LOCUS       NM_015358               4224 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MORC family CW-type zinc finger 3 (MORC3), transcript
            variant 1, mRNA.
ACCESSION   NM_015358
VERSION     NM_015358.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4224)
  AUTHORS   Champion,A., Rowland,A., Yee,L., van den Boomen,D., Reeves,M.,
            Lehner,P., Sinclair,J. and Poole,E.
  TITLE     MORC3 represses the HCMV major immediate early promoter in myeloid
            cells in the absence of PML nuclear bodies
  JOURNAL   J Med Virol 95 (11), e29227 (2023)
   PUBMED   38009611
  REMARK    GeneRIF: MORC3 represses the HCMV major immediate early promoter in
            myeloid cells in the absence of PML nuclear bodies.
REFERENCE   2  (bases 1 to 4224)
  AUTHORS   Ma,X.H., Yao,Y.X., Wang,X.Z., Zhou,Y.P., Huang,S.N., Li,D.,
            Mei,M.J., Wu,J.P., Pan,Y.T., Cheng,S., Jiang,X., Sun,J.Y.,
            Zeng,W.B., Gong,S., Cheng,H., Luo,M.H. and Yang,B.
  TITLE     MORC3 restricts human cytomegalovirus infection by suppressing the
            major immediate-early promoter activity
  JOURNAL   J Med Virol 94 (11), 5492-5506 (2022)
   PUBMED   35879101
  REMARK    GeneRIF: MORC3 restricts human cytomegalovirus infection by
            suppressing the major immediate-early promoter activity.
REFERENCE   3  (bases 1 to 4224)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4224)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4224)
  AUTHORS   Fox,L.E. and Lenschow,D.J.
  TITLE     En garde! The duel functions of MORC3
  JOURNAL   Cell Host Microbe 30 (1), 8-9 (2022)
   PUBMED   35026136
  REMARK    GeneRIF: En garde! The duel functions of MORC3.
REFERENCE   6  (bases 1 to 4224)
  AUTHORS   Takahashi,K., Yoshida,N., Murakami,N., Kawata,K., Ishizaki,H.,
            Tanaka-Okamoto,M., Miyoshi,J., Zinn,A.R., Shime,H. and Inoue,N.
  TITLE     Dynamic regulation of p53 subnuclear localization and senescence by
            MORC3
  JOURNAL   Mol Biol Cell 18 (5), 1701-1709 (2007)
   PUBMED   17332504
  REMARK    GeneRIF: MORC3 (microrchidia3)-ATPase activated p53 and induced
            cellular senescence in normal fibroblasts but not p53-/-
            fibroblasts
REFERENCE   7  (bases 1 to 4224)
  AUTHORS   Rosendorff,A., Sakakibara,S., Lu,S., Kieff,E., Xuan,Y., DiBacco,A.,
            Shi,Y., Shi,Y. and Gill,G.
  TITLE     NXP-2 association with SUMO-2 depends on lysines required for
            transcriptional repression
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5308-5313 (2006)
   PUBMED   16567619
  REMARK    GeneRIF: When tethered to a promoter by fusion to Gal4, NXP-2
            repressed transcription, consistent with a role for NXP-2 in
            SUMO-mediated repression
REFERENCE   8  (bases 1 to 4224)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 4224)
  AUTHORS   Perry,J. and Zhao,Y.
  TITLE     The CW domain, a structural module shared amongst vertebrates,
            vertebrate-infecting parasites and higher plants
  JOURNAL   Trends Biochem Sci 28 (11), 576-580 (2003)
   PUBMED   14607086
  REMARK    Review article
REFERENCE   10 (bases 1 to 4224)
  AUTHORS   Kimura,Y., Sakai,F., Nakano,O., Kisaki,O., Sugimoto,H.,
            Sawamura,T., Sadano,H. and Osumi,T.
  TITLE     The newly identified human nuclear protein NXP-2 possesses three
            distinct domains, the nuclear matrix-binding, RNA-binding, and
            coiled-coil domains
  JOURNAL   J Biol Chem 277 (23), 20611-20617 (2002)
   PUBMED   11927593
  REMARK    GeneRIF: determination of nuclear matrix-binding, RNA-binding, and
            coiled-coil domans
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA702537.1, D50926.2 and
            BC094779.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015358.2.
            
            Summary: This gene encodes a protein that localizes to the nuclear
            matrix and forms nuclear bodies via an ATP-dependent mechanism. The
            protein is predicted to have coiled-coil and zinc finger domains
            and has RNA binding activity. Alternative splicing produces
            multiple transcript variants encoding distinct isoforms. [provided
            by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094779.1, SRR1660805.178161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400485.6/ ENSP00000383333.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA702537.1         136-168
            34-3750             D50926.2           1-3717
            3751-4224           BC094779.1         3716-4189
FEATURES             Location/Qualifiers
     source          1..4224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.12"
     gene            1..4224
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /note="MORC family CW-type zinc finger 3"
                     /db_xref="GeneID:23515"
                     /db_xref="HGNC:HGNC:23572"
                     /db_xref="MIM:610078"
     exon            1..107
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2888
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger, CW type with coiled-coil domain 3; nuclear matrix
                     protein NXP2; MORC family CW-type zinc finger protein 3;
                     zinc finger CW-type coiled-coil domain protein 3; nuclear
                     matrix protein 2"
                     /codon_start=1
                     /product="MORC family CW-type zinc finger protein 3
                     isoform 1"
                     /protein_id="NP_056173.1"
                     /db_xref="CCDS:CCDS42924.1"
                     /db_xref="GeneID:23515"
                     /db_xref="HGNC:HGNC:23572"
                     /db_xref="MIM:610078"
                     /translation="MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPD
                     VNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGN
                     GFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLA
                     ESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYD
                     IRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQ
                     LVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQL
                     RANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTE
                     YPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPE
                     EPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESV
                     PRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENS
                     VYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGS
                     TSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQ
                     ETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVK
                     KETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECS
                     QCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKT
                     EVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQ
                     VNYDVDVVDEILGQVVEQMSEISST"
     exon            108..180
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            181..313
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            314..528
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..676
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..824
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..953
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1073
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1171
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1276
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1399
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1474
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1520
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1687
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..2576
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2734
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..4224
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4198..4203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /note="hexamer: AATAAA"
     regulatory      4203..4208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /note="hexamer: AATAAA"
     polyA_site      4221
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
     polyA_site      4224
                     /gene="MORC3"
                     /gene_synonym="NXP2; ZCW5; ZCWCC3"
                     /note="major polyA site"
ORIGIN      
        1 acagtcgttc cgccacctcc cagtcgggtt gcggcggagg ccgttcctgg ctttgtagct
       61 cgctcaagat ggcggcgcag ccaccccgcg ggatacgcct cagcgcgctt tgcccgaagt
      121 ttttacatac aaattctact agtcacacct ggccattcag tgcagttgct gaattaatag
      181 ataatgctta tgatcctgat gtgaacgcta aacaaatatg gattgacaaa acagtgataa
      241 atgaccatat atgcttgaca ttcaccgaca atgggaatgg tatgacttct gataaattac
      301 ataaaatgct aagctttggc ttcagtgaca aagtcaccat gaatggtcat gtcccagttg
      361 gattatatgg gaatggcttc aagtcgggtt ctatgcgtct gggtaaagac gcaatcgttt
      421 ttaccaaaaa tggagaaagc atgagcgtgg gccttttgtc tcagacctac ttggaagtca
      481 taaaagcgga gcatgttgtt gttccaatag tggcattcaa caagcaccga cagatgatta
      541 atttagcaga atcaaaagcc agccttgctg caattctgga acattctctg ttttccacgg
      601 aacagaagtt actggcagaa cttgatgcta ttataggcaa gaaggggacg aggatcatca
      661 tttggaatct tagaagctac aaaaatgcaa cagagttcga ttttgaaaag gataaatatg
      721 atatcagaat tcccgaggat ttagatgaga taacagggaa gaaggggtac aagaagcagg
      781 aaaggatgga ccagattgcc cctgagagtg actattccct gagggcttat tgcagtatat
      841 tatatctaaa gccaagaatg cagatcatcc tacgtggaca gaaagtgaag acacagctgg
      901 tttcgaagag tcttgcctac atcgaacgtg atgtttatcg accaaaattt ttatctaaaa
      961 cagtgagaat tacctttgga ttcaactgca gaaataaaga tcattatggg ataatgatgt
     1021 atcacagaaa tagactcatc aaagcttatg aaaaagttgg atgtcagtta agggcaaaca
     1081 acatgggtgt tggagtggtt ggaattatag agtgtaattt ccttaagcca actcataata
     1141 aacaagattt cgactatact aatgagtaca gacttacaat aacagcacta ggagaaaagc
     1201 tgaatgatta ctggaatgaa atgaaagtga agaaaaatac agaatatcct ctaaatttgc
     1261 cagttgaaga tatacagaag cgtcctgatc agacatgggt tcagtgtgat gcctgtctaa
     1321 agtggcggaa attacctgat gggatggatc aacttcctga aaaatggtat tgctccaata
     1381 accctgaccc acagttcaga aattgtgagg ttccagaaga acctgaagat gaggatttgg
     1441 tacatcccac ttatgaaaaa acctacaaaa agaccaacaa ggaaaaattc aggatcagac
     1501 aaccggaaat gatccctcgg attaatgctg aactgttgtt tcggccaact gctctttcaa
     1561 ctccaagctt ttcttctcct aaggaaagtg ttccaagaag acatctttca gaaggaacaa
     1621 attcttatgc gacaagactt ctaaataatc atcaagttcc acctcagtct gaacctgaga
     1681 gcaacagctt gaaacggaga ctttctactc gttcctcaat tttgaatgca aagaatcgga
     1741 gattgagtag tcagtttgaa aattcagttt ataaaggtga tgatgatgat gaagatgtca
     1801 tcatcttaga agaaaacagt acccccaaac ctgcagtaga tcatgatatt gacatgaaat
     1861 cagaacagag tcacgttgag caaggtggtg ttcaggttga gtttgtgggt gacagtgaac
     1921 cttgtggcca gactggttca acaagcacct catcatcccg atgcgaccag ggaaatactg
     1981 cagctaccca gactgaagta ccaagtttag ttgttaaaaa agaagaaact gttgaagacg
     2041 agatagacgt aagaaatgat gcagtgattc tgccctcctg tgtagaagct gaagcaaaga
     2101 tacatgaaac ccaggaaacc accgataaat ctgcagatga tgcaggctgc caattacaag
     2161 aactgagaaa ccagctactc cttgtcactg aggaaaaaga gaattataaa agacagtgtc
     2221 atatgtttac tgatcaaatc aaagtgttac aacagaggat actagaaatg aatgacaagt
     2281 atgttaagaa agaaacttgc catcagtcca ctgaaaccga tgctgtattt ttacttgaaa
     2341 gtattaatgg caaatctgaa agtccagacc atatggtatc tcagtatcag caagctttgg
     2401 aagaaataga aaggctgaaa aaacaatgta gtgctttgca acatgtaaag gctgaatgca
     2461 gccagtgttc caataatgag agtaaaagtg aaatggatga gatggctgtg cagcttgacg
     2521 atgtgtttag acaactggac aaatgcagta ttgagaggga ccagtataaa agtgaggttg
     2581 aattgctgga aatggaaaag tcacaaatcc gttcacagtg tgaagaactc aaaactgaag
     2641 tagaacagtt aaaatctaca aatcaacaga cggcaacaga tgtttcaaca tcaagtaaca
     2701 ttgaggagtc tgtaaatcat atggatggag aaagcctcaa actccgatct cttcgagtta
     2761 acgtaggaca actgctggct atgattgtgc ctgatcttga tcttcagcaa gtgaattacg
     2821 atgttgatgt agttgatgag attttaggac aagttgttga acaaatgagt gaaatcagta
     2881 gtacttaaag tatatgttat gtaagataaa atatttgctc aattcttttg gttgtacagc
     2941 tttcaaaata taattaattt tgttttatag atatgatagg caacagactg aaaaccataa
     3001 tctttactgt attctatgca ttcaaatgtg gtcacaaata ttgtggacac attatcttat
     3061 gttttgaaat acctgtgaat tgttggcatt gagcagctga agctaactca tgactctgtt
     3121 ttgaatgtaa atatttgtaa ttaagcctgc acatattttt ttattgccct agagtactca
     3181 agtgtttttc accaagagct tttcaggttg cccctaagct ttgtgcaatt ttttctggtt
     3241 ccccaaagtg tatttttctc taagtcgagg gctatgccat aatacaaatg gaaatgttac
     3301 ctttgatttt cttataaagg agtttaaata ggatttttaa ataatgtagt aacactcctg
     3361 atacaactct ggttataagt gaattgagca ttaatgtttc ttttgtataa attcctgtcc
     3421 tgaaatattt tattcatgaa aataaggtaa gcaaaaacca actccatttt gccaggattt
     3481 tgttgtgctg agattgccaa tcacggttaa acacaaagtg tttttataga atgaagaaac
     3541 agtctttaac agaaaaaagg tattgaaata ttaaatggcc accaagttta ctttgaagcc
     3601 catttttggc tgtttagtca gcatgaagtg ggcatgataa ttttttaata tttctttttg
     3661 tgaaatttcc tgtacagcct tttgtaggat tactacaggt taatgtgagt tgaggaagac
     3721 agtctttctc aaacaatact acataccttt tattatatta caaacctaag tgttttatat
     3781 cctagagtca aggaacaaat ttccttagga ttatagtatt acatgccata aaatactatg
     3841 ctttattggt cccatgtttt gtgcaatttt aaagagatgg ctttctatta agtataaact
     3901 atgtatatat aagaaccata ttttccacaa ctaaaatgtg cattattttt tccaaagttt
     3961 tatcattgct atttattttt acctttgttt ttgaacattc aatccgttca ttttgtatgt
     4021 atgcttaata cgtgtcggtc atatacagta ttgaattttt actgtatagt aattctggaa
     4081 agagcaaata aatgaagatt gtttttattt gcctgataaa gtaattgaaa gtgtattttt
     4141 ggtatgaagc tggttttctg tcacaattgt aatttcccaa attttaaaat atcttataat
     4201 aaaataaaaa tatatgatgg ctaa
//
