LOCUS       NM_001321324            3380 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens Mov10 RNA helicase (MOV10), transcript variant 4,
            mRNA.
ACCESSION   NM_001321324 XM_005270868
VERSION     NM_001321324.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Yang,L., Shen,A., Wang,R. and Zheng,Z.
  TITLE     S100A16 stabilizes the ITGA3-mediated ECM-receptor interaction
            pathway to drive the malignant properties of lung adenocarcinoma
            cells via binding MOV10
  JOURNAL   Mol Med Rep 31 (1) (2025)
   PUBMED   39450567
  REMARK    GeneRIF: S100A16 stabilizes the ITGA3-mediated ECM-receptor
            interaction pathway to drive the malignant properties of lung
            adenocarcinoma cells via binding MOV10.
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Liu,Q., Yi,D., Ding,J., Mao,Y., Wang,S., Ma,L., Li,Q., Wang,J.,
            Zhang,Y., Zhao,J., Guo,S., Liu,Z., Guo,F., Zhao,D., Liang,C.,
            Li,X., Peng,X. and Cen,S.
  TITLE     MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large
            cytoplasmic granules with phase separation properties
  JOURNAL   EMBO Rep 24 (9), e56512 (2023)
   PUBMED   37437058
  REMARK    GeneRIF: MOV10 recruits DCP2 to decap human LINE-1 RNA by forming
            large cytoplasmic granules with phase separation properties.
REFERENCE   3  (bases 1 to 3380)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 3380)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   5  (bases 1 to 3380)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3380)
  AUTHORS   Nakano,M., Kakiuchi,Y., Shimada,Y., Ohyama,M., Ogiwara,Y.,
            Sasaki-Higashiyama,N., Yano,N., Ikeda,F., Yamada,E., Iwamatsu,A.,
            Kobayashi,K., Nishiyama,K., Ichikawa,S., Kaji,K., Ide,T.,
            Murofushi,H. and Murakami-Murofushi,K.
  TITLE     MOV10 as a novel telomerase-associated protein
  JOURNAL   Biochem Biophys Res Commun 388 (2), 328-332 (2009)
   PUBMED   19665004
  REMARK    GeneRIF: These data suggest that MOV10 is involved in the
            progression of telomerase-catalyzing reaction via the interaction
            of telomerase protein and telomere DNA.
REFERENCE   7  (bases 1 to 3380)
  AUTHORS   Haussecker,D., Cao,D., Huang,Y., Parameswaran,P., Fire,A.Z. and
            Kay,M.A.
  TITLE     Capped small RNAs and MOV10 in human hepatitis delta virus
            replication
  JOURNAL   Nat Struct Mol Biol 15 (7), 714-721 (2008)
   PUBMED   18552826
  REMARK    GeneRIF: The identification of capped small RNAs and the
            involvement of MOV10 in hepatitis delta virus replication further
            suggest a conserved mechanism related to RNA-directed transcription
            in lower eukaryotes.
REFERENCE   8  (bases 1 to 3380)
  AUTHORS   Chendrimada,T.P., Finn,K.J., Ji,X., Baillat,D., Gregory,R.I.,
            Liebhaber,S.A., Pasquinelli,A.E. and Shiekhattar,R.
  TITLE     MicroRNA silencing through RISC recruitment of eIF6
  JOURNAL   Nature 447 (7146), 823-828 (2007)
   PUBMED   17507929
REFERENCE   9  (bases 1 to 3380)
  AUTHORS   Meister,G., Landthaler,M., Peters,L., Chen,P.Y., Urlaub,H.,
            Luhrmann,R. and Tuschl,T.
  TITLE     Identification of novel argonaute-associated proteins
  JOURNAL   Curr Biol 15 (23), 2149-2155 (2005)
   PUBMED   16289642
  REMARK    GeneRIF: Mov10 coimmunoprecipitates with human Ago1 and Ago2 and
            also colocalizes with them in cytoplasmic P-bodies.
REFERENCE   10 (bases 1 to 3380)
  AUTHORS   Zhou,Z., Licklider,L.J., Gygi,S.P. and Reed,R.
  TITLE     Comprehensive proteomic analysis of the human spliceosome
  JOURNAL   Nature 419 (6903), 182-185 (2002)
   PUBMED   12226669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603832.28.
            
            On Jan 5, 2021 this sequence version replaced NM_001321324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.148761.1,
                                           SRR1803612.121244.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369645.6/ ENSP00000358659.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL603832.28        27217-27287
            72-273              AL603832.28        27406-27607
            274-477             AL603832.28        41493-41696
            478-713             AL603832.28        41973-42208
            714-972             AL603832.28        42398-42656
            973-1107            AL603832.28        44223-44357
            1108-1276           AL603832.28        45319-45487
            1277-1431           AL603832.28        46576-46730
            1432-1608           AL603832.28        47011-47187
            1609-1756           AL603832.28        47307-47454
            1757-1915           AL603832.28        47974-48132
            1916-2019           AL603832.28        48706-48809
            2020-2117           AL603832.28        48995-49092
            2118-2334           AL603832.28        49188-49404
            2335-2452           AL603832.28        50552-50669
            2453-2644           AL603832.28        50845-51036
            2645-2719           AL603832.28        51273-51347
            2720-2845           AL603832.28        52243-52368
            2846-2934           AL603832.28        52452-52540
            2935-3056           AL603832.28        52777-52898
            3057-3380           AL603832.28        52974-53297
FEATURES             Location/Qualifiers
     source          1..3380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..3380
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /note="Mov10 RNA helicase"
                     /db_xref="GeneID:4343"
                     /db_xref="HGNC:HGNC:7200"
                     /db_xref="MIM:610742"
     exon            1..71
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            72..273
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3148
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 4;
                     functional spliceosome-associated protein 113; Mov10 RISC
                     complex RNA helicase; putative helicase MOV-10; moloney
                     leukemia virus 10 protein; Mov10, Moloney leukemia virus
                     10, homolog; armitage homolog"
                     /codon_start=1
                     /product="helicase MOV-10 isoform 1"
                     /protein_id="NP_001308253.1"
                     /db_xref="CCDS:CCDS853.1"
                     /db_xref="GeneID:4343"
                     /db_xref="HGNC:HGNC:7200"
                     /db_xref="MIM:610742"
                     /translation="MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFK
                     ISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKH
                     HKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGT
                     QSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWEL
                     LGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGER
                     PDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWR
                     NYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVL
                     RGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFN
                     RQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMR
                     HIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQR
                     LRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLI
                     TAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPR
                     QLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILD
                     IPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPE
                     EAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDD
                     IKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKA
                     LLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPST
                     SGPHSHDYLPQEREGEGGLSLQVEPEWRNEL"
     exon            274..477
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            478..713
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            714..972
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1107
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1276
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1431
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1608
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1756
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1915
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2019
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2117
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2334
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2452
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2644
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2719
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2845
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2934
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3056
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3380
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3343..3348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /note="hexamer: AAGAAA"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /note="hexamer: AACAAA"
     polyA_site      3363
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
     polyA_site      3380
                     /gene="MOV10"
                     /gene_synonym="fSAP113; gb110"
                     /note="major polyA site"
ORIGIN      
        1 agacgcttta ggaaagagtt aatgcgaaga gggggagggg ataggacgaa gaaaccgaag
       61 ggaaagctca gctgcagcgg cgactttcag tttcatttcc acggaccctc ctgcctgggc
      121 cgcagccgcc gccgcgatgc ccagtaagtt cagctgccgg cagctccggg aggcgggcca
      181 gtgtttcgag agtttcctgg tcgttcgggg actggacatg gagacagatc gcgagcggct
      241 gcggaccatt tataaccgcg acttcaagat cagctttggg acccccgccc ctggcttctc
      301 ctccatgctg tatggaatga agattgcaaa tctggcctac gtcaccaaga ctcgggtcag
      361 gttcttcaga ctcgaccgct gggccgacgt gcggttccca gaaaagagga gaatgaagct
      421 ggggtcagat atcagcaaac accacaagtc actgctagcc aagatctttt atgacagggc
      481 tgagtatctt catgggaaac atggtgtgga tgtggaagtc caggggcccc atgaagcccg
      541 agatgggcag ctccttatcc gcctggattt gaaccgcaaa gaggtgctga ccctgaggct
      601 tcggaatggc ggaacccagt ctgttaccct cactcacctc ttcccactct gccggacacc
      661 ccagtttgct ttctacaatg aagaccagga gttgccctgt ccactgggcc ccggtgaatg
      721 ctatgaactc catgtccatt gtaagaccag ctttgtgggc tacttcccag ccacagtgct
      781 ctgggagctg ctgggacctg gggagtcggg ttcagaagga gccggcacat tctacattgc
      841 ccgcttcttg gctgccgtcg cccacagccc cctggctgca cagctgaagc ccatgactcc
      901 cttcaagcgg acccggatca ccggaaaccc tgtggtgacc aatcggatag aggaaggaga
      961 gagacctgac cgcgctaagg gctatgacct ggagttaagt atggcgctgg ggacatacta
     1021 cccacctccc cgcctcaggc agctgctccc catgcttctt cagggaacaa gtatcttcac
     1081 tgcccctaag gagatcgcag agatcaaggc ccagctggag acagccctga agtggaggaa
     1141 ctatgaggtg aagctgcggc tgctgctgca cctggaggaa ctgcagatgg agcatgatat
     1201 ccggcactat gacctggagt cggtgcccat gacctgggac cctgtggacc agaaccccag
     1261 gctgctcacg ctggaggttc ctggagtgac tgagagccgc ccctcagtgc tacggggcga
     1321 ccacctgttt gcccttttgt cctcggagac acaccaggag gaccccatca catataaggg
     1381 ctttgtgcac aaggtggaat tggaccgtgt caagctgagc ttttccatga gcctcctgag
     1441 ccgctttgtg gatgggctga ccttcaaggt gaactttacc ttcaaccgcc agccgctgcg
     1501 agtccagcac cgtgccctgg agctgacagg gcgctggctg ctgtggccca tgctctttcc
     1561 tgtggcacct cgggacgtcc cgctgctgcc ctcagatgtg aaactcaagc tgtacgaccg
     1621 gagtctggag tcaaacccag agcagctgca ggccatgagg cacattgtta cgggcaccac
     1681 ccgtccagcc ccctacatca tctttgggcc tccaggcacc ggcaagactg tcacgttagt
     1741 ggaggcaatt aagcaggtgg tgaagcactt gcccaaagcc cacatcttgg cctgcgctcc
     1801 atccaactca ggggctgacc tactctgtca aaggctccgg gtccaccttc ctagctccat
     1861 ctaccgcctc ctggccccca gcagggacat ccgcatggta cctgaggaca tcaagccctg
     1921 ctgcaactgg gacgcaaaga agggggagta tgtatttccc gccaagaaga agctgcagga
     1981 ataccgggtc ttaattacca ccctcatcac tgccggcagg ttggtctcgg cccagtttcc
     2041 cattgatcac ttcacacaca tcttcatcga tgaggctggc cactgcatgg agcctgagag
     2101 tctggtagct atagcagggc tgatggaagt aaaggaaaca ggtgatccag gagggcagct
     2161 ggtgctggca ggagaccctc ggcagctggg gcctgtgctg cgttccccac tgacccagaa
     2221 gcatggactg ggatactcac tgctggagcg gctgctcacc tacaactccc tgtacaagaa
     2281 gggccctgat ggctatgacc cccagttcat aaccaagctg ctccgcaact acaggtctca
     2341 tcccaccatc ctggacattc ctaaccagct ctattatgaa ggggagctgc aggcctgtgc
     2401 tgatgtcgtg gatcgagaac gcttctgccg ctgggcgggc ctacctcgac agggctttcc
     2461 catcatcttt cacggcgtaa tgggcaaaga tgagcgtgaa ggcaacagcc catccttctt
     2521 caaccctgaa gaggctgcca cagtgacttc ctacctgaag ctgctcctgg ccccctcctc
     2581 caagaagggc aaagctcgcc tgagccctcg aagtgtgggc gtcatctccc cgtaccggaa
     2641 acaggtggag aaaatccgtt actgcatcac caaacttgac agggagcttc gaggactgga
     2701 tgacatcaag gacttgaagg tgggttcagt agaagaattc caaggccaag aacgaagcgt
     2761 catcctcatc tccaccgtgc gaagcagcca gagctttgtg cagctggatc tggactttaa
     2821 tctgggtttc cttaagaacc ccaagaggtt caatgtagct gtgacccggg ccaaggccct
     2881 gctcatcatc gtggggaacc cccttctcct gggccatgac cctgactgga aagtattcct
     2941 ggagttctgt aaagaaaacg gagggtatac cgggtgtccc ttccctgcca aactggacct
     3001 gcaacaggga cagaatttac tgcaaggtct gagcaagctc agcccctcta cctcagggcc
     3061 ccacagccat gactacctcc cccaggagcg ggagggtgaa gggggcctgt ctctgcaagt
     3121 ggagccagag tggaggaatg agctctgaag acacagcacc cagccttctc gcaccagcca
     3181 agccttaact gcctgcctga ccctgaacca gaacccagct gaactgcccc tccaagggac
     3241 aggaaggctg ggggagggag tttacaaccc aagccattcc accccctccc ctgctgggga
     3301 gaatgacaca tcaagctgct aacaattggg ggaaggggaa ggaagaaaac tctgaaaaca
     3361 aaatcttgtt ctatgcaaaa
//
