LOCUS       NM_005791               2164 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens M-phase phosphoprotein 10 (MPHOSPH10), mRNA.
ACCESSION   NM_005791
VERSION     NM_005791.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2164)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 2164)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2164)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 2164)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2164)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   6  (bases 1 to 2164)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 2164)
  AUTHORS   Granneman,S., Gallagher,J.E., Vogelzangs,J., Horstman,W., van
            Venrooij,W.J., Baserga,S.J. and Pruijn,G.J.
  TITLE     The human Imp3 and Imp4 proteins form a ternary complex with
            hMpp10, which only interacts with the U3 snoRNA in 60-80S
            ribonucleoprotein complexes
  JOURNAL   Nucleic Acids Res 31 (7), 1877-1887 (2003)
   PUBMED   12655004
REFERENCE   8  (bases 1 to 2164)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 2164)
  AUTHORS   Westendorf,J.M., Konstantinov,K.N., Wormsley,S., Shu,M.D.,
            Matsumoto-Taniura,N., Pirollet,F., Klier,F.G., Gerace,L. and
            Baserga,S.J.
  TITLE     M phase phosphoprotein 10 is a human U3 small nucleolar
            ribonucleoprotein component
  JOURNAL   Mol Biol Cell 9 (2), 437-449 (1998)
   PUBMED   9450966
REFERENCE   10 (bases 1 to 2164)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126389.1 and BC041084.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005791.2.
            
            Summary: This gene encodes a protein that is phosphorylated during
            mitosis. The protein localizes to the nucleolus during interphase
            and to the chromosomes during M phase. The protein associates with
            the U3 small nucleolar ribonucleoprotein 60-80S complexes and may
            be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.151375.1,
                                           SRR1660803.210472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244230.7/ ENSP00000244230.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2140              BC126389.1         258-2397
            2141-2164           BC041084.1         2111-2134
FEATURES             Location/Qualifiers
     source          1..2164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2164
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /note="M-phase phosphoprotein 10"
                     /db_xref="GeneID:10199"
                     /db_xref="HGNC:HGNC:7213"
                     /db_xref="MIM:605503"
     exon            1..121
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2078
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /note="m phase phosphoprotein 10; protein phosphatase 1,
                     regulatory subunit 106; U3 small nucleolar
                     ribonucleoprotein"
                     /codon_start=1
                     /product="U3 small nucleolar ribonucleoprotein protein
                     MPP10"
                     /protein_id="NP_005782.1"
                     /db_xref="CCDS:CCDS1916.1"
                     /db_xref="GeneID:10199"
                     /db_xref="HGNC:HGNC:7213"
                     /db_xref="MIM:605503"
                     /translation="MAPQVWRRRTLERCLTEVGKATGRPECFLTIQEGLASKFTSLTK
                     VLYDFNKILENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDE
                     DISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDL
                     RKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIE
                     KEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESD
                     EDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFA
                     LPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTA
                     QKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKED
                     AYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLD
                     ALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTA
                     AEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTK
                     TGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKLKL"
     exon            122..800
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            801..958
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1130
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1272
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1340
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1478
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1589
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1697
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1928
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2164
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /note="hexamer: AATAAA"
     polyA_site      2164
                     /gene="MPHOSPH10"
                     /gene_synonym="CT90; MPP10; MPP10P; PPP1R106"
                     /note="major polyA site"
ORIGIN      
        1 atgctgcatt gtgtcgggag ttgctgacag ccatggcgcc gcaggtctgg cgtcgacgga
       61 ccctggagcg gtgtctgacg gaagtcggca aagccacggg tcggcccgag tgcttcctca
      121 cgattcaaga gggattggca tcaaagttca cttctttaac aaaagtgctt tatgacttta
      181 ataaaatatt agagaatggt aggatccatg gaagcccctt gcaaaaactt gtgatagaaa
      241 attttgatga tgagcagatt tggcaacaac tggaattgca aaatgaacca attttacaat
      301 actttcagaa tgcagttagt gaaacaatta atgatgaaga tatcagtctt ctcccagaga
      361 gtgaagaaca ggaacgtgaa gaggatggtt cagagataga ggctgatgac aaggaggacc
      421 tagaagattt agaggaggag gaagtgtccg acatgggtaa tgatgatcct gaaatgggtg
      481 agagagctga aaactcaagc aaatctgatc tgaggaaaag ccccgttttc agtgatgagg
      541 attctgacct tgactttgat atcagcaaat tggaacagca gagcaaggtg caaaacaaag
      601 gacagggaaa accaagagaa aagtccatag tagatgataa attcttcaaa ctctctgaaa
      661 tggaggccta tttagaaaac atagaaaaag aagaggaacg aaaagatgat aatgatgagg
      721 aggaggaaga tattgatttt tttgaagata ttgattctga tgaagatgaa gggggactgt
      781 ttggaagtaa aaaacttaag tcaggtaaaa gttccagaaa tctgaaatac aaagattttt
      841 ttgatccagt tgaaagtgat gaagacataa caaatgttca tgatgatgag ctggattcaa
      901 acaaagaaga tgatgaaatt gctgaagaag aagcagaaga actaagtatt tcggaaacgg
      961 atgaagatga tgaccttcaa gaaaatgaag acaataaaca acataaagaa agcttgaaaa
     1021 gagtgacctt tgctttacca gatgatgcgg aaactgaaga tacaggtgtt ttaaatgtaa
     1081 agaaaaattc tgatgaagtt aaatcctcct ttgaaaaaag acaggaaaag atgaatgaaa
     1141 aaattgcatc tttagaaaaa gagttgttag aaaaaaagcc gtggcagctt cagggggaag
     1201 tgacagcaca gaagaggcca gagaacagcc tcctggagga gaccctacac tttgaccatg
     1261 ctgtccggat ggcacctgtg attacagagg aaaccaccct tcaactggaa gatatcatta
     1321 aacagaggat aagagatcag gcttgggatg atgtagtacg taaagaaaaa cctaaagagg
     1381 atgcatatga atataaaaag cgtttaacct tagaccatga gaagagtaaa ttgagccttg
     1441 ctgaaattta tgaacaggag tacatcaaac tcaaccagca aaaaacagca gaagaagaaa
     1501 atccagaaca tgtagaaatt cagaagatga tggattccct cttcttaaaa ttggatgccc
     1561 tctcaaactt ccactttatc cctaaaccgc ctgtaccaga gattaaagtt gtgtcaaatc
     1621 tgccagccat aaccatggag gaagtagccc cagtgagtgt tagtgatgca gctctcctgg
     1681 ccccagagga gatcaaggag aaaaataaag ctggagatat aaaaacagct gctgaaaaaa
     1741 cagctacaga caagaaacga gagcgaagga aaaagaaata tcaaaagcgt atgaaaataa
     1801 aagagaagga gaagcggaga aaactgcttg aaaagagcag tgtagatcaa gcagggaaat
     1861 acagcaaaac agtagcttcg gagaagttaa aacagctgac caaaactggc aaagcttcct
     1921 tcataaagga tgaaggtaaa gacaaggcct taaagtcctc tcaagcattc ttttctaaat
     1981 tacaagatca agtaaaaatg caaatcaatg atgcaaagaa aacagaaaag aaaaagaaga
     2041 aaagacagga tatttctgtt cataaattaa agctgtaata tattttgaat ataatgtaaa
     2101 tattaatgtg taagcttata ttgtgtcatt gttctgtttt ataataaaat tcttgagaac
     2161 cttc
//
