LOCUS       NM_001145450             727 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens MORN repeat containing 2 (MORN2), mRNA.
ACCESSION   NM_001145450 XR_041208 XR_041209 XR_041210
VERSION     NM_001145450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 727)
  AUTHORS   Morita,M., Kajiye,M., Sakurai,C., Kubo,S., Takahashi,M.,
            Kinoshita,D., Hori,N. and Hatsuzawa,K.
  TITLE     Characterization of MORN2 stability and regulatory function in
            LC3-associated phagocytosis in macrophages
  JOURNAL   Biol Open 9 (6) (2020)
   PUBMED   32414768
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 727)
  AUTHORS   Abnave,P., Mottola,G., Gimenez,G., Boucherit,N., Trouplin,V.,
            Torre,C., Conti,F., Ben Amara,A., Lepolard,C., Djian,B.,
            Hamaoui,D., Mettouchi,A., Kumar,A., Pagnotta,S., Bonatti,S.,
            Lepidi,H., Salvetti,A., Abi-Rached,L., Lemichez,E., Mege,J.L. and
            Ghigo,E.
  TITLE     Screening in planarians identifies MORN2 as a key component in
            LC3-associated phagocytosis and resistance to bacterial infection
  JOURNAL   Cell Host Microbe 16 (3), 338-350 (2014)
   PUBMED   25211076
REFERENCE   3  (bases 1 to 727)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 727)
  AUTHORS   Choi,Y.J., Hwang,K.C., Park,J.Y., Park,K.K., Kim,J.H., Park,S.B.,
            Hwang,S., Park,H., Park,C. and Kim,J.H.
  TITLE     Identification and characterization of a novel mouse and human MOPT
            gene containing MORN-motif protein in testis
  JOURNAL   Theriogenology 73 (3), 273-281 (2010)
   PUBMED   19913896
  REMARK    GeneRIF: MOPT is associated with dynamic regulation of acrosome
            biogenesis during late spermiogenesis.
REFERENCE   5  (bases 1 to 727)
  AUTHORS   Landers,J.E., Melki,J., Meininger,V., Glass,J.D., van den
            Berg,L.H., van Es,M.A., Sapp,P.C., van Vught,P.W.,
            McKenna-Yasek,D.M., Blauw,H.M., Cho,T.J., Polak,M., Shi,L.,
            Wills,A.M., Broom,W.J., Ticozzi,N., Silani,V., Ozoguz,A.,
            Rodriguez-Leyva,I., Veldink,J.H., Ivinson,A.J., Saris,C.G.,
            Hosler,B.A., Barnes-Nessa,A., Couture,N., Wokke,J.H.,
            Kwiatkowski,T.J. Jr., Ophoff,R.A., Cronin,S., Hardiman,O.,
            Diekstra,F.P., Leigh,P.N., Shaw,C.E., Simpson,C.L., Hansen,V.K.,
            Powell,J.F., Corcia,P., Salachas,F., Heath,S., Galan,P.,
            Georges,F., Horvitz,H.R., Lathrop,M., Purcell,S., Al-Chalabi,A. and
            Brown,R.H. Jr.
  TITLE     Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3)
            gene increases survival in sporadic amyotrophic lateral sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 106 (22), 9004-9009 (2009)
   PUBMED   19451621
REFERENCE   6  (bases 1 to 727)
  AUTHORS   Yu,L.R., Zhu,Z., Chan,K.C., Issaq,H.J., Dimitrov,D.S. and
            Veenstra,T.D.
  TITLE     Improved titanium dioxide enrichment of phosphopeptides from HeLa
            cells and high confident phosphopeptide identification by
            cross-validation of MS/MS and MS/MS/MS spectra
  JOURNAL   J Proteome Res 6 (11), 4150-4162 (2007)
   PUBMED   17924679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF510812.1 and AC018693.8.
            
            On Feb 22, 2021 this sequence version replaced NM_001145450.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU930257.1, HY169833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000644631.4/ ENSP00000494143.2
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                KF510812.1         1-93                c
            94-135              AC018693.8         111572-111613
            136-186             AC018693.8         115682-115732
            187-293             AC018693.8         116103-116209
            294-430             AC018693.8         116945-117081
            431-727             AC018693.8         117916-118212
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..727
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /note="MORN repeat containing 2"
                     /db_xref="GeneID:729967"
                     /db_xref="HGNC:HGNC:30166"
     exon            1..135
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..533
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /note="non-AUG (CUG) translation initiation codon; protein
                     containing single MORN motif in testis; MORN motif protein
                     in testis"
                     /codon_start=1
                     /product="MORN repeat-containing protein 2"
                     /protein_id="NP_001138922.2"
                     /db_xref="CCDS:CCDS46262.2"
                     /db_xref="GeneID:729967"
                     /db_xref="HGNC:HGNC:30166"
                     /translation="MAAQGESQSLEDLSNTSRPTSEVYKISFIFPNGDKYDGDCTRTS
                     SGIYERNGIGIHTTPNGIVYTGSWKDDKMNGFGRLEHFSGAVYEGQFKDNMFHGLGTY
                     TFPNGAKYTGNFNENRVEGEGEYTDIQGLEWSGNFHFTAAPDLKLKLHM"
     exon            136..186
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            187..293
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            294..430
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            431..727
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      645..650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /note="hexamer: AATAAA"
     polyA_site      667
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /note="major polyA site"
     regulatory      709..714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
                     /note="hexamer: AATAAA"
     polyA_site      727
                     /gene="MORN2"
                     /gene_synonym="BLOCK27; MOPT"
ORIGIN      
        1 gagaggtgcc cggtcgcccc agcaaccaag tcgcacctgg agctgtccta gcgcctagtt
       61 ctctcccggc cgcagagctg gccgcccagg gggagtcgca gagtttggaa gatctctcta
      121 acacctctcg gccaacttca gaagtgtata agatcagctt tatctttcca aatggagaca
      181 agtatgatgg tgactgtaca agaacatctt ctggaatcta cgagagaaat ggaataggta
      241 ttcataccac tcctaatggg attgtctaca caggaagctg gaaagatgac aagatgaatg
      301 gttttggaag acttgagcat ttttcaggag cagtatatga aggacaattt aaggataata
      361 tgtttcatgg actggggact tacacattcc caaatggggc aaagtatact ggaaatttca
      421 atgaaaatag ggtggaaggt gaaggggaat atactgatat ccaaggacta gaatggagtg
      481 gtaactttca ttttacagct gctccagacc tgaaattaaa gcttcacatg tagatgtgat
      541 gttaaattaa agttgaaatg tagtaattga agcttttagt tgtaaggaaa gcaacttaat
      601 ctgttatttg aaatgacttc atacactacc cctataagtt tgccaataaa accatcacct
      661 gcttacacct ttttgaactt tatattcatt gtcttacaat tagtttaaaa taaatgacat
      721 gattcaa
//
