LOCUS       NM_173855               3803 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MORN repeat containing 3 (MORN3), transcript variant
            1, mRNA.
ACCESSION   NM_173855
VERSION     NM_173855.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3803)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3803)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3803)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3803)
  AUTHORS   Liang,L., Wang,H., Shi,H., Li,Z., Yao,H., Bu,Z., Song,N., Li,C.,
            Xiang,D., Zhang,Y., Wang,J., Hu,Y., Xu,Q., Ma,Y., Cheng,Z.,
            Wang,Y., Zhao,S., Qian,J., Chen,Y., Fang,J.Y. and Xu,J.
  TITLE     A Designed Peptide Targets Two Types of Modifications of p53 with
            Anti-cancer Activity
  JOURNAL   Cell Chem Biol 25 (6), 761-774 (2018)
   PUBMED   29681526
REFERENCE   5  (bases 1 to 3803)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3803)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3803)
  AUTHORS   Zhang,L., Shang,X.J., Li,H.F., Shi,Y.Q., Li,W., Teves,M.E.,
            Wang,Z.Q., Jiang,G.F., Song,S.Z. and Zhang,Z.B.
  TITLE     Characterization of membrane occupation and recognition nexus
            repeat containing 3, meiosis expressed gene 1 binding partner, in
            mouse male germ cells
  JOURNAL   Asian J Androl 17 (1), 86-93 (2015)
   PUBMED   25248657
REFERENCE   8  (bases 1 to 3803)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057760.1, AC084018.28 and AC140062.11.
            
            On Nov 23, 2018 this sequence version replaced NM_173855.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057760.1, SRR5189667.241973.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355329.7/ ENSP00000347486.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               BC057760.1         1-297
            298-298             AC084018.28        12527-12527         c
            299-1158            BC057760.1         299-1158
            1159-3803           AC140062.11        54519-57163         c
FEATURES             Location/Qualifiers
     source          1..3803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3803
                     /gene="MORN3"
                     /note="MORN repeat containing 3"
                     /db_xref="GeneID:283385"
                     /db_xref="HGNC:HGNC:29807"
     exon            1..316
                     /gene="MORN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..894
                     /gene="MORN3"
                     /note="membrane occupation and recognition nexus repeat
                     containing protein"
                     /codon_start=1
                     /product="MORN repeat-containing protein 3"
                     /protein_id="NP_776254.3"
                     /db_xref="CCDS:CCDS31917.1"
                     /db_xref="GeneID:283385"
                     /db_xref="HGNC:HGNC:29807"
                     /translation="MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWKD
                     NVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSG
                     YGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRY
                     EGCWERGMKNGAGRFFHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVK
                     ILDPDGVLAEALAMFRKTEEGD"
     exon            317..474
                     /gene="MORN3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..634
                     /gene="MORN3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..819
                     /gene="MORN3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..900
                     /gene="MORN3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..3803
                     /gene="MORN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1134..1139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORN3"
                     /note="hexamer: AATAAA"
     polyA_site      1158
                     /gene="MORN3"
                     /note="major polyA site"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORN3"
                     /note="hexamer: AATAAA"
     polyA_site      3803
                     /gene="MORN3"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcac taaaggatcc ccactaaggg ctgttcacct gccccaggga ctcagaacac
       61 acatgactct ccccacttga gctcaggatc ccggcattac acggggcgcg ctgagcccca
      121 gatgtcccta acccctttcc agcaccctcc agccttgcag aagcagccac catgccagtc
      181 tctaagtgcc caaaaaagtc ggagtccctg tggaaggggt gggaccggaa ggcccagagg
      241 aacggcctgc ggagccaggt atacgctgtg aatggcgact actatgtggg cgagtggaag
      301 gacaacgtga aacacgggaa aggaacacag gtctggaaga agaaaggagc catctatgag
      361 ggggactgga agtttgggaa gcgagacggc tacggcaccc tcagccttcc tgaccaacag
      421 acaggaaagt gcaggagagt ctactcaggc tggtggaaag gtgataagaa atcgggttat
      481 gggatccagt ttttcggacc caaggagtat tatgagggtg actggtgtgg cagccagcgc
      541 agcgggtggg gccgcatgta ttacagcaac ggcgacatct acgagggaca gtgggagaac
      601 gacaagccca acggggaggg catgctgcgc ctgaagaacg ggaaccgcta cgagggctgc
      661 tgggagagag gcatgaagaa cggggcgggg cgtttcttcc atctggacca cggccagctg
      721 tttgaaggct tctgggtgga caatatggcc aaatgcggga cgatgatcga ctttggccgt
      781 gacgaggccc ctgagcccac tcagttcccc attcctgagg tcaaaatcct agaccctgat
      841 ggtgtgctgg cggaggcctt ggccatgttc aggaagacag aggaaggaga ttgatgccag
      901 agaacacaaa cgcttcagga gaaattcaag cctgtgtcac ccgatcgctc agaccagtgc
      961 ggctctggct ggaggagtca gcagcagctc caggcatgac cccggcaccc tcatagggcc
     1021 cctcactacc cccagcactg ggtcatttct tgccaatagg aaggctggtg cttctctccc
     1081 aggctgtcct cgggaccctc ttcattctct gatctcatcc tggaatgcat gagaataaag
     1141 aataaccaag tggtataagc ctgggcctat gggataagga tggggcactc gagggggctc
     1201 agcagggctt tcaggtttag aagagggaag acctgccttg gctgggctgc ctgggtttag
     1261 cttgggggag taagggcagg tcttaggccg ggtgcagtgg ctcattcctg taatcccaga
     1321 acttgggagg ccaaggtaag aggactgcct gaggccagga gttcgagacc agcttaggca
     1381 acatagcaag accctgactc tacaaaaaaa aattttaaaa tataaaagaa aggaaaagaa
     1441 aaagagaaag aaatggcagg tcccctgtga gataacccag atgacccaga gagaaggcct
     1501 gtatcctgcc acactggctg ccaagattgg agatcataaa atttcctgac cacttctcag
     1561 cctaacacag ggctctcaac cttgaaatcc catggaaact ttgcaaagct gtggaagccc
     1621 aggtcccatg cccagagatt cacaggttca catctaattc atctggggtg aggcctgagc
     1681 tttcagaaaa ttccccaggt gatttttttt ttttaagacg tagtctccct ctattgccca
     1741 ggctggaatg cagtggcgcg atctcagctc actgcaacct ctgcctccca tgttcaagcg
     1801 attctcctac ctcagcctcc tgagtagctg ggattacagg cgcatgccac tgagcccagc
     1861 taatttttgt atttttagta gagatggggt atcaccatgt tggtcaggct ggtcttgaac
     1921 tcctgacctc gtgatctgcc ccgctcagtc tcctaaagtg ctgggattac aggtgtgagc
     1981 catcgagcct ggcctttttt tttttttttt tttttttttt gagacagagt cttgctctgt
     2041 cacccaggct ggagtgcagt ggcacaatct cggctcactg caacctcgcc tccctggttc
     2101 aagcgattat cctgcctcag cctcccaagt agctgggatt acaggcacct gccaccaagg
     2161 ctaatttttt gtatttttag tagagacagg gtttcaccat gttggccagg acggtctcga
     2221 tctcctgacc tcgtgatctg cccgccttgg actcccaaag tgctgggatt acaggtgtga
     2281 gccactgctc ccagccaaga tcagatgttc ttgcataatg ggcaggtgag ctctggagtc
     2341 acagtgcctg ggcgtgaatc tcggagctgt gtgttctcag gaatgtcacc caaactctgt
     2401 tctgttggtc tcctcacttg caatatgggg cattaacagt acttaccacc tggggttact
     2461 gtggttagtt actgtgagga tgagataagg cggtggtttt aaactgtggg taggattttg
     2521 tcctccctca gccccactct ttcttgggga catttggcaa tgtatgacat ttttgatgtc
     2581 acaacaggca ggaagaaggc tactggcatt gagtgagtag agaccaggga tgcggttaag
     2641 catagtgcaa tatcaccatg ctacaaaaaa aaaaaaaaaa aagaattcag cacctgtaat
     2701 cccaactact tgggaggctg aggcaggaga attgcttgaa cctgggtggc agaggttgca
     2761 gtgagccgag attgcgccat tgcactccag cctgggcgac agagcgagac accatctcca
     2821 aaaaaaaaaa aaaaaaaaat gttgagaaac cctgaaatac cacgattcta gctaagacct
     2881 cagcaagagg cacatagcac atagtaaagc ctcaataaac accactgacc ttactgaggt
     2941 tctctctgcc ccctaagtca taagtagggt ggcctcacca agggtgtggt tctcagtctg
     3001 tacctctggc actgggaagc cccgcctggc caccctagga tgcagaatta atcataactt
     3061 ccagatatgg agcactcact ctattccagg ccgtgtgctg acagcttcgc agcaagcatt
     3121 ctctcctggc actccccgac aacagtgagg tgtcttgcta ttactgccat tttagaggag
     3181 gaaacaggtt cagggaggat cacaagtcat caagctagta ctgtgcttaa acttaggtct
     3241 agctgttctt aatgtgcaga agagtgtaaa gggttaccat ttttaaagaa aaagtggggg
     3301 cagggcatgg tggctcatgc ctgtaatcct agcactttga gaggccgagg caggcggatc
     3361 aagaggtcag gagttcgaga ccagcctgac caacatggtg aaaccctgtc tctactaaaa
     3421 atacaaaaat tagctgggtg tggtggagtg catctataat cccagctact caggaggctg
     3481 aggcaggaga atcacttgaa cccaggaggc ggaggtagtg gtgagccaag atcacgccga
     3541 gccgagatcg tgccgctgct ctccagcctg ggcaacagag cgagactcca tctcaaaaaa
     3601 aaaaaaaatg ttggaagagg gtgtgcttgt ttatgtacaa aatgtcgcta gatttaaaca
     3661 caataaactg gcaaagatgg ttgtctctgg ggagaattgg ggacttggga acaggagctg
     3721 aagaacaact tttcagtgtt gtgtttggaa ccatgtgaat gtattatgta ttcaaaatgt
     3781 aaataaaaat gaagttaaag aga
//
