LOCUS       NM_012286               1866 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mortality factor 4 like 2 (MORF4L2), transcript
            variant 2, mRNA.
ACCESSION   NM_012286
VERSION     NM_012286.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Kooblall,K.G., Stokes,V.J., Shariq,O.A., English,K.A.,
            Stevenson,M., Broxholme,J., Wright,B., Lockstone,H.E., Buck,D.,
            Grozinsky-Glasberg,S., Yates,C.J., Thakker,R.V. and Lines,K.E.
  TITLE     miR-3156-5p is downregulated in serum of MEN1 patients and
            regulates expression of MORF4L2
  JOURNAL   Endocr Relat Cancer 29 (10), 557-568 (2022)
   PUBMED   35900839
  REMARK    GeneRIF: miR-3156-5p is downregulated in serum of MEN1 patients and
            regulates expression of MORF4L2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Zheng,X., Sun,Z., Yu,L., Shi,D., Zhu,M., Yao,H. and Li,L.
  TITLE     Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2
            Virus
  JOURNAL   Pathogens 10 (9), 1155 (2021)
   PUBMED   34578187
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Zhang,R., Ji,Z., Yao,Y., Zuo,W., Yang,M., Qu,Y., Su,Y., Ma,G. and
            Li,Y.
  TITLE     Identification of hub genes in unstable atherosclerotic plaque by
            conjoint analysis of bioinformatics
  JOURNAL   Life Sci 262, 118517 (2020)
   PUBMED   33011223
  REMARK    GeneRIF: Identification of hub genes in unstable atherosclerotic
            plaque by conjoint analysis of bioinformatics.
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Yochum,G.S. and Ayer,D.E.
  TITLE     Role for the mortality factors MORF4, MRGX, and MRG15 in
            transcriptional repression via associations with Pf1, mSin3A, and
            Transducin-Like Enhancer of Split
  JOURNAL   Mol Cell Biol 22 (22), 7868-7876 (2002)
   PUBMED   12391155
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Sakai,K., Shirakawa,T., Li,Y., Kitagawa,Y. and Hirose,G.
  TITLE     Interaction of a paraneoplastic cerebellar degeneration-associated
            neuronal protein with the nuclear helix-loop-helix leucine zipper
            protein MRG X
  JOURNAL   Mol Cell Neurosci 19 (4), 477-484 (2002)
   PUBMED   11988016
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Bertram,M.J., Berube,N.G., Hang-Swanson,X., Ran,Q., Leung,J.K.,
            Bryce,S., Spurgers,K., Bick,R.J., Baldini,A., Ning,Y., Clark,L.J.,
            Parkinson,E.K., Barrett,J.C., Smith,J.R. and Pereira-Smith,O.M.
  TITLE     Identification of a gene that reverses the immortal phenotype of a
            subset of cells and is a member of a novel family of transcription
            factor-like genes
  JOURNAL   Mol Cell Biol 19 (2), 1479-1485 (1999)
   PUBMED   9891081
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA987770.1, AL049610.9 and BC093013.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012286.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.65532.1,
                                           SRR5189655.79087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441076.7/ ENSP00000391969.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA987770.1         211-222
            13-69               AL049610.9         68546-68602         c
            70-159              AL049610.9         67086-67175         c
            160-312             AL049610.9         60414-60566         c
            313-1850            AL049610.9         57429-58966         c
            1851-1866           BC093013.1         1849-1864
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..1866
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /note="mortality factor 4 like 2"
                     /db_xref="GeneID:9643"
                     /db_xref="HGNC:HGNC:16849"
                     /db_xref="MIM:300409"
     exon            1..69
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /inference="alignment:Splign:2.1.0"
     exon            70..159
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /inference="alignment:Splign:2.1.0"
     exon            160..312
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /inference="alignment:Splign:2.1.0"
     exon            313..1866
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1203
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /note="MSL3-2 protein; protein MSL3-2; MORF-related gene X
                     protein; transcription factor-like protein MRGX"
                     /codon_start=1
                     /product="mortality factor 4-like protein 2"
                     /protein_id="NP_036418.1"
                     /db_xref="CCDS:CCDS14512.1"
                     /db_xref="GeneID:9643"
                     /db_xref="HGNC:HGNC:16849"
                     /db_xref="MIM:300409"
                     /translation="MSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTA
                     GPQQKNLEPALPGRWGGRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKR
                     ARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILE
                     EYANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAP
                     MSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDY
                     KVASAEYHRKAL"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="MORF4L2"
                     /gene_synonym="MORFL2; MRGX"
                     /note="major polyA site"
ORIGIN      
        1 actatggcgg ttggaggaac ggcagtgatc acacgtcggc tgctgggaag atctggattc
       61 tcgtttcagg tcaccatcag aaaagctaag tttgctgtat agtgaggatc aggagatctg
      121 atcctgattg cagaaccttc cctgattaca gaatcttgga tgatttcaca aaagttcatc
      181 ttcattgcag atacctgcct ttctttctag gttgtatctc ccacttcacc cttctagacc
      241 atcccagaag atctataaga tttcatctgg gaaatcacta ggagttcttg gaagggaaag
      301 aaggaagatt gttggttgga ataaaaacag ggttgaatga gttccagaaa gcagggttct
      361 caacctcgtg gacagcaatc tgcagaagaa gagaacttca aaaaaccaac tagaagcaac
      421 atgcagagaa gtaaaatgag aggggcctcc tcaggaaaga agacagctgg tccacagcag
      481 aaaaatcttg aaccagctct cccaggaaga tggggtggtc gctctgcaga gaacccccct
      541 tcaggatccg tgaggaagac cagaaagaac aagcagaaga ctcctggaaa cggagatggt
      601 ggcagtacca gcgaagcacc tcagccccct cggaagaaaa gggcccgggc agaccccact
      661 gttgaaagtg aggaggcgtt taagaataga atggaggtta aagtgaagat tcctgaagaa
      721 ttaaaaccat ggcttgttga ggactgggac ttagttacca ggcagaagca gctgtttcaa
      781 ctccctgcca agaaaaatgt agatgcaatt ctggaggagt atgcaaattg caagaaatcg
      841 cagggaaatg ttgataataa ggaatatgcg gttaatgaag ttgtggcagg aataaaagaa
      901 tatttcaatg tgatgttggg cactcagctg ctctacaaat ttgagaggcc ccagtatgct
      961 gaaatcctct tggctcaccc tgatgctcca atgtcccagg tttatggagc accacaccta
     1021 ctgagattat ttgtaagaat tggagcaatg ttggcctata cgccccttga tgagaaaagc
     1081 cttgcattat tgttgggcta tttgcatgat ttcctaaaat atctggcaaa gaattctgca
     1141 tctctcttta ctgccagtga ttacaaagtg gcttctgctg agtaccaccg caaagccctg
     1201 tgagcgtcta cagacagctc accatttttg tcctgtatct gtaaacactt tttgttctta
     1261 gtctttttct tgtaaaattg atgttcttta aaatcgttaa tgtataacag ggcttatgtt
     1321 tcagtttgtt ttccgttctg ttttaaacag aaaataaaag gagtgtaagc tccttttctc
     1381 atttcaaagt tgctaccagt gtatgcagta attagaacaa agaagaaaca ttcagtagaa
     1441 cattttattg cctagttgac aacattgctt gaatgctggt ggttcctatc cctttgacac
     1501 tacacaattt tctaatatgt gttaatgcta tgtgacaaaa cgccctgatt cctagtgcca
     1561 aaggttcaac ttaatgtata tacctgaaaa cccatgcatt tgtgctcttt tttttttttt
     1621 atggtgcttg aagtaaaaca gcccatcctc tgcaagtcca tctatgttgt tcttaggcat
     1681 tctatctttg ctcaaattgt tgaaggatgg tgatttgttt catggttttt gtatttgagt
     1741 ctaatgcacg ttctaacatg atagaggcaa tgcattattg tgtagccacg gttttctgga
     1801 aaagttgata ttttaggaat tgtatttcag atcttaaata aaatttgttt ctaaatttca
     1861 aagcaa
//
