LOCUS       NM_138701               7627 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP),
            mRNA.
ACCESSION   NM_138701
VERSION     NM_138701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7627)
  AUTHORS   Theil,A.F., Pines,A., Kalayci,T., Heredia-Genestar,J.M., Raams,A.,
            Rietveld,M.H., Sridharan,S., Tanis,S.E., Mulder,K.W.,
            Buyukbabani,N., Karaman,B., Uyguner,Z.O., Kayserili,H.,
            Hoeijmakers,J.H., Lans,H., Demmers,J.A., Pothof,J., Altunoglu,U.,
            El Ghalbzouri,A. and Vermeulen,W.
  TITLE     Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for
            proper lariat debranching and ectodermal differentiation
  JOURNAL   EMBO Mol Med 15 (11), e17973 (2023)
   PUBMED   37800682
  REMARK    GeneRIF: Trichothiodystrophy-associated MPLKIP maintains DBR1
            levels for proper lariat debranching and ectodermal
            differentiation.
REFERENCE   2  (bases 1 to 7627)
  AUTHORS   Clark,N.E., Katolik,A., Gallant,P., Welch,A., Murphy,E., Buerer,L.,
            Schorl,C., Naik,N., Naik,M.T., Holloway,S.P., Cano,K.,
            Weintraub,S.T., Howard,K.M., Hart,P.J., Jogl,G., Damha,M.J. and
            Fairbrother,W.G.
  TITLE     Activation of human RNA lariat debranching enzyme Dbr1 by binding
            protein TTDN1 occurs though an intrinsically disordered C-terminal
            domain
  JOURNAL   J Biol Chem 299 (9), 105100 (2023)
   PUBMED   37507019
  REMARK    GeneRIF: Activation of human RNA lariat debranching enzyme Dbr1 by
            binding protein TTDN1 occurs though an intrinsically disordered
            C-terminal domain.
REFERENCE   3  (bases 1 to 7627)
  AUTHORS   Strang-Karlsson,S., von Willebrand,M., Avela,K. and
            Wallgren-Pettersson,C.
  TITLE     A novel MPLKIP-variant in three Finnish patients with
            non-photosensitive trichothiodystrophy type 4
  JOURNAL   Am J Med Genet A 185 (6), 1875-1882 (2021)
   PUBMED   33729667
  REMARK    GeneRIF: A novel MPLKIP-variant in three Finnish patients with
            non-photosensitive trichothiodystrophy type 4.
REFERENCE   4  (bases 1 to 7627)
  AUTHORS   Pande,S., Shukla,A. and Girisha,K.M.
  TITLE     Trichothiodystrophy type 4 in an Indian family
  JOURNAL   Am J Med Genet A 182 (10), 2226-2229 (2020)
   PUBMED   33043633
  REMARK    GeneRIF: Trichothiodystrophy type 4 in an Indian family.
REFERENCE   5  (bases 1 to 7627)
  AUTHORS   Pode-Shakked,B., Marek-Yagel,D., Greenberger,S., Pode-Shakked,N.,
            Pras,E., Barzilai,A., Yassin,S., Sidi,Y. and Anikster,Y.
  TITLE     A novel mutation in the C7orf11 gene causes nonphotosensitive
            trichothiodystrophy in a multiplex highly consanguineous kindred
  JOURNAL   Eur J Med Genet 58 (12), 685-688 (2015)
   PUBMED   26518168
  REMARK    GeneRIF: A novel mutation in the C7orf11 gene causes
            nonphotosensitive trichothiodystrophy in a multiplex highly
            consanguineous kindred
REFERENCE   6  (bases 1 to 7627)
  AUTHORS   Heller,E.R., Khan,S.G., Kuschal,C., Tamura,D., DiGiovanna,J.J. and
            Kraemer,K.H.
  TITLE     Mutations in the TTDN1 gene are associated with a distinct
            trichothiodystrophy phenotype
  JOURNAL   J Invest Dermatol 135 (3), 734-741 (2015)
   PUBMED   25290684
  REMARK    GeneRIF: There is a distinct phenotype relationship in
            trichothiodystrophy caused by TTDN1 mutations.
REFERENCE   7  (bases 1 to 7627)
  AUTHORS   Zhang,Y., Tian,Y., Chen,Q., Chen,D., Zhai,Z. and Shu,H.B.
  TITLE     TTDN1 is a Plk1-interacting protein involved in maintenance of cell
            cycle integrity
  JOURNAL   Cell Mol Life Sci 64 (5), 632-640 (2007)
   PUBMED   17310276
  REMARK    GeneRIF: TTDN1 is phosphorylated in mitosis, and this is required
            for its interaction with polo-like kinase 1.
REFERENCE   8  (bases 1 to 7627)
  AUTHORS   Botta,E., Offman,J., Nardo,T., Ricotti,R., Zambruno,G., Sansone,D.,
            Balestri,P., Raams,A., Kleijer,W.J., Jaspers,N.G., Sarasin,A.,
            Lehmann,A.R. and Stefanini,M.
  TITLE     Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive
            trichothiodystrophy patients: no obvious genotype-phenotype
            relationships
  JOURNAL   Hum Mutat 28 (1), 92-96 (2007)
   PUBMED   16977596
  REMARK    GeneRIF: Reported mutations in Trichothiodystrophy do not affect
            TTDN1 response to ultraviolet (UV) light or the steady state level
            of the repair/transcription factor IIH (TFIIH), which is central to
            the onset of the photosensitive form of TTD.
REFERENCE   9  (bases 1 to 7627)
  AUTHORS   Nakabayashi,K., Amann,D., Ren,Y., Saarialho-Kere,U., Avidan,N.,
            Gentles,S., MacDonald,J.R., Puffenberger,E.G., Christiano,A.M.,
            Martinez-Mir,A., Salas-Alanis,J.C., Rizzo,R., Vamos,E., Raams,A.,
            Les,C., Seboun,E., Jaspers,N.G., Beckmann,J.S., Jackson,C.E. and
            Scherer,S.W.
  TITLE     Identification of C7orf11 (TTDN1) gene mutations and genetic
            heterogeneity in nonphotosensitive trichothiodystrophy
  JOURNAL   Am J Hum Genet 76 (3), 510-516 (2005)
   PUBMED   15645389
  REMARK    GeneRIF: Given the absence of cutaneous photosensitivity in the
            patients with C7orf11 mutations, together with the protein's
            nuclear localization, C7orf11 may be involved in transcription but
            not DNA repair.
REFERENCE   10 (bases 1 to 7627)
  AUTHORS   Nakabayashi,K., Fernandez,B.A., Teshima,I., Shuman,C., Proud,V.K.,
            Curry,C.J., Chitayat,D., Grebe,T., Ming,J., Oshimura,M., Meguro,M.,
            Mitsuya,K., Deb-Rinker,P., Herbrick,J.A., Weksberg,R. and
            Scherer,S.W.
  TITLE     Molecular genetic studies of human chromosome 7 in Russell-Silver
            syndrome
  JOURNAL   Genomics 79 (2), 186-196 (2002)
   PUBMED   11829489
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG501110.1, BC026265.1 and
            AC006023.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138701.3.
            
            Summary: The protein encoded by this gene localizes to the
            centrosome during mitosis and to the midbody during cytokinesis.
            The protein is phosphorylated by cyclin-dependent kinase 1 during
            mitosis and subsequently interacts with polo-like kinase 1. The
            protein is thought to function in regulating mitosis and
            cytokinesis. Mutations in this gene result in nonphotosensitive
            trichothiodystrophy. [provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.216983.1,
                                           SRR1660803.50670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306984.8/ ENSP00000304553.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BG501110.1         31-35
            6-911               BC026265.1         1-906
            912-7627            AC006023.2         91954-98669         c
FEATURES             Location/Qualifiers
     source          1..7627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..7627
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /note="M-phase specific PLK1 interacting protein"
                     /db_xref="GeneID:136647"
                     /db_xref="HGNC:HGNC:16002"
                     /db_xref="MIM:609188"
     exon            1..394
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..595
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /note="Russell-Silver syndrome region; TTD
                     non-photosensitive 1 protein"
                     /codon_start=1
                     /product="M-phase-specific PLK1-interacting protein"
                     /protein_id="NP_619646.1"
                     /db_xref="CCDS:CCDS5463.1"
                     /db_xref="GeneID:136647"
                     /db_xref="HGNC:HGNC:16002"
                     /db_xref="MIM:609188"
                     /translation="MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDG
                     YGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFG
                     YSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDI
                     SQQYSNTQTFTGKKGRYFC"
     exon            395..7627
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      891..896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /note="hexamer: AATAAA"
     polyA_site      911
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /note="major polyA site"
     regulatory      7605..7610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
                     /note="hexamer: ATTAAA"
     polyA_site      7627
                     /gene="MPLKIP"
                     /gene_synonym="ABHS; C7orf11; ORF20; TTD4"
ORIGIN      
        1 gatacagttc cggtgggaga acgcggctgc gaggttttcg gctttggctc ctgatatgca
       61 gcgacagaat tttcggcccc caactcctcc ttaccctggt ccgggtggag gaggttgggg
      121 tagcggaagc agcttccggg gaaccccggg cgggggcgga ccacggccgc cctcccctcg
      181 agacgggtac gggagtccgc accacacgcc gccgtacggg ccccggtcta ggccgtacgg
      241 gagcagtcac tctccgcgac acggcggcag cttcccgggg ggccggttcg ggtctccgtc
      301 ccctggcggc taccctggct cctactccag gtcccccgcg gggtcccagc agcaattcgg
      361 ctactcccca gggcagcagc agacccaccc ccagggttct ccaaggacat ctacaccatt
      421 tggatcaggg cgtgttagag aaaaaagaat gtctaatgag ttggaaaatt atttcaagcc
      481 ttcaatgctt gaagatcctt gggctggcct agaaccagta tctgtagtgg atataagcca
      541 acaatacagc aatactcaaa cattcacagg caaaaaagga agatactttt gttaacattt
      601 ctgaaattca actggaagct tcatgtgtca ggaacatctt ggacaaaact ttaagttgtg
      661 ttgatataaa tttacccaaa gatgatgact ttgattggat aattagtaag gtctttttgt
      721 tatttttcat cgtatcaggt attgttgata ttagagaaaa aagtaggata acttgcaaca
      781 tttagctctg gaagtaccta ccacatttta gagatttacc gtttccatat atttaacatt
      841 cctggttaca taatggacat ttgtctttta atgttttttc aatgttttaa aataaaacat
      901 tttgtcttct agctattgtg gttttgtggt atgataaaga agtagactta ctacagtaat
      961 gctttgtagt cacttagagt tcataggtaa atgttttgca aattattttt gaaaatgaaa
     1021 taggtaaacc atcctttgag ctgtagacag ctctgtattt gttcgtaaat aatgaggatg
     1081 agaataacag agttctgttc atactcattt tatctaatgc ttctgttaaa atgcattaaa
     1141 acttgaagcc ccagaaaccc atttaagcat aactttatac tcatttaact ggaaaaggca
     1201 agaatagacc atgcattgct aaatcaaagt gttctatctg aatttctcta tacctcttag
     1261 cattatggag ttagtttctc ttgaggccaa agaagatagc taccagcagc ctcaaatcac
     1321 ttccattgca aaaagaacat ctctcatctc catcaatcca agagaagaca aatttgccat
     1381 acttagatca tgtttctgta ttattgaacc aattaactgt ggccaaggcc acagtgagac
     1441 ctaattaact tgaatcatgg acacatcacc ataatgagac aggattctgt gaccttgaac
     1501 accactgggc ctacctggag tagagaagtg gttttccaaa ttaagggatg ctatggatat
     1561 atacctatag ttctggagag aaaaatatgg aagaattgtt accccaacta ttttttaaaa
     1621 atcaagtggt tttttgtttg ttttttgaga tggagtctgt tgcccaagct ggagtgcagt
     1681 ggtgcaatct tggctcactg caaccttcgg ctcctgagta gctgggacta caggcacatg
     1741 tcaccatgcc tggctaattt ttgtattttt agtagagacc atgttttgtt ttttttgttt
     1801 gttttgtttt gtttttgaaa tagggtctca ctctgttgcc cacgctggag tgcagtggcg
     1861 caatcttggc tcactgcaac gtccgcctcc caggttcata cgagtctccc gcctcgacct
     1921 cctgagtagc tgggaataca ggcacgcgcc tggctcattt ttgtattttg aatagagatg
     1981 gggtttcacc gtgttggcca ggctggtctc gattgaactc ctggtctcaa gtgatcccct
     2041 accttggctt cccaaagtgc tgggatttca ggcatgagcc accgtgccca gcccagaaca
     2101 tgtattttta gtatttttag tatttttagt ttcaccatgt tgaccaggct ggtctcgaac
     2161 tcatgatctc aaatgatcca cccatctcag cctcccacag tgctgagttt acaggcgtga
     2221 gccaccatgc ccggccaaaa tcaggtgttt taacatgtaa cacagactct aggcattttg
     2281 aagttacaaa atacgaagat agagctagta aaacttttgt ttcaacattc ccagaaagaa
     2341 acgtgtaaaa acaaaatggt cacacctcct atttgaacca tacccacaga aatttgttca
     2401 ttaggtattt cacagagact agaaaataag aatggaaggc ttttagatta ataaaagctc
     2461 catgaaagcc aggattttgg aaatgctgtt tctacaagtt actagctgga tgagttcact
     2521 tctctatgcc tcaattttct catgtgtaag atgagaaaat taatagtacc tgtgtcatag
     2581 aggtgttgtg ttggaggatt aaatgaattt atgtatgaaa ctcttaagcc agagcctggc
     2641 acatagtaag cactcaataa gtggtagctg ttactttctc atttaccccc atttccttag
     2701 tttttagaat agtgtctgca agatagtagg tacttaagtg ataaatggat gtagaaattc
     2761 tgattgtaac tactatattg ttctacctac accctgtata taaaagggat aacttagtaa
     2821 tttttcccca gtattttaaa gaaaaagtcc ttattcccaa cattatgtct ttccagatat
     2881 gttgaggtca tgatgtataa tggaaattaa agcaaaggga atactttttt aaatacttta
     2941 ttgaacttta taggtaagaa atgttgtctt taggaaatga catttggaga taatttactg
     3001 aagcatctct tagatcattg ggttattagt aaagacgaaa acagaagtta ggattttgtg
     3061 ccagtgtatt tatatcatat ttggaagaca ttcaaactgt aactcttcta atggtctacg
     3121 tacattttat ttcactgtaa gtgtaacata aaacaaaggt aaaatttctt gctaacgctt
     3181 accaacatct acttctagag acctggcctg agttttttaa gaaaaatttt tgtcctcagg
     3241 aaagatgcat acactgtaag tagtgtattc agttatcaaa attcttgtgg cattggccat
     3301 ttggtttgtt accgttactc tatttttatt tatctgagta aaaggaattg attattcttt
     3361 aaaatgaaag ggattgtttt ttaatgttct aggatacaca ttttacctct ataaaaatgc
     3421 tgaataactt tttagaaaaa cttacaatta agtatacatc ttaaaaattc atatgcttaa
     3481 aggatggaag tgtagtctat agtagagtct tcaaacaagg gtctacatac tcctgggaat
     3541 attaaacttt ctaagggata tgcaggcata aatagcttta agggaatgca aattcagatc
     3601 gcagtgccca tgtaaatcct ttattaaaat tgacctacat aaaaacatat ccatatcaag
     3661 ggatcatgcc agttcttttt ccctgctgcc ttttggtaat cactggtctc ccattttaca
     3721 aaagaaacct atggcaagtt gtgttttgca gaaatgaccc caacaatatt taaagtctca
     3781 tacccttctc gaaccttgcc actaccctta tcaagatgtg gagttacgtc ccttcccttt
     3841 gaacattaac agactttttt tttttttcaa agagttagag ggtctcctta taggggcctc
     3901 cctgtattac ccaggctggt ctctaactct taggcttaag gggtcctcca gcctcggcct
     3961 cccaaagtgc tggaattaca ggtgtgagcc accacgcttg gccccttagc caacttctga
     4021 ctgccataat taagagaata tgatggaagt taatctattt tcattgtggg taaagtgtgg
     4081 tgttaaaaat gagttatagg ccaggcacta tggctcacac ctgtaatccc agcactttgg
     4141 gagcccaggt gggcagatca cttgaggttc ggagtttgag accagcctgg ccaatatggt
     4201 aaagcctcgt ctccactaaa aacacaaaaa taagctgggc atggtggcgc gcgcctgtaa
     4261 taccagctac tggggaggct gaggcagaag aatcacttga acccaggagg cagaggttgc
     4321 agtgagccga gatagtgcca ctgcactcca gcctgggtga cagagtgata ctccatctca
     4381 aaaaaaaaaa aaaataagtt atattggccc gtgtggagat gttcagaatt cagatgtatt
     4441 atcaagttgg gaaataatga tgaaagtgtt cagtgacctt gcctttttgt ttctggacta
     4501 ttcaaaaaat catttccttt gtgggtacat tgtgtgaaag gaaagcaaag agcatgagtt
     4561 taacatgaag gaaaagatac cttattttta ggcaaaaagc aaatggtgag gctctttgcc
     4621 tcatctacct aagaattaaa atattcaaga ttagtaaaaa agcatgatta gttttggtga
     4681 atctcctgtg aagcaaactc tgtatttcca ccattctttt tttttttttt ttttttttga
     4741 gacgaagtct tgttctgtca cccatgctgg agtgcagtgg cacgatctca gctcactaca
     4801 acctctgcct cccaagttca agcaattctc ctgcctcagc ctcccgagta gttgggacta
     4861 caggcatgtg ccaccacacc cagctaattt tttgtatttt tagtagaggc agggtttcac
     4921 cctgttagcc aggatggtct caatctcctg acctcatgat ctgcccagcc tcagcctccc
     4981 aaagtgctgg gattacaggc gtgagccacc gcgcccggcc ctccaccatt cttgataatt
     5041 ataaagagcc tgatgaagat atctcaattc ctgtctcagt agcatagttt gcatgatatc
     5101 aaggaggagg aagttaaaag tttcatgttt acttctgaca tactaacatt acatcttcaa
     5161 gttaaaaaca ttttagaagt aagttcatga atttatattt tctgaaacat tttcagattc
     5221 ttaagagaaa cattttcatt aacccttgcc agtacattta ttattaggtt ctataaattc
     5281 catattaatt gttttacata ggccaaagtc tcctgctatt gtcactcaac catttctctg
     5341 tatcattcat tcctaccata tacttaggtt taagttaaca gaaatatgtt gtagttttta
     5401 ctgtaaataa gacacataat cgcctggttg gaaggtagtg agttatctta attgattgtt
     5461 cagtcagtta cagatcgaac tctttgttct cgtcttcccc ccgcttctca ctgctgcact
     5521 tgactagtct gaaaaaaaaa aatacatagt agtcatcagt acacctgata taagccctga
     5581 acttcctaat gacctctttt tttgtgtgtg tgtgacagag tcttactgtg ttgcccaggc
     5641 tggagtgcag tggtgtgatc tcggctcact gcaacctccg cctcctgggt tcaagcagtt
     5701 ctcctgcctt agcctcctga gtagatggga ttacaggtgc aagccaccat gcctggctaa
     5761 tttttatatt tttagtagag atggagtttc gccatgttgg ccaggctggt tttgaacagc
     5821 tgacctcagg tgatccaccc acctcagcct cccaaagtgc tgggcttaca tgggtgaggc
     5881 agtgcaccca gcctgaatta cctcttttat tttgctcata atttccataa tttatcatct
     5941 aatttaagat gctttgagat tcactattat tttatatgcc acttagtaaa aatactgcca
     6001 gttaagctgt gacatgtcat tgattataag atacatctta atttcagaga tgttaaatac
     6061 atgtcttagt ttgataaaat accatacaat acttttcttt tttttgagac cgatcctgct
     6121 atgttgccca ggctggtctc caactcctgc ctcagcctcc caagtagctg ggattacagg
     6181 tgtgtgacac tacacccagc tcacatacaa tactgttttt tgtttgtttg tttgtttttt
     6241 gagacagagt cttgccctgt cgcccaggct gcagtgcagt ggcgtgatct cgcctcactg
     6301 caacctccac ctcccgggtt caagcaattc ttctgcctca gcctcccaag taactgggac
     6361 aacaggcacg caccaccaca ccctgctaat tttttatatt tggtagagat ggggtttcac
     6421 catattggca aggctggtct cgaactcctg acctcgtgat ctgcccacct cggcctccca
     6481 aagtgctgag attacaggcc taagccaccg ttcctggcct atagtactct taaaagcaga
     6541 acatatactt agatataagt aggtatatag aagtaaatgt ctccaaaagg tagtgtagga
     6601 caatacattt gaaaattggc tttaacccat cctggctaac acagtgaaac cccgtctcta
     6661 ctaaaaataa aaaaaaaaaa atagccaggc atggtggcgg gcgcctgtag tcccagctag
     6721 tcgggaggct gaggcaggag aatggcatga acccgggagg cagaggttgc agtgagttaa
     6781 gatggcgcca ctgcactcca gcctgggcga cagagcgaga ctctgtctca aaataaaaaa
     6841 aaaaaaaaga aaatcggctt tatttaatta gggttaactc ttctcagata cttgtatttg
     6901 ttcaaattca ttaaaaacca taattgaggc tgggcgcggt ggctcacgcc tgtaatccca
     6961 gcactttggg aggccgaggc gggcagatca tgaggtcagg agttcgagac cagcctgccc
     7021 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agacatggtg gcatgtgcct
     7081 gtatcccagc tacttgggag gctgaggcag gagaattgct tgagcccagg aagtgaaggt
     7141 tgcagtgagc caagatctca ccactgcact ccagcctggg caacacaggg agatcctgtc
     7201 tcaaaaaaga aaaaaatttt tacagttgaa agattgccaa caatctaaat gaccatagga
     7261 gaaaggataa ataagttgca tatttgcaca gtataacaag atagttgatt aaattagagc
     7321 catttgatac aacatgaata aatctaaaat tgtgtacaaa caaaagccaa agcaaaactt
     7381 atgtgatatt ctttacgtca aatttaaaag tctgcaaaac aatatgctgt actctctata
     7441 aatggtaaat ataaggtcat agtgtaaata caaatgaagg taacatgctt tagatatagt
     7501 aattattttg gggtgggttc agggagatac aagcttcaga tggacatgga tgtgtgagtg
     7561 gatatgtatt tcaagtcaac caaatttgga aaatgttaaa atttattaaa cctcaccatg
     7621 gaataca
//
