LOCUS       NM_024657               3798 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MORC family CW-type zinc finger 4 (MORC4), transcript
            variant 1, mRNA.
ACCESSION   NM_024657
VERSION     NM_024657.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Liang,Y., Wu,D., Qu,Q., Li,Z. and Yin,H.
  TITLE     MORC4 plays a tumor-promoting role in colorectal cancer via
            regulating PCGF1/CDKN1A axis in vitro and in vivo
  JOURNAL   Cancer Gene Ther 30 (7), 985-996 (2023)
   PUBMED   36932196
  REMARK    GeneRIF: MORC4 plays a tumor-promoting role in colorectal cancer
            via regulating PCGF1/CDKN1A axis in vitro and in vivo.
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Yang,Z., Zhuang,Q., Hu,G. and Geng,S.
  TITLE     MORC4 is a novel breast cancer oncogene regulated by miR-193b-3p
  JOURNAL   J Cell Biochem 120 (3), 4634-4643 (2019)
   PUBMED   30320920
  REMARK    GeneRIF: These results identified MORC4 as differentially expressed
            in breast cancer cells and tissues and its downregulation by
            miR-193b-3p, as well as its roles in regulating the growth of
            breast cancer cells via regulation of apoptosis.
REFERENCE   3  (bases 1 to 3798)
  AUTHORS   Campa,D., Pastore,M., Capurso,G., Hackert,T., Di Leo,M.,
            Izbicki,J.R., Khaw,K.T., Gioffreda,D., Kupcinskas,J., Pasquali,C.,
            Macinga,P., Kaaks,R., Stigliano,S., Peeters,P.H., Key,T.J.,
            Talar-Wojnarowska,R., Vodicka,P., Valente,R., Vashist,Y.K.,
            Salvia,R., Papaconstantinou,I., Shimizu,Y., Valsuani,C.,
            Zambon,C.F., Gazouli,M., Valantiene,I., Niesen,W.,
            Mohelnikova-Duchonova,B., Hara,K., Soucek,P., Malecka-Panas,E.,
            Bueno-de-Mesquita,H.B.A., Johnson,T., Brenner,H., Tavano,F.,
            Fogar,P., Ito,H., Sperti,C., Butterbach,K., Latiano,A.,
            Andriulli,A., Cavestro,G.M., Busch,O.R.C., Dijk,F., Greenhalf,W.,
            Matsuo,K., Lombardo,C., Strobel,O., Konig,A.K., Cuk,K.,
            Strothmann,H., Katzke,V., Cantore,M., Mambrini,A., Oliverius,M.,
            Pezzilli,R., Landi,S. and Canzian,F.
  TITLE     Do pancreatic cancer and chronic pancreatitis share the same
            genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA)
            consortium investigation
  JOURNAL   Int J Cancer 142 (2), 290-296 (2018)
   PUBMED   28913878
  REMARK    GeneRIF: SNP in the MORC4-rs 12837024 is associated with Chronic
            pancreatitis.
REFERENCE   4  (bases 1 to 3798)
  AUTHORS   Liu,Y., Tempel,W., Zhang,Q., Liang,X., Loppnau,P., Qin,S. and
            Min,J.
  TITLE     Family-wide Characterization of Histone Binding Abilities of Human
            CW Domain-containing Proteins
  JOURNAL   J Biol Chem 291 (17), 9000-9013 (2016)
   PUBMED   26933034
REFERENCE   5  (bases 1 to 3798)
  AUTHORS   Noren,E., Verma,D., Soderkvist,P., Weisselberg,T., Soderman,J.,
            Lotfi,K. and Almer,S.
  TITLE     Single Nucleotide Polymorphisms in MORC4, CD14, and TLR4 Are
            Related to Outcome of Allogeneic Stem Cell Transplantation
  JOURNAL   Ann Transplant 21, 56-67 (2016)
   PUBMED   26827181
  REMARK    GeneRIF: Genetic variation in MORC4, CD14, and TLR4 may affect the
            outcome of allogeneic stem cell transplantation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3798)
  AUTHORS   Whitcomb,D.C., LaRusch,J., Krasinskas,A.M., Klei,L., Smith,J.P.,
            Brand,R.E., Neoptolemos,J.P., Lerch,M.M., Tector,M., Sandhu,B.S.,
            Guda,N.M., Orlichenko,L., Alkaade,S., Amann,S.T., Anderson,M.A.,
            Baillie,J., Banks,P.A., Conwell,D., Cote,G.A., Cotton,P.B.,
            DiSario,J., Farrer,L.A., Forsmark,C.E., Johnstone,M., Gardner,T.B.,
            Gelrud,A., Greenhalf,W., Haines,J.L., Hartman,D.J., Hawes,R.A.,
            Lawrence,C., Lewis,M., Mayerle,J., Mayeux,R., Melhem,N.M.,
            Money,M.E., Muniraj,T., Papachristou,G.I., Pericak-Vance,M.A.,
            Romagnuolo,J., Schellenberg,G.D., Sherman,S., Simon,P., Singh,V.P.,
            Slivka,A., Stolz,D., Sutton,R., Weiss,F.U., Wilcox,C.M.,
            Zarnescu,N.O., Wisniewski,S.R., O'Connell,M.R., Kienholz,M.L.,
            Roeder,K., Barmada,M.M., Yadav,D. and Devlin,B.
  CONSRTM   Alzheimer's Disease Genetics Consortium
  TITLE     Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter
            risk for alcohol-related and sporadic pancreatitis
  JOURNAL   Nat Genet 44 (12), 1349-1354 (2012)
   PUBMED   23143602
REFERENCE   7  (bases 1 to 3798)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3798)
  AUTHORS   Liggins,A.P., Cooper,C.D., Lawrie,C.H., Brown,P.J., Collins,G.P.,
            Hatton,C.S., Pulford,K. and Banham,A.H.
  TITLE     MORC4, a novel member of the MORC family, is highly expressed in a
            subset of diffuse large B-cell lymphomas
  JOURNAL   Br J Haematol 138 (4), 479-486 (2007)
   PUBMED   17608765
REFERENCE   9  (bases 1 to 3798)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 3798)
  AUTHORS   Perry,J. and Zhao,Y.
  TITLE     The CW domain, a structural module shared amongst vertebrates,
            vertebrate-infecting parasites and higher plants
  JOURNAL   Trends Biochem Sci 28 (11), 576-580 (2003)
   PUBMED   14607086
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB989767.1, EF125209.1,
            AK300305.1, BQ101064.1 and CA448781.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024657.4.
            
            Summary: In human, the four current members of the microrchidia
            (morc) gene family share an N-terminal ATPase-like ATP-binding
            region and a CW four-cysteine zinc-finger motif. The protein
            encoded by this gene also has a nuclear matrix binding domain and a
            two-stranded coiled-coil motif near its C-terminus. This gene is
            widely expressed at low levels in normal tissues and has elevated
            expression in placenta and testis. Alternative splicing results in
            multiple transcript variants encoding distinct proteins. [provided
            by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355610.9/ ENSP00000347821.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               CB989767.1         28-270
            244-1798            EF125209.1         1-1555
            1799-2808           AK300305.1         1406-2415
            2809-3352           BQ101064.1         1-544
            3353-3798           CA448781.1         18-463              c
FEATURES             Location/Qualifiers
     source          1..3798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..3798
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /note="MORC family CW-type zinc finger 4"
                     /db_xref="GeneID:79710"
                     /db_xref="HGNC:HGNC:23485"
                     /db_xref="MIM:300970"
     exon            1..345
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..3057
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger, CW type with coiled-coil domain 2; MORC family
                     CW-type zinc finger protein 4; zinc finger CW-type
                     coiled-coil domain protein 2; zinc finger CW-type domain
                     protein 4"
                     /codon_start=1
                     /product="MORC family CW-type zinc finger protein 4
                     isoform a"
                     /protein_id="NP_078933.3"
                     /db_xref="CCDS:CCDS14525.2"
                     /db_xref="GeneID:79710"
                     /db_xref="HGNC:HGNC:23485"
                     /db_xref="MIM:300970"
                     /translation="MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNS
                     SSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRML
                     SFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQ
                     AQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRV
                     LIWNIRRNKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILY
                     MKPRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMM
                     YHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINAL
                     AQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPAR
                     WFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQEQTVEEKKKMPMENENHQVFSNP
                     PKILTVQEMAGLNNKTIGYEGIHSPSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKW
                     ILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVEAPVAYPEGENSHDKSSSERSTPPY
                     LFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPEELEDQMPRLVAEESNRGSTTIN
                     KEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASAAI
                     PAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLERVLAERNLFQQKVEELEQ
                     ERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEEKQEL
                     KEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVSYLLTSVLPHLELRE
                     IGYDSEQVDGILYTVLEANHILD"
     exon            346..418
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..551
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..769
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..917
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1050
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1179
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1299
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1400
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1499
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1628
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1697
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1752
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1928
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2619
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2903
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3798
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3778..3783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /note="hexamer: AATAAA"
     polyA_site      3798
                     /gene="MORC4"
                     /gene_synonym="dJ75H8.2; ZCW4; ZCWCC2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgccggg tcggtagagg tgctgacagg gcggagccgc cgcttgcctc agccggcctc
       61 acccctcccg cccgggacag gtggctggag cgcgctccgc ctccgccagc tgcgagtggg
      121 agcgagggag ggccggtccc ggacggtcgc cgccagctgc gagtggaagt gagcgagggc
      181 tagtcccgga ccgccgggcc aggggtccgg cggcagcaga cgggtaccgt ggcggccaaa
      241 aaaatgctcc tgtaccgagg ggcccccgcc ggccctggcg cgccgggctg cgggctggcc
      301 cggcccggcg gcggcccgca ggccttcggg atccgcctga gcacgatgag cccccgctac
      361 ctccagagca actccagcag ccacacgcga cccttcagtg ccatcgcgga gctgctagat
      421 aatgctgtag atccagatgt atctgccagg acggtcttta tagatgttga ggaggtcaag
      481 aataaatctt gtttgacctt taccgatgat ggatgtggga tgacacctca taaactacac
      541 cgaatgctca gctttggctt tacagataaa gtaataaaga agagccagtg tcccattggg
      601 gtctttggta atggtttcaa gtcaggctcc atgcggctag gaaaggacgc ccttgtcttc
      661 accaagaatg ggggtactct cactgttgga cttctatcac agacctatct ggaatgtgtc
      721 caggcccagg cagttattgt accaattgtt ccattcaacc agcaaaacaa aaaaatgatt
      781 attaccgagg attcattgcc cagcctagaa gccatcttga actattccat tttcaaccgt
      841 gaaaatgacc tgctggccca gtttgatgcc atcccaggca aaaaaggcac tcgtgttctc
      901 atttggaaca tccgcagaaa taaaaatgga aaatctgagt tggactttga tacagatcaa
      961 tatgacatcc tggtatcaga ctttgacaca gaagaaaaaa tgactggcgg tgttacctct
     1021 gagctaccag aaacagaata ttctttaagg gcattttgtg gtattctata catgaagcca
     1081 cgcatgaaaa tttttctgcg tcaaaagaag gtgactaccc agatgattgc caagagcctg
     1141 gccaatgtag aatatgatac atataaacct accttcacaa ataagcaggt gagaatcacc
     1201 tttgggttct cttgcaagaa tagtaaccag tttggaataa tgatgtatca taacaaccga
     1261 ctcataaaat cttttgagaa ggtggggtgc caggtgaagc caactcgtgg agaaggtgta
     1321 ggagtaattg gagtcattga gtgcaatttc ctaaaacctg cctacaacaa acaagacttt
     1381 gagtatacca aggagtaccg gctaacaata aatgcccttg cccagaagct caatgcttac
     1441 tggaaggaaa aaacatctca agataatttt gagacctcaa ctgtagccag gccaataccg
     1501 aaggttcctg accagacatg ggttcagtgt gatgagtgtc ttaaatggag aaagcttcct
     1561 gggaagattg atccatccat gttacctgca agatggtttt gttattataa ttcccatcca
     1621 aagtacagga gatgctctgt tccagaggaa caagaactca ctgatgaaga cctgtgcttg
     1681 agcaaagcta agaaacaaga acaaactgtt gaggagaaga agaagatgcc tatggaaaat
     1741 gagaaccacc aggtattcag taatccacca aagatcctta ctgttcaaga aatggctgga
     1801 ttgaataaca agacaattgg atatgaggga attcatagcc ctagtgtgct tccttctggt
     1861 ggagaagaaa gcagatcacc atctcttcaa cttaagcctc tggattccag tgttttacag
     1921 ttttccagta agtacaaatg gatcctaggt gaagaaccgg tggagaaacg aagaaggctc
     1981 cagaatgaga tgacaacacc ttctctagat tattccatgc ctgctcctta caggagggta
     2041 gaagcacctg ttgcctaccc agaaggggag aacagccatg ataaatcgag ttctgagaga
     2101 agtacaccac catacctttt cccagaatac ccagaagcaa gcaagaatac aggtcagaat
     2161 agggaggttt caattctgta tccaggggcc aaagaccaac gccaggggtc cctgcttcct
     2221 gaagaattag aagatcagat gccaagattg gtggcagaag aatctaacag aggtagcaca
     2281 accataaaca aagaagaagt caacaaggga ccttttgtag ctgttgtggg tgttgccaaa
     2341 ggtgttagag attcaggagc tcccattcag ctgatccctt ttaacagaga ggagcttgct
     2401 gagagacgaa aagcagttga atcctggaac ccagtgcctt attctgtggc ctctgctgca
     2461 atccctgctg cagccattgg ggagaaagca agaggctatg aggagagcga aggtcataat
     2521 acaccaaagt tgaagaacca gagagagctg gaagaattga agagaaccac agaaaaattg
     2581 gaacgtgttt tggctgaaag gaatttgttc cagcaaaagg tggaggagct ggaacaggag
     2641 aggaatcact ggcagtctga attcaagaaa gtccaacatg aattggtgat ctacagtacc
     2701 caggaggcgg aaggcttgta ctggagcaag aaacacatgg gttatcgcca agctgaattc
     2761 cagattctga aagctgagct ggaaagaacc aaagaggaaa agcaagagtt aaaagagaaa
     2821 ctgaaggaaa cagagacaca cctggaaatg ctgcagaagg ctcaggtctc ctaccggacc
     2881 ccagagggag atgacctaga aagggctttg gcaaagctta cgcggctacg tatccacgtc
     2941 agctatctcc ttacttctgt cctccctcac ttggagcttc gtgagatcgg gtatgactca
     3001 gaacaagtgg atgggatcct gtacacggtg ctggaggcaa atcacatact ggattgagca
     3061 ccagactgta tacccttctc ttctcttatc ttctgtctgt tctcttttct ctccctccct
     3121 cacgtctctc tctctctctc tctctctctc tctctctctc tctcaccctc acctttatgc
     3181 cttatataga gaatctctgt gtaaatcctg gctcataatc agtctccttt ttatcagttt
     3241 tggtgtggag aaagaggcca gtttaaatag gctttcaaga gtctagggtc agaaaagcaa
     3301 tagtcactaa gctaggtgac ctgaaagctt taattttcat gacctggata tgtggtctat
     3361 tgtatatctt tttctgaaat ggtttgtatt catttaggtt agatcaatca gcagatattg
     3421 ggtccggtat accaggtatt attttggggt aagctaacaa gtacaactca tgtttgcagc
     3481 cttcgaagat gtaacaatct cgttggaaac ataagacata catcacatta tacacaaaag
     3541 tgtatgatat gtacaactga gtggtacaga tatgacatgg aagatctggg ggaggaagtt
     3601 caaggaaggc accacaccag aaatgggacc taaattaagg cttaaagaat gagcatggcc
     3661 acactgtcag tgagtgttct ttaggtggta ggactatggt tgatattttt cttcttccta
     3721 tcttcctgcc tttttcagat tttcaatatt aaacttgtta ttcttacatt ggaaaaaaat
     3781 aaattgtttt taaaaaga
//
