.M., Timmerman,E., Vandekerckhove,J., Gevaert,K. and
            Hall,A.
  TITLE     The MAGUK protein MPP7 binds to the polarity protein hDlg1 and
            facilitates epithelial tight junction formation
  JOURNAL   Mol Biol Cell 18 (5), 1744-1755 (2007)
   PUBMED   17332497
  REMARK    GeneRIF: MPP7 targets to the lateral surface of epithelial cells
            via its L27N domain, through an interaction with Dlg1.
REFERENCE   9  (bases 1 to 5138)
  AUTHORS   Bohl,J., Brimer,N., Lyons,C. and Vande Pol,S.B.
  TITLE     The stardust family protein MPP7 forms a tripartite complex with
            LIN7 and DLG1 that regulates the stability and localization of DLG1
            to cell junctions
  JOURNAL   J Biol Chem 282 (13), 9392-9400 (2007)
   PUBMED   17237226
  REMARK    GeneRIF: MPP7 is a PDZ protein that interacts with human
            papillomavirus-16 E6 and forms a tripartite complex with LIN7A or
            LIN7C and DLG1, regulating the stability and localization of DLG1
            to cell junctions.
REFERENCE   10 (bases 1 to 5138)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human MPP7 gene and mouse
            Mpp7 gene in silico
  JOURNAL   Int J Mol Med 13 (2), 333-338 (2004)
   PUBMED   14719143
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301592.1, AK315046.1,
            AL832380.1, BG542434.1 and BQ774044.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001318170.1.
            
            Summary: The protein encoded by this gene is a member of the p55
            Stardust family of membrane-associated guanylate kinase (MAGUK)
            proteins, which function in the establishment of epithelial cell
            polarity. This family member forms a complex with the polarity
            protein DLG1 (discs, large homolog 1) and facilitates epithelial
            cell polarity and tight junction formation. Polymorphisms in this
            gene are associated with variations in site-specific bone mineral
            density (BMD). Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the supported protein.
            Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.113584.1,
                                           SRR1803615.47011.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683449.1/ ENSP00000507917.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AK301592.1         3-55
            54-1299             AK315046.1         1-1246
            1300-1458           AK301592.1         1183-1341
            1459-2066           AK315046.1         1406-2013
            2067-3552           AL832380.1         1999-3484
            3553-3808           BG542434.1         128-383
            3809-4245           AL832380.1         3741-4177
            4246-4963           AL832380.1         4179-4896
            4964-5138           BQ774044.1         16-190              c
FEATURES             Location/Qualifiers
     source          1..5138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..5138
                     /gene="MPP7"
                     /note="MAGUK p55 scaffold protein 7"
                     /db_xref="GeneID:143098"
                     /db_xref="HGNC:HGNC:26542"
                     /db_xref="MIM:610973"
     exon            1..204
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            205..372
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..2066
                     /gene="MPP7"
                     /note="membrane palmitoylated protein 7; membrane protein,
                     palmitoylated 7 (MAGUK p55 subfamily member 7)"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 7"
                     /protein_id="NP_001305099.1"
                     /db_xref="CCDS:CCDS7158.1"
                     /db_xref="GeneID:143098"
                     /db_xref="HGNC:HGNC:26542"
                     /db_xref="MIM:610973"
                     /translation="MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGE
                     KSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKP
                     NVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTG
                     AIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIP
                     GSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAK
                     HEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTN
                     KSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISD
                     TQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSID
                     SVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRD
                     DQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETET
                     HWVPVSWLHS"
     exon            373..491
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            492..569
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            570..650
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            651..782
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            783..864
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            865..950
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1025
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1222
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1287
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1458
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1539
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1633
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1742
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1886
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..5138
                     /gene="MPP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPP7"
                     /note="hexamer: AATAAA"
     polyA_site      4957
                     /gene="MPP7"
                     /note="major polyA site"
     regulatory      5111..5116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPP7"
                     /note="hexamer: ATTAAA"
     polyA_site      5138
                     /gene="MPP7"
                     /note="major polyA site"
ORIGIN      
        1 gttggttact agccgggctg gaggcggggg ccgggctccc actgggctcg tgcgttctgc
       61 gcccgccgcg gcggtgccga gcccgctggc tcccgattgt cctctgcggc ggtggcggtc
      121 gctgcctcct tgcctccggg cccggggctg caggggccag agcgagtgcg cctcctgccc
      181 gcggaccgcg gcagcccaga gcagaaacgg cttacaaaat atacagatct tggtagacaa
      241 cgtggctgca ggctgttgaa ttggaattcc ctgtggctgt ccgaaggcag ggtgtccgga
      301 gagcggtggg ctgacctgtt cctacacctt gcatcatgcc agctttgtca acgggatctg
      361 ggagtgacac tggtctgtat gagctgttgg ctgctctgcc agcccagctg cagccacatg
      421 tggatagcca ggaagacctg accttcctct gggatatgtt tggtgaaaaa agcctgcatt
      481 cattggtaaa gattcatgaa aaactacact actatgagaa gcagagtccg gtgcccattc
      541 tccatggtgc ggcggccttg gccgatgatc tggccgaaga gcttcagaac aagccattaa
      601 acagtgagat cagagagctg ttgaaactac tgtcaaaacc caatgtgaag gctttgctct
      661 ctgtacatga tactgtggct cagaagaatt acgacccagt gttgcctcct atgcctgaag
      721 atattgacga tgaggaagac tcagtaaaaa taatccgtct ggtcaaaaat agagaaccac
      781 tgggagctac cattaagaag gatgaacaga ccggggcgat cattgtggcc agaatcatga
      841 gaggaggagc tgcagataga agtggtctta ttcatgttgg tgatgaactt agggaagtca
      901 acgggatacc agtggaggat aaaaggcctg aggaaataat acagattttg gctcagtctc
      961 agggagcaat tacatttaag attatacccg gcagcaaaga ggagacacca tcaaaagaag
     1021 gcaagatgtt tatcaaagcc ctctttgact ataatcctaa tgaggataag gcaattccat
     1081 gtaaggaagc tgggctttct ttcaaaaagg gagatattct tcagattatg agccaagatg
     1141 atgcaacttg gtggcaagcg aaacacgaag ctgatgccaa ccccagggca ggcttgatcc
     1201 cctcaaagca tttccaggaa aggagattgg ctttgagacg accagaaata ttggttcagc
     1261 ccctgaaagt ttccaacagg aaatcatctg gttttagaaa aagttttcgt cttagtagaa
     1321 aagataagaa aacaaataaa tccatgtatg aatgcaagaa gagtgatcag tacgacacag
     1381 ctgacgtacc cacatacgaa gaagtgacac cgtatcggcg acaaactaat gaaaaataca
     1441 gactcgttgt cttggttggt cccgtgggag tagggctgaa tgaactgaaa cgaaagctgc
     1501 tgatcagtga cacccagcac tatggcgtga cagtgcccca taccaccaga gcaagaagaa
     1561 gccaggagag tgatggtgtt gaatacattt tcatttccaa gcatttgttt gagacagatg
     1621 tacaaaataa caagtttatt gaatatggag aatataaaaa caactactac ggcacaagta
     1681 tagactcagt tcggtctgtc cttgctaaaa acaaagtttg tttgttggat gttcagcctc
     1741 atacagtgaa gcatttaagg acactagaat ttaagcccta tgtgatattt ataaagcctc
     1801 catcaataga gcgtttgaga gaaacaagaa aaaatgcaaa gattatttca agcagagatg
     1861 accaaggtgc tgcaaaaccc ttcacagaag aagattttca agaaatgatt aaatctgcac
     1921 agataatgga aagtcaatat ggtcatcttt ttgacaaaat tataataaat gatgacctca
     1981 ctgtggcatt caatgagctc aaaacaactt ttgacaaatt agagacagag acccattggg
     2041 tgccagtgag ctggttacat tcataactaa gagaaatttc cataattgtc tttttctata
     2101 gagtgcatga tgaaatcaat tacagttttg gtagtagggt ttttaaatct atatcactgt
     2161 catagatgta caatcttggt tcaagttgaa tgctggtttt gtttgtatct ttttacagcc
     2221 ttatttcaaa cgccatgtgt tagtataaga tccgaaatca aaatatgcac agtactgtat
     2281 tctaagcaaa acctcaaacc ttctcgttgt cttcaatacc gctctatctc caagatgagg
     2341 ctgaaatttt cagagagact tagctagagg cttagtatgt atgggagttc agcgcttctg
     2401 ctggtctcag gtgtggctgc tgctgtcgag tttgaatgtt agctgttgaa ggtatcaatt
     2461 cagcagccat gagcagctcc agacagacag gtgagctctg ctgtttctgg gtggatcatc
     2521 acagatttag ccgggcaggc agtaaggtgt cctcttacta ttcaaaaagt gtagactttc
     2581 ttacatattc gcaatacgtt cacagtgtgt gcattttaaa ataattctta aaggagtaac
     2641 tgaaatttta ccttgagtga atggccttca taatatagct tgagaagtcc ttttgagtac
     2701 ctgtcagtga ctcaacaaca tttaataagg gaaagtagac ttttaacagt tattatatat
     2761 gtaacgaaaa gcctttcctt tgggattaat ataagtaaga atggtagcct tgtggcaaga
     2821 aatgattaca aaggatattt ttatttgtaa ttcctcagaa gacaatttat gaagtcaccc
     2881 aaaatgttat tttagctggt tttggatttt tccaataaat tagaagaagg atttctattc
     2941 taaaacatgt aaaacctgtt ttacatatta ctgatacaat taaagattat ttttcatcta
     3001 tgtgcaatag atcacccctc tttaaattgc tctaagattt attttagaaa acttttcatg
     3061 tgatgttatt tctttgtcat caaaatgctt gttaacactg tccagacacc atcctaacct
     3121 tgccattgtt aaagaagttt aggaaagact cttatattgt aaatatttag atgggttctc
     3181 tcacttttct ttgatactac tgattttcag caagtgaatt atataattca aaatgctaga
     3241 aatgtctatc cgttctataa gagagcatat cctgccgttc ttgcatgcag tgaagccctg
     3301 cccgtcgaaa atcattgcat ctgtgacttt caaagtggaa aaaaaaatgt tatttttttg
     3361 ttgatttgta aagagagttt aaatgtcatg tgaaaaaaaa tagaatgtag taaaattcta
     3421 tatatttatg aaatatttta aaggcatatt tttttaaata tcaaacgggg ctattcataa
     3481 aataaactga ttgtatgtca agatgtccta atttaaaaga gtagttttat aaatcatggt
     3541 caacattcca tgtaaatatt tgagctttac aaagatagat ccaagtgtgc gatctgtgca
     3601 ctgcacattt gatagcatta ttcactggtt ttccttcata cttgtcaagt tcatattaga
     3661 agcagagaca aaaaccactc caatggcctt gacacatagt cacaccaaaa tagataatca
     3721 gactaagtat tatataacaa cgtgatccag acagtgagtt ctaagtgtat taattaaata
     3781 gcaaaaaatt ttgtttttaa aaaatgaaag agggagggtt gccaacctga agtcttaagt
     3841 agattgtttg ggtagcatat ttccttcttt gaacattgtc tgaaattttc tataaatcaa
     3901 gacttcttgt acaaagaatg atgggacata tgtaataatt caggcaatca cctgagtaat
     3961 ttaggcagtc caaattcttt accctgaaat acccacattt taaaaaaatt gcagataatt
     4021 gcttcagtta tttactttgg ggacagagat atagtgtaaa gtgggagaaa ctgagtcctt
     4081 ttttggtggt ggtaataata agatgttata aaaatataac attttaaaaa agaaaggtcc
     4141 agaccttaag cgcagagcta gaacaatatt ttttaaataa tggggggaaa agggggcact
     4201 ttggtaattt tagaaatcag gtagtatact tttttttttt tttttgagac agggtcttgc
     4261 catgttgctc aggctggtct tgaactcctg ggctcaagca atcctcctgc cttggcctcc
     4321 caaagtgctg ggattacagg catgatccac cgtgcccagc cggtagacgt ggtcttaaaa
     4381 acagtgttta catggccatc ttgatgctta gaaagataat tgattaaaat ttaataaggc
     4441 agggccaact ccgagagttc attgacaacg gcagcaaaaa ggccctgaat tctgtacttt
     4501 cttcccccag cctccttctc cagcaaggag aatagcactc ctccctccag aagccagctc
     4561 cctaagttgg agccactatg taagagaaga ggaacgttca ctttttaaaa ttcatatatt
     4621 taaaaatcaa gaccaaaaag taaattctgt actcctatta ttgactgtag tcaatcaaac
     4681 ataaaaaggt gaaagtaaaa tttaattttt tacccttatt ttactgacca atatggaagt
     4741 tcttggtatc tttaaggctg accttcctgg tattgtgtaa tgattgaatg tatctaaact
     4801 gtaataattt gaaactgaca aacataacct tctcagactt acaaaactat gttctttcta
     4861 aagatacaga tttttattat tttattttga ctaggaagga tttataaata aatgtaatga
     4921 aaaatctttg atcttaataa agtaccttca aacagtgtgt gtacttactt gaaaattgtt
     4981 tttgcacttg gatattctat tttattatac tactattgtg atctattcca ttatactatt
     5041 tcccatggta gaacaaatta tattttctac tgtgatatga agtgatgtaa ttgaacttgc
     5101 catgtctaaa attaaatttc atattttttt caatcaaa
//
