LOCUS       NM_002436               2006 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens MAGUK p55 scaffold protein 1 (MPP1), transcript
            variant 1, mRNA.
ACCESSION   NM_002436
VERSION     NM_002436.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2006)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2006)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2006)
  AUTHORS   Pitre,A., Ge,Y., Lin,W., Wang,Y., Fukuda,Y., Temirov,J.,
            Phillips,A.H., Peters,J.L., Fan,Y., Ma,J., Nourse,A., Sinha,C.,
            Lin,H., Kriwacki,R., Downing,J.R., Gruber,T.A., Centonze,V.E.,
            Naren,A.P., Chen,T. and Schuetz,J.D.
  TITLE     An unexpected protein interaction promotes drug resistance in
            leukemia
  JOURNAL   Nat Commun 8 (1), 1547 (2017)
   PUBMED   29146910
  REMARK    GeneRIF: Data suggest that targeting the ATP binding cassette
            subfamily C member 4 (ABCC4)-membrane palmitoylated protein 1
            (MPP1) protein complex can lead to new therapies to improve
            treatment outcome of acute myeloid leukemia (AML).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2006)
  AUTHORS   Biernatowska,A., Augoff,K., Podkalicka,J., Tabaczar,S.,
            Gajdzik-Nowak,W., Czogalla,A. and Sikorski,A.F.
  TITLE     MPP1 directly interacts with flotillins in erythrocyte membrane -
            Possible mechanism of raft domain formation
  JOURNAL   Biochim Biophys Acta Biomembr 1859 (11), 2203-2212 (2017)
   PUBMED   28865798
  REMARK    GeneRIF: A new perspective on the role of MPP1 in erythroid cells
            suggests that direct MPP1-flotillins interactions could be the
            major driving-force behind the formation of raft domains in red
            blood cells.
REFERENCE   5  (bases 1 to 2006)
  AUTHORS   Elderdfi,M., Zegarlinska,J., Jones,W. and Sikorski,A.F.
  TITLE     MPP1 interacts with DOPC/SM/Cholesterol in an artificial membrane
            system using Langmuir-Blodgett monolayer
  JOURNAL   Gen Physiol Biophys 36 (4), 443-454 (2017)
   PUBMED   28653654
  REMARK    GeneRIF: conclusion, the data demonstrates that MPP1 interacts with
            lipid mixtures in two different model membrane systems.
REFERENCE   6  (bases 1 to 2006)
  AUTHORS   Kim,A.C., Metzenberg,A.B., Sahr,K.E., Marfatia,S.M. and
            Chishti,A.H.
  TITLE     Complete genomic organization of the human erythroid p55 gene
            (MPP1), a membrane-associated guanylate kinase homologue
  JOURNAL   Genomics 31 (2), 223-229 (1996)
   PUBMED   8824805
REFERENCE   7  (bases 1 to 2006)
  AUTHORS   Marfatia,S.M., Leu,R.A., Branton,D. and Chishti,A.H.
  TITLE     Identification of the protein 4.1 binding interface on glycophorin
            C and p55, a homologue of the Drosophila discs-large tumor
            suppressor protein
  JOURNAL   J Biol Chem 270 (2), 715-719 (1995)
   PUBMED   7822301
REFERENCE   8  (bases 1 to 2006)
  AUTHORS   Metzenberg,A.B. and Gitschier,J.
  TITLE     The gene encoding the palmitoylated erythrocyte membrane protein,
            p55, originates at the CpG island 3' to the factor VIII gene
  JOURNAL   Hum Mol Genet 1 (2), 97-101 (1992)
   PUBMED   1301163
REFERENCE   9  (bases 1 to 2006)
  AUTHORS   Bryant,P.J. and Woods,D.F.
  TITLE     A major palmitoylated membrane protein of human erythrocytes shows
            homology to yeast guanylate kinase and to the product of a
            Drosophila tumor suppressor gene
  JOURNAL   Cell 68 (4), 621-622 (1992)
   PUBMED   1310897
REFERENCE   10 (bases 1 to 2006)
  AUTHORS   Ruff,P., Speicher,D.W. and Husain-Chishti,A.
  TITLE     Molecular identification of a major palmitoylated erythrocyte
            membrane protein containing the src homology 3 motif
  JOURNAL   Proc Natl Acad Sci U S A 88 (15), 6595-6599 (1991)
   PUBMED   1713685
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA074686.1 and BC002392.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002436.3.
            
            Summary: This gene encodes the prototype of the membrane-associated
            guanylate kinase (MAGUK) family proteins. MAGUKs interact with the
            cytoskeleton and regulate cell proliferation, signaling pathways,
            and intercellular junctions. The encoded protein is an extensively
            palmitoylated membrane phosphoprotein containing a PDZ domain, a
            Src homology 3 (SH3) motif, and a guanylate kinase domain. This
            gene product interacts with various cytoskeletal proteins and cell
            junctional proteins in different tissue and cell types, and may be
            involved in the regulation of cell shape, hair cell development,
            neural patterning of the retina, and apico-basal polarity and tumor
            suppression pathways in non-erythroid cells. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.691793.1,
                                           SRR3476690.938605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369534.8/ ENSP00000358547.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               DA074686.1         43-150
            109-2006            BC002392.2         27-1924
FEATURES             Location/Qualifiers
     source          1..2006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2006
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /note="MAGUK p55 scaffold protein 1"
                     /db_xref="GeneID:4354"
                     /db_xref="HGNC:HGNC:7219"
                     /db_xref="MIM:305360"
     exon            1..214
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1513
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythrocyte membrane protein p55; 55 kDa erythrocyte
                     membrane protein; palmitoylated erythrocyte membrane
                     protein; migration-related gene 1; aging-associated gene
                     12; membrane protein, palmitoylated 1, 55kDa; membrane
                     palmitoylated protein 1"
                     /codon_start=1
                     /product="55 kDa erythrocyte membrane protein isoform 1"
                     /protein_id="NP_002427.1"
                     /db_xref="CCDS:CCDS14762.1"
                     /db_xref="GeneID:4354"
                     /db_xref="HGNC:HGNC:7219"
                     /db_xref="MIM:305360"
                     /translation="MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVT
                     EDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHG
                     GMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQ
                     MFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLI
                     PSPELQEWRVASMAQSAPSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVR
                     LPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFI
                     STEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAE
                     LSPFIVFIAPTDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAF
                     DQACSSPQWVPVSWVY"
     exon            215..358
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            359..437
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            438..523
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            524..592
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            593..789
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            790..896
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            897..977
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1058
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1261
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1336
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..2006
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /note="hexamer: AATAAA"
     polyA_site      2006
                     /gene="MPP1"
                     /gene_synonym="AAG12; DXS552E; EMP55; MRG1; PEMP"
                     /note="major polyA site"
ORIGIN      
        1 gactggccca gccgcaccgc gtctcccgcc ttctccgcag ccccgcaggc cccgggccct
       61 gtcattccca gcgctgccct gtcttgcgtt ccagtgttcc agcttctgcg agatgaccct
      121 caaggcgagc gagggcgaga gtgggggcag catgcacacg gcgctctccg acctctacct
      181 ggagcatttg ctgcagaagc gtagtcggcc agaggctgta tcgcatccat tgaatactgt
      241 gaccgaggac atgtacacca acgggtctcc tgccccaggt agccctgccc aggtcaaggg
      301 acaggaggtg cggaaagtgc gactcataca gtttgagaag gtcacagaag agcccatggg
      361 aatcacgctg aagctgaatg aaaaacagtc ctgtacggtg gccagaattc ttcatggtgg
      421 catgatccat agacaaggct cccttcacgt gggggatgag atcctagaaa tcaatggcac
      481 aaatgtgaca aatcattcag tggatcagct gcagaaggcg atgaaagaaa ccaaaggaat
      541 gatctcatta aaagtaattc ccaaccagca aagccgtctt cctgcactac agatgttcat
      601 gagagcgcag tttgactatg atcccaaaaa ggacaatctg atcccttgca aggaggcggg
      661 actgaagttt gctactgggg acattatcca gattatcaac aaggatgaca gcaattggtg
      721 gcagggacgg gtggaaggct cctccaagga gtcagcagga ttgatccctt cccctgagct
      781 gcaggaatgg cgagtggcaa gtatggctca gtcagctcct agcgaagccc cgagctgcag
      841 tccctttggg aagaagaaga agtacaaaga caaatatctg gccaagcaca gctcgatttt
      901 tgatcagttg gatgttgttt cctacgagga agtcgttcgg ctccctgcat tcaagaggaa
      961 gaccctggtg ctgatcggag ccagtggggt gggtcgcagc cacattaaga atgccctgct
     1021 cagccagaat ccggagaagt ttgtgtaccc tgtcccatat acaacacggc cgccaaggaa
     1081 gagtgaggaa gatgggaagg agtaccactt tatctcaacg gaggagatga cgaggaacat
     1141 ctctgccaat gagttcttgg agtttggcag ctaccaaggc aacatgtttg gcaccaaatt
     1201 tgaaacagtg caccagatcc ataagcagaa caagattgcc atccttgaca ttgagcccca
     1261 gaccctgaaa attgttcgga cagcagaact ttcgcctttc attgtgttca ttgcacctac
     1321 tgaccagggc actcagacag aagccctgca gcagctgcag aaggactctg aggccatccg
     1381 cagccagtac gctcactact ttgacctctc actggtcaat aatggtgttg atgaaaccct
     1441 taagaaatta caagaagcct tcgaccaagc gtgcagttct ccacagtggg tgcctgtctc
     1501 ctgggtttac taagcttgta gaatggggga acccactgta tgcccctctc cagcatttgg
     1561 aattccaccc gccttgcttt aagacaaaca gggctgctcc aactagtttt gtgtcagctt
     1621 ccagctctct gcagctatcc taattcagcc agtaaggttc agtcttcttg ctcaggctcc
     1681 tgaagggttg attctcctga tagatggggc cccactgatc tggatttgaa aaggatttct
     1741 agaaattggg ggtaagaagt actaccaaaa tgtaactgct aatcaagggt gatgcacagc
     1801 aaaagcaatg gaccccatcc ctctaaagcc tgccctcctt tgccttcaac tgtatatgct
     1861 gggtatttca tttgtctttt tattttggag aaagcgtttt taactgcaac tttctataat
     1921 gccaaaatga cacatctgtg caatagaatg atgtctgctc tagggaaacc ttcaaaagca
     1981 ataaaaatgc tgtgttgaaa tgccaa
//
