LOCUS       NM_001164579            4469 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens modulator of smoothened (MOSMO), mRNA.
ACCESSION   NM_001164579 XR_109267
VERSION     NM_001164579.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4469)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi:
            10.1016/j.devcel.2018.01.002.. PMID: 29401421]
REFERENCE   2  (bases 1 to 4469)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092119.3 and AC009019.10.
            
            On Nov 23, 2018 this sequence version replaced NM_001164579.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.156092.1,
                                           SRR1803611.296302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542527.7/ ENSP00000454926.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AC092119.3         140653-140949
            298-510             AC009019.10        57678-57890
            511-4469            AC009019.10        62887-66845
FEATURES             Location/Qualifiers
     source          1..4469
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..4469
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /note="modulator of smoothened"
                     /db_xref="GeneID:730094"
                     /db_xref="HGNC:HGNC:27087"
     exon            1..297
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..695
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /note="uncharacterized protein C16orf52; Attenuator of
                     Hedgehog; modulator of smoothened protein"
                     /codon_start=1
                     /product="modulator of smoothened protein precursor"
                     /protein_id="NP_001158051.1"
                     /db_xref="CCDS:CCDS58431.1"
                     /db_xref="GeneID:730094"
                     /db_xref="HGNC:HGNC:27087"
                     /translation="MDKLTIISGCLFLAADIFAIASIANPDWINTGESAGALTVGLVR
                     QCQTIHGRDRTCIPPRLPPEWVTTLFFIIMGIISLTVTCGLLVASHWRREATKYARWI
                     AFTGMILFCMAALIFPIGFYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFA
                     GKVCLPG"
     exon            298..510
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            511..4469
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4441..4446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /note="hexamer: AATAAA"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /note="hexamer: ACTAAA"
     polyA_site      4462
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
     polyA_site      4469
                     /gene="MOSMO"
                     /gene_synonym="ATTHOG; BC030336; C16orf52"
                     /note="major polyA site"
ORIGIN      
        1 ggttccgtct gtgcgggccg cgccgcggct gctggtcccg ggcgcgcgga gggcgcgagc
       61 ggcgcgcggg ggccgagggg gcgcgaggca gcggcgcggg gactccgggc cccggcggcg
      121 gcccatgggg cgggaggcgt gaggccgctg cctgtccggg gctcgggggg tggggggagc
      181 ggggcgggga gatggataaa ctgaccatca tctcaggatg tctctttctg gccgccgata
      241 tcttcgccat cgccagcatc gccaacccgg actggatcaa caccggggag tctgcgggag
      301 cactcactgt gggcctcgtg cgacagtgtc aaacaatcca tggacgagac cggacgtgca
      361 tccctccccg gcttcccccg gagtgggtca ccacactgtt ttttatcatc atgggaatca
      421 tttcattgac tgtcacatgt ggtttgctgg tggcttccca ctggcgaaga gaagctacaa
      481 aatatgctcg atggatagca ttcactggaa tgatcctttt ctgtatggct gccctaatat
      541 ttccaatagg attttacatc aatgaagtcg gaggtcaacc ttataaatta cccaacaaca
      601 cagtagttgg gtcatcatat gtactttttg tcttatcaat tttctttaca atagtaggac
      661 ttctatttgc tggcaaagtt tgtttaccag gctgatgaat gtctaaattg cttgactctt
      721 attatttttt attttatttt atttttttat ttttggaggg tggagaggac aaaggcgagg
      781 catctgagca ggcctctcat gggaagatgc tcagatgaaa ctgatgctga gaaggaaaaa
      841 aaaatgcttt ggtttgttct cactatgcac tttggattta aaaaaaaaaa aaaaaaggag
      901 agccttttcc ataaccaaat acagacaata ttgactaaat ctcctgagca tattcaggca
      961 gtcaggtctg cactgtgata gcaacctaga gaaggagaat gctttatacc gaaaagcatg
     1021 tggccctttg tgactctgtt attccgtttt taatgtctaa tgattcatta gaggaaaaaa
     1081 aaaagtctaa gtatttatgt gtcatggtgg accagaggga tgcaagagaa gttcatgtgg
     1141 ggctggcctc acctcctaag aaattagtgt tcacaacttc cttgtaatag tatgagcctt
     1201 tggcaccaga atggattgcc gttgcattac tgcaccaaga agccaataga tcaaaacttg
     1261 tttgctaaaa tgtatgtaaa aattctgaaa ttccctctct ctgtgtacaa aaaaaaaaaa
     1321 aaatcaaaca ctaagacaca tgttttgggt gggtgggtgg gggaaatctt ccttatattt
     1381 atataaatat atataatata tatattttgc tgatgcagta tacagtgtgt atatatgtgt
     1441 gtgtgtgtgt gtgtgtatgt gtgtgtaaat ttatatacac acacatgcaa acagttcctg
     1501 gaagagaatt ctgaatgctt tgctagcaaa acactgtggt gtgcaaacct agaacccaat
     1561 agaaaaaaaa gccatttatc tgaaggctgc atagtggaga gagtcttcag tttacctcat
     1621 tctttgtagc agcccttgat tttaacaggt ttttgtaata ggtacagata atcccatacc
     1681 tttctaggtg cgattttaag ttaagctaaa aattatttgt agggttaatt tatttgtata
     1741 tgatagtaga aggtaagatc atgtcaaacc ttataatttg gggaatctga cactatttaa
     1801 attattggca actgttgtct gttgtacaga gattcttttt ctactggctc agtctgttac
     1861 attaataatg cattttatat gttcaggcac actttacata aatacaaagt tcgctagtaa
     1921 atatctggct attttggcta tttacaacac taatttcatt atttttatct gtaagcatta
     1981 ttaatacatc tttaccaaaa cctgagcaat acaatatttt ctttatatgt tatatgcctt
     2041 tgtttgctaa aagctaatat ttttgcattt actttaaagg gctgtactaa acccacagct
     2101 ttaagttctt ccctaaaaga agcattgcag ctaacccttg aactcacagt tttaaaatac
     2161 agtatttctc ttctccacat ctccatgcct tcgcatcaat gcttgttttt cctggtgaac
     2221 actatagata atctcctgtt tgaaatgtgg gacagggtgt ttcatggcag tggagctaag
     2281 tttctcctct ttatagtgaa ctggtgaccc aaatgtccct gtcatttata gtgaactgat
     2341 gacccaaatg actccctgtc agtagagtcc catgtggccc atgcttcaca caagcagaaa
     2401 tgaacgcact gtttttaagg ctagattatc agttctagaa tgattacttc aaagatggga
     2461 gctacctcct cagatattca cactatgaaa tggaggtgct tgatgtgttt cacactggct
     2521 tgtttgacag tcttctatct tactgttaat tcagcagtat tttattgtga aagaaaaccc
     2581 cagtgtttga gctcactcag gaattgggga gagagatgga ccaccactgt ggtgcatttc
     2641 ttaagtgttc tgggagaatg tcatactttt ccttcccaga gtaaaagaaa cctttgggag
     2701 atcctgaggg agactgtttc tccccaagta tgatgatgtc tagtcaagtc taagaatacc
     2761 actggacatg ttctatggac atttgggatt gcagttgcta ttctgatttg attggtcctc
     2821 agtcaaatgg atcactttga aggaaagctt tggttgtcac cgttatatac cactgagata
     2881 aagtgttagc aaagtatggt tcaaattaac ttatgacatg accaagagct tttctcttcc
     2941 aaaagatgaa ttgtattgta aatagtttct caaaatattt ttaactggat catgagcatg
     3001 gggagagaaa gtttctcagc tgctaagaat ttccccactg tttacttctt tcacttatgg
     3061 tggtattgca tttaagatta caaaatttaa ggttttattt gtatctatta cccaaaccat
     3121 taaattgtct ttaatttcat tgttgtcttg gaggtccagt gcatacaggg ctgatggggg
     3181 aaaactccct ctagccagtc agcactctaa cccaggatta aaccatccca tcaagtagta
     3241 tgtgaagtca agtcttcgta ctcttgcaga ccagacattg aaatggattc attcatatag
     3301 atttctataa atcctataag tgaaaagata gacaactgtc cgcagttgct tttaaaaaag
     3361 gtcactataa taagtactat atagtacagt attaatttat agcaggaaat cgtatcttgt
     3421 aaactgtata taaaacactg ttttatggtg caatcatttg tcaaactttt gtctgtttca
     3481 ttgtttttag agtgtgtgca ttcttctcat acctaagaat atcactgtaa aatctgctga
     3541 aaactatttt taggttttat ttgcacaaga ctgaattagt ttgacatttt tggaagctcc
     3601 tattgaacat acccaaacat ctgtaaacat gaaaaatctt caatttatta aaagcaaaca
     3661 tttcagtatg attctttcca aaggtaatcc atgttctatg ttgttaatgt gtgtatgtaa
     3721 tttttctgac tcttccacct cttataaacc tattttctgt ttcatttgtt ttgtttttga
     3781 aggatggctc ttttttcttt ttaatgttct agatgaccaa aacactattg gtttttaccc
     3841 ttttgcctaa agctttgata tccccacttg atgttctgtg aattcactgt ttaatctatt
     3901 aagtgaaata ataaatagtc ctggtgacaa acaatctgtt gatttagagg aaaggccctg
     3961 aaaaatacag tattggaaac taactttgca tatgctgtta gctattattt tgcatcatgg
     4021 gcttcatggg aagaacatgt tgcatttatt ttgtctttat taaaagacta ctagccacaa
     4081 gttactctga ttatagtaac tgttttatca acccacttca tctttaaaaa attaaattta
     4141 cattcacaat tcaaaacagt aagctgtctt tcagaaaatt tttgaaggat aaaaacatga
     4201 aggaaaaaag tggcccgtgt aggtaggatt ccctacacag gacttttagt tgtatcacct
     4261 caagagattt tgaagtttgt gatcaaggtc tgtatattat cccaaacttt attaagaatt
     4321 gttttctaat tggttataac atttttcaat taatagtttc aaaacaaatt gttaatacaa
     4381 ctgtataaaa tgaacataat tttcctcact tgtatttttg ttattgagca agtttatcaa
     4441 aataaattgt ctactaaaga aactaaaaa
//
