LOCUS       NM_152581               4183 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens motile sperm domain containing 2 (MOSPD2), transcript
            variant 1, mRNA.
ACCESSION   NM_152581
VERSION     NM_152581.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Zouiouich,M., Di Mattia,T., Martinet,A., Eichler,J., Wendling,C.,
            Tomishige,N., Grandgirard,E., Fuggetta,N., Fromental-Ramain,C.,
            Mizzon,G., Dumesnil,C., Carpentier,M., Reina-San-Martin,B.,
            Mathelin,C., Schwab,Y., Thiam,A.R., Kobayashi,T., Drin,G.,
            Tomasetto,C. and Alpy,F.
  TITLE     MOSPD2 is an endoplasmic reticulum-lipid droplet tether functioning
            in LD homeostasis
  JOURNAL   J Cell Biol 221 (6) (2022)
   PUBMED   35389430
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4183)
  AUTHORS   Di Mattia,T., Martinet,A., Ikhlef,S., McEwen,A.G., Nomine,Y.,
            Wendling,C., Poussin-Courmontagne,P., Voilquin,L., Eberling,P.,
            Ruffenach,F., Cavarelli,J., Slee,J., Levine,T.P., Drin,G.,
            Tomasetto,C. and Alpy,F.
  TITLE     FFAT motif phosphorylation controls formation and lipid transfer
            function of inter-organelle contacts
  JOURNAL   EMBO J 39 (23), e104369 (2020)
   PUBMED   33124732
REFERENCE   4  (bases 1 to 4183)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4183)
  AUTHORS   Salem,Y., Yacov,N., Propheta-Meiran,O., Breitbart,E. and Mendel,I.
  TITLE     Newly characterized motile sperm domain-containing protein 2
            promotes human breast cancer metastasis
  JOURNAL   Int J Cancer 144 (1), 125-135 (2019)
   PUBMED   29978511
  REMARK    GeneRIF: Results indicate that motile sperm domain containing 2
            (MOSPD2) plays a key role in the migration and metastasis of breast
            cancer cells and may be used to prevent the spreading of breast
            cancer cells and to mediate their death.
REFERENCE   6  (bases 1 to 4183)
  AUTHORS   Di Mattia,T., Wilhelm,L.P., Ikhlef,S., Wendling,C., Spehner,D.,
            Nomine,Y., Giordano,F., Mathelin,C., Drin,G., Tomasetto,C. and
            Alpy,F.
  TITLE     Identification of MOSPD2, a novel scaffold for endoplasmic
            reticulum membrane contact sites
  JOURNAL   EMBO Rep 19 (7) (2018)
   PUBMED   29858488
  REMARK    GeneRIF: Thus, we characterized here MOSPD2, a novel tethering
            component related to VAP proteins(VAP-A and VAP-B), bridging the
            endoplasmic reticulum with a variety of distinct organelles.
REFERENCE   7  (bases 1 to 4183)
  AUTHORS   Mendel,I., Yacov,N., Salem,Y., Propheta-Meiran,O., Ishai,E. and
            Breitbart,E.
  TITLE     Identification of Motile Sperm Domain-Containing Protein 2 as
            Regulator of Human Monocyte Migration
  JOURNAL   J Immunol 198 (5), 2125-2132 (2017)
   PUBMED   28137892
  REMARK    GeneRIF: this study shows that silencing MOSPD2 inhibited signaling
            events following chemokine receptor ligation and monocyte migration
            induced by chemokines
REFERENCE   8  (bases 1 to 4183)
  AUTHORS   Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M.,
            Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E.,
            O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L.
  TITLE     Gene-environment interactions and obesity traits among
            postmenopausal African-American and Hispanic women in the Women's
            Health Initiative SHARe Study
  JOURNAL   Hum Genet 132 (3), 323-336 (2013)
   PUBMED   23192594
REFERENCE   9  (bases 1 to 4183)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA708010.1, BC030641.1, AC121340.4 and AI744083.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152581.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.51996.1,
                                           SRR1660807.204329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380492.8/ ENSP00000369860.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA708010.1         17-36
            21-2302             BC030641.1         4-2285
            2303-2303           AC121340.4         39855-39855
            2304-3191           BC030641.1         2287-3174
            3192-3193           AI744083.1         11-12               c
            3194-4183           AC121340.4         40746-41735
FEATURES             Location/Qualifiers
     source          1..4183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..4183
                     /gene="MOSPD2"
                     /note="motile sperm domain containing 2"
                     /db_xref="GeneID:158747"
                     /db_xref="HGNC:HGNC:28381"
                     /db_xref="MIM:301086"
     exon            1..117
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1665
                     /gene="MOSPD2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     motile sperm domain-containing protein 2"
                     /codon_start=1
                     /product="motile sperm domain-containing protein 2 isoform
                     1"
                     /protein_id="NP_689794.1"
                     /db_xref="CCDS:CCDS14162.1"
                     /db_xref="GeneID:158747"
                     /db_xref="HGNC:HGNC:28381"
                     /db_xref="MIM:301086"
                     /translation="MAENHAQNKAKLISETRRRFEAEYVTDKSDKYDARDVERLQQDD
                     NWVESYLSWRHNIVDETLKMLDESFQWRKEISVNDLNESSIPRWLLEIGVIYLHGYDK
                     EGNKLFWIRVKYHVKDQKTILDKKKLIAFWLERYAKRENGKPVTVMFDLSETGINSID
                     MDFVRFIINCFKVYYPKYLSKIVIFDMPWLMNAAFKIVKTWLGPEAVSLLKFTSKNEV
                     QDYVSVEYLPPHMGGTDPFKYSYPPLVDDDFQTPLCENGPITSEDETSSKEDIESDGK
                     ETLETISNEEQTPLLKKINPTESTSKAEENEKVDSKVKAFKKPLSVFKGPLLHISPAE
                     ELYFGSTESGEKKTLIVLTNVTKNIVAFKVRTTAPEKYRVKPSNSSCDPGASVDIVVS
                     PHGGLTVSAQDRFLIMAAEMEQSSGTGPAELTQFWKEVPRNKVMEHRLRCHTVESSKP
                     NTLTLKDNAFNMSDKTSEDICLQLSRLLESNRKLEDQVQRCIWFQQLLLSLTMLLLAF
                     VTSFFYLLYS"
     exon            118..187
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..343
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..430
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..585
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..646
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..685
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..810
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..987
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1100
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1197
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1294
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1424
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1527
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..4183
                     /gene="MOSPD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4161..4166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSPD2"
                     /note="hexamer: AATAAA"
     polyA_site      4183
                     /gene="MOSPD2"
                     /note="major polyA site"
ORIGIN      
        1 acccttctct gtctacctct gggcgggact gccgggtgat gagatactcg gtcggcgacg
       61 gtagaacggg cgacggcgac aaccgcaatc acatccacga cggtgatcat ggcagagaat
      121 cacgcccaga ataaagccaa gctcatctct gagacccgga ggaggttcga agctgagtat
      181 gtgacagata agtcagataa atatgatgca cgtgatgttg aaaggctaca acaagatgat
      241 aactgggttg aaagttactt atcttggaga cataatattg tagatgaaac actgaagatg
      301 ctcgatgaga gttttcagtg gaggaaagaa atttctgtca atgaccttaa tgaatcctcc
      361 attcccagat ggttattgga aattggtgtt atttatctcc atggttatga caaagaaggt
      421 aacaaattgt tctggatcag ggtgaagtat catgtaaaag accagaaaac catattggac
      481 aaaaagaagc tcatagcatt ctggttggaa cgttatgcta agagggaaaa tgggaaacct
      541 gtaacagtga tgtttgacct gtcagaaact ggaataaata gcattgacat ggactttgta
      601 cgctttatca tcaactgctt taaggtttat taccctaaat acctctcaaa aatagtgatc
      661 tttgatatgc cttggttaat gaatgctgct ttcaaaattg tgaaaacctg gcttggtcca
      721 gaagcagtga gcttgttgaa gtttacaagc aaaaatgaag tccaggacta tgtcagtgta
      781 gaatacctgc ctccccacat gggtggaact gatcctttca agtatagcta tccaccacta
      841 gtagatgatg acttccagac cccactgtgt gagaatgggc ctattaccag tgaggatgaa
      901 acttcaagta aagaagacat agaaagtgat ggcaaagaaa cattggaaac aatttctaat
      961 gaagaacaaa cacctcttct taaaaagatt aacccaaccg aatctacttc caaagcagaa
     1021 gaaaatgaaa aagttgattc aaaagtgaaa gctttcaaga aaccattgag tgtatttaaa
     1081 ggccccttac tacacatcag cccagcagaa gaactgtact ttggaagtac agaatccgga
     1141 gagaagaaaa ccttaatagt gttgacaaat gtaactaaaa atatagtggc atttaaggtg
     1201 agaacaacag ctccagaaaa atacagagtc aagccaagca atagcagctg tgacccgggt
     1261 gcatcagtgg atatagttgt gtctccccat gggggtttaa cagtctctgc ccaagaccgt
     1321 tttctgataa tggctgcaga aatggaacag tcatctggca caggcccagc agaattaact
     1381 cagttttgga aagaagttcc cagaaacaaa gtgatggaac ataggttaag atgccatact
     1441 gttgaaagca gtaaaccaaa cactcttacg ttaaaagaca atgctttcaa tatgtcagat
     1501 aaaaccagtg aagatatatg tctacaactc agtcgtttac tagaaagcaa taggaagctt
     1561 gaagaccaag ttcagcgttg tatctggttc cagcagctgc tgctttcctt aacaatgctc
     1621 ttgcttgctt ttgtcacctc tttcttctat ttattgtaca gttaaagaag tggtgccggg
     1681 taggaaccac ggttccttcg tccattagtt ggaaaaagta acagacctaa aactctacca
     1741 agctactaaa aacattgcac atctgtgctt cctaaaagga aatatgcagc acgtggaggg
     1801 gaacacatac atgtcttgaa aataaactgc tagaataaag aaatgctgga gaaattgatt
     1861 ataagagact atagctattt agtaaagtaa gtaaaggcat atccattgtg taaattaata
     1921 gtttaaatat aatttatttt ttccttttga tctgaatact tttaaagctt aagttttatc
     1981 gtgtaaatac attagctaaa ctgaaaagta taagtaacat gctttgttgc agccaaaaaa
     2041 tgtaatctgc ttttttatga cagaattatt atagctgagc tgacttacta gcttttctat
     2101 actatgtata tagaagaaca tgtatattga gaaagaaaac atacttatat agaggaattt
     2161 atgtaaccat gactttgtaa ttttgagaat tcctcccagt gatggtcagt attcttttgg
     2221 aatgtaaacc gatttaatgc caaaccacct taacctttgt ttctcagtgt tccttaacag
     2281 cctgcctttt attaatctca ggctttttta tgaacactct catttcagta gaatttggaa
     2341 aactaagcgt ggttggaatt tctttgaatt ctgttagtaa tgcccaaaag aaaagtctca
     2401 agcagtcccc ctatccagtc atttttatgg agtttcatgt tgtccactat agctggacac
     2461 tgaacctttt gcctaattta ttataaaggc ctgaccctct attgtcccat cttcaccccc
     2521 attccagagc agaggagtct ctgtggacca tgaattgcac tgtctccctc ctcatttcta
     2581 aatgaaaggt attagatata aatttttttg aaaggttagt tgtttgagat gctaagcagg
     2641 ataataaatt tagattttaa aatgttccct gtaaaagtca gcccatgaca aggaaattta
     2701 caaaatacta gagtatctag aagggtgaaa acaaaaaaaa ataaaaagaa acacagacgc
     2761 ccaggtgtca gctctccgtt taaagaatga aaaatgtaac tcatgatgat ctgtgaaacc
     2821 ttcaaactag gaccaattga cttacttgat attctgcctt tgatatggta gtacccaccc
     2881 ggtattccta aaatcctaaa aagatacacc ttgcagtagc agaggcaatg acatgagttt
     2941 gttttctcat taatatgacc agtttgggtc tatgttggtt cacatgtaca tctactttat
     3001 atgaaagaaa aaacagttgt ctgcctgtaa aatgttgagt ttcgattgag ccatgtttgg
     3061 agattttatt actattctga agggtagtgt tgttggtttt catcttcaag aagttgattc
     3121 caaaactgag ttatgaagaa tgatataaca gttccttcaa aattggccta ggaaataaaa
     3181 ccttaaaagg acactggtgt gctactttgt cttaatttgg gcttttctgt ttcagtttgc
     3241 cacctccagc tgtgaaatgg actgcagtcc accctaagta ctgtgcacag tatctccctg
     3301 tgtgtgtgca cagtggcttc cccttacatg gtagattttt ggccttaata taatctaatc
     3361 ccaaagtagt tgtgtatgtt ttctgttcct tggcaaataa atgaagaaat aattagccaa
     3421 gattgaaaat gtattgtcct aacggtgtcc ctttaatgtt tcatatgaaa aattatgttg
     3481 acccactaaa atatccttgc tcaatgtctg gtcagttgaa tttaataaca tatcttgtta
     3541 atgtttgtgt gtctattaaa tgtgactaag caggattact gaaaattcac tataaaatca
     3601 aaggcatcta aacgtttgta cttgtcttga ttaatcatat atttacactt gatttttttc
     3661 tgtcttcatt tgtttttatt taatcataat tgcatgattt ttttggtact ctaatcagta
     3721 attttatttt taatcatgtc attacctatt catgaccaaa ttaccaagga accaacattt
     3781 agatttagat atttgttttc acttaggaat ggaaattaat agattttcca tgaaagcatt
     3841 agtgaaatat cattaccttg atctgcaagt agcctaaaaa tgcgattgct ggtaaacctg
     3901 gcctcaaatt tcatactacc ataactgttt ttatatattg ccactaattt tgactggatt
     3961 taatagcact ttattgtaca actacaaaaa aaaatatatt cctagaattg ttgccagtgt
     4021 aatttctcta atgttctggt gcttttcata tattttcagt atttttatta ctatattggt
     4081 attttctttg tataaattga ttgattaaaa gaacatgttt tctattttaa tatgttttag
     4141 aaaaataatt acatttatga aataaatatc atcaggaaaa aaa
//
