LOCUS       NM_005372               1041 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MOS proto-oncogene, serine/threonine kinase (MOS),
            mRNA.
ACCESSION   NM_005372
VERSION     NM_005372.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1041)
  AUTHORS   Jiao,G., Lian,H., Xing,J., Chen,L., Du,Z. and Liu,X.
  TITLE     MOS mutation causes female infertility with large polar body
            oocytes
  JOURNAL   Gynecol Endocrinol 38 (12), 1158-1163 (2022)
   PUBMED   36403623
  REMARK    GeneRIF: MOS mutation causes female infertility with large polar
            body oocytes.
REFERENCE   2  (bases 1 to 1041)
  AUTHORS   Zhang,Y.L., Zheng,W., Ren,P., Jin,J., Hu,Z., Liu,Q., Fan,H.Y.,
            Gong,F., Lu,G.X., Lin,G., Zhang,S. and Tong,X.
  TITLE     Biallelic variants in MOS cause large polar body in oocyte and
            human female infertility
  JOURNAL   Hum Reprod 37 (8), 1932-1944 (2022)
   PUBMED   35670744
REFERENCE   3  (bases 1 to 1041)
  AUTHORS   Zeng,Y., Shi,J., Xu,S., Shi,R., Wu,T., Li,H., Xue,X., Zhu,Y.,
            Chen,B., Sang,Q. and Wang,L.
  TITLE     Bi-allelic mutations in MOS cause female infertility characterized
            by preimplantation embryonic arrest
  JOURNAL   Hum Reprod 37 (3), 612-620 (2022)
   PUBMED   34997960
REFERENCE   4  (bases 1 to 1041)
  AUTHORS   Zhang,Y.L., Zheng,W., Ren,P., Hu,H., Tong,X., Zhang,S.P., Li,X.,
            Wang,H., Jiang,J.C., Jin,J., Yang,W., Cao,L., He,Y., Ma,Y.,
            Zhang,Y., Gu,Y., Hu,L., Luo,K., Gong,F., Lu,G.X., Lin,G., Fan,H.Y.
            and Zhang,S.
  TITLE     Biallelic mutations in MOS cause female infertility characterized
            by human early embryonic arrest and fragmentation
  JOURNAL   EMBO Mol Med 13 (12), e14887 (2021)
   PUBMED   34779126
REFERENCE   5  (bases 1 to 1041)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1041)
  AUTHORS   Lenormand,J.L., Benayoun,B., Guillier,M., Vandromme,M.,
            Leibovitch,M.P. and Leibovitch,S.A.
  TITLE     Mos activates myogenic differentiation by promoting
            heterodimerization of MyoD and E12 proteins
  JOURNAL   Mol Cell Biol 17 (2), 584-593 (1997)
   PUBMED   9001211
REFERENCE   7  (bases 1 to 1041)
  AUTHORS   Sagata,N.
  TITLE     What does Mos do in oocytes and somatic cells?
  JOURNAL   Bioessays 19 (1), 13-21 (1997)
   PUBMED   9008413
  REMARK    Review article
REFERENCE   8  (bases 1 to 1041)
  AUTHORS   Heikinheimo,O., Lanzendorf,S.E., Baka,S.G. and Gibbons,W.E.
  TITLE     Cell cycle genes c-mos and cyclin-B1 are expressed in a specific
            pattern in human oocytes and preimplantation embryos
  JOURNAL   Hum Reprod 10 (3), 699-707 (1995)
   PUBMED   7540181
REFERENCE   9  (bases 1 to 1041)
  AUTHORS   Caubet,J.F., Mathieu-Mahul,D., Bernheim,A., Larsen,C.J. and
            Berger,R.
  TITLE     Human proto-oncogene c-mos maps to 8q11
  JOURNAL   EMBO J 4 (9), 2245-2248 (1985)
   PUBMED   3000766
REFERENCE   10 (bases 1 to 1041)
  AUTHORS   Watson,R., Oskarsson,M. and Vande Woude,G.F.
  TITLE     Human DNA sequence homologous to the transforming gene (mos) of
            Moloney murine sarcoma virus
  JOURNAL   Proc Natl Acad Sci U S A 79 (13), 4078-4082 (1982)
   PUBMED   6287464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107376.7.
            
            Summary: MOS is a serine/threonine kinase that activates the MAP
            kinase cascade through direct phosphorylation of the MAP kinase
            activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed
            18246541]).[supplied by OMIM, Jul 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC106737.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311923.1/ ENSP00000310722.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1041              AC107376.7         83385-84425         c
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..1041
                     /gene="MOS"
                     /gene_synonym="MSV; OZEMA20"
                     /note="MOS proto-oncogene, serine/threonine kinase"
                     /db_xref="GeneID:4342"
                     /db_xref="HGNC:HGNC:7199"
                     /db_xref="MIM:190060"
     CDS             1..1041
                     /gene="MOS"
                     /gene_synonym="MSV; OZEMA20"
                     /EC_number="2.7.11.1"
                     /note="oocyte maturation factor mos; v-mos Moloney murine
                     sarcoma viral oncogene homolog; oncogene MOS, Moloney
                     murine sarcoma virus; c-mos; proto-oncogene c-Mos"
                     /codon_start=1
                     /product="proto-oncogene serine/threonine-protein kinase
                     mos"
                     /protein_id="NP_005363.1"
                     /db_xref="CCDS:CCDS6164.1"
                     /db_xref="GeneID:4342"
                     /db_xref="HGNC:HGNC:7199"
                     /db_xref="MIM:190060"
                     /translation="MPSPLALRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAP
                     RLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRS
                     FWAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEG
                     DAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKIS
                     DFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQ
                     APYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL
                     LVDLTSLKAELG"
     exon            1..1041
                     /gene="MOS"
                     /gene_synonym="MSV; OZEMA20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccctcgc ccctggccct acgcccctac ctccggagcg agttttcccc atcggtggac
       61 gcgcggccct gcagcagtcc ctcagagcta cctgcgaagc tgcttctggg ggccactctt
      121 cctcgggccc cgcggctgcc gcgccggctg gcctggtgct ccattgactg ggagcaggtg
      181 tgcttgctgc agaggctggg agctggaggg tttggctcgg tgtacaaggc gacttaccgc
      241 ggtgttcctg tggccataaa gcaagtgaac aagtgcacca agaaccgact agcatctcgg
      301 cggagtttct gggctgagct caacgtagca aggctgcgcc acgataacat cgtgcgcgtg
      361 gtggctgcca gcacgcgcac gcccgcaggg tccaatagcc tagggaccat catcatggag
      421 ttcggtggca acgtcacttt acaccaagtc atctatggcg ccgccggcca ccctgagggg
      481 gacgcagggg agcctcactg ccgcactgga ggacagttaa gtttgggaaa gtgtctcaag
      541 tactcactag atgttgtgaa cggcctgctc ttcctccact cgcaaagcat tgtgcacttg
      601 gacctgaagc ccgcgaacat cttgatcagt gagcaggatg tctgtaaaat tagtgacttc
      661 ggttgctctg agaagttgga agatctgctg tgcttccaga caccctctta ccctctagga
      721 ggcacataca cccaccgcgc cccggagctc ctgaaaggag agggcgtgac gcctaaagcc
      781 gacatttatt cctttgccat cactctctgg caaatgacta ccaagcaggc gccgtattcg
      841 ggggagcggc agcacatact gtacgcggtg gtggcctacg acctgcgccc gtccctctcc
      901 gctgccgtct tcgaggactc gctccccggg cagcgccttg gggacgtcat ccagcgctgc
      961 tggagaccca gcgcggcgca gaggccgagc gcgcggctgc ttttggtgga tctcacctct
     1021 ttgaaagctg aactcggctg a
//
