LOCUS       NM_022782               6369 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens M-phase phosphoprotein 9 (MPHOSPH9), transcript
            variant 1, mRNA.
ACCESSION   NM_022782
VERSION     NM_022782.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6369)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6369)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 6369)
  AUTHORS   Xu,L.L., Shang,Y., Qu,X.N. and He,H.M.
  TITLE     M-Phase Phosphoprotein 9 upregulation associates with poor
            prognosis and activates mTOR signaling in gastric cancer
  JOURNAL   Kaohsiung J Med Sci 37 (3), 208-214 (2021)
   PUBMED   33174370
  REMARK    GeneRIF: M-Phase Phosphoprotein 9 upregulation associates with poor
            prognosis and activates mTOR signaling in gastric cancer.
REFERENCE   4  (bases 1 to 6369)
  AUTHORS   Huang,N., Zhang,D., Li,F., Chai,P., Wang,S., Teng,J. and Chen,J.
  TITLE     M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating
            CP110-CEP97 complex localization at the mother centriole
  JOURNAL   Nat Commun 9 (1), 4511 (2018)
   PUBMED   30375385
  REMARK    GeneRIF: MPP9 acts as a regulator of ciliogenesis by regulating the
            localization of CP110-CEP97 at the mother centriole.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6369)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   6  (bases 1 to 6369)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   7  (bases 1 to 6369)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 6369)
  AUTHORS   De Jager,P.L., Chibnik,L.B., Cui,J., Reischl,J., Lehr,S.,
            Simon,K.C., Aubin,C., Bauer,D., Heubach,J.F., Sandbrink,R.,
            Tyblova,M., Lelkova,P., Havrdova,E., Pohl,C., Horakova,D.,
            Ascherio,A., Hafler,D.A. and Karlson,E.W.
  CONSRTM   Steering committee of the BENEFIT study; Steering committee of the
            BEYOND study; Steering committee of the LTF study; Steering
            committee of the CCR1 study
  TITLE     Integration of genetic risk factors into a clinical algorithm for
            multiple sclerosis susceptibility: a weighted genetic risk score
  JOURNAL   Lancet Neurol 8 (12), 1111-1119 (2009)
   PUBMED   19879194
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6369)
  AUTHORS   De Jager,P.L., Jia,X., Wang,J., de Bakker,P.I., Ottoboni,L.,
            Aggarwal,N.T., Piccio,L., Raychaudhuri,S., Tran,D., Aubin,C.,
            Briskin,R., Romano,S., Baranzini,S.E., McCauley,J.L.,
            Pericak-Vance,M.A., Haines,J.L., Gibson,R.A., Naeglin,Y.,
            Uitdehaag,B., Matthews,P.M., Kappos,L., Polman,C., McArdle,W.L.,
            Strachan,D.P., Evans,D., Cross,A.H., Daly,M.J., Compston,A.,
            Sawcer,S.J., Weiner,H.L., Hauser,S.L., Hafler,D.A. and
            Oksenberg,J.R.
  CONSRTM   International MS Genetics Consortium
  TITLE     Meta-analysis of genome scans and replication identify CD6, IRF8
            and TNFRSF1A as new multiple sclerosis susceptibility loci
  JOURNAL   Nat Genet 41 (7), 776-782 (2009)
   PUBMED   19525953
REFERENCE   10 (bases 1 to 6369)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB071469.1, CX782912.1, BC130440.1, AK091181.1, BF793354.1 and
            AC073857.30.
            
            On May 17, 2019 this sequence version replaced NM_022782.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein. This variant lacks
            full-length human transcript support but is supported by tiled
            partial transcript data and by homologous transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.86565.1,
                                           SRR1803612.49248.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606320.6/ ENSP00000475489.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               DB071469.1         30-549
            521-621             CX782912.1         159-259
            622-3948            BC130440.1         1-3327
            3949-4183           AK091181.1         3375-3609
            4184-4188           BF793354.1         712-716
            4189-6369           AC073857.30        81118-83298
FEATURES             Location/Qualifiers
     source          1..6369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..6369
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /note="M-phase phosphoprotein 9"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
     exon            1..67
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            68..329
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..3777
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /codon_start=1
                     /product="M-phase phosphoprotein 9"
                     /protein_id="NP_073619.3"
                     /db_xref="CCDS:CCDS9243.2"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
                     /translation="MEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNG
                     VSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCETRWLQLFNLVEKQCQE
                     QIVAQQEQFHNQIQHIQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSS
                     ERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEF
                     MEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFL
                     GENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSD
                     FAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSST
                     DVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHM
                     KPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPK
                     YPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVS
                     QSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQK
                     LEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERF
                     SAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQ
                     ENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVE
                     HENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQ
                     LEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALKELDEGKIFKNWGTQ
                     TEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKR
                     EIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTN
                     PRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWEKNKSVSYE
                     QCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQT
                     RLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL"
     exon            330..483
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            484..573
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1097
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1221
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1312
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1419
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1545
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2006
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2162
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2250
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2466
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2514
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2579
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2681
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2816
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2992
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3133
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3254
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3358
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3606
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3675
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..6369
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4162..4167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /note="hexamer: AATAAA"
     polyA_site      4185
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /note="major polyA site"
     regulatory      4210..4215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /note="hexamer: CATAAA"
     polyA_site      4235
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
     regulatory      5860..5865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /note="hexamer: ATTAAA"
     polyA_site      5879
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
     regulatory      5938..5943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /note="hexamer: ATTAAA"
     polyA_site      5961
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
ORIGIN      
        1 ccctcgggta acggtcgcga gaggccgctt gcatgaccct gacatcggca gcgggagcgg
       61 cggccagact ctcttggaag tttaggatat ttcacagttc tgaatgttag ccactgaaaa
      121 tgccagtaga tgatgaagcc tctgaagatg acacggattc atttttctca aacagcccaa
      181 gaacctttat tttccaataa gagaatataa caatttctgt acactatgga agagtttgac
      241 ttggtgaaaa ccttacacaa aacttcatct tctgtaggat ctgatgaaaa ttctcttcat
      301 tctcttggac tgaacttaaa tactgataga agtagtcccc accttagtac aaatggggta
      361 tcctctttct cagggaagac cagaccatct gtaattcaag gtacagttga agtcctaact
      421 tctttaatgc aagagctaca aaacagtgga aagactgatt cggaactttg gaaaaactgt
      481 gagaccaggt ggttacagct attcaatttg gtggaaaaac aatgccaaga acagatagtt
      541 gcccagcagg agcagttcca caaccaaatt caacatatac aggaggagat aaaaaattta
      601 gtcaaattac agactagtag tgcttcctta gcttcctgtg aaggaaattc ttcaaacaaa
      661 caagtatctt cggaaagtca aatgggtttt ttttctctaa gcagtgagag aaatgaatct
      721 gttatccatt atcctgaatc cacagaacct gaaatacagc aagaaatgtc cacgtcacaa
      781 ccagactgca atgtggatag ttgctcagta agcagtggat atggcacctt ttgtatctca
      841 gaattaaatc tgtacaaatc taaagaccct aaggagttca tggagcacat agatgttccc
      901 aaaggacagt atgtagcacc tgcggtgccg gctgagtcac ttgtagatgg tgtgaaaaat
      961 gagaattttt atatacagac tcctgaagag tgtcatgtgt ctttaaagga agatgtatcc
     1021 atttctcctg gtgaatttga acataatttt cttggtgaaa ataaggtttc tgaagtatac
     1081 agtgggaaaa caaatagtaa tgctataaca tcatgggcac aaaaactgaa gcagaaccaa
     1141 ccaaagagag cacatgtaga agatggaggt tcaagatcta aacaaggaaa tgagcaaagt
     1201 aagaagacac caattgagaa atctgatttt gctgctgcta cacatcctcg tgctttttac
     1261 ctcagtaaac cagatgaaac tccaaatgct tggatgtctg attcaggaac aggattgact
     1321 tactggaaac tagaggaaaa ggatatgcac cactctttgc ctgaaacttt agagaagacg
     1381 ttcatatcat tgtcttccac agatgtgtca ccaaaccagt ctaatactag taatgagatg
     1441 aagctaccgt cactgaagga tatttattat aaaaaacaaa gggaaaacaa gcagttacct
     1501 gagaggaatc tcacttctgc ttccaaccca aatcatccac cagaggtcct gactctagat
     1561 cctacgttac acatgaagcc aaagcagcag atttcaggga ttcaacctca cggccttccg
     1621 aatgcccttg atgacagaat atccttttcc ccggactctg ttctagagcc tagtatgtct
     1681 agtccctctg acatagactc attttcacaa gcaagtaatg tcacttctca gttacctgga
     1741 tttccaaaat atccctcaca cacaaaagct tctccggtgg actcttggaa aaatcagaca
     1801 ttccaaaacg aaagtaggac cagttccacg tttccgtcag tatataccat tactagtaat
     1861 gatatctcgg tcaacactgt agatgaagaa aacactgtca tggttgcttc ggcctcagtc
     1921 agtcagtccc agcttccagg tacagccaac agtgtcccag aatgcatttc attgacttcc
     1981 ttggaagatc ctgtgatatt gtctaagatt aggcagaatc tgaaggaaaa gcatgctcga
     2041 cacatagcag atcttcgagc ttattatgaa tcagaaataa atagtttgaa acagaagctg
     2101 gaggcaaaag aaatctctgg agttgaagat tggaagataa ccaatcaaat tcttgtagac
     2161 agatgtggcc aattagatag tgctttgcat gaagctacta gtcgcgtgag aacacttgaa
     2221 aataagaata acttactgga aattgaagtg aatgatttga gagaacgctt cagtgcagcc
     2281 agcagtgctt ccaaaatttt gcaggaacga attgaagaaa tgagaacaag cagtaaagaa
     2341 aaagacaata ccatcattcg actaaaatct agactgcaag atttagaaga agcatttgag
     2401 aatgcttaca aactctcaga tgataaagaa gctcaactaa aacaagagaa caaaatgttt
     2461 caagatcttt taggagagta tgagtccctt ggaaaagaac acaggagagt aaaggatgca
     2521 ttaaatacaa ctgagaacaa attgcttgat gcatatactc agatttctga tttgaaaaga
     2581 atgatttcaa aacttgaagc tcaggtcaag caagtagaac atgaaaatat gttaagcctt
     2641 cgtcataatt ctagaattca cgtgagaccc tcgcgtgcca acacactagc aacttcagac
     2701 gtcagcaggc ggaaatggct gattccaggt gcagagtatt ccatctttac tggccagcct
     2761 ctggacaccc aggacagtaa cgtggataac cagctggagg aaacctgtag cctagggcac
     2821 cgttcacctc tggaaaagga ttcttcacct ggaagttcat caacaagctt gttgataaaa
     2881 aagcaaagag agacttcaga cacgccgatc atgagagctt taaaagaact tgatgaggga
     2941 aaaatattta aaaattgggg gacacagaca gagaaagagg acacctcaaa tataaatcct
     3001 cggcaaactg aaacttcagt taatgcaagt cgttctccag aaaagtgtgc ccaacagaga
     3061 caaaagagac ttaattcggc ctcacagaga tcatcatctt taccaccttc aaatcgtaaa
     3121 tcaagtactc caacaaaaag agagattatg ctaacaccag tgactgtggc ttatagtcca
     3181 aagcgatccc ctaaagaaaa cttgtcccca ggatttagtc atctgcttag caaaaatgag
     3241 agcagtccaa ttcgatttga tatacttttg gatgatttag atactgttcc tgtgtctaca
     3301 ttacaacgta ccaatccaag aaagcaactc cagtttcttc ctctagatga ctcggaagaa
     3361 aaaacttatt ctgagaaagc caccgataac catgttaatc atagctcttg ccctgaaccg
     3421 gtgccaaatg gagtgaagaa agtatctgtg agaacagcct gggagaagaa taaatcagtt
     3481 agctacgaac agtgtaagcc ggtttcagtc actccacagg ggaatgattt tgaatataca
     3541 gcaaaaattc ggaccctagc tgaaacagaa cgattttttg atgaacttac aaaagaaaag
     3601 gaccagattg aggcagcact aagcaggatg ccttctcctg gaggacgaat cactttacag
     3661 acaagattaa atcaggaagc cttggaagat cgtttggaaa ggattaatcg agaactgggt
     3721 tcagttcgca tgacgctaaa gaaattccat gttttgcgca cctctgcaaa tctttgagat
     3781 ttgtagccat taaattttga gacatttttg tttgcactaa tgtataatta tgcagtcaga
     3841 aaaggcaaac tattttgtac tgtttataag ccttcaaaca gtagttttac aatcatgcta
     3901 ttcttacact tgctatttta tacttcaaat ggccacatat tttcaagata tttttgttat
     3961 gctcaggaat ctcttgtata ttttactatt taaaaagcat tatttttaaa tagtatctgt
     4021 ctccaattta tatcaagaat aaggaaatat aaacagagga agcagcttgt ttctaaacaa
     4081 atagtgttat ccttttacaa ttaactgcac atcaatttta tagacttgtt ctacattgta
     4141 aatacaattc agtttttaaa aaataaagct taatagcttc cataatgata gactagtaca
     4201 tgctgaatac ataaacaatt acagtgtacc ttggatttca gttgtgttga ggtttttaaa
     4261 aaatgataat gcaattcgta tttgaaacgt gtcttagagt gaatatcaga atagtaataa
     4321 tggactcttg gaaagctttg aaaactacat gaatataact cattttcttt aaactttatt
     4381 gtctgtaaga gaaaaaagag agattgtaat tctctaattt tatcttttct aaaaaagtta
     4441 aacaattgga gagccctctc tggagggctc tcagagtagc tctctgccca ttgttctgaa
     4501 ttaacttgtg tcccaccctg gacaataaat ggacagataa accctttgaa atacaagcca
     4561 ccaccccgtg agggattaag agggcagcct ggttttctta gtgtgcatgg cttcagctgt
     4621 ccgtcatagt tgtcatctgg atatgttcac ccctttccac tccttcaccc tggccaaaag
     4681 gaaaatattt ccactgtagg tgctgtaaga acactagact ttagatcatc acaatctact
     4741 gtatttgtta atggacaggg agtgtgtccg gatggagcct ggtgccttcc cctcggcctt
     4801 gcagagggct ccagcccact gcctctgtgg tagccgctgg ctctcagaag tagcacgtgg
     4861 gcaggagtct ctcctctgat ccaggagcat tggcaggttt gtgttgggac tgctggttaa
     4921 gttggagctg tgtaactact tagtttttgg tagccaatca gaacgcagtg ccccacatat
     4981 tccagctcgg tacatgttga taaacagact catccaaact ttcaaaatgg attcgtacta
     5041 aacatgctca ggttttaaat tttggtttgc ttttgagctt ttcctcttta tgtggctctt
     5101 aataataagt agttagaatg aaccaagcca tcccagttat tccaagcagg ctctcaaatg
     5161 acctttgagc acccttcacc tggctggtcc ccaggccagg ggtccacagc cctgctccct
     5221 tctcagcaag gagggtggcc tgtctgacag tgcagttgaa cctttgctcc ctactctgca
     5281 acttttgaag acttcaggct aatcaaaatt acttataatt agaatcaagt gcctttattc
     5341 ttgtttttta tttttatttt attttattta tttatttttt tagatggagt tttgcccttg
     5401 ttgcccaggc tggagtgcaa tggcatgatc tcagctcact gcaacctctg cctcccgggt
     5461 tcaagcgatt ctcctgcctc agcctgctgg gtagctggga ttacaggcat ctgccaccac
     5521 gcccggctaa ttttgtgtgt gtgtatatgt ctatgtgtgt gtgtgtatgt atatatcttt
     5581 tttttttttt tagtagagat ggtgtttcac catattggcc aggctggtct caaactcctg
     5641 aactcatgtg atccgcctgc cttggcccct caaagtgctg ggattacagg catgagccac
     5701 cacacccggc ctattcttgg tattctttat tcttggtttt ctagccttta gaaaaaaaaa
     5761 atctagtctt ggtaaagaaa atgttcattt taatcaagct ccagtacagc ttgtgtcaag
     5821 acctagtaag accaccttta atgtgttcct ggatatgaca ttaaaaacta acttgaaaat
     5881 tgttaggata tttccttgtt ccctactttt attgtaaaat ctactacatt cttaagaatt
     5941 aaaaaatgcc atttcagaag agatgatagt tttatcttgc caaggaatta tcttcttagt
     6001 agcctatatt ggcttattcc aaaaaaggcg ttaacctcca tcaaaacatc ttctgcgcct
     6061 ctctctcagc atatgctttg atatttgaag tgtgtaatag attggagcta tcagtcactt
     6121 atttctaaaa aatgtattct tttttcttca tagctgtgaa gagggatacc aaggaaagtt
     6181 ctttctgctg tctttctctt cggtaatgct tatcttatga acactcaact gaaaaaacac
     6241 tccacctaaa agcaggaaag atggcaattc taaatagcag ctattatccc cgggtataaa
     6301 ctatttttgt tgttggcttg gggctttgct gcaggtatta atagtttaaa aagaaaaaaa
     6361 aaaaaaaaa
//
