LOCUS       NM_001378778            7821 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens multiple PDZ domain crumbs cell polarity complex
            component (MPDZ), transcript variant 18, mRNA.
ACCESSION   NM_001378778 XM_006716885
VERSION     NM_001378778.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7821)
  AUTHORS   Chen,Z., Ba,Y., Zhao,N., Dang,Q., Xu,H., Weng,S., Zhang,Y., Liu,S.,
            Zuo,A., Han,X. and Liu,Z.
  TITLE     MPDZ is associated with immune infiltration and regulates migration
            and invasion by switching YAP1 phosphorylation in colorectal cancer
  JOURNAL   Cell Signal 114, 110967 (2024)
   PUBMED   37949382
  REMARK    GeneRIF: MPDZ is associated with immune infiltration and regulates
            migration and invasion by switching YAP1 phosphorylation in
            colorectal cancer.
REFERENCE   2  (bases 1 to 7821)
  AUTHORS   Iyengar,R., Deardorff,M., Schmidt,R. and Nagiel,A.
  TITLE     Retinal manifestations in autosomal recessive MPDZ maculopathy:
            report of two cases and literature review
  JOURNAL   Ophthalmic Genet 44 (6), 572-576 (2023)
   PUBMED   36594712
  REMARK    GeneRIF: Retinal manifestations in autosomal recessive MPDZ
            maculopathy: report of two cases and literature review.
            Review article
REFERENCE   3  (bases 1 to 7821)
  AUTHORS   Yuan,S., Li,D., Ma,M., Zhou,L., Ma,Z., Shi,B., Zhang,S., Li,H.,
            Sheng,X. and Liu,J.
  TITLE     Evaluating the association between MPDZ-NF1B rs1324183 and
            keratoconus in an independent northwestern Chinese population
  JOURNAL   BMC Ophthalmol 22 (1), 129 (2022)
   PUBMED   35305607
  REMARK    GeneRIF: Evaluating the association between MPDZ-NF1B rs1324183 and
            keratoconus in an independent northwestern Chinese population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7821)
  AUTHORS   Bharadwaj,T., Schrauwen,I., Rehman,S., Liaqat,K., Acharya,A.,
            Giese,A.P.J., Nouel-Saied,L.M., Nasir,A., Everard,J.L.,
            Pollock,L.M., Zhu,S., Bamshad,M.J., Nickerson,D.A., Ali,R.H.,
            Ullah,A., Wali,A., Ali,G., Santos-Cortez,R.L.P., Ahmed,Z.M.,
            McDermott,B.M. Jr., Ansar,M., Riazuddin,S., Ahmad,W. and Leal,S.M.
  TITLE     ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal
            recessive nonsyndromic hearing impairment
  JOURNAL   Eur J Hum Genet 30 (1), 22-33 (2022)
   PUBMED   34135477
  REMARK    GeneRIF: ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for
            autosomal recessive nonsyndromic hearing impairment.
REFERENCE   5  (bases 1 to 7821)
  AUTHORS   Liu,W., Huang,Y., Wang,D., Han,F., Chen,H., Chen,J., Jiang,X.,
            Cao,J. and Liu,J.
  TITLE     MPDZ as a novel epigenetic silenced tumor suppressor inhibits
            growth and progression of lung cancer through the Hippo-YAP pathway
  JOURNAL   Oncogene 40 (26), 4468-4485 (2021)
   PUBMED   34108620
  REMARK    GeneRIF: MPDZ as a novel epigenetic silenced tumor suppressor
            inhibits growth and progression of lung cancer through the
            Hippo-YAP pathway.
REFERENCE   6  (bases 1 to 7821)
  AUTHORS   Becamel,C., Figge,A., Poliak,S., Dumuis,A., Peles,E., Bockaert,J.,
            Lubbert,H. and Ullmer,C.
  TITLE     Interaction of serotonin 5-hydroxytryptamine type 2C receptors with
            PDZ10 of the multi-PDZ domain protein MUPP1
  JOURNAL   J Biol Chem 276 (16), 12974-12982 (2001)
   PUBMED   11150294
REFERENCE   7  (bases 1 to 7821)
  AUTHORS   Lee,S.S., Glaunsinger,B., Mantovani,F., Banks,L. and Javier,R.T.
  TITLE     Multi-PDZ domain protein MUPP1 is a cellular target for both
            adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6
            oncoproteins
  JOURNAL   J Virol 74 (20), 9680-9693 (2000)
   PUBMED   11000240
REFERENCE   8  (bases 1 to 7821)
  AUTHORS   Mancini,A., Koch,A., Stefan,M., Niemann,H. and Tamura,T.
  TITLE     The direct association of the multiple PDZ domain containing
            proteins (MUPP-1) with the human c-Kit C-terminus is regulated by
            tyrosine kinase activity
  JOURNAL   FEBS Lett 482 (1-2), 54-58 (2000)
   PUBMED   11018522
REFERENCE   9  (bases 1 to 7821)
  AUTHORS   Barritt,D.S., Pearn,M.T., Zisch,A.H., Lee,S.S., Javier,R.T.,
            Pasquale,E.B. and Stallcup,W.B.
  TITLE     The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the
            membrane-spanning proteoglycan NG2
  JOURNAL   J Cell Biochem 79 (2), 213-224 (2000)
   PUBMED   10967549
REFERENCE   10 (bases 1 to 7821)
  AUTHORS   Ullmer,C., Schmuck,K., Figge,A. and Lubbert,H.
  TITLE     Cloning and characterization of MUPP1, a novel PDZ domain protein
  JOURNAL   FEBS Lett 424 (1-2), 63-68 (1998)
   PUBMED   9537516
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162386.17, AL353639.10,
            AL161449.7 and KF458902.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 10, 2020 this sequence version replaced XM_006716885.3.
            
            Summary: The protein encoded by this gene has multiple PDZ domains,
            which are hallmarks of protein-protein interactions. The encoded
            protein is known to interact with the HTR2C receptor and may cause
            it to clump at the cell surface. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1886138.1,
                                           SRR14038191.3542628.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319217.12/ ENSP00000320006.7
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AL162386.17        49647-49939         c
            294-366             AL162386.17        20547-20619         c
            367-533             AL162386.17        17882-18048         c
            534-743             AL353639.10        96443-96652         c
            744-883             AL353639.10        95640-95779         c
            884-1097            AL353639.10        94302-94515         c
            1098-1226           AL353639.10        93441-93569         c
            1227-1436           AL353639.10        91628-91837         c
            1437-1551           AL353639.10        89249-89363         c
            1552-1640           AL353639.10        88843-88931         c
            1641-1824           AL353639.10        77985-78168         c
            1825-1896           AL353639.10        77105-77176         c
            1897-2006           AL353639.10        68190-68299         c
            2007-2153           AL353639.10        65236-65382         c
            2154-2318           AL353639.10        64200-64364         c
            2319-2504           AL353639.10        62183-62368         c
            2505-2714           AL353639.10        60853-61062         c
            2715-2831           AL353639.10        58339-58455         c
            2832-2999           AL353639.10        55487-55654         c
            3000-3281           AL353639.10        48205-48486         c
            3282-3405           AL353639.10        47821-47944         c
            3406-3604           AL353639.10        40435-40633         c
            3605-3709           AL353639.10        34760-34864         c
            3710-3802           AL353639.10        30087-30179         c
            3803-3980           AL353639.10        22580-22757         c
            3981-4091           AL353639.10        19617-19727         c
            4092-4190           AL353639.10        15535-15633         c
            4191-4353           AL353639.10        12056-12218         c
            4354-4550           AL353639.10        10026-10222         c
            4551-4642           AL353639.10        8781-8872           c
            4643-4733           AL353639.10        8161-8251           c
            4734-4814           AL353639.10        5893-5973           c
            4815-4907           AL161449.7         166409-166501       c
            4908-4982           AL161449.7         166245-166319       c
            4983-5157           AL161449.7         164945-165119       c
            5158-5303           AL161449.7         162882-163027       c
            5304-5387           AL161449.7         161816-161899       c
            5388-5581           AL161449.7         161468-161661       c
            5582-5729           AL161449.7         159231-159378       c
            5730-5816           AL161449.7         154977-155063       c
            5817-5907           AL161449.7         153660-153750       c
            5908-5951           AL161449.7         152740-152783       c
            5952-6074           KF458902.1         111-233
            6075-6179           AL161449.7         150365-150469       c
            6180-6292           AL161449.7         149681-149793       c
            6293-6416           AL161449.7         148665-148788       c
            6417-7821           AL161449.7         145436-146840       c
FEATURES             Location/Qualifiers
     source          1..7821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23"
     gene            1..7821
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /note="multiple PDZ domain crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:8777"
                     /db_xref="HGNC:HGNC:7208"
                     /db_xref="MIM:603785"
     exon            1..293
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..366
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..6563
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /note="isoform 4 is encoded by transcript variant 18;
                     multi-PDZ domain protein 1; multiple PDZ domain protein"
                     /codon_start=1
                     /product="multiple PDZ domain protein isoform 4"
                     /protein_id="NP_001365707.1"
                     /db_xref="CCDS:CCDS83342.1"
                     /db_xref="GeneID:8777"
                     /db_xref="HGNC:HGNC:7208"
                     /db_xref="MIM:603785"
                     /translation="MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPL
                     FSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNL
                     EALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENR
                     GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQL
                     VIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKA
                     TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIA
                     RGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIA
                     GYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH
                     TGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTN
                     ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLG
                     ISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI
                     EVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQ
                     STEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAE
                     KDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSA
                     KEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQ
                     ASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDE
                     NTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLP
                     DSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLG
                     MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITY
                     VPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNW
                     NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKP
                     GDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKY
                     NFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKI
                     SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIV
                     GIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV
                     NQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLG
                     IAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA
                     KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTP
                     AIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKD
                     GRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTI
                     ELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT
                     QEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSE
                     SLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGV
                     AAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQ
                     EPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYV
                     KTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS"
     exon            367..533
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..743
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..883
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1097
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1226
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1436
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1551
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1640
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1824
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1896
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2006
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2153
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2318
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2504
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2714
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2831
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2999
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3281
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3405
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3604
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3709
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3802
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3980
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4091
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4190
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4353
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4550
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4551..4642
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4643..4733
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4734..4814
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4907
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4908..4982
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5157
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5158..5303
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5304..5387
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5581
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5582..5729
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5730..5816
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5817..5907
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..5951
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5952..6074
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6075..6179
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6180..6292
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6293..6416
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6417..7821
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7796..7801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /note="hexamer: AATAAG"
     polyA_site      7821
                     /gene="MPDZ"
                     /gene_synonym="HYC2; MUPP1"
                     /note="major polyA site"
ORIGIN      
        1 agcctgggcc ccgccaccgc ctccgcggca gccccggtcg gcgcaagtgc ggcgcgcgct
       61 gggggagggg gcgcggcgga gcgctaggct ggcgtcgggc caccgcggga ttaagtttct
      121 cagtcacgcg tgagtgtctg tgcgttttga tccgaagctc ctcgccgggt cgttacttca
      181 gaagagaaga cagtgagcgt gggcgaggcg aggcatccag aggccccggc gacccctgct
      241 ccccagtcct ccgccccctc gcgtcgcggc cctgggcggg cgccgcgagc cggagttcca
      301 ttttaattgc tgttaatcat ttcagagaag aacactgaac tttgaaaaaa atgttggaag
      361 ccattgacaa aaatcgggcc ctgcatgcag cagagcgctt gcaaaccaag ctgcgagaac
      421 gtggggatgt agcaaatgaa gacaaactga gccttctgaa gtcagtcctg cagagccctc
      481 tcttcagtca gattctgagc cttcagactt ctgtacagca gctgaaagac caggtaaata
      541 ttgcaacttc agcaacttca aatattgaat atgcccacgt tcctcatctc agcccagctg
      601 tgattcctac tctgcaaaat gaatcgtttt tattatcccc aaacaatggg aatctggaag
      661 cacttacagg acctggtatt ccacacatta atgggaaacc tgcttgtgat gaatttgatc
      721 agcttatcaa aaatatggcc cagggtcgcc atgtagaagt ttttgagctc ctcaaacctc
      781 catctggagg ccttgggttt agtgttgtgg gactaagaag tgaaaacaga ggagagctgg
      841 gaatatttgt tcaagagata caagagggca gtgtggccca tagagatgga agattgaaag
      901 aaactgatca aattcttgct atcaatggac aggctcttga tcagacaatt acacatcagc
      961 aggctatcag catcctgcag aaagccaaag atactgtcca gctagttatt gccagaggct
     1021 cattgcctca gcttgtcagc cccatagttt cccgttctcc atctgcagcc agcacaattt
     1081 cagctcactc taatccggtt cactggcaac acatggaaac gattgaattg gtgaatgatg
     1141 gatctggttt gggatttggc atcataggag gaaaagcaac tggtgtgata gtaaaaacca
     1201 ttctgcctgg aggagtagct gatcagcatg ggcgtttatg cagtggagac cacattctaa
     1261 agattggtga cacagatcta gcaggaatga gcagtgagca agtagcacaa gtccttaggc
     1321 aatgtggaaa tagagttaag ttgatgattg caagaggtgc catagaagaa cgtacagcac
     1381 ccactgcttt gggcatcacc ctctcctcat ccccaacttc aacaccagag ttgcgggttg
     1441 atgcttctac tcagaaaggt gaagaaagtg agacatttga tgtagaactc actaaaaatg
     1501 tccaaggatt aggaattacc attgctggct acattggaga taaaaaattg gaaccttcag
     1561 gaatctttgt aaagagcatt acaaaaagca gtgccgttga gcatgatgga agaatccaaa
     1621 ttggagacca aattatagca gtagatggca caaaccttca gggttttact aatcagcaag
     1681 cagtagaggt attgcgacat acaggacaaa ctgtgctcct gacactaatg aggagaggaa
     1741 tgaagcagga agccgagctc atgtcaaggg aagacgtcac aaaagatgca gatttgtctc
     1801 ctgttaatgc cagcataatc aaagaaaatt atgaaaaaga tgaagatttt ttatcttcga
     1861 cgagaaacac caacatatta ccaactgaag aagaagggta tccattactg tcagctgaga
     1921 tagaagaaat agaagatgca caaaaacaag aagctgctct gctgacaaaa tggcaaagga
     1981 ttatgggaat taactatgaa atagtggtgg cccatgtgag caagtttagt gagaacagtg
     2041 gattggggat aagcctggaa gcgacagtgg gacatcattt tatccgatct gttctaccag
     2101 agggtcctgt tggacacagc gggaagctct tcagtggaga cgagctattg gaagtaaatg
     2161 gcataacttt acttggggaa aatcaccaag atgtggtgaa tatcttaaaa gaactgccta
     2221 tagaagtgac aatggtgtgc tgtcgtcgaa ctgtgccacc caccacccaa tcagaattgg
     2281 atagcctgga cttatgtgat attgagctaa cagaaaagcc tcacgtagat ctaggtgagt
     2341 tcatcgggtc atcagagaca gaggatccag tgctggcgat gactgatgcg ggtcagagta
     2401 cagaagaggt tcaagcacct ttggccatgt gggaggctgg cattcagcac atagagctgg
     2461 agaaagggag caaaggactt ggttttagca ttttagatta tcaggatcca attgatccag
     2521 caagcactgt gattataatt cgttctttgg tgcctggcgg cattgctgaa aaggatggac
     2581 gacttcttcc tggtgaccga ctcatgtttg taaacgatgt taacttggaa aacagcagtc
     2641 ttgaggaagc tgtagaagca ctgaagggag caccgtcagg gactgtgaga ataggagttg
     2701 ctaagccttt acccctttca ccagaagaag gttatgtttc tgctaaggag gattcctttc
     2761 tctacccacc acactcctgt gaggaagcag ggctggctga caaacccctc ttcagggctg
     2821 acttggctct ggtgggcaca aatgatgctg acttagtaga tgaatccaca tttgagtctc
     2881 catactctcc tgaaaatgac agcatctact ctactcaagc ctctatttta tctcttcatg
     2941 gcagttcttg tggtgatggc ctgaactatg gttcttccct tccatcatct cctcctaagg
     3001 atgttattga aaattcttgt gatccagtac ttgatctgca tatgtctctg gaggaactat
     3061 atacccagaa tctcctgcaa agacaggatg agaatacacc ttcggtggac ataagtatgg
     3121 ggcctgcttc tggctttact ataaatgact acacacctgc aaatgctatt gaacaacaat
     3181 atgaatgtga aaacacaata gtgtggactg aatctcattt accaagtgaa gttatatcaa
     3241 gtgcagaact tccttctgtg ctacccgatt cagctggaaa gggctctgag tacctgcttg
     3301 aacagagctc cctggcctgt aatgctgagt gtgtcatgct tcaaaatgta tctaaagaat
     3361 cttttgaaag gactattaat atagcaaaag gcaattctag cctaggaatg acagttagtg
     3421 ctaataaaga tggcttgggg atgatcgttc gaagcattat tcatggaggt gccattagtc
     3481 gagatggccg gattgccatt ggggactgca tcttgtccat taatgaagag tctaccatca
     3541 gtgtaaccaa tgcccaggca cgagctatgt tgagaagaca ttctctcatt ggccctgaca
     3601 taaaaattac ttatgtgcct gcagaacatt tggaagagtt caaaataagc ttgggacaac
     3661 aatctggaag agtaatggca ctggatattt tttcttcata cactggcaga gacattccag
     3721 aattaccaga gcgagaagag ggagagggtg aagaaagcga acttcaaaac acagcatata
     3781 gcaattggaa tcagcccagg cgggtggaac tctggagaga accaagcaaa tccttaggca
     3841 tcagcattgt tggtggacga gggatgggga gtcggctaag caatggagaa gtgatgaggg
     3901 gcattttcat caaacatgtt ctggaagata gtccagctgg caaaaatgga accttgaaac
     3961 ctggagatag aatcgtagag gtggatggaa tggacctcag agatgcaagc catgaacaag
     4021 ctgtggaagc cattcggaaa gcaggcaacc ctgtagtctt tatggtacag agcattataa
     4081 acagaccaag gaaatcccct ttgccttcct tgctgcacaa cctttaccct aagtacaact
     4141 tcagcagcac taacccattt gctgactctc tacaaatcaa cgccgacaag gcacccagtc
     4201 agtcagagtc agagccagag aaggctccat tgtgcagtgt gcccccaccc cctccttcag
     4261 cctttgccga aatgggtagt gatcacacac agtcatctgc aagcaaaatc tcacaagatg
     4321 tggacaaaga ggatgagttt ggttacagct ggaaaaatat cagagagcgt tatggaaccc
     4381 taacaggcga gctgcatatg attgaactgg agaaaggtca tagtggtttg ggcctaagtc
     4441 ttgctgggaa caaagaccga tccaggatga gtgtcttcat agtggggatt gatccaaatg
     4501 gagctgcagg aaaagatggt cgattgcaaa ttgcagatga gcttctagag atcaatggtc
     4561 agattttata tggaagaagt catcagaatg cctcatcaat cattaaatgt gccccttcta
     4621 aagtgaaaat aatttttatc agaaataaag atgcagtgaa tcagatggcc gtatgtcctg
     4681 gaaatgcagt agaacctttg ccttctaact cagaaaatct tcaaaataag gagacagagc
     4741 caactgttac tacttctgat gcagctgtgg acctcagttc atttaaaaat gtgcaacatc
     4801 tggagcttcc caaggatcag gggggtttgg gtattgctat cagcgaagaa gatacactca
     4861 gtggagtcat cataaagagc ttaacagagc atggggtagc agccacggat ggacgactca
     4921 aagtcggaga tcagatactg gctgtagatg atgaaattgt tgttggttac cctattgaaa
     4981 agtttattag ccttctgaag acagcaaaga tgacagtaaa acttaccatc catgctgaga
     5041 atccagattc ccaggctgtt ccttcagcag ctggtgcagc cagtggagaa aaaaagaaca
     5101 gctcccagtc tctgatggtc ccacagtctg gctccccaga accggagtcc atccgaaata
     5161 caagcagatc atcaacacca gcaatttttg cttctgatcc tgcaacctgc cccattatcc
     5221 ctggctgcga aacaaccatc gagatttcca aagggcgaac agggctgggc ctgagcatcg
     5281 ttgggggttc agacacgctg ctgggtgcca ttattatcca tgaagtttat gaagaaggag
     5341 cagcatgtaa agatggaaga ctctgggctg gagatcagat cttagaggtg aatggaattg
     5401 acttgagaaa ggccacacat gatgaagcaa tcaatgtcct gagacagacg ccacagagag
     5461 tgcgcctgac actctacaga gatgaggccc catacaaaga ggaggaagtg tgtgacaccc
     5521 tcactattga gctgcagaag aagccgggaa aaggcctagg attaagtatt gttggtaaaa
     5581 gaaacgatac tggagtattt gtgtcagaca ttgtcaaagg aggaattgca gatgccgatg
     5641 gaagactgat gcagggagac cagatattaa tggtgaatgg ggaagacgtt cgtaatgcca
     5701 cccaagaagc ggttgccgct ttgctaaagt gttccctagg cacagtaacc ttggaagttg
     5761 gaagaatcaa agctggtcca ttccattcag agaggaggcc atctcaaagc agccaggtga
     5821 gtgaaggcag cctgtcatct ttcacttttc cactctctgg atccagtaca tctgagtcac
     5881 tggaaagtag ctcaaagaag aatgcattgg catctgaaat acagggatta agaacagtcg
     5941 aaatgaaaaa gggccctact gactcactgg gaatcagcat cgctggagga gtaggcagcc
     6001 cacttggtga tgtgcctata tttattgcaa tgatgcaccc aactggagtt gcagcacaga
     6061 cccaaaaact cagagttggg gataggattg tcaccatctg tggcacatcc actgagggca
     6121 tgactcacac ccaagcagtt aacctactga aaaatgcatc tggctccatt gaaatgcagg
     6181 tggttgctgg aggagacgtg agtgtggtca caggtcatca gcaggagcct gcaagttcca
     6241 gtctttcttt cactgggctg acgtcaagca gtatatttca ggatgattta ggacctcctc
     6301 aatgtaagtc tattacacta gagcgaggac cagatggctt aggcttcagt atagttggag
     6361 gatatggcag ccctcatgga gacttaccca tttatgttaa aacagtgttt gcaaagggag
     6421 cagcctctga agacggacgt ctgaaaaggg gcgatcagat cattgctgtc aatgggcaga
     6481 gtctagaagg agtcacccat gaagaagctg ttgccatcct taaacggaca aaaggcactg
     6541 tcactttgat ggttctctct tgaattggct gccagaattg aaccaaccca acccctagct
     6601 cacctcctac tgtaaagaga atgcactggt cctgacaatt tttatgctgt gttcagccgg
     6661 gtcttcaaaa ctgtaggggg gaaataacac ttaagtttct ttttctcatc tagaaatgct
     6721 ttccttactg acaacctaac atcatttttc ttttcttctt gcattttgtg aacttaaaga
     6781 gaaggaatat ttgtgtaggt gaatctcgtt tttatttgtg gagatatcta atgttttgta
     6841 gtcacatggg caagaattat tacatgctaa gctggttagt ataaagaaag ataattctaa
     6901 agctaaccaa agaaaatggc ttcagtaaat taggatgaaa aatgaaaata taaaataaag
     6961 aagaaaatct cggggagttt aaaaaaaatg cctcaatttg gcaatctacc tcctctcccc
     7021 accccaaact aaaaaaagaa aaaaaggttt tctaatgaaa atctttaaaa atactgtcag
     7081 tattttaaaa ttttcaacag tattataaaa acattgcatc tccccacctc taatatgcat
     7141 atatattttt cctgctaaaa ttggtttcta caattgagta aatggcaaat acatgaagca
     7201 atgtccctaa attttataaa gaaattatat ttaatgcaca tttcaatttt cattcttatt
     7261 tttgaccttt tgtaaaatat tttcatgttg ctataagtaa atgatgatgc caccccatgt
     7321 tgactatggt ttttctagaa agcaactatg ctgctaacca tagaggaaca tagaagggtt
     7381 ccagaatctt tagtgctggt tttaacaacc gatgcaacat taaaaatgtg ttagtgtgct
     7441 gtgcaattgg ttttcaattc atattaatct taatgacaga gaacaatgtg ttactaatta
     7501 ttttggttgt atgccattag taaattgata gaaaaattaa ggggattaac ataacttcat
     7561 ttcattgact tatattaaca tcttataata caatagttta agactaaggg aaacagatgg
     7621 agctgtttat tgagacaact ggtgaggaat tatcatgtgt tcattcccat tttagagcgt
     7681 gaaactccta cattagaata tataaagtca ctttaaatat ctatatttgt aacagaagta
     7741 gtgtacagat attttattac agcatttttg tgtaaatgca gaattaaagt gaataaataa
     7801 gaattttcag tggtgcacaa a
//
