LOCUS       NM_018995               3957 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Mov10 like RNA helicase 1 (MOV10L1), transcript
            variant 1, mRNA.
ACCESSION   NM_018995
VERSION     NM_018995.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3957)
  AUTHORS   Sarkardeh,H., Totonchi,M., Asadpour,O., Sadighi Gilani,M.A., Zamani
            Esteki,M., Almadani,N., Borjian Boroujeni,P. and Gourabi,H.
  TITLE     Association of MOV10L1 gene polymorphisms and male infertility in
            azoospermic men with complete maturation arrest
  JOURNAL   J Assist Reprod Genet 31 (7), 865-871 (2014)
   PUBMED   24817005
  REMARK    GeneRIF: Our results suggest that MOV10L1 gene polymorphisms in the
            studied infertile males with complete maturation arrest are linked
            to infertility.
REFERENCE   2  (bases 1 to 3957)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3957)
  AUTHORS   McGue,M., Zhang,Y., Miller,M.B., Basu,S., Vrieze,S., Hicks,B.,
            Malone,S., Oetting,W.S. and Iacono,W.G.
  TITLE     A genome-wide association study of behavioral disinhibition
  JOURNAL   Behav Genet 43 (5), 363-373 (2013)
   PUBMED   23942779
REFERENCE   4  (bases 1 to 3957)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 3957)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   6  (bases 1 to 3957)
  AUTHORS   Caruthers,J.M. and McKay,D.B.
  TITLE     Helicase structure and mechanism
  JOURNAL   Curr Opin Struct Biol 12 (1), 123-133 (2002)
   PUBMED   11839499
  REMARK    Review article
REFERENCE   7  (bases 1 to 3957)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
REFERENCE   8  (bases 1 to 3957)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451595.2, AF285604.1 and
            AL022328.21.
            
            On Nov 23, 2018 this sequence version replaced NM_018995.2.
            
            Summary: This gene is similar to a mouse gene that encodes a
            putative RNA helicase and shows testis-specific expression.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285604.1, CR456466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262794.10/ ENSP00000262794.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DB451595.2         1-59
            60-799              AF285604.1         4-743
            800-800             AL022328.21        8973-8973
            801-1375            AF285604.1         745-1319
            1376-1376           AL022328.21        17345-17345
            1377-2842           AF285604.1         1321-2786
            2843-2843           AL022328.21        50922-50922
            2844-3957           AF285604.1         2788-3901
FEATURES             Location/Qualifiers
     source          1..3957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..3957
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /note="Mov10 like RNA helicase 1"
                     /db_xref="GeneID:54456"
                     /db_xref="HGNC:HGNC:7201"
                     /db_xref="MIM:605794"
     exon            1..180
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3719
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Mov10-like 1; putative helicase Mov10l1; MOV10-like
                     protein 1; moloney leukemia virus 10-like protein 1;
                     cardiac helicase activated by MEF2C protein; Mov10l1,
                     Moloney leukemia virus 10-like 1, homolog; RNA helicase
                     Mov10l1; Mov10 RISC complex RNA helicase like 1; Mov10
                     like RISC complex RNA helicase 1"
                     /codon_start=1
                     /product="RNA helicase Mov10l1 isoform 1"
                     /protein_id="NP_061868.1"
                     /db_xref="CCDS:CCDS14084.1"
                     /db_xref="GeneID:54456"
                     /db_xref="HGNC:HGNC:7201"
                     /db_xref="MIM:605794"
                     /translation="MLSLAAKLVAFFWRTADTPREEAGQLEPELAEGDTKLKTVRGVV
                     TRYCSDYGMIDDMIYFSSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKW
                     EDDSRNHGSPSDCGPRVLIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAE
                     YRIRPGTWSSEATSVKPLRYKRVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPR
                     RGDVVNAVVVESSQSCYVWRALCMTLVKRRDAAPVHEATHFYGTILLKNKGDIEVTQV
                     THFGTLKEGRSKTMVIWIENKGDIPQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSF
                     VSVPEKENSSDENINSLNSHTKNKTSQMSESSLVNNRGISPGDCTCKGENGEKDNILS
                     RKQMTEPEPGGLVPPGGKTFIVVICDGKNPGRCKELLLLCFSDFLIGRYLEVNVISGE
                     ESLIAAREPFSWKKLKSSQALTSAKTTVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCV
                     EQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIYAEMELKEYNMSGIILRRNGDLL
                     VLEVPGLAEGRPSLYAGDKLILKTQEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAY
                     NFEPMDVEFTYNRTTSRRCHFALEHVIHLGVKVLFPEEIILQSPQVTGNWNHAQDTKS
                     SGQSTSKKNRKTMTDQAEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQTPKARKMEF
                     FNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRILV
                     CAPSNSAADLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKPYCRDGEDIWKASR
                     FRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEPECLIPLGLMSDISGQIVLAG
                     DPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNY
                     RSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGK
                     SPSWFNPAEAVQVLRYCCLLAHSISSQVSASDIGVITPYRKQVEKIRILLRNVDLMDI
                     KVGSVEEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVL
                     GNPHVLVRDPCFGALLEYSITNGVYMGCDLPPALQSLQNCGEGVADPSYPVVPESTGP
                     EKHQEPS"
     exon            181..365
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            366..525
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            526..638
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            639..826
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            827..967
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1209
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1342
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1537
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1652
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1830
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1901
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1993
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2052
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2153
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2262
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2441
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2588
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2710
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2810
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2975
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3149
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3299
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3407
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3545
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3637
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3957
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3935..3940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /note="hexamer: AATAAA"
     polyA_site      3957
                     /gene="MOV10L1"
                     /gene_synonym="CHAMP; DJ402G11.8; SPGF73"
                     /note="major polyA site"
ORIGIN      
        1 attggtggcg ggcggcggga gcggcgcggg cgcgtgcggg cggcggcagc ggcggtgacg
       61 gcagcctagg ccgggcgagg gccatgctga gcctcgcagc caagctggtg gccttcttct
      121 ggaggacggc ggacacccct agggaggaag ccgggcagct ggagcccgag ctcgcggaag
      181 gtgacactaa gctgaaaact gtacggggtg tcgtgacaag gtactgcagc gattatggca
      241 tgattgatga tatgatctac ttctccagtg atgctgtgac tagcagagtg cttctgaatg
      301 ttggacagga agtgattgca gttgtggaag aaaataaagt gtccaatgga ctgaaagcaa
      361 tcagggtaga agctgtctct gataagtggg aagacgacag cagaaaccat gggagtccct
      421 cagactgcgg cccccgagtg ttgattggct gtgtgacttc cctggtggag ggcgcaggct
      481 gtatcagtca gaccacctac ttctctctgg agagtgtgtg cgaaggcttc gagccctgca
      541 agggagactg ggtggaggct gagtaccgga tccggcctgg cacgtggagc agcgaagcca
      601 cctcagtgaa gccactgaga tacaagcgcg tggacaaggt ctgcatctct agcctctgtg
      661 gaaggaacgg ggtgttagag gaaagcatct tctttacctt ggactccttg aaactgccag
      721 atgggtacac accccggaga ggtgacgtgg tcaatgcagt ggtggtggag agcagccagt
      781 catgctatgt ctggagggca ctttgtatga ccctagtgaa gaggcgagac gccgcccctg
      841 ttcatgaggc cactcatttc tatggaacga ttttgctgaa gaacaaaggt gatattgaag
      901 ttacacaggt gacgcatttt ggaaccctaa aggaaggaag aagtaaaacc atggtgatct
      961 ggatagagaa taaaggagac attcctcaaa acttagtcag ctgtaaactg gctggctggg
     1021 ataaatctaa acaattcaga ttccaaatgc tggataaaga ccagatgtgc cccgtggtat
     1081 cttttgtttc tgttcctgag aaggagaatt catcagatga aaatattaat tcattaaata
     1141 gccacacaaa aaacaaaacc tctcagatgt cggagagcag tttggtgaac aacagaggaa
     1201 tctctccagg tgattgtacc tgtaaaggag aaaatggaga aaaagacaac attctatcaa
     1261 ggaagcagat gacagagcct gagcctgggg ggcttgtccc tccaggggga aaaaccttca
     1321 ttgtggtcat ctgtgacgga aaaaatcctg gccgctgcaa ggagctcctt ttgctctgtt
     1381 tttccgattt cctaattggg cgataccttg aagtaaatgt tatcagtggg gaggagtcac
     1441 taattgctgc gcgcgaacca ttttcttgga aaaagcttaa aagttcacaa gcgttaacat
     1501 ccgcaaaaac tacagttgtt gtgaccgcac agaaaaggaa ctcaagacga caacttccaa
     1561 gttttcttcc ccaatatcca atcccagata gacttagaaa atgtgtggaa caaaaaattg
     1621 acatcctgac tttccagcca ttacttgcag agcttctgaa catgtcaaat tacaaggaga
     1681 agttttcgac tttgctgtgg cttgaggaga tttatgcaga aatggaactg aaagagtata
     1741 acatgagcgg gatcatctta agaaggaatg gggatctgct ggttctggag gtcccagggt
     1801 tggccgaagg gaggccttct ctctacgcag gtgataaact gattttaaaa actcaagagt
     1861 acaatggaca tgccatcgaa tacatcagct acgtgactga gattcatgaa gaagatgtaa
     1921 ctcttaaaat taatccagaa tttgaacaag cctataactt tgaacctatg gatgtggaat
     1981 ttacatataa taggaccaca agcagacggt gtcactttgc acttgaacac gtcatccact
     2041 taggtgtaaa agtgttgttt ccagaagaaa ttattttaca gtctccacaa gtgacgggaa
     2101 attggaacca tgcacaagac accaaaagca gtggacagtc caccagcaaa aagaatagga
     2161 aaacaatgac ggaccaagct gagcatggaa cagaggagag gcgtgttggt gacaaggacc
     2221 tgccggtgct ggcacccttt actgcagaga tgagcgattg ggtagatgaa attcagaccc
     2281 ctaaagcaag aaagatggag tttttcaacc cagtgctaaa tgaaaatcag aagttagcag
     2341 ttaaaaggat tctgagtggt gactgccgtc ccctcccgta tattctcttt ggacctcctg
     2401 gtactggaaa gacagtgaca ataatagagg ctgttttaca ggtacacttt gccttgccgg
     2461 acagtcggat tttagtctgt gcgccctcca acagtgctgc tgacctcgtg tgtctgcggc
     2521 tgcacgagag caaggtgcta cagccggcca ccatggtccg ggtgaacgcc acctgcaggt
     2581 tcgaggagat agttattgac gccgtcaaac cgtattgcag agacggagaa gacatctgga
     2641 aagcctcacg cttccggata atcatcacca catgcagcag ctcagggctg ttttaccaaa
     2701 taggagtgag agttgggcac ttcactcacg tgtttgtgga cgaggctggg caggcaagtg
     2761 agccggaatg cctcattcct ctggggctga tgtcggacat cagtggccag atcgtgctgg
     2821 caggagaccc catgcagctc ggcccagtca ttaagtccag actcgccatg gcctatgggc
     2881 tgaacgtgtc ctttttggaa cggctgatgt ctcgacccgc gtaccagagg gacgaaaatg
     2941 ctttcggtgc ttgtggcgca cataatcccc tgttggtcac aaagctggtg aagaactacc
     3001 ggtcccacga ggccctgctg atgctgccct cacggctgtt ctaccacagg gaactcgagg
     3061 tctgtgcgga ccccacagtg gtgacctcct tgctgggctg ggagaagttg cctaagaaag
     3121 gcttccctct catcttccat ggtgtgcggg gcagcgaggc acgggaggga aaaagcccat
     3181 cgtggttcaa cccggccgag gccgtccagg tcctgcgcta ctgctgcctc ctggcccaca
     3241 gcatctccag tcaggtgtct gccagcgaca ttggcgtcat cacgccctac cggaagcagg
     3301 tggagaaaat cagaattctt ttgcgtaatg ttgatctgat ggatataaag gttggatcag
     3361 tagaggagtt tcaaggacaa gagtatctgg tcatcatcat ttcgaccgta cggtcaaatg
     3421 aagatagatt tgaagatgat cgatattttt tgggtttctt gtccaactca aaaagattta
     3481 atgttgcaat caccagaccc aaagctttgc tgatagtgct gggaaacccc catgttctcg
     3541 ttcgagaccc ctgttttggt gctttgctgg aatacagtat tacaaacggt gtttacatgg
     3601 gatgcgattt acctcctgca ctgcagtctc tgcaaaactg tggcgagggg gtggcagacc
     3661 cctcctaccc agtggtgcca gaatccacag gaccagagaa gcatcaggag cccagctgat
     3721 ctgcagtggc tgacagcagg gaggccatgt gctcagcctg gccacgttgc cgttacagtc
     3781 tgctccgtgg ctcctgtggc ctgcccttgt ctcgcagcca ggcagggtcg tgtgtgggtg
     3841 tggggctgcc aggttggacg cagctgctgc tgccctgact ttggcatatg ccagcctgtt
     3901 cctgccacag ggcagtcact gccgcctacc ctgaaataaa ccctcgagtg accccca
//
