LOCUS       NM_001300862            1614 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens MPN domain containing (MPND), transcript variant 3,
            mRNA.
ACCESSION   NM_001300862 XM_005259663
VERSION     NM_001300862.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007292.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001300862.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4281748.1,
                                           SRR1163655.375461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599840.6/ ENSP00000471735.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC007292.1         6702-6740
            40-326              AC007292.1         6848-7134
            327-563             AC007292.1         8885-9121
            564-696             AC007292.1         16037-16169
            697-781             AC007292.1         17185-17269
            782-878             AC007292.1         17464-17560
            879-951             AC007292.1         18089-18161
            952-1028            AC007292.1         18237-18313
            1029-1197           AC007292.1         20393-20561
            1198-1268           AC007292.1         20655-20725
            1269-1358           AC007292.1         21223-21312
            1359-1451           AC007292.1         22303-22395
            1452-1614           AC007292.1         23056-23218
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1614
                     /gene="MPND"
                     /note="MPN domain containing"
                     /db_xref="GeneID:84954"
                     /db_xref="HGNC:HGNC:25934"
     exon            1..39
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1538
                     /gene="MPND"
                     /note="isoform 3 is encoded by transcript variant 3; MPN
                     domain-containing protein"
                     /codon_start=1
                     /product="MPN domain-containing protein isoform 3"
                     /protein_id="NP_001287791.1"
                     /db_xref="CCDS:CCDS74261.1"
                     /db_xref="GeneID:84954"
                     /db_xref="HGNC:HGNC:25934"
                     /translation="MAAPEPLSPAGGAGEEAPEEDEDEAEAEDPERPNAGAGGGRSGG
                     GGSSVSGGGGGGGAGAGGCGGPGGALTRRAVTLRVLLKDALLEPGAGVLSIYYLGKKF
                     LGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKGQKLDKYKA
                     TWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEP
                     AHPEATTPGKRVDSKIRVPVRYCMLGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSS
                     NVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEEIY
                     QSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYY
                     SGNPGPESKISPFWVMPPPEQRPSDYGIPMDVEMAYVQDSFLTNDILHEMMLLVEFYK
                     GSPDLVRLQEPWSQEHTYLDKLKISLASRTPKDQSLCHVLEQVCGVLKQGS"
     exon            40..326
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            327..563
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            564..696
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            697..781
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            782..878
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            879..951
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1028
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1197
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1268
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1451
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1614
                     /gene="MPND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPND"
                     /note="hexamer: AATAAA"
     polyA_site      1614
                     /gene="MPND"
                     /note="major polyA site"
ORIGIN      
        1 gtctagagct ccgggcgcgg ggaggcgcgg ccatggcagc tccggagccg ctgtccccgg
       61 cgggcggtgc gggcgaggag gcgccggagg aggacgagga cgaagcggag gccgaggacc
      121 ctgagcggcc gaatgcggga gcgggcggtg gacgcagtgg cggcggcggc agtagcgtca
      181 gcggaggagg cggcggcggc ggggccgggg cggggggctg cggcgggccc gggggcgcgc
      241 tcaccaggcg cgcggtcaca ctgcgggtgc tcctcaaaga cgcgctgctg gagcctggcg
      301 ccggggtgct gtccatctac tacctgggga agaagttcct gggcgacctg cagccagacg
      361 gaaggatcat gtggcaggag accgggcaga ccttcaactc acccagcgcc tgggccaccc
      421 actgcaagaa gctggtgaac cctgccaaga agtcgggctg tggctgggcc tctgtcaagt
      481 acaaaggcca gaaactggac aagtacaagg ccacctggct ccggctgcac cagctgcaca
      541 cgcctgccac ggctgctgat gagagcccag ccagtgaagg ggaggaggag gagttgctga
      601 tggaagagga ggaggaggac gttctggcag gggtctcagc agaggacaag agtcggagac
      661 cactggggaa gagcccttca gagcctgccc acccggaggc cacaacccca gggaagcggg
      721 tggacagcaa gatccgggtt ccggtccgct actgcatgct gggcagccgc gacttggcca
      781 ggaaccccca caccctggtg gaagtaacat cctttgcagc catcaacaag ttccagccgt
      841 tcaacgtggc tgtttctagc aacgtgctgt tcctgctgga cttccacagt cacctgacac
      901 ggagtgaggt cgtgggttac ctggggggcc gctgggacgt caacagccag atgctgacgg
      961 tgctcagagc cttcccttgt cggagccggc tcggggacgc agagactgca gctgccatcg
     1021 aagaggagat ctaccagagc ctgttcctgc ggggcctgtc cctggtgggc tggtaccaca
     1081 gccacccaca cagcccggcg ctgccatctc tgcaggacat cgacgcacag atggactacc
     1141 agctgcggct gcagggctcc agcaatggct tccagccctg cctcgccctg ctctgctccc
     1201 cttactattc tggcaaccca ggccccgagt ccaagatctc acctttctgg gtgatgcctc
     1261 ctcccgagca aaggcccagt gactatggca tccccatgga tgtggagatg gcctacgtcc
     1321 aggacagctt cctgaccaat gacatccttc acgagatgat gctgctggtg gagttctaca
     1381 agggttcccc tgacctcgtg aggctccagg aaccctggag ccaggagcac acctacctcg
     1441 acaagcttaa gatctccttg gccagcagga cgcccaagga ccagagcctg tgtcacgtcc
     1501 tggaacaggt gtgcggcgtc ctcaagcagg ggagctgagc cttccagggc agggtgggct
     1561 ccagttgtct tgagggtccg gatgggctca ggtaataaag aaacggaagc agca
//
