LOCUS       NM_006791               2172 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mortality factor 4 like 1 (MORF4L1), transcript
            variant 1, mRNA.
ACCESSION   NM_006791
VERSION     NM_006791.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2172)
  AUTHORS   Al-Harthi,S., Li,H., Winkler,A., Szczepski,K., Deng,J.,
            Grembecka,J., Cierpicki,T. and Jaremko,L.
  TITLE     MRG15 activates histone methyltransferase activity of ASH1L by
            recruiting it to the nucleosomes
  JOURNAL   Structure 31 (10), 1200-1207 (2023)
   PUBMED   37527654
  REMARK    GeneRIF: MRG15 activates histone methyltransferase activity of
            ASH1L by recruiting it to the nucleosomes.
REFERENCE   2  (bases 1 to 2172)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 2172)
  AUTHORS   Tian,C., Min,X., Zhao,Y., Wang,Y., Wu,X., Liu,S., Dou,W., Zhou,T.,
            Liu,Y., Luo,R., Li,Z., Lui,K.O., Li,Y., Zhou,B. and Ding,Q.
  TITLE     MRG15 aggravates non-alcoholic steatohepatitis progression by
            regulating the mitochondrial proteolytic degradation of TUFM
  JOURNAL   J Hepatol 77 (6), 1491-1503 (2022)
   PUBMED   35985547
  REMARK    GeneRIF: MRG15 aggravates non-alcoholic steatohepatitis progression
            by regulating the mitochondrial proteolytic degradation of TUFM.
REFERENCE   4  (bases 1 to 2172)
  AUTHORS   Redington,J., Deveryshetty,J., Kanikkannan,L., Miller,I. and
            Korolev,S.
  TITLE     Structural Insight into the Mechanism of PALB2 Interaction with
            MRG15
  JOURNAL   Genes (Basel) 12 (12), 2002 (2021)
   PUBMED   34946951
  REMARK    GeneRIF: Structural Insight into the Mechanism of PALB2 Interaction
            with MRG15.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2172)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2172)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   7  (bases 1 to 2172)
  AUTHORS   Pardo,P.S., Leung,J.K., Lucchesi,J.C. and Pereira-Smith,O.M.
  TITLE     MRG15, a novel chromodomain protein, is present in two distinct
            multiprotein complexes involved in transcriptional activation
  JOURNAL   J Biol Chem 277 (52), 50860-50866 (2002)
   PUBMED   12397079
  REMARK    GeneRIF: a novel chromodomain protein that is present in two
            distinct multiprotein complexes involved in transcriptional
            activation
REFERENCE   8  (bases 1 to 2172)
  AUTHORS   Yochum,G.S. and Ayer,D.E.
  TITLE     Role for the mortality factors MORF4, MRGX, and MRG15 in
            transcriptional repression via associations with Pf1, mSin3A, and
            Transducin-Like Enhancer of Split
  JOURNAL   Mol Cell Biol 22 (22), 7868-7876 (2002)
   PUBMED   12391155
REFERENCE   9  (bases 1 to 2172)
  AUTHORS   Leung,J.K., Berube,N., Venable,S., Ahmed,S., Timchenko,N. and
            Pereira-Smith,O.M.
  TITLE     MRG15 activates the B-myb promoter through formation of a nuclear
            complex with the retinoblastoma protein and the novel protein PAM14
  JOURNAL   J Biol Chem 276 (42), 39171-39178 (2001)
   PUBMED   11500496
REFERENCE   10 (bases 1 to 2172)
  AUTHORS   Bertram,M.J., Berube,N.G., Hang-Swanson,X., Ran,Q., Leung,J.K.,
            Bryce,S., Spurgers,K., Bick,R.J., Baldini,A., Ning,Y., Clark,L.J.,
            Parkinson,E.K., Barrett,J.C., Smith,J.R. and Pereira-Smith,O.M.
  TITLE     Identification of a gene that reverses the immortal phenotype of a
            subset of cells and is a member of a novel family of transcription
            factor-like genes
  JOURNAL   Mol Cell Biol 19 (2), 1479-1485 (1999)
   PUBMED   9891081
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF100615.1, BM996530.1 and AC011944.12.
            
            On May 17, 2019 this sequence version replaced NM_006791.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.124007.1,
                                           SRR1803617.60061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426013.7/ ENSP00000408880.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1763              AF100615.1         4-1766
            1764-1772           BM996530.1         14-22               c
            1773-2172           AC011944.12        128215-128614       c
FEATURES             Location/Qualifiers
     source          1..2172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..2172
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:10933"
                     /db_xref="HGNC:HGNC:16989"
                     /db_xref="MIM:607303"
     exon            1..168
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1100
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Esa1p-associated factor 3 homolog; MORF-related gene on
                     chromosome 15; mortality factor 4-like protein 1; protein
                     MSL3-1; MORF-related gene 15 protein; transcription
                     factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 1"
                     /protein_id="NP_006782.1"
                     /db_xref="CCDS:CCDS32304.1"
                     /db_xref="GeneID:10933"
                     /db_xref="HGNC:HGNC:16989"
                     /db_xref="MIM:607303"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFI
                     HYSGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQ
                     QKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKI
                     PEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVV
                     AGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAY
                     TPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV"
     exon            169..215
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            216..283
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            284..370
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            371..451
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            452..477
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            478..566
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            567..668
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            669..757
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            758..930
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1015
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..2172
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="hexamer: AATAAA"
     polyA_site      1263
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="major polyA site"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="hexamer: AATAAA"
     polyA_site      1772
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="major polyA site"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
                     /note="hexamer: ATTAAA"
     polyA_site      2172
                     /gene="MORF4L1"
                     /gene_synonym="Eaf3; FWP006; HsT17725; MEAF3; MORFRG15;
                     MRG15; S863-6"
ORIGIN      
        1 aaatccggcc caggatgtag agctggcagt gcctgacggc gcgtctgacg cggagttggg
       61 tggggtagag agtagggggc ggtagtcggg ggtggtggga gaaggaggag gcggcgaatc
      121 acttataaat ggcgccgaag caggacccga agcctaaatt ccaggagggt gagcgagtgc
      181 tgtgctttca tgggcctctt ctttatgaag caaagtgtgt aaaggttgcc ataaaggaca
      241 aacaagtgaa atacttcata cattacagtg gttggaataa aaattgggat gaatgggttc
      301 cggagagcag agtactcaaa tacgtggaca ccaatttgca gaaacagcga gaacttcaaa
      361 aagccaatca ggagcagtat gcagagggga agatgagagg ggctgcccca ggaaagaaga
      421 catctggtct gcaacagaaa aatgttgaag tgaaaacgaa aaagaacaaa cagaaaacac
      481 ctggaaatgg agatggtggc agtaccagtg agacccctca gcctcctcgg aagaaaaggg
      541 cccgggtaga tcctactgtt gaaaatgagg aaacattcat gaacagagtt gaagttaaag
      601 taaagattcc tgaagagcta aaaccgtggc ttgttgatga ctgggactta attaccaggc
      661 aaaaacagct cttttatctt cctgccaaga agaatgtgga ttccattctt gaggattatg
      721 caaattacaa gaaatctcgt ggaaacacag ataataagga gtatgcggtt aatgaagttg
      781 tggcagggat aaaagaatac ttcaacgtaa tgttgggtac ccagctactc tataaatttg
      841 agagaccaca gtatgctgaa attcttgcag atcatcccga tgcacccatg tcccaggtgt
      901 atggagcgcc acatctcctg agattatttg tacgaattgg agcaatgttg gcttatacac
      961 ctctggatga gaagagcctt gctttattac tcaattatct tcacgatttc ctaaagtacc
     1021 tggcaaagaa ttctgcaact ttgttcagtg ccagcgatta tgaagtggct cctcctgagt
     1081 accatcggaa agctgtgtga gaggcactct cactcactta tgtttggatc tccgtaaaca
     1141 catttttgtt cttagtctat ctcttgtaca aacgatgtgc tttgaagatg ttagtgtata
     1201 acaattgatg tttgttttct gtttgatttt aaacagagaa aaaataaaag ggggtaatag
     1261 ctcctttttt cttctttctt tttttttttc atttcaaaat tgctgccagt gttttcaatg
     1321 atggacaaca gagggatatg ctgtagagtg ttttattgcc tagttgacaa agctgctttt
     1381 gaatgctggt ggttctattc ctttgacact acgcactttt ataatacatg ttaatgctat
     1441 atgacaaaat gctctgattc ctagtgccaa aggttcaatt cagtgtatat aactgaacac
     1501 actcatccat ttgtgctttt gttttttttt atggtgctta aagtaaagag cccatccttt
     1561 gcaagtcatc catgttgtta cttaggcatt ttatcttggc tcaaattgtt gaagaatggt
     1621 ggcttgtttc atggtttttg tatttgtgtc taatgcacgt tttaacatga tagacgcaat
     1681 gcattgtgta gctagttttc tggaaaagtc aatcttttag gaattgtttt tcagatcttc
     1741 aataaatttt ttctttaaat ttcaaagaac aatgtgcttg tgttgatgcc ttacaaaaac
     1801 cattgtatat ttgtgtattc cttcttgtat ttagacagtg gtttttcagg tgcgtgcttt
     1861 gttttctggt atggccttta tggaatgaga cgctttagct ttggtacgta gcgctaatcc
     1921 atagcagctt tggcagtttg ctgtcttgag tcttagctaa aaagttagaa gtttacatga
     1981 ctgttttttt tattttccct aaattattac ttactctgag cattaattaa gggcattttc
     2041 acctgtgtaa aattatggtc agcttttttc tgtctataat tgtttacttt tgtgggttta
     2101 ctctagaaac atgagccaaa aatgtcaata gacaacacag tattaaaata acccaaaagt
     2161 tgtaaagggc aa
//
