LOCUS       NM_023948               1154 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens motile sperm domain containing 3 (MOSPD3), transcript
            variant 1, mRNA.
ACCESSION   NM_023948
VERSION     NM_023948.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Cabukusta,B., Berlin,I., van Elsland,D.M., Forkink,I., Spits,M., de
            Jong,A.W.M., Akkermans,J.J.L.L., Wijdeven,R.H.M., Janssen,G.M.C.,
            van Veelen,P.A. and Neefjes,J.
  TITLE     Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact
            Site Proteins Interacting with FFAT-Related FFNT Motifs
  JOURNAL   Cell Rep 33 (10), 108475 (2020)
   PUBMED   33296653
  REMARK    GeneRIF: Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as
            Membrane Contact Site Proteins Interacting with FFAT-Related FFNT
            Motifs.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112849. doi:
            10.1016/j.celrep.2023.112849.. PMID: 37440407]
REFERENCE   2  (bases 1 to 1154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1154)
  AUTHORS   Pall,G.S., Wallis,J., Axton,R., Brownstein,D.G., Gautier,P.,
            Buerger,K., Mulford,C., Mullins,J.J. and Forrester,L.M.
  TITLE     A novel transmembrane MSP-containing protein that plays a role in
            right ventricle development
  JOURNAL   Genomics 84 (6), 1051-1059 (2004)
   PUBMED   15533722
  REMARK    GeneRIF: Deletion fo the Mospd3 locus is mutagenic and breeding to
            homozygosity results in a characteristic right ventricle defect and
            neonatal lethality in 50% of mice.
REFERENCE   4  (bases 1 to 1154)
  AUTHORS   Glockner,G., Scherer,S., Schattevoy,R., Boright,A., Weber,J.,
            Tsui,L.C. and Rosenthal,A.
  TITLE     Large-scale sequencing of two regions in human chromosome 7q22:
            analysis of 650 kb of genomic sequence around the EPO and CUTL1
            loci reveals 17 genes
  JOURNAL   Genome Res 8 (10), 1060-1073 (1998)
   PUBMED   9799793
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC011653.2.
            
            On Nov 23, 2018 this sequence version replaced NM_023948.4.
            
            Summary: This gene encodes a multi-pass membrane protein with a
            major sperm protein (MSP) domain. The deletion of a similar mouse
            gene is associated with defective cardiac development and neonatal
            lethality. Alternate transcriptional splice variants, encoding
            different isoforms, have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2 and 3
            encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011653.2, SRR3476690.1014050.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393950.7/ ENSP00000377522.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1154              BC011653.2         31-1184
FEATURES             Location/Qualifiers
     source          1..1154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1154
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="motile sperm domain containing 3"
                     /db_xref="GeneID:64598"
                     /db_xref="HGNC:HGNC:25078"
                     /db_xref="MIM:609125"
     exon            1..457
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..960
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="isoform a is encoded by transcript variant 1;
                     motile sperm domain-containing protein 3"
                     /codon_start=1
                     /product="motile sperm domain-containing protein 3 isoform
                     a"
                     /protein_id="NP_076438.1"
                     /db_xref="CCDS:CCDS5701.1"
                     /db_xref="GeneID:64598"
                     /db_xref="HGNC:HGNC:25078"
                     /db_xref="MIM:609125"
                     /translation="MRRGAPQDQELVGPGPPGRGSRGAPPPLGPVVPVLVFPPDLVFR
                     ADQRSGPRQLLTLYNPTGTALRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPI
                     PSHYDVQDRFRIELSEEGAEGRVVGRKDITSILRAPAYPLELQGQPDPAPRPGPPAGT
                     PPPTARHFQEHPRQQLATSSFLLFLLTGIVSVAFLLLPLPDELGSQLPQVLHVSLGQK
                     LVAAYVLGLLTMVFLRT"
     exon            458..533
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            534..763
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            764..928
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1154
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1129..1134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="hexamer: AATAAA"
     regulatory      1134..1139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="hexamer: AATACA"
     polyA_site      1151
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="major polyA site"
     polyA_site      1154
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgtcg aggtggggct cggcgggtcc gaaggaacct ggggcagagc tggaagagga
       61 aaggtcttgg gggccctggg cctgggtctg cgggagcccc atctagcggg gttccaaggc
      121 ggcggcggca tcagtcgagg ccctgctccg ggagctcatc ttgtcccctt tcgcccctca
      181 cgccccccag ctctgactcc aggccctgtc ccctgagctc tgccctcgga tgtccgaccg
      241 cccagagcct gcatgcgccg tggggcgccc caggaccagg agctggtggg tccggggccc
      301 cctgggcggg ggtcccgggg cgcccctcct cccttgggac ccgttgtccc ggtcctggtc
      361 tttcccccgg atctagtatt cagggcggac cagcggagcg gaccccgaca gctgctgacc
      421 ctctataacc ccacaggaac tgcgcttcgc ttccgagtcc tgtgcacagc acctgccaaa
      481 tacacggtgt ttgacgcaga gggatatgtg aagccccagt cttgcattga cattgtgatt
      541 cgccatgtgg cacccattcc cagccactat gatgtccagg accgcttccg cattgagctg
      601 tctgaggaag gagctgaggg ccgagtggtg ggacgcaagg acattacctc cattctgaga
      661 gccccagcgt acccccttga gcttcaggga cagccagatc cagcgcctcg cccagggcct
      721 cctgctggga caccaccacc cacggccaga cacttccagg agcacccccg ccagcaactg
      781 gccaccagct ccttcctcct cttcttgctg acggggattg tgtctgtggc cttcctgctg
      841 ctcccactcc cggacgaact cggcagccag ctgcctcaag tcctgcacgt ctccctggga
      901 caaaagttgg tggccgccta cgtcttgggc ctcctcacca tggtgttcct ccggacctga
      961 gctccgtgct caacccccag cccaccccac cctccctggg cagggtcttg aggcagccac
     1021 tgtgatgctc ataccttacc ttgcctccta ccctcttctc tttcctgcct actccccact
     1081 cctccctgac aaaaaacacc cagggatttg tactcatttt ccaagttgaa taaaatacat
     1141 ttttaaaatg ataa
//
