LOCUS       NM_024848               1645 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens MORN repeat containing 1 (MORN1), transcript variant
            1, mRNA.
ACCESSION   NM_024848
VERSION     NM_024848.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Xu,Z., Gu,Y., Chen,J., Chen,X., Song,Y., Fan,J., Ji,X., Li,Y.,
            Zhang,W. and Zhang,R.
  TITLE     Epigenome-wide gene-age interaction study reveals reversed effects
            of MORN1 DNA methylation on survival between young and elderly oral
            squamous cell carcinoma patients
  JOURNAL   Front Oncol 12, 941731 (2022)
   PUBMED   35965572
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK024003.1 and AI674190.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024848.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024003.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378531.8/ ENSP00000367792.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1641              AK024003.1         1-1641
            1642-1645           AI674190.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..1645
                     /gene="MORN1"
                     /note="MORN repeat containing 1"
                     /db_xref="GeneID:79906"
                     /db_xref="HGNC:HGNC:25852"
     exon            1..97
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1515
                     /gene="MORN1"
                     /note="isoform 1 is encoded by transcript variant 1; MORN
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="MORN repeat-containing protein 1 isoform 1"
                     /protein_id="NP_079124.1"
                     /db_xref="CCDS:CCDS40.1"
                     /db_xref="GeneID:79906"
                     /db_xref="HGNC:HGNC:25852"
                     /translation="MAAAGEGTPSSRGPRRDPPRRPPRNGYGVYVYPNSFFRYEGEWK
                     AGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWSGDTFSGQFVLGEPQGYGVME
                     YKAGGCYEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGDWV
                     RDRRQGHGVLRCADGSTYKGQWHSDVFSGLGSMAHCSGVTYYGLWINGHPAEQATRIV
                     ILGPEVMEVAQGSPFSVNVQLLQDHGEIAKSESGRVLQISAGVRYVQLSAYSEVNFFK
                     VDRDNQETLIQTPFGFECIPYPVSSPAAGVPGPRAAKGGAEADVPLPRGDLELHLGAL
                     HGQEDTPGGLLARGHAPHCPGACQRVEQGCAEFTDVLLGPPPPGYHPFLFLDSLHKKA
                     GGRSRGGLHPRGTPPTAQEPPGGSRPEGRATEEQAAAAHLGEYVLMIRDVTTPPFLGR
                     RLPPAFKHLRVVAKRAGQPPHVLEEGPEASSSWQAAHSCTPEPPAPR"
     exon            98..169
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..268
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..379
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..470
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..558
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..655
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..766
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..890
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1057
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1191
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1271
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1318
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1645
                     /gene="MORN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORN1"
                     /note="hexamer: AATAAA"
     polyA_site      1645
                     /gene="MORN1"
                     /note="major polyA site"
ORIGIN      
        1 aagagaaccc tcggcggcaa gatggcagcg gcgggcgagg gcaccccgag ctcccgcggg
       61 ccgcgtcggg acccgcctag gcggccgccc cggaacggtt atggtgtcta cgtataccca
      121 aattccttct ttcgatatga aggagaatgg aaagcaggga ggaagcacgg tcacgggaag
      181 ttgttattta aagatggcag ttattacgaa ggggcgtttg tggacggaga gatcacggga
      241 gaaggccgcc ggcactgggc ctggtcagga gacaccttct ctggacagtt tgttctggga
      301 gagcctcaag gctacggcgt catggagtac aaagccggcg gatgttatga aggggaggtc
      361 tcccacggca tgcgggaagg acacgggttt ctggtggacc gggatggaca agtgtaccag
      421 ggctccttcc atgacaacaa gaggcacggc cctgggcaga tgctctttca gaacggtgac
      481 aagtacgacg gcgactgggt ccgggaccgg cgtcagggac acggggtgct gcgctgcgcc
      541 gacggctcca cctacaaggg acagtggcac agcgacgtct tcagtggact gggcagcatg
      601 gcccactgct caggggtcac ctattatggg ttgtggatca atggccaccc agcagaacaa
      661 gctacgagga tcgtgatctt gggtccggag gtgatggaag tggcccaagg gtctcccttc
      721 tcggtgaacg ttcagctgct gcaggaccac ggggaaattg ccaagagcga gagcggccgg
      781 gtcctgcaga tctcagcggg cgtcagatac gtgcagctgt cagcctactc tgaggtcaac
      841 tttttcaaag tggacagaga caaccaagag acactcatcc agaccccatt tgggttcgaa
      901 tgcatccctt atcctgtgtc cagccccgca gctggggtgc cggggcccag agctgccaag
      961 ggaggggcag aagccgacgt gcccctgccc aggggagacc tggagctgca tttgggtgcc
     1021 ctccatggcc aggaggacac ccctggtggc ctgcttgcca ggggacatgc gccccattgt
     1081 cccggggcct gtcagcgagt ggagcagggc tgtgccgagt tcacagatgt cctcctgggg
     1141 ccgcccccgc ctgggtacca ccccttcctg ttcctggaca gcctccacaa gaaggcaggc
     1201 ggcagatcca gaggcggcct gcaccccagg gggacaccac ccacggcaca ggagcctcct
     1261 ggaggcagca ggcctgaggg gagagccacg gaggagcagg ctgcggcagc acacctaggg
     1321 gagtacgtgc tcatgatccg cgacgtgacc accccgccgt tcctggggcg caggctgccc
     1381 ccggccttca aacacctgcg ggtcgtagcg aagagggctg gccagccacc ccatgtcctg
     1441 gaagaaggcc ctgaagcctc aagcagctgg caggccgccc acagctgcac cccagagccg
     1501 ccagcgcctc ggtgaggccc cgtgtccaca ggaggccacc tcggtgtgaa tggaaggaaa
     1561 cgctgcctct gcttgcgtga ctctgctccc cgattctcca gagccccgtg gttgctggct
     1621 tgaataaaat gctcagtggc ggcta
//
