LOCUS       NM_002435               5793 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens mannose phosphate isomerase (MPI), transcript variant
            1, mRNA.
ACCESSION   NM_002435
VERSION     NM_002435.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5793)
  AUTHORS   Wang,K., Zhao,L., Li,T., Wang,Q., Ding,Z. and Dong,W.
  TITLE     Selective Immobilization of His-Tagged Phosphomannose Isomerase on
            Ni Chelated Nanoparticles with Good Reusability and Activity
  JOURNAL   Chembiochem 23 (4), e202100497 (2022)
   PUBMED   34958513
  REMARK    GeneRIF: Selective Immobilization of His-Tagged Phosphomannose
            Isomerase on Ni Chelated Nanoparticles with Good Reusability and
            Activity.
REFERENCE   2  (bases 1 to 5793)
  AUTHORS   Yao,Y., Liu,W., Li,J., Zhou,M., Qu,C. and Wang,K.
  TITLE     MPI-based bioinformatic analysis and co-inhibitory therapy with
            mannose for oral squamous cell carcinoma
  JOURNAL   Med Oncol 38 (9), 103 (2021)
   PUBMED   34313879
  REMARK    GeneRIF: MPI-based bioinformatic analysis and co-inhibitory therapy
            with mannose for oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5793)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5793)
  AUTHORS   DeRossi,C., Bambino,K., Morrison,J., Sakarin,I.,
            Villacorta-Martin,C., Zhang,C., Ellis,J.L., Fiel,M.I., Ybanez,M.,
            Lee,Y.A., Huang,K.L., Yin,C., Sakaguchi,T.F., Friedman,S.L.,
            Villanueva,A. and Chu,J.
  TITLE     Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate
            Cell Activation and Fibrosis in Zebrafish and Humans
  JOURNAL   Hepatology 70 (6), 2107-2122 (2019)
   PUBMED   31016744
  REMARK    GeneRIF: MPI loss is a driver of liver fibrosis and suggest that
            modulating mannose metabolism pathways could reduce hepatic
            stellate cell activation and improve hepatic fibrosis.
REFERENCE   5  (bases 1 to 5793)
  AUTHORS   Shtraizent,N., DeRossi,C., Nayar,S., Sachidanandam,R., Katz,L.S.,
            Prince,A., Koh,A.P., Vincek,A., Hadas,Y., Hoshida,Y., Scott,D.K.,
            Eliyahu,E., Freeze,H.H., Sadler,K.C. and Chu,J.
  TITLE     MPI depletion enhances O-GlcNAcylation of p53 and suppresses the
            Warburg effect
  JOURNAL   Elife 6, e22477 (2017)
   PUBMED   28644127
  REMARK    GeneRIF: This work provides mechanistic evidence by which mannose
            phosphate isomerase loss induces p53, and identifies mannose
            phosphate isomerase as a novel regulator of p53 and Warburg
            metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5793)
  AUTHORS   Alton,G., Hasilik,M., Niehues,R., Panneerselvam,K., Etchison,J.R.,
            Fana,F. and Freeze,H.H.
  TITLE     Direct utilization of mannose for mammalian glycoprotein
            biosynthesis
  JOURNAL   Glycobiology 8 (3), 285-295 (1998)
   PUBMED   9451038
REFERENCE   7  (bases 1 to 5793)
  AUTHORS   Proudfoot,A.E., Turcatti,G., Wells,T.N., Payton,M.A. and Smith,D.J.
  TITLE     Purification, cDNA cloning and heterologous expression of human
            phosphomannose isomerase
  JOURNAL   Eur J Biochem 219 (1-2), 415-423 (1994)
   PUBMED   8307007
REFERENCE   8  (bases 1 to 5793)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
REFERENCE   9  (bases 1 to 5793)
  AUTHORS   Chern,C.J., Kennett,R., Engel,E., Mellman,W.J. and Croce,C.M.
  TITLE     Assignment of the structural genes for the alpha subunit of
            hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase
            to the region q22-qter of human chromosome 15
  JOURNAL   Somatic Cell Genet 3 (6), 553-560 (1977)
   PUBMED   341373
REFERENCE   10 (bases 1 to 5793)
  AUTHORS   Chern,C.J. and Croce,C.M.
  TITLE     Confirmation of the synteny of the human genes for mannose
            phosphate isomerase and pyruvate kinase and of their assignment to
            chromosome 15
  JOURNAL   Cytogenet Cell Genet 15 (5), 299-305 (1975)
   PUBMED   1222586
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD706167.1, BC046357.1,
            AW813817.1, AC125435.8, BX648475.1 and AW445009.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002435.2.
            
            Summary: Phosphomannose isomerase catalyzes the interconversion of
            fructose-6-phosphate and mannose-6-phosphate and plays a critical
            role in maintaining the supply of D-mannose derivatives, which are
            required for most glycosylation reactions. Mutations in the MPI
            gene were found in patients with carbohydrate-deficient
            glycoprotein syndrome, type Ib. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.218978.1,
                                           SRR1803614.74938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352410.9/ ENSP00000318318.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CD706167.1         49-62
            15-1790             BC046357.1         1-1776
            1791-2117           AW813817.1         194-520
            2118-2152           AC125435.8         55537-55571         c
            2153-3015           BX648475.1         1952-2814
            3016-3031           AW445009.1         16-31               c
            3032-5793           AC125435.8         51896-54657         c
FEATURES             Location/Qualifiers
     source          1..5793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1-q24.2"
     gene            1..5793
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="mannose phosphate isomerase"
                     /db_xref="GeneID:4351"
                     /db_xref="HGNC:HGNC:7216"
                     /db_xref="MIM:154550"
     exon            1..48
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1304
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /EC_number="5.3.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mannose-6-phosphate isomerase; phosphomannose isomerase 1;
                     phosphohexomutase"
                     /codon_start=1
                     /product="mannose-6-phosphate isomerase isoform 1"
                     /protein_id="NP_002426.1"
                     /db_xref="CCDS:CCDS10272.1"
                     /db_xref="GeneID:4351"
                     /db_xref="HGNC:HGNC:7216"
                     /db_xref="MIM:154550"
                     /translation="MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDK
                     PYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLS
                     VETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTF
                     LKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVK
                     RISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPH
                     AYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPY
                     LSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQR
                     GGVLFIGANESVSLKLTEPKDLLIFRACCLL"
     exon            49..176
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     exon            177..377
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..519
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..702
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..876
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1085
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..5793
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="hexamer: ATTAAA"
     polyA_site      1802
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="major polyA site"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="hexamer: AATAAA"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="hexamer: AAGAAA"
     polyA_site      3015
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
     polyA_site      3031
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
     regulatory      5454..5459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="hexamer: AATAAA"
     polyA_site      5472
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
     regulatory      5775..5780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /note="hexamer: AATAAA"
     polyA_site      5793
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
ORIGIN      
        1 atacgtgctt aatcctggtg cagggggcga gcatggccgc tccgcgagta ttcccacttt
       61 cctgtgcggt gcagcagtat gcctggggga agatgggttc caacagcgaa gtggcgcggc
      121 tgttggccag cagtgatcca ctggcccaga tcgcagagga caagccttat gcagagttgt
      181 ggatggggac tcacccccga ggggatgcca agatccttga caaccgcatc tcacagaaga
      241 ccctaagcca gtggattgct gagaaccagg acagcttggg ctcaaaggtc aaggacacct
      301 ttaatggcaa cctgcccttc ctcttcaaag tgctctcagt tgaaacaccc ctgtccatcc
      361 aggcacaccc taacaaggag ctggcagaga agctgcacct ccaggctccg cagcactacc
      421 ccgatgccaa ccacaagcca gagatggcca ttgccctcac ccccttccag ggcttgtgtg
      481 gcttccggcc agttgaggag attgtaacct ttctaaagaa ggtgcctgag tttcagttcc
      541 tgattggaga tgaggcagca acacacctga agcagaccat gagccatgac tcccaggctg
      601 tggcctcctc tctgcagagc tgtttctccc acctgatgaa gagtgagaag aaggtggtgg
      661 tggaacagct caacctgttg gtgaagcgga tctcccagca agcggctgcc ggaaacaaca
      721 tggaggacat ctttggggag cttttgctac agctgcacca gcagtaccca ggtgatatcg
      781 gctgctttgc catctacttc ctgaacctgc ttaccctgaa gcctggggag gccatgtttc
      841 tggaggccaa cgtaccccat gcctacctga aaggagactg cgtggagtgc atggcgtgtt
      901 cagacaacac agttcgtgct ggcctgacac ccaagttcat tgatgtgcca accctgtgtg
      961 aaatgctcag ctatacccct agctccagca aggacaggct ctttctccca acacggagtc
     1021 aggaagaccc ctacctctca atctatgacc cccctgtacc agacttcacc attatgaaga
     1081 cggaggtccc tggctctgtc actgaataca aggtcttggc actggactct gccagcatcc
     1141 tcctgatggt acaggggaca gtaatagcca gcacacccac aacccagaca ccaatccctc
     1201 tgcaacgtgg tggcgtgctc ttcattgggg ccaatgagag tgtctcactg aagcttactg
     1261 agccgaagga cctgctgata ttccgtgcct gctgtctgct gtaaaggctg cagcctcccc
     1321 agctctcctc tgccagccac cctaaattcc agccaacctc acctcctcgg gcccagctca
     1381 agcccccttc cttgctctgg accccttagg tataccctgg aagagctggg gtgggggagg
     1441 agggagcgtg aaggtagtga ctcctgaaca cacccaggtg gaaccatctt tggggaggag
     1501 aggcccgtgt gaggggtctg atactccctt tgtcttccct ctctactcct cgctacacct
     1561 gagccaggct cttgccaact ctgttccagc ctatggcttt aggctagctg ttaaatatgt
     1621 gacccagcat tagctcagca tctgtcagag caagagacca ggtaatttct aagaacaggg
     1681 ttctagcgat gggactgccc atttcctcag ctgcagagga ggaaagggaa agggtaggcc
     1741 tgtagactaa cgctgtttac acccttgttc tgtcaaagca attaaagatc acttgtgttg
     1801 aggctgtggg gtaatgagca ctcagccttt ggggtacctg ttcctaaagt gggccaaaag
     1861 agccctccct acatgatgcc ccagtttttg ctttattcct atttcataca gcttctcggg
     1921 ggagtgagca ggctacactc cagaacaccg gtatgggaag gagtgggaga ggaagccagc
     1981 tttggcctca caggcacagc ttgcaagcag gccttgggtc tgcccagagg cacagcttgc
     2041 aagcagccct acagagaagg tgactcaaag gatacaccag tcaccagtgc aagactcttc
     2101 gctcctgttt ttctcttttt tttttttttg agacggagtc tcggtctgta gcccaggctg
     2161 gagtgcagtg gcacgatctc ggctcattgc aagctccgcc tcccgggttc acgccactct
     2221 tctgcctcag cctcccaagt agctgggacc acaggcgccc accaccacgc ccagccaatt
     2281 tttttggtat ttttagtaga gatggggttt cactgtgtta gccaggatgg tctcgatctt
     2341 ctgacctcgt gatccgccca cctcagcctc ccaaagtgct gggattacag gcgtgagcca
     2401 ccacgcctgg cccggctcct gtttttcaac tggccctaga ggaggggtcc gcaaaccagg
     2461 ctggcaggcc agttctggcc atacctgttc atttccatac tgtctggctg ctttcaagcc
     2521 acagtggcaa agttgaagag ttgcactaga ctgtacggcc tgcaaaactg aaaccattga
     2581 ctgtcaacca cttctctaca acatactcaa ctgttgcaga ttacagggac tcaggaaccg
     2641 aattagacaa ttttcatggc gaggagaagc ccagttagct ttcctaaacg ggcaggaagt
     2701 gtgaaggagg gaatctcctg atgccctgct ccaggggtgg cacacacctg caagaggctg
     2761 tcggctgtct gctgctgctg aggtttctga cctgcaatcg tagatcctgt caccacagac
     2821 taatcactta gtccactggc tccttcctgt gggataaagg tttaaattca tgcaaaagaa
     2881 tctttctggg cttctgccca cactagagtc cctatacaat ggagttccag gaaaccacct
     2941 tcaaaaatct cctgggtttt cttgcctcca aattttcttc agctaaaaaa caataaagat
     3001 gagctggaaa gaaaaggtct gctaaaggga acccattcta cagaagtgac ttgcaagagc
     3061 ctatttcact catgccgtcc agtgaaacag gcccgaaagt gatgcccagt gggaacagca
     3121 gaaaggggag ggagtttcca gaaggaattg ctgtagtcag ctgttaagct atttcttcat
     3181 ttcaggatat ccaggatatt cttaactttt atttttttga gacggagtct cgcactgtct
     3241 cccgggctgg agtgcagtgg cgcgatagct cactgcaacc tccgcccact gggttcaagc
     3301 gattcttctg cctcagctcc tgagtagctg ggactacagg cgcctgccac cacacccagc
     3361 taagtttttg tatttttagt agagacgggg tttcagtaga gacggggtga caggatctac
     3421 aattccaggt aaggtcaggt tggtctcaaa ctcctgacct tgtgatttgc ttgcctcagc
     3481 ctctgaaagt gctgggatta caagcatgag ccattgtgcc tggccaaggc ctttaaaatc
     3541 cactgcaaca cagacacagc tcaactagtg tgattgcatt tattcttata aatgtacaga
     3601 gctgtagaag tgcaagccaa gagttctata gagtagtaca taaacaccat atggtaccac
     3661 tcctgctggg aggtaagcct ggatacaccc ctctcctcag gaaactgtca cctgcagaac
     3721 acacagcact cagaattaag gcagtttggc cctgggcaca ttggtggtat tttggtatgt
     3781 ggccactggc cctaaacaac tgaccatttc taccctgcct cactgcactg tcccaccagg
     3841 tccctccagc tttttctaca aggtaacacc ctcctacatg gggtcagcca gctcagaaac
     3901 ctcttcttca gggacagttg cagctgaata tgccagagct gattattaca acaacgatgc
     3961 agagggcctt ggttttgggg tcctgccacc ctcaccccta gaagctgcta aacacccagg
     4021 ccattctgcc ctgaccacct ccccaacaga gatgtaggtc tatacttacc ttccacagcc
     4081 acctcccagc acacactggg tccctctacc tgtgttgctg tctttcttta cactgtgcta
     4141 catttgatcc ctttccacat gtgcacttca cctctgcaga cacaagaaag gcctggacat
     4201 ggtctctgca gatggggaag gggttctgga tggagatgtt cttgagctct acaagcattt
     4261 gcacaaagtg ctcagaatgt tggccactgc atagagctgc agagtcccat tccagaacag
     4321 agtaaccatc tgcctctctt cccaagaccc caagctggca tgactctggt ctctgtccta
     4381 tctctctgct gtgatgctcc tagctagtag agtaagtcag cccccagata ctgtatattc
     4441 ctctcaacct tccatggttt gagaaaaaca caaagataga tgtccatcag gcactcacag
     4501 gattaccatc gtaaggatgg ttgtcagaca aataacaaat aaggccgtat ctttttatta
     4561 gacttgctca tcttctagtc accccttgtg gtagagcgaa aagagtgtgt tgtccctctc
     4621 atgcctctgg tggtcacagg acactgagta aagcaagaga ctggatactt tcccatgtag
     4681 aacctatacc ccaatcccga ctattgggct gggaaccctg tctatgccca ttcaaagctc
     4741 accatgtggg aggactgctt gggcctggga ggttgaggct gcagtgagct gtgattacac
     4801 cactgcactc cagcctgggt gacagagacc ctgtctccaa caaaacaaag cagaacgctc
     4861 accatggttc tgagttaagc caaaaaacaa aacaaaacct gttggaaaaa ttctagaaag
     4921 aggcttggta tagagtatag caagatatac tctccaattt gtgggtaggg ggtgtcacag
     4981 cagaaattat gcctatttct gctgtttggg ctgggggctg aaagaggctg tgtcacaccc
     5041 agaggtctgc ttaaagccca atcctgagta tccagtaagg cccatgctgt gaccagaaga
     5101 atctggcaat agaatggtcc atgctggagt gaagggaggc cctctacact ggtggactga
     5161 tttcctcagg caagggtcta ggagctggct taggtctctc ttacccttcc tgtctgtaag
     5221 cctcagtcta ggacaaagcc cacacagctg tatacccact ctcacgagtc cattgctact
     5281 tctcaaaagt ttaaaaagta aacaatagga aggcaccgga ctgctccctg tagctccctc
     5341 tgctggtaat aataaaaact gcaggcttct ggggccagcc ccagtacctt cgacctaatc
     5401 tttagctcaa agactgggtg aagaaactca cccagaccaa ggaaatacaa ataaataaat
     5461 atgaacatgt cagagcagtt tttctctaac tagggaaggg caaaccagaa tcactaaact
     5521 cacccggacg gttggaccag ttggggatgc cccaggtcca gggattctgg aagccaggat
     5581 cctgctgtat cattaagcaa cctgctatga tccctgtcat agttagacag gtgcaacctg
     5641 aagagggaca aaaggactca ctttatgctg tcttgaaggt caagcctgca aaccatctta
     5701 gagctaggaa gaatagagca aacggaattt ctcgaactgg tctcaaacag tttctttttt
     5761 ggattgccag ctataataaa ccataaagtg cta
//
