LOCUS       NM_001932               2790 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens MAGUK p55 scaffold protein 3 (MPP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001932
VERSION     NM_001932.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Milewski,K., Bogacinska-Karas,M., Fresko,I., Hilgier,W.,
            Jazwiec,R., Albrecht,J. and Zielinska,M.
  TITLE     Ammonia Reduces Intracellular Asymmetric Dimethylarginine in
            Cultured Astrocytes Stimulating Its yLAT2 Carrier-Mediated Loss
  JOURNAL   Int J Mol Sci 18 (11), 2308 (2017)
   PUBMED   29099056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Sakurai-Yageta,M., Maruyama,T., Suzuki,T., Ichikawa,K. and
            Murakami,Y.
  TITLE     Dynamic regulation of a cell adhesion protein complex including
            CADM1 by combinatorial analysis of FRAP with exponential
            curve-fitting
  JOURNAL   PLoS One 10 (3), e0116637 (2015)
   PUBMED   25780926
  REMARK    GeneRIF: a central role of CADM1 in stabilizing the complex with
            4.1B and MPP3
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Kantardzhieva,A., Alexeeva,S., Versteeg,I. and Wijnholds,J.
  TITLE     MPP3 is recruited to the MPP5 protein scaffold at the retinal outer
            limiting membrane
  JOURNAL   FEBS J 273 (6), 1152-1165 (2006)
   PUBMED   16519681
  REMARK    GeneRIF: These data implicate a role for MPP3 in photoreceptor
            polarity and, by association with MPP5, pinpoint MPP3 as a
            functional candidate gene for inherited retinopathies.
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Fukuhara,H., Masuda,M., Yageta,M., Fukami,T., Kuramochi,M.,
            Maruyama,T., Kitamura,T. and Murakami,Y.
  TITLE     Association of a lung tumor suppressor TSLC1 with MPP3, a human
            homologue of Drosophila tumor suppressor Dlg
  JOURNAL   Oncogene 22 (40), 6160-6165 (2003)
   PUBMED   13679854
  REMARK    GeneRIF: MPP3, a human homologue of a Drosophila tumor suppressor
            gene (Discs large), associates with TSCL1, a tumor suppressor gene.
            Erratum:[Oncogene. 2004 Jan 15;23(2):629. Masvuda Maria [corrected
            to Masuda Maria]]
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Shin,B.K., Wang,H., Yim,A.M., Le Naour,F., Brichory,F., Jang,J.H.,
            Zhao,R., Puravs,E., Tra,J., Michael,C.W., Misek,D.E. and
            Hanash,S.M.
  TITLE     Global profiling of the cell surface proteome of cancer cells
            uncovers an abundance of proteins with chaperone function
  JOURNAL   J Biol Chem 278 (9), 7607-7616 (2003)
   PUBMED   12493773
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Smith,S.A., Holik,P., Stevens,J., Mazoyer,S., Melis,R.,
            Williams,B., White,R. and Albertsen,H.
  TITLE     Isolation of a gene (DLG3) encoding a second member of the
            discs-large family on chromosome 17q12-q21
  JOURNAL   Genomics 31 (2), 145-150 (1996)
   PUBMED   8824795
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA585178.1, BC056865.1,
            DB357996.1 and U37707.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001932.5.
            
            Summary: This gene product is a member of a family of
            membrane-associated proteins termed MAGUKs (membrane-associated
            guanylate kinase homologs). MAGUKs interact with the cytoskeleton
            and regulate cell proliferation, signaling pathways, and
            intracellular junctions. This protein contains a conserved
            sequence, called the SH3 (src homology 3) motif, found in several
            other proteins that associate with the cytoskeleton and are
            suspected to play important roles in signal transduction.
            Alternatively spliced transcript variants have been identified. One
            transcript variant is experimentally supported, but it doesn't
            encode a protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313045.1, SRR3476690.1136307.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398389.9/ ENSP00000381425.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DA585178.1         34-86
            54-2158             BC056865.1         1-2105
            2159-2375           DB357996.1         1-217               c
            2376-2790           U37707.1           2570-2984
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2790
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /note="MAGUK p55 scaffold protein 3"
                     /db_xref="GeneID:4356"
                     /db_xref="HGNC:HGNC:7221"
                     /db_xref="MIM:601114"
     exon            1..46
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            47..105
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            106..167
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1900
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /note="isoform 1 is encoded by transcript variant 1; MAGUK
                     p55 subfamily member 3; discs, large homolog 3; membrane
                     protein palmitoylated 3; membrane protein, palmitoylated 3
                     (MAGUK p55 subfamily member 3); membrane palmitoylated
                     protein 3"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 3 isoform 1"
                     /protein_id="NP_001923.2"
                     /db_xref="CCDS:CCDS42344.1"
                     /db_xref="GeneID:4356"
                     /db_xref="HGNC:HGNC:7221"
                     /db_xref="MIM:601114"
                     /translation="MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLS
                     YLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRA
                     VLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAV
                     VVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPAT
                     QEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRV
                     GDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGH
                     YVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIG
                     SLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNK
                     FLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQ
                     EKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLK
                     VVLEKLSKDTHWVPVSWVR"
     exon            168..286
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            287..364
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..445
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            446..583
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..665
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..751
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..826
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1023
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1088
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1109
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1151
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1316
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1397
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1491
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1600
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1723
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2790
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /note="hexamer: ATTAAA"
     polyA_site      2183
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /note="major polyA site"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /note="hexamer: AATAAA"
     polyA_site      2790
                     /gene="MPP3"
                     /gene_synonym="DLG3"
                     /note="major polyA site"
ORIGIN      
        1 actcgcgcgg ctcccgttcg cggagcacac atcccggcgc gacgaggttc cttcggagag
       61 cgagcgggag tcggtgctcg gcctcctgcg gggagcagcc cgaggaatct gcagggagag
      121 gtcgggaggt gacaacgcca gcatgccagt gctatcggag gactctggtt tgcatgaaac
      181 cctggccctg ctgacctccc agctcagacc tgactccaac cacaaggagg agatgggctt
      241 cctgagggat gttttcagtg aaaaaagcct cagttactta atgaagattc atgagaagct
      301 tcgctattat gaaaggcaaa gtccaacccc agttctgcac agcgctgtgg ccctcgctga
      361 ggacgtgatg gaggagttgc aggccgcctc cgtgcacagt gatgagaggg agctgctcca
      421 gctgctgtcc accccgcacc tgagggctgt gctcatggta catgacacgg ttgcccagaa
      481 gaattttgac cccgttctcc cgcctctgcc tgacaatatc gatgaggatt ttgatgagga
      541 atcggtgaag atcgtccgct tggtgaagaa caaggaaccc ctgggtgcca ccatccggcg
      601 ggacgagcac tcaggggctg ttgtggtggc caggatcatg cgaggaggcg cagcagacag
      661 gagcggcctg gtccacgttg gagatgagct ccgagaagtg aacgggatcg cagtcctgca
      721 caagcggccc gacgagatca gccagattct ggcccagtcc cagggatcca tcaccctaaa
      781 aatcatccca gccacccagg aggaagatcg cttaaaggag agcaaggtgt tcatgcgcgc
      841 cctcttccac tacaaccctc gggaggaccg ggccatccct tgccaggagg cgggcctgcc
      901 cttccagcgc aggcaggtcc tggaggtggt gagccaggac gaccccacgt ggtggcaggc
      961 caagcgagtc ggggacacca accttcgagc cggcctcatc ccctccaagg ggttccagga
     1021 gagacgacta agctaccgga gagccgcggg caccctgccg agcccccaga gcctcaggaa
     1081 gcccccctat gatcagcctt gtgacaaaga gacctgtgac tgtgagggct acctcaaagg
     1141 gcactatgtg gctggtcttc ggaggagctt ccggctgggc tgtagggaga gactgggtgg
     1201 ctcgcaggaa ggaaagatgt cctccggagc tgagtctccg gagctgctga cttacgaaga
     1261 ggtggccagg taccaacacc agcccggaga gcggccccgc ctggtggttc tgatcgggtc
     1321 tctgggagcc cgactgcacg agctgaagca aaaggtggtg gctgagaacc cacagcactt
     1381 tggcgtcgct gttccacata ccaccaggcc ccgaaagagc catgagaagg aaggagtgga
     1441 atatcacttt gtgtctaagc aagcatttga ggccgactta catcacaaca agttcctgga
     1501 acatggtgaa tataaggaaa atctgtatgg aaccagcctg gaggccattc aggctgttat
     1561 ggccaaaaac aaagtttgtt tggtggatgt ggagccagaa gcactgaaac aactgaggac
     1621 ctcagaattt aaaccctata ttatatttgt aaagcctgca attcaggaaa aaagaaaaac
     1681 gccacctatg tccccagctt gtgaggacac agcagcccca tttgatgagc agcagcaaga
     1741 gatggccgct tctgccgcct tcatagaccg gcattacggg cacctggtag acgccgtgct
     1801 ggtgaaggag gatctccagg gtgcctacag ccagctcaaa gtggtcttag agaagctgag
     1861 caaggacact cactgggtac ctgttagttg ggtcaggtaa ctttatccca gaacatccaa
     1921 gctggacggg accttgaaga tcatctagtc cagactccct cattttacca tcaaggaatc
     1981 tcaagcgcag agagggagag aattctccac aaattccatc atcgagaaga gtataagtgg
     2041 gaagtcttgt ttgttgttgg tttttgtctg ttgtttttca ctgcacctct ttggatcatg
     2101 atttgaaagg ggcatatcag aaaacaacac atttcattta ttaaagtatc acaggcaagc
     2161 tgaccctgat tctttgtacc aaagttaagt agccactgtc ttttgtgggt ggtagtggtt
     2221 aatttataca gtactgattc gcagaatgtt taagcttttt aaacatagtg acgcttagta
     2281 gtttttttgg aagctaactt gttttatcca aggggatttt acatgtaact gaagttcccc
     2341 tgtcttcaag cactaaaacg ttgatcttaa cctttttttt gaagtgcttg cctggtaata
     2401 gaaaacgggt tctctgccta ttttaaaata gtgaatatac gtaaattttc tctggaaggc
     2461 tgaggcacac ttcaccatca acatgaatta ctgtactatc ctgtactgca gtggtgcctt
     2521 cagggactcg aggaatgtaa ggttgccttt cccctttcta aataccctca gattcctaac
     2581 atcgagccca tgctttgttt gatttgttct attccatcca ttgtcccttt tgttactgac
     2641 agttgccttg gtcctagcca gtccctgcca tgagatcata ggggttccca ttgtgctaga
     2701 tcttgggaaa ccagatgact ctccctgtca aaactatggc tacgtcactg taaaccattt
     2761 ctgtcaagaa taaaagtatg tagacccaga
//
