LOCUS       NM_001363416            1057 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens motile sperm domain containing 3 (MOSPD3), transcript
            variant 6, mRNA.
ACCESSION   NM_001363416 XM_005250531
VERSION     NM_001363416.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1057)
  AUTHORS   Cabukusta,B., Berlin,I., van Elsland,D.M., Forkink,I., Spits,M., de
            Jong,A.W.M., Akkermans,J.J.L.L., Wijdeven,R.H.M., Janssen,G.M.C.,
            van Veelen,P.A. and Neefjes,J.
  TITLE     Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact
            Site Proteins Interacting with FFAT-Related FFNT Motifs
  JOURNAL   Cell Rep 33 (10), 108475 (2020)
   PUBMED   33296653
  REMARK    GeneRIF: Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as
            Membrane Contact Site Proteins Interacting with FFAT-Related FFNT
            Motifs.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112849. doi:
            10.1016/j.celrep.2023.112849.. PMID: 37440407]
REFERENCE   2  (bases 1 to 1057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1057)
  AUTHORS   Pall,G.S., Wallis,J., Axton,R., Brownstein,D.G., Gautier,P.,
            Buerger,K., Mulford,C., Mullins,J.J. and Forrester,L.M.
  TITLE     A novel transmembrane MSP-containing protein that plays a role in
            right ventricle development
  JOURNAL   Genomics 84 (6), 1051-1059 (2004)
   PUBMED   15533722
  REMARK    GeneRIF: Deletion fo the Mospd3 locus is mutagenic and breeding to
            homozygosity results in a characteristic right ventricle defect and
            neonatal lethality in 50% of mice.
REFERENCE   4  (bases 1 to 1057)
  AUTHORS   Glockner,G., Scherer,S., Schattevoy,R., Boright,A., Weber,J.,
            Tsui,L.C. and Rosenthal,A.
  TITLE     Large-scale sequencing of two regions in human chromosome 7q22:
            analysis of 650 kb of genomic sequence around the EPO and CUTL1
            loci reveals 17 genes
  JOURNAL   Genome Res 8 (10), 1060-1073 (1998)
   PUBMED   9799793
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099394.6, HY025137.1 and
            CN256396.1.
            
            On May 18, 2018 this sequence version replaced XM_005250531.3.
            
            Summary: This gene encodes a multi-pass membrane protein with a
            major sperm protein (MSP) domain. The deletion of a similar mouse
            gene is associated with defective cardiac development and neonatal
            lethality. Alternate transcriptional splice variants, encoding
            different isoforms, have been described. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.144723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC099394.6         11216-11217
            3-401               HY025137.1         2-400
            402-860             CN256396.1         181-639
            861-1057            AC099394.6         14015-14211
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1057
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="motile sperm domain containing 3"
                     /db_xref="GeneID:64598"
                     /db_xref="HGNC:HGNC:25078"
                     /db_xref="MIM:609125"
     exon            1..93
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            94..360
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..863
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="isoform a is encoded by transcript variant 6;
                     motile sperm domain-containing protein 3"
                     /codon_start=1
                     /product="motile sperm domain-containing protein 3 isoform
                     a"
                     /protein_id="NP_001350345.1"
                     /db_xref="CCDS:CCDS5701.1"
                     /db_xref="GeneID:64598"
                     /db_xref="HGNC:HGNC:25078"
                     /db_xref="MIM:609125"
                     /translation="MRRGAPQDQELVGPGPPGRGSRGAPPPLGPVVPVLVFPPDLVFR
                     ADQRSGPRQLLTLYNPTGTALRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPI
                     PSHYDVQDRFRIELSEEGAEGRVVGRKDITSILRAPAYPLELQGQPDPAPRPGPPAGT
                     PPPTARHFQEHPRQQLATSSFLLFLLTGIVSVAFLLLPLPDELGSQLPQVLHVSLGQK
                     LVAAYVLGLLTMVFLRT"
     exon            361..436
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            437..666
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            667..831
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1057
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="hexamer: AATAAA"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="hexamer: AATACA"
     polyA_site      1054
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="major polyA site"
     polyA_site      1057
                     /gene="MOSPD3"
                     /gene_synonym="CDS3; NET30"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgggcg gagtctggct ggagagagga ggcgggcgtc cgggaacgcc cggaaggggc
       61 gaggccagcg gcggggcggg gcttatggag atcctctgac tccaggccct gtcccctgag
      121 ctctgccctc ggatgtccga ccgcccagag cctgcatgcg ccgtggggcg ccccaggacc
      181 aggagctggt gggtccgggg ccccctgggc gggggtcccg gggcgcccct cctcccttgg
      241 gacccgttgt cccggtcctg gtctttcccc cggatctagt attcagggcg gaccagcgga
      301 gcggaccccg acagctgctg accctctata accccacagg aactgcgctt cgcttccgag
      361 tcctgtgcac agcacctgcc aaatacacgg tgtttgacgc agagggatat gtgaagcccc
      421 agtcttgcat tgacattgtg attcgccatg tggcacccat tcccagccac tatgatgtcc
      481 aggaccgctt ccgcattgag ctgtctgagg aaggagctga gggccgagtg gtgggacgca
      541 aggacattac ctccattctg agagccccag cgtaccccct tgagcttcag ggacagccag
      601 atccagcgcc tcgcccaggg cctcctgctg ggacaccacc acccacggcc agacacttcc
      661 aggagcaccc ccgccagcaa ctggccacca gctccttcct cctcttcttg ctgacgggga
      721 ttgtgtctgt ggccttcctg ctgctcccac tcccggacga actcggcagc cagctgcctc
      781 aagtcctgca cgtctccctg ggacaaaagt tggtggccgc ctacgtcttg ggcctcctca
      841 ccatggtgtt cctccggacc tgagctccgt gctcaacccc cagcccaccc caccctccct
      901 gggcagggtc ttgaggcagc cactgtgatg ctcatacctt accttgcctc ctaccctctt
      961 ctctttcctg cctactcccc actcctccct gacaaaaaac acccagggat ttgtactcat
     1021 tttccaagtt gaataaaata catttttaaa atgataa
//
