LOCUS       NM_017520               4239 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens M-phase phosphoprotein 8 (MPHOSPH8), mRNA.
ACCESSION   NM_017520 XM_167894
VERSION     NM_017520.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4239)
  AUTHORS   Li,T., Li,N., Wang,L., Li,J. and Zhang,X.
  TITLE     MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma
            by Regulating p38alphaMAPK Pathway
  JOURNAL   Technol Cancer Res Treat 20, 1533033821995272 (2021)
   PUBMED   33596786
  REMARK    GeneRIF: MPP8 Promotes Proliferation and Restrains Apoptosis in
            Osteosarcoma by Regulating p38alphaMAPK Pathway.
REFERENCE   2  (bases 1 to 4239)
  AUTHORS   Wang,Y., Xiao,H., Wang,C., Wu,H., He,H., Yao,C., Cui,J. and Li,W.
  TITLE     M-phase phosphoprotein 8 promotes gastric cancer growth and
            metastasis via p53/Bcl-2 and EMT-related signaling pathways
  JOURNAL   J Cell Biochem 121 (3), 2330-2342 (2020)
   PUBMED   31692032
  REMARK    GeneRIF: M-phase phosphoprotein 8 promotes gastric cancer growth
            and metastasis via p53/Bcl-2 and EMT-related signaling pathways.
REFERENCE   3  (bases 1 to 4239)
  AUTHORS   Gao,X.Y., Qiao,Y.L., Zhang,Y., Wang,J., Shen,X. and Xu,C.W.
  TITLE     Knockdown of MPP8 suppresses cell proliferation via regulation of
            HOXA5 in non-small cell lung cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 64 (1), 27-31 (2018)
   PUBMED   29412790
  REMARK    GeneRIF: The study demonstrated that MPP8 was associated with
            non-small cell lung cancer cell proliferation through regulation of
            HOXA5.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4239)
  AUTHORS   Liu,N., Lee,C.H., Swigut,T., Grow,E., Gu,B., Bassik,M.C. and
            Wysocka,J.
  TITLE     Selective silencing of euchromatic L1s revealed by genome-wide
            screens for L1 regulators
  JOURNAL   Nature 553 (7687), 228-232 (2018)
   PUBMED   29211708
REFERENCE   5  (bases 1 to 4239)
  AUTHORS   Tchasovnikarova,I.A., Timms,R.T., Douse,C.H., Roberts,R.C.,
            Dougan,G., Kingston,R.E., Modis,Y. and Lehner,P.J.
  TITLE     Hyperactivation of HUSH complex function by Charcot-Marie-Tooth
            disease mutation in MORC2
  JOURNAL   Nat Genet 49 (7), 1035-1044 (2017)
   PUBMED   28581500
REFERENCE   6  (bases 1 to 4239)
  AUTHORS   Kokura,K., Sun,L., Bedford,M.T. and Fang,J.
  TITLE     Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing
            and promotes tumour cell motility and invasion
  JOURNAL   EMBO J 29 (21), 3673-3687 (2010)
   PUBMED   20871592
  REMARK    GeneRIF: MPP8 mediates E-cadherin gene silencing and promotes
            breast tumour cell motility and invasion.
REFERENCE   7  (bases 1 to 4239)
  AUTHORS   Maksimov,V.V., Arman,I.P. and Tarantul,V.Z.
  TITLE     [Identification of the proteins interacting with neuroprotective
            peptide humanin in a yeast two-hybrid system]
  JOURNAL   Genetika 42 (2), 274-277 (2006)
   PUBMED   16583711
REFERENCE   8  (bases 1 to 4239)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 4239)
  AUTHORS   Umeda,M., Nishitani,H. and Nishimoto,T.
  TITLE     A novel nuclear protein, Twa1, and Muskelin comprise a complex with
            RanBPM
  JOURNAL   Gene 303, 47-54 (2003)
   PUBMED   12559565
REFERENCE   10 (bases 1 to 4239)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA672302.1, BC003542.1, AL354808.24 and R60056.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017520.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.262443.1, BC003542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361479.10/ ENSP00000355388.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                DA672302.1         12-92
            82-2631             BC003542.1         1-2550
            2632-4211           AL354808.24        6737-8316
            4212-4239           R60056.1           32-59               c
FEATURES             Location/Qualifiers
     source          1..4239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..4239
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /note="M-phase phosphoprotein 8"
                     /db_xref="GeneID:54737"
                     /db_xref="HGNC:HGNC:29810"
                     /db_xref="MIM:611626"
     exon            1..303
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2673
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /EC_number="2.4.2.30"
                     /note="M-phase phosphoprotein, mpp8; two hybrid-associated
                     protein 3 with RanBPM"
                     /codon_start=1
                     /product="M-phase phosphoprotein 8"
                     /protein_id="NP_059990.2"
                     /db_xref="CCDS:CCDS9287.1"
                     /db_xref="GeneID:54737"
                     /db_xref="HGNC:HGNC:29810"
                     /db_xref="MIM:611626"
                     /translation="MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARG
                     AEAFGDSEEDGEDVFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEV
                     LLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQR
                     EEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKK
                     DEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPE
                     DDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKT
                     PRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLS
                     GEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDL
                     FKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAA
                     EGDQEVLDSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIP
                     SNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKG
                     AKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDI
                     VRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEA
                     RLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARL
                     CGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYR
                     VQLQ"
     exon            304..459
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..1308
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1408
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1666
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1792
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1881
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2022
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2109
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2264
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2419
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2547
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2631
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..4239
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4221..4226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /note="hexamer: AATAAA"
     polyA_site      4239
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /note="major polyA site"
ORIGIN      
        1 gatgtggagt agggccgagc gcggaacgcg aggggctgct ggggtgtttg tcgcagcggg
       61 ttttcctcgg cggtttgcgg agctgctagg atggagcagg ttgcggaggg agcaagggtg
      121 accgcagtcc ctgtgtcagc tgccgacagc actgaggagt tggccgaagt cgaagaagga
      181 gttggagtag tgggcgaaga taatgacgca gccgcgagag gagcggaggc ctttggcgac
      241 agtgaggagg acggagagga tgtgttcgag gtggagaaga tcctggacat gaagaccgag
      301 gggggtaaag ttctttacaa agttcgctgg aaaggctata catcggatga tgatacctgg
      361 gagcccgaga ttcacctgga ggactgtaaa gaagtgcttc ttgaatttag gaagaaaatt
      421 gcagagaaca aagccaaagc agtcaggaag gatattcaga gactatcctt aaataacgac
      481 atatttgagg cgaactctga tagcgatcag caaagtgaga caaaagaaga tacttcccca
      541 aagaagaaaa agaaaaaatt gaggcagaga gaagagaaaa gcccagatga tctgaaaaag
      601 aaaaaagcaa aggccgggaa gctaaaagac aagtccaaac cagacctgga gagctccttg
      661 gaaagtttag tttttgattt aaggacaaag aaaagaattt ctgaagccaa agaagaacta
      721 aaggagtcca aaaagcccaa aaaagatgaa gtaaaagaaa caaaagaatt aaagaaagtt
      781 aaaaagggtg aaataagaga tttaaagacg aaaacaagag aagatcccaa agaaaataga
      841 aaaacaaaaa aagaaaaatt tgtcgaatcc caggtggaat ctgaatcaag tgtacttaat
      901 gattctccct ttccagagga tgacagtgaa gggctacatt ccgacagcag agaagagaaa
      961 caaaacacta aaagtgcaag agagagagca gggcaggaca tggggctgga gcatggcttt
     1021 gagaagcccc tagacagtgc catgagtgct gaggaggata ccgatgtcag aggcaggagg
     1081 aaaaagaaga ccccgagaaa ggctgaggac actagagaga acaggaagct agagaacaag
     1141 aacgctttct tagagaagaa aactgtgcct aaaaagcaga ggaatcaaga cagaagcaaa
     1201 agtgctgcag agttagagaa gctgatgcct gtatctgccc aaacgccaaa gggccggagg
     1261 ttgagcgggg aagagagagg cctctggtcc acggactcag ccgaggagga caaagaaacc
     1321 aaaagaaatg aatccaaaga aaaatatcag aaaaggcatg attctgacaa ggaagaaaaa
     1381 ggcagaaaag agccaaaagg attaaagaca cttaaggaaa tcagaaatgc atttgattta
     1441 tttaaattaa ctccagaaga aaaaaatgat gtttctgaga ataatcggaa aagggaagaa
     1501 ataccactgg attttaaaac catagacgat cacaaaacca aggaaaacaa acagtcactt
     1561 aaagaaagga gaaacaccag agacgaaacg gatacttggg catacattgc tgcagaaggt
     1621 gatcaggagg ttttagacag cgtgtgccaa gcagatgaga attcagatgg caggcagcag
     1681 attctgagtt tgggcatgga cctgcagttg gaatggatga agttggaaga tttccaaaag
     1741 caccttgatg ggaaagatga gaattttgct gcaacagatg caattccaag taatgtgtta
     1801 agggatgctg tgaaaaatgg ggattatatt actgtaaaag ttgcacttaa ttcaaatgaa
     1861 gaatataacc tggaccaaga ggattccagt ggaatgacac tggtgatgct tgccgccgcc
     1921 ggagggcagg acgacctcct gcgactcctc atcacaaaag gcgcgaaagt gaacggtcgg
     1981 cagaagaacg ggaccaccgc cctcattcat gctgcagaga agaacttttt aacaacagtg
     2041 gctattcttt tggaagcagg agcttttgta aatgtccagc aaagcaatgg tgagactgca
     2101 ctgatgaagg cctgtaaaag aggaaattca gacatcgtac gactcgtaat tgaatgtgga
     2161 gctgactgca atattttgtc aaagcaccag aatagtgccc tgcactttgc gaagcagtct
     2221 aacaatgtgc ttgtgtacga cttgctgaag aaccatttag agacactttc aagagtagca
     2281 gaagagacaa taaaggatta ctttgaagct cgccttgctc tgctagaacc agtttttcca
     2341 atcgcatgtc atcgactctg tgagggtcca gatttttcaa cagatttcaa ttacaaaccc
     2401 ccacagaaca taccagaagg ctctggcatc ctgctgttta tcttccatgc aaactttttg
     2461 ggtaaagaag ttattgctcg gctctgtgga ccgtgtagtg tacaagctgt agttctgaat
     2521 gataaatttc agcttcctgt ttttctggac agtcattttg tttactcatt cagccctgtt
     2581 gcaggtccca ataaactctt cataaggttg acagaagcac cctctgccaa ggttaagttg
     2641 ctaataggtg catacagagt gcagctgcag tgaccaaaca gaagggactg ggcggagttc
     2701 tcttcagacc gattcctata ctctctttga cagcagtttg gaattcttct agcacatcta
     2761 tgtaaagttt tgtctgtaaa cctcttgcag ttaagcctgt tgtctgttgt agtctgtaag
     2821 atgcgacata gctgtgtctg tgccagtatg ccggaatctc agtgcagtgt ccagactgcg
     2881 tatttcagtt tttccacaat gtggatagta catatgagga ttatttaaga aaattaaaga
     2941 cttcactttc ttttttctgg agacggagtt tcgctcttgt tgcccaggct ggagtgcaat
     3001 ggtgcgatct cggctcactg caagctctgc ctcctgggtt caagtgattc tcctgcctca
     3061 gcctcctgag tagctgggat tacagacacc cgccatggca cccagctaat tttgtatttt
     3121 tagtagagat ggggtttatc catgttggtc aggctggtct tgaactcctg acctcaggtg
     3181 atccgcccgc ctcggcctcc caaagtgctt ggattacagg catgagccac cgcacccagc
     3241 aagagttatt ttcttaactt gaaattttct actagccctg gtgaacttct gtgcttaaaa
     3301 aaaaaaaaaa aaaaaggaaa aattcagctc taaaacattt gcttacagca agggagccat
     3361 gttatattca agttacccaa gcaccaaata aagtgtgggt ttgctgccct tgaaagggtt
     3421 gggaggcctg atctttttct agtagacagt tgccacacat tccccaagca caaaaggtgg
     3481 agatggcagt cactttgtaa atatgctgta gtcacttatc atcttttcaa agggtaacaa
     3541 gagaatctaa gatgtagtaa gaatgtaaac cagtacacta tgagacctaa aagagagtat
     3601 taaatgtgaa cttttagcag agcgtggtgg ctcacaccta taatcccagc gctttggagg
     3661 ctgaggttgg aggattgctt aagtccagga gttcaagacc agcctgggta acatggggtg
     3721 gaacaagcct gtagtcccag atactcagga ggctgaggtg aaaggattgc ttgagccagg
     3781 gaggtcaagg ctgcagtgag ccgtgaaagg ccactgcact ccagcctgag tgacagaatg
     3841 agaccttgtc tcaaaaaaaa aaaaaagttt cttggaacct atacggtttt tttttgtttt
     3901 ttttttttga aaagccagac cttgtgccct tgttttgaac accgactggg aagatggggc
     3961 ttaggtaaca gccaaacctg gctgtcagct gtgtgggagc caccaccctc tctgggaaga
     4021 gttcctgctt ctgtatggca agcataaatc aagctcagtc tgggttatgg agaagttgaa
     4081 aattgttttg ttcctcatta gtttataatt gtatgaaata cgattttaat gaaaactttt
     4141 cagaattcac gtttgtgtag atatttcaga gaaccatttt tactttacat cctaaaactg
     4201 ccttttccta tggttttgtc aataaaacac tatgatgtt
//
