LOCUS       NM_005792               1101 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens M-phase phosphoprotein 6 (MPHOSPH6), mRNA.
ACCESSION   NM_005792
VERSION     NM_005792.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1101)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1101)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1101)
  AUTHORS   Yoshikatsu,Y., Ishida,Y., Sudo,H., Yuasa,K., Tsuji,A. and
            Nagahama,M.
  TITLE     NVL2, a nucleolar AAA-ATPase, is associated with the nuclear
            exosome and is involved in pre-rRNA processing
  JOURNAL   Biochem Biophys Res Commun 464 (3), 780-786 (2015)
   PUBMED   26166824
REFERENCE   4  (bases 1 to 1101)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 1101)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   6  (bases 1 to 1101)
  AUTHORS   Schilders,G., Raijmakers,R., Raats,J.M. and Pruijn,G.J.
  TITLE     MPP6 is an exosome-associated RNA-binding protein involved in 5.8S
            rRNA maturation
  JOURNAL   Nucleic Acids Res 33 (21), 6795-6804 (2005)
   PUBMED   16396833
  REMARK    GeneRIF: MPP6 is a nucleolus-specific exosome co-factor required
            for its role in the maturation of 5.8S rRNA.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1101)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 1101)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 1101)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
  REMARK    GeneRIF: MPP6 was found to be associated with the exosome, a
            multiprotein complex involved in RNA degradation.
REFERENCE   10 (bases 1 to 1101)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW175781.1, BU595100.1, BU622913.1 and AI831131.1.
            
            On Nov 30, 2006 this sequence version replaced NM_005792.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222667.1, SRR1163657.208941.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258169.9/ ENSP00000258169.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AW175781.1         33-75
            44-399              BU595100.1         40-395
            400-992             BU622913.1         17-609              c
            993-1101            AI831131.1         1-109               c
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.3"
     gene            1..1101
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /note="M-phase phosphoprotein 6"
                     /db_xref="GeneID:10200"
                     /db_xref="HGNC:HGNC:7214"
                     /db_xref="MIM:605500"
     exon            1..100
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..532
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /codon_start=1
                     /product="M-phase phosphoprotein 6"
                     /protein_id="NP_005783.2"
                     /db_xref="CCDS:CCDS10937.1"
                     /db_xref="GeneID:10200"
                     /db_xref="HGNC:HGNC:7214"
                     /db_xref="MIM:605500"
                     /translation="MAAERKTRLSKNLLRMKFMQRGLDSETKKQLEEEEKKIISEEHW
                     YLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVED
                     ETVELDVSDEEMARRYETLVGTIGKKFARKRDHANYEEDENGDITPIKAKKMFLKPQD
                     "
     exon            101..213
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            214..304
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            305..399
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1101
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      968..973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /note="hexamer: AATAAA"
     polyA_site      992
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /note="major polyA site"
     regulatory      1080..1085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /note="hexamer: AATAAA"
     polyA_site      1101
                     /gene="MPHOSPH6"
                     /gene_synonym="MPP; MPP-6; MPP6"
                     /note="major polyA site"
ORIGIN      
        1 atgtgcggtg aggctcgcgg ccggagtgcg gcgctgggcg gaagctacca tggcggccga
       61 gcgaaagaca aggttgtcca agaatctact gcgcatgaag tttatgcaaa ggggactgga
      121 ctcagaaacc aagaaacaac tagaagaaga agaaaagaaa atcattagtg aagagcactg
      181 gtacttggat ttgccagagc ttaaagagaa agagagtttc ataatagaag agcagagttt
      241 cttactatgt gaagatcttc tctatggaag aatgtcattc agaggattta atcctgaggt
      301 tgagaaattg atgcttcaga tgaatgctaa gcacaaagca gaagaagttg aagatgaaac
      361 agtagagctt gatgtgtcag atgaagagat ggctagaaga tatgagacct tggtggggac
      421 aattgggaaa aagtttgcca gaaagagaga ccatgccaat tatgaagaag atgaaaatgg
      481 agacataaca ccaattaaag caaagaagat gttcttaaag ccccaggatt aagatggatg
      541 ccttaagcga tggcccaggg gtgcttggtg gaagtcagca gggcatctgg agctcatccc
      601 aatggtgtct ctatagttat taatactgta acgtttactt gtaaagagat tatcatttta
      661 gaaacatgct gtttttgaaa cagatgtgtg atggatgttg tacatccttt gcttcttggt
      721 attcattcag agtggatttt tagcccctga tctacaaatg tacattgtta cagggctgct
      781 tcctaaagat tttttttacc tcaggtttct cttaatatag ttctccagtc actgaccttg
      841 aattgactta cataaactac tgccaatgtt taaattgccc ttatgtttat atttattatg
      901 tcaagccaat tcgtacatac aatttggaat caaatgtcat aagaatttat tatataaatt
      961 tatcaagaat aaaaatgcct ctccagcctt aagtatttac atgctcccag gtcattgtca
     1021 gtttatggta ttatgttgtt ttatttaaag cattgaattg atagaaaaat ttgctctgta
     1081 ataaaaatct actttcacat a
//
