LOCUS       NM_178832               2333 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MORN repeat containing 4 (MORN4), transcript variant
            1, mRNA.
ACCESSION   NM_178832
VERSION     NM_178832.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Mecklenburg,K.L., Freed,S.A., Raval,M., Quintero,O.A., Yengo,C.M.
            and O'Tousa,J.E.
  TITLE     Invertebrate and vertebrate class III myosins interact with MORN
            repeat-containing adaptor proteins
  JOURNAL   PLoS One 10 (3), e0122502 (2015)
   PUBMED   25822849
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Bhattacharya,M.R., Gerdts,J., Naylor,S.A., Royse,E.X.,
            Ebstein,S.Y., Sasaki,Y., Milbrandt,J. and DiAntonio,A.
  TITLE     A model of toxic neuropathy in Drosophila reveals a role for MORN4
            in promoting axonal degeneration
  JOURNAL   J Neurosci 32 (15), 5054-5061 (2012)
   PUBMED   22496551
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Mecklenburg,K.L.
  TITLE     Drosophila retinophilin contains MORN repeats and is conserved in
            humans
  JOURNAL   Mol Genet Genomics 277 (5), 481-489 (2007)
   PUBMED   17285308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ312050.1 and AL834132.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178832.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093023.1, SRR1803614.28751.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307450.11/ ENSP00000307636.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AJ312050.1         88-107
            21-2333             AL834132.1         1-2313
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..2333
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /note="MORN repeat containing 4"
                     /db_xref="GeneID:118812"
                     /db_xref="HGNC:HGNC:24001"
                     /db_xref="MIM:617736"
     exon            1..154
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /inference="alignment:Splign:2.1.0"
     exon            155..251
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..625
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /note="44050 protein; protein 44050; retinophilin homolog"
                     /codon_start=1
                     /product="MORN repeat-containing protein 4"
                     /protein_id="NP_849154.1"
                     /db_xref="CCDS:CCDS7468.1"
                     /db_xref="GeneID:118812"
                     /db_xref="HGNC:HGNC:24001"
                     /db_xref="MIM:617736"
                     /translation="MTLTKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFE
                     NGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTF
                     PDGSHGIPRNEGLFENNKLLRREKCSAIVQRAQSASKSARNLTA"
     exon            252..366
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /inference="alignment:Splign:2.1.0"
     exon            367..476
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /inference="alignment:Splign:2.1.0"
     exon            477..2333
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /note="hexamer: AATAAA"
     polyA_site      2333
                     /gene="MORN4"
                     /gene_synonym="bA548K23.4; C10orf83; rtp; UTA"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggtcg cccaggatgg cggcgtcaag tggggcaatc gctggtggag gtggcggaga
       61 gcaaggtggc agccgggagc ccatcagagg aaaagtccga ggcgctggaa ccctgcgtcc
      121 aggcgtgacg gtcatcccga aaggccggcc ccagtttcat ccttttatcc tgtaatctgt
      181 caccatgacc ctgacaaaag gttccttcac ctactccagt ggggaggaat atcgtggcga
      241 gtggaaggag ggccgcaggc atggttttgg tcaactgatg tttgcagatg gtggcaccta
      301 cctgggtcat tttgagaatg ggctctttaa tggctttggg gtattgacct tctcagatgg
      361 ttcaaggtat gagggggagt ttgcccaggg caagtttaat ggcgtcggag tcttcattcg
      421 atatgacaac atgacctttg agggggaatt taaaaatggc agagtagatg gttttggcct
      481 gctgactttc cctgatggtt ctcatggaat cccccgcaat gaaggtctct ttgagaacaa
      541 caagctgctg cgacgtgaga agtgttctgc cattgttcag cgggcccaga gcgcctccaa
      601 gtcagccaga aatctcactg cctgacagcg cagtgggcac cagctgataa gtattgggta
      661 aagccagtgc ccctgttgtt gattcgaggt gaacaaatga atcagagctg agatgagttg
      721 acaatgacag tggagcagag gccttgtatg tgccctgtca cctgccattc cagaactgga
      781 ccacagaaaa gtgctgagga tgctggccag cagaccctgc agcagtcatt ggtggttctg
      841 tctttcccta acccttatgt gctggaggac agaggagcca cctcttctca ctggttgata
      901 ctctgttcct aagacctcag gttacccagt gtagcctgct gtgacccttc tgcttcattt
      961 tctgccaagt gatacagaac cttcgttctg ctgctttggg gacaggtgat cctagcccca
     1021 gcttagggcc agtgctctgt gccactctgg agaaataggg aaaagatagg ggtggctcag
     1081 tacagcagcc ctgtgaaagt caaggccaga gcttttcttt tttaattttt ttattattat
     1141 tattattatt ttatttttta tttttgagat ggagttttac tctcgcccag gctagagtgc
     1201 agtggcatga tctcagctca ctgcaacttc tgcctcccag gttcaagcaa ttcccctgcc
     1261 tcagcttcct gagtagctgg gactacagga gcgcgccacc acacccagct aatttttgta
     1321 ttttttttta gtagagacgg ggtttcacca tattggccag gctggtctca aactcctgac
     1381 ctcgtgatcc acccgccttg gtctcccaaa gtgctgggat tacaggcgtg agccaccacg
     1441 ctcagccttt aattttatta ttataaaaaa ttgagccagg gtcttgctat gtggctcagg
     1501 ctcatctcaa aatcctgggc tcaagtgatc ctcctgcctg ggcctgccaa agtgctagga
     1561 ttgcaggtgt gagccactgt gcctggctgg cagagctttt ccatatgtta ctcctcatgc
     1621 tggttggaat catggctgca ggcttccact tggtctgatc agactggtat tcattcctgc
     1681 ctatgtcccc gtgaaggatt cggtaagagt gctatttcct cctcccttta gaagacaggc
     1741 tgtcttcttt catcaactta gagcagataa tccccatgtg tgcctctctc cttccttaga
     1801 tggggaacag gatccctttt tgggacaatc aagaaaaaaa ctcatgtaaa cagtaatctt
     1861 attacttgta tttgtgacta actccaggga aaagggtaga atatttaggc cacttcaggc
     1921 actaccatgg agtgaactga attcatacgg atggcttggg ctgacacagt ttcttcccag
     1981 tggaccaata aatcagactc acccgaaccc ctggggtttt ggtagaattg gacctactct
     2041 aggactgtgg ggaactaaag gagcatttgg ctcactgtag ctcttctatc atgagccttg
     2101 accgtcaggc cgcaatcaga ccttactgat gggatctctg cagtttatta cgtaggcctc
     2161 ccgttaccct ggtacccaaa tacgtccccc acctctagct ccctagcctc acattgaatg
     2221 tctcttcaac agcagattgt ggtggaagtt atagccgtgt gcctctattt attctctgaa
     2281 ttgtactgta gaaaaaggtg tttataaaga ataaagaaat caccagaact gcc
//
