LOCUS       NM_015529               2989 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens monooxygenase DBH like 1 (MOXD1), mRNA.
ACCESSION   NM_015529 NM_001031699
VERSION     NM_015529.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Fredlund,E., Andersson,S., Hilgert,E., Monferrer,E.,
            Alvarez-Hernan,G., Karakaya,S., Loontiens,S., Bek,J.W., Gregor,T.,
            Lecomte,E., Magnusson,E., Miltenyte,E., Cabirol,M., Kyknas,M.,
            Engstrom,N., Henriksson,M.A., Hammarlund,E., Rosenblum,J.S.,
            Noguera,R., Speleman,F., van Nes,J. and Mohlin,S.
  TITLE     MOXD1 is a lineage-specific gene and a tumor suppressor in
            neuroblastoma
  JOURNAL   Sci Adv 10 (25), eado1583 (2024)
   PUBMED   38905335
  REMARK    GeneRIF: MOXD1 is a lineage-specific gene and a tumor suppressor in
            neuroblastoma.
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Lai,Y., Dong,H., Xu,P., Wang,J., Feng,W., Zhao,Z. and Sha,L.
  TITLE     RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the
            malignant phenotype of gastric cancer
  JOURNAL   BMC Gastroenterol 24 (1), 29 (2024)
   PUBMED   38200441
  REMARK    GeneRIF: RNA N6-methyladenosine demethylase FTO targets MOXD1
            promoting the malignant phenotype of gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2989)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 2989)
  AUTHORS   Xin,X., Mains,R.E. and Eipper,B.A.
  TITLE     Monooxygenase X, a member of the copper-dependent monooxygenase
            family localized to the endoplasmic reticulum
  JOURNAL   J Biol Chem 279 (46), 48159-48167 (2004)
   PUBMED   15337741
  REMARK    GeneRIF: Based on its sequence and localization, MOX (monooxygenase
            X) is predicted to hydroxylate a hydrophobic substrate in the
            endoplasmic reticulum.
REFERENCE   9  (bases 1 to 2989)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2989)
  AUTHORS   Chambers,K.J., Tonkin,L.A., Chang,E., Shelton,D.N., Linskens,M.H.
            and Funk,W.D.
  TITLE     Identification and cloning of a sequence homologue of dopamine
            beta-hydroxylase
  JOURNAL   Gene 218 (1-2), 111-120 (1998)
   PUBMED   9751809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018756.1, AK074879.1, AY007239.1 and AJ420565.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015529.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.157743.1,
                                           SRR1803615.43836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMN03267750
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367963.8/ ENSP00000356940.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               BC018756.1         19-244
            227-490             AK074879.1         1-264
            491-628             AY007239.1         466-603
            629-2980            AK074879.1         403-2754
            2981-2989           AJ420565.1         1300-1308
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..2989
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /note="monooxygenase DBH like 1"
                     /db_xref="GeneID:26002"
                     /db_xref="HGNC:HGNC:21063"
                     /db_xref="MIM:609000"
     exon            1..313
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1891
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /note="DBH-like monooxygenase protein 1;
                     dopamine-oxygenase; monooxygenase X"
                     /codon_start=1
                     /product="DBH-like monooxygenase protein 1 precursor"
                     /protein_id="NP_056344.2"
                     /db_xref="CCDS:CCDS5152.2"
                     /db_xref="GeneID:26002"
                     /db_xref="HGNC:HGNC:21063"
                     /db_xref="MIM:609000"
                     /translation="MCCWPLLLLWGLLPGTAAGGSGRTYPHRTLLDSEGKYWLGWSQR
                     GSQIAFRLQVRTAGYVGFGFSPTGAMASADIVVGGVAHGRPYLQDYFTNANRELKKDA
                     QQDYHLEYAMENSTHTIIEFTRELHTCDINDKSITDSTVRVIWAYHHEDAGEAGPKYH
                     DSNRGTKSLRLLNPEKTSVLSTALPYFDLVNQDVPIPNKDTTYWCQMFKIPVFQEKHH
                     VIKVEPVIQRGHESLVHHILLYQCSNNFNDSVLESGHECYHPNMPDAFLTCETVIFAW
                     AIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYEEGLIDNSGLRLFYTMDIRKY
                     DAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHL
                     AGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDR
                     AEMTWGGLSTRSEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTTWPFI
                     IKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNVRCSKTDNAEWSIQGMTAL
                     PPDIERPYKAEPLVCGTSSSSSLHRDFSINLLVCLLLLSCTLSTKSL"
     exon            314..460
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            461..628
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            629..712
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            713..892
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            893..995
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1162
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1354
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1414
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1557
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1726
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2989
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /note="hexamer: AATAAA"
     polyA_site      2189
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /note="major polyA site"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /note="hexamer: AATAAA"
     polyA_site      2989
                     /gene="MOXD1"
                     /gene_synonym="dJ248E1.1; MOX; PRO5780"
                     /note="major polyA site"
ORIGIN      
        1 actccccagc ggctggaggc cggtaccggc gggcaggagg cgcccgagga tgtgctgctg
       61 gccgctgctc ctgctgtggg ggctgctccc cgggacggcg gcggggggct cgggccgaac
      121 ctatccgcac cggaccctcc tggactcgga gggcaagtac tggctgggct ggagccagcg
      181 gggcagccag atcgccttcc gcctccaggt gcgcactgca ggctacgtgg gcttcggctt
      241 ctcgcccacc ggggccatgg cgtccgccga catcgtcgtg ggcggggtgg cccacgggcg
      301 gccctacctc caggattatt ttacaaatgc aaatagagag ttgaaaaaag atgctcagca
      361 agattaccat ctagaatatg ccatggaaaa tagcacacac acaataattg aatttaccag
      421 agagctgcat acatgtgaca taaatgacaa gagtataacg gatagcactg tgagagtgat
      481 ctgggcctac caccatgaag atgcaggaga agctggtccc aagtaccatg actccaatag
      541 gggcaccaag agtttgcggt tattgaatcc tgagaaaact agtgtgctat ctacagcctt
      601 accatacttt gatctggtaa atcaggacgt ccccatccca aacaaagata caacatattg
      661 gtgccaaatg tttaagattc ctgtgttcca agaaaagcat catgtaataa aggttgagcc
      721 agtgatacag agaggccatg agagtctggt gcaccacatc ctgctctatc agtgcagcaa
      781 caactttaac gacagcgttc tggagtccgg ccacgagtgc tatcacccca acatgcccga
      841 tgcattcctc acctgtgaaa ctgtgatttt tgcctgggct attggtggag agggcttttc
      901 ttatccacct catgttggat tatcccttgg cactccatta gatccgcatt atgtgctcct
      961 agaagtccat tatgataatc ccacttatga ggaaggctta atagataatt ctggactgag
     1021 gttattttac acaatggata taaggaaata tgatgctggg gtgattgagg ctggcctctg
     1081 ggtgagcctc ttccatacca tccctccagg gatgcctgag ttccagtctg agggtcactg
     1141 cactttggag tgcctggaag aggctctgga agccgaaaag ccaagtggaa ttcatgtgtt
     1201 tgctgttctt ctccatgctc acctggctgg cagaggcatc aggctgcgtc attttcgaaa
     1261 agggaaggaa atgaaattac ttgcctatga tgatgatttt gacttcaatt tccaggagtt
     1321 tcagtatcta aaggaagaac aaacaatctt accaggagat aacctaatta ctgagtgtcg
     1381 ctacaacacg aaagatagag ctgagatgac ttggggagga ctaagcacca ggagtgaaat
     1441 gtgtctctca taccttcttt attacccaag aattaatctt actcgatgtg caagtattcc
     1501 agacattatg gaacaacttc agttcattgg ggttaaggag atctacagac cagtcacgac
     1561 ctggcctttc attatcaaaa gtcccaagca atataaaaac ctttctttca tggatgctat
     1621 gaataagttt aaatggacta aaaaggaagg tctctccttc aacaagctgg tcctcagcct
     1681 gccagtgaat gtgagatgtt ccaagacaga caatgctgag tggtcgattc aaggaatgac
     1741 agcattacct ccagatatag aaagacccta taaagcagaa cctttggtgt gtggcacgtc
     1801 ttcttcctct tccctgcaca gagatttctc catcaacttg cttgtttgcc ttctgctact
     1861 cagctgcacg ctgagcacca agagcttgtg atcaaaattc tgttggactt gacaatgttt
     1921 tctatgatct gaacctgtca tttgaagtac aggttaaaga ctgtgtccac tttgggcatg
     1981 aagagtgtgg agacttttct tccccatttt ccctccctcc tttttccttt ccatgttaca
     2041 tgagagacat caatcaggtt ctcttctctt tcttagaaat atctgatgtt atatatacat
     2101 ggtcaataaa ataaaactgg cctgacttaa gataaccatt ttaaaaaatt gggctgtcat
     2161 gtgggaataa aagaattctt tctttcctac tacattctgt tttatttaaa tactcattgt
     2221 tgctatttca ctttttgact tgacttttat atttctttaa aaaattcctt ccttttaaaa
     2281 aatataaaag ggactactgt tcattccagt tttcttcttc tttgttgttc ttctagtgtg
     2341 acttttcaag tgtaacagcc attcttcctg actttaatat tgtccagttc tggtcttttc
     2401 tgtgaattac cactgggccc cttacctcaa tgctttttgt tgatgcccac tctggttccc
     2461 ttgtttatct gagtctgttg gtaccccaaa tgaccccaca cccatcttaa agtacttttt
     2521 ttcaccttcc ctgtttagta ctggccagat gagttttttc tagagctctg tcactatctg
     2581 aaaagaaaga ggctatggga aacatagaaa tggtatgtat taataactga tcataggctg
     2641 aggagaaaaa atgtagctgg ctgcaaaccc agtgctgtga ggtgacttat atgaggttcc
     2701 agatcaaaga caggccgtgt gagccagtcc aggagggtgt aagttctgaa tggttccttg
     2761 ctgactttgg gtgacacatg taccacatac tggctcagtt taagtcatgg ttctattgta
     2821 gatttatttt tatattagtt aataaatgac tttaaattgt caccaattga aaatcttgtc
     2881 actcttttgg ttttctttat atagctcagc caaatcttgt tttatgtcct gtcctcatct
     2941 cttaagctaa atctgtttgg atcatattaa taaactaaat gaaattaca
//
