LOCUS       NM_001195522             709 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens mitochondrial pyruvate carrier 1 like (MPC1L), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001195522 XM_001715781 XM_293325 XM_936849
VERSION     NM_001195522.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 709)
  AUTHORS   Tavoulari,S., Schirris,T.J.J., Mavridou,V., Thangaratnarajah,C.,
            King,M.S., Jones,D.T.D., Ding,S., Fearnley,I.M. and Kunji,E.R.S.
  TITLE     Key features of inhibitor binding to the human mitochondrial
            pyruvate carrier hetero-dimer
  JOURNAL   Mol Metab 60, 101469 (2022)
   PUBMED   35278701
REFERENCE   2  (bases 1 to 709)
  AUTHORS   Vanderperre,B., Cermakova,K., Escoffier,J., Kaba,M., Bender,T.,
            Nef,S. and Martinou,J.C.
  TITLE     MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate
            Carrier Subunit Expressed in Postmeiotic Male Germ Cells
  JOURNAL   J Biol Chem 291 (32), 16448-16461 (2016)
   PUBMED   27317664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092473.4.
            
            On Sep 30, 2020 this sequence version replaced NM_001195522.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189667.119857.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000423387.4/
                                                  ENSP00000489748.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               AC092473.4         130317-131025
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..709
                     /gene="MPC1L"
                     /gene_synonym="SLC54A3"
                     /note="mitochondrial pyruvate carrier 1 like"
                     /db_xref="GeneID:347411"
                     /db_xref="HGNC:HGNC:44205"
                     /db_xref="MIM:301103"
     exon            1..709
                     /gene="MPC1L"
                     /gene_synonym="SLC54A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..549
                     /gene="MPC1L"
                     /gene_synonym="SLC54A3"
                     /note="brain protein 44-like protein 2"
                     /codon_start=1
                     /product="mitochondrial pyruvate carrier 1-like protein"
                     /protein_id="NP_001182451.1"
                     /db_xref="CCDS:CCDS83466.1"
                     /db_xref="GeneID:347411"
                     /db_xref="HGNC:HGNC:44205"
                     /db_xref="MIM:301103"
                     /translation="MARMAVLWRKMRDNFQSKEFREYVSSTHFWGPAFSWGLPLAAFK
                     DMKASPEIISGRMTTALILYSAIFMRFAYRVQPRNLLLMACHCTNVMAQSVQASRYLL
                     YYYGGGGAEAKARDPPATAAAATSPGSQPPKQAS"
     regulatory      691..696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MPC1L"
                     /gene_synonym="SLC54A3"
                     /note="hexamer: AATACA"
     polyA_site      709
                     /gene="MPC1L"
                     /gene_synonym="SLC54A3"
                     /note="major polyA site"
ORIGIN      
        1 gcactttgtg gcagccacgc gaaggctcga ggtcgcgagc gtgtgcccag tcagggtcgg
       61 ctgcgggtac tcggctttgc gctctatttc gttgtggtct ggctgttgat ccgtaggcac
      121 gcctacggct attccatcat ggcgaggatg gcggtactgt ggcggaagat gagagataac
      181 ttccagagca aggagttccg ggaatacgtg agcagcactc acttctgggg tcccgcgttc
      241 agctggggcc ttccgctggc tgcctttaaa gacatgaagg cgtcgccgga gatcatcagt
      301 ggccgcatga caacagcgct catcttgtac tcggcgatct tcatgcgctt cgcctaccgc
      361 gtacagcctc gaaacctgct gctgatggcg tgccactgta ccaacgtgat ggcgcagagt
      421 gtgcaggcca gtcgctacct actctactac tacggcggcg gcggcgccga ggctaaagcc
      481 cgcgaccctc cggctaccgc cgccgctgcc accagcccgg gttcccagcc cccgaaacaa
      541 gcttcttaag aactgagagg gcctgatctc atctctgcag gtcacaagca ctgaactgcc
      601 attcctcctg aaaaaagacc aatgaagacc tcggttttga ctctaaaaca gtgcgaatct
      661 gacttaaacc tgcagtttga ttaataaaga aatacaaagt aacattgaa
//
