LOCUS       NM_001303256            5657 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens MORC family CW-type zinc finger 2 (MORC2), transcript
            variant 1, mRNA.
ACCESSION   NM_001303256 XM_005261391
VERSION     NM_001303256.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5657)
  AUTHORS   He,Y., Shao,Y., Zhou,Z., Li,T., Gao,Y., Liu,X., Yuan,G., Yang,G.,
            Zhang,L. and Li,F.
  TITLE     MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to
            promote EMT and metastasis in colon cancer
  JOURNAL   Cell Death Dis 15 (7), 530 (2024)
   PUBMED   39048555
  REMARK    GeneRIF: MORC2 regulates RBM39-mediated CDK5RAP2 alternative
            splicing to promote EMT and metastasis in colon cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5657)
  AUTHORS   Chung,H.Y., Lee,G.S., Nam,S.H., Lee,J.H., Han,J.P., Song,S.,
            Kim,G.D., Jung,C., Hyeon,D.Y., Hwang,D., Choi,B.O. and Yeom,S.C.
  TITLE     Morc2a variants cause hydroxyl radical-mediated neuropathy and are
            rescued by restoring GHKL ATPase
  JOURNAL   Brain 147 (6), 2114-2127 (2024)
   PUBMED   38227798
  REMARK    GeneRIF: Morc2a variants cause hydroxyl radical-mediated neuropathy
            and are rescued by restoring GHKL ATPase.
REFERENCE   3  (bases 1 to 5657)
  AUTHORS   Chutani,N., Ragula,S., Syed,K. and Pakala,S.B.
  TITLE     Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer
  JOURNAL   Biomolecules 13 (10), 1527 (2023)
   PUBMED   37892209
  REMARK    GeneRIF: Novel Insights into the Role of Chromatin Remodeler MORC2
            in Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5657)
  AUTHORS   Tan,Y., Zheng,T., Su,Z., Chen,M., Chen,S., Zhang,R., Wang,R., Li,K.
            and Na,N.
  TITLE     Alternative polyadenylation reprogramming of MORC2 induced by
            NUDT21 loss promotes KIRC carcinogenesis
  JOURNAL   JCI Insight 8 (18), e162893 (2023)
   PUBMED   37737260
  REMARK    GeneRIF: Alternative polyadenylation reprogramming of MORC2 induced
            by NUDT21 loss promotes KIRC carcinogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5657)
  AUTHORS   Hu,S.Y., Qian,J.X., Yang,S.Y., Andriani,L., Liao,L., Deng,L.,
            Huang,M.Y., Zhang,Y.L., Zhang,F.L., Shao,Z.M. and Li,D.Q.
  TITLE     Destabilization of microrchidia family CW-type zinc finger 2 via
            the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway
            promotes mitotic arrest and enhances cancer cellular sensitivity to
            microtubule-targeting agents
  JOURNAL   Clin Transl Med 13 (3), e1210 (2023)
   PUBMED   36967563
  REMARK    GeneRIF: Destabilization of microrchidia family CW-type zinc finger
            2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy
            pathway promotes mitotic arrest and enhances cancer cellular
            sensitivity to microtubule-targeting agents.
REFERENCE   6  (bases 1 to 5657)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 5657)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 5657)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 5657)
  AUTHORS   Perry,J. and Zhao,Y.
  TITLE     The CW domain, a structural module shared amongst vertebrates,
            vertebrate-infecting parasites and higher plants
  JOURNAL   Trends Biochem Sci 28 (11), 576-580 (2003)
   PUBMED   14607086
  REMARK    Review article
REFERENCE   10 (bases 1 to 5657)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004542.1, CD653611.1,
            DR000665.1, BC019257.1 and BM683680.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001303256.2.
            
            Summary: This gene encodes a member of the Microrchidia (MORC)
            protein superfamily. The encoded protein is known to regulate the
            condensation of heterochromatin in response to DNA damage and play
            a role in repressing transcription. The protein has been found to
            regulate the activity of ATP citrate lyase via specific interaction
            with this enzyme in the cytosol of lipogenic breast cancer cells.
            The protein also plays a role in lipogenesis and adipocyte
            differentiation. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.228224.1,
                                           SRR14038193.1499388.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397641.8/ ENSP00000380763.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               AC004542.1         122946-123432       c
            488-546             CD653611.1         14-72
            547-960             DR000665.1         8-421
            961-4176            BC019257.1         1-3216
            4177-5074           AC004542.1         80372-81269         c
            5075-5657           BM683680.1         17-599              c
FEATURES             Location/Qualifiers
     source          1..5657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..5657
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /note="MORC family CW-type zinc finger 2"
                     /db_xref="GeneID:22880"
                     /db_xref="HGNC:HGNC:23573"
                     /db_xref="MIM:616661"
     exon            1..953
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             886..3984
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /EC_number="3.6.1.3"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CW-type coiled-coil domain protein 1; ATPase MORC2"
                     /codon_start=1
                     /product="ATPase MORC2 isoform 1"
                     /protein_id="NP_001290185.1"
                     /db_xref="CCDS:CCDS77668.1"
                     /db_xref="GeneID:22880"
                     /db_xref="HGNC:HGNC:23573"
                     /db_xref="MIM:616661"
                     /translation="MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDAD
                     ATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGN
                     GLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTD
                     NVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNLKLMDNGEPELDIIS
                     NPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRM
                     YKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQ
                     VQNRAITLRREADVKKRIKEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIK
                     MYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQY
                     WKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTL
                     PFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFRKDMKTQEEKQKQLTE
                     KIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRN
                     APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLV
                     KTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSV
                     AVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLH
                     VEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPS
                     PEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQI
                     LRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSR
                     AKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITK
                     GD"
     exon            954..1007
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1042
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1111
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1202
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1311
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1471
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1583
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1709
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1789
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1872
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1958
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2099
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2254
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2383
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2489
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2622
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2697
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..3078
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3210
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3265
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3407
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3632
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3726
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3915
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..5657
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4152..4157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /note="hexamer: TATAAA"
     polyA_site      4176
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /note="major polyA site"
     regulatory      5629..5634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
                     /note="hexamer: TATAAA"
     polyA_site      5657
                     /gene="MORC2"
                     /gene_synonym="CMT2Z; DIGFAN; ZCW3; ZCWCC1"
ORIGIN      
        1 agttgtgaga tccgggtagt gcccggtcag gtggtgcgct cgccactgcc ctcgatccgg
       61 tccttggaag ccgggagtag ctcctcttcg tggggaggcg gccacgggac cgaggcccgg
      121 gaagggcctg ggaggctgag gctgttgtct gagggacgtg ggggcggggc gcggcctgcc
      181 cgaggtgctg tgggcgggtc atttgtgagg tgtttatgtg ggccaagtgt gaggtaatct
      241 gaccaccacc ctgaactggg tttggtccgg ctttgaaaaa agaaatcgtg agtgcctagg
      301 agctttttca cttgggaggt ggtgaagctg caacttgcgc catataacac tccgtcgaca
      361 tcttggtctc cggtcttggg cctgtttaag aatcctggca tcacgtgtgg cgaagacatg
      421 gctgatcagt tttctgacag aagtgggtaa atttccgcgt tggtaaattt cctgacagga
      481 aatttcgggg aaccaaaaaa ggctggaaga acatgaagat ggagcagtca taaaccaccc
      541 actcaaggac catctccttc aggaccatcc acacgagact cagattgtct gaattgagct
      601 atcgcaactt aatgctaaaa gctccttaaa gctacagatt tatgacatag ttccttccaa
      661 aatattacat cataaatcat tgagaagatt aaaaaaaaac acttgaagaa attgtagttt
      721 taaacatctc tgcatatatt ttggatagct actaggttac tttaactgtc attaaggagc
      781 acagacttac tgaagcttta ctggacagaa tcctgggaaa tcgatatcat tataaggtta
      841 tatttcccag ttagcgggtg aagggctgga gaccttattg cagtcatggc tttcacaaat
      901 tacagcagtc tgaatcgagc tcagctaacc tttgaatatc tgcacacaaa ttcaaccact
      961 cacgaattct tgtttggtgc ccttgctgaa ctggttgata atgcaagaga tgctgatgcc
     1021 accagaatag atatttatgc agaaagacga gaggaccttc gaggaggatt tatgctttgc
     1081 tttttggatg atggagcagg aatggatcca agtgatgctg ccagtgtgat ccagtttggg
     1141 aagtcggcca agcgaacacc tgagtctact cagattgggc agtacgggaa tgggttaaaa
     1201 tcgggctcaa tgcgcattgg gaaggatttt atcctgttca ccaagaagga agacaccatg
     1261 acctgcctct tcctgtctcg cacgtttcat gaggaagaag gcattgatga agtgatagtc
     1321 ccactgccca cctggaatgc tcggacccgg gaacctgtca cagacaatgt agagaaattt
     1381 gccattgaga cagaactcat ctataagtac tctccattcc gcactgagga ggaagtgatg
     1441 acccagttta tgaagattcc tggggacagc ggaacattgg tgatcatctt caatctcaaa
     1501 ctcatggata atggagagcc agaactagac ataatctcaa atccaagaga tatccagatg
     1561 gcagagacgt ccccagaggg cacgaagcca gagcggcgct cgttccgtgc ctatgccgct
     1621 gtgctctata ttgatccccg gatgaggatc ttcatccatg ggcacaaggt gcagaccaag
     1681 aggctctcct gctgcctgta caagcccagg atgtacaagt acacgtcaag ccgtttcaag
     1741 acccgtgcgg agcaggaggt gaagaaagca gagcacgtag caaggattgc tgaagagaag
     1801 gcgcgggagg cagagagcaa agctcggaca ttagaagtac gcctaggtgg agacctcacg
     1861 cgggactcca gggtgatgtt gcgacaggtc cagaacagag ccatcactct gcgcagagaa
     1921 gccgatgtca agaagaggat caaggaggcc aagcagcgag cacttaaaga acctaaggaa
     1981 ctgaattttg tttttggtgt caacattgaa caccgggatc tggatggcat gttcatctac
     2041 aactgtagcc gactgatcaa aatgtatgag aaagtgggcc cacagctgga agggggcatg
     2101 gcatgtggcg gggttgttgg ggttgttgat gtgccctacc tggtcctgga gcctacacac
     2161 aacaaacagg actttgctga tgccaaggag taccggcacc tgctccgagc aatgggggag
     2221 cacctggcgc agtattggaa ggatattgcc atcgcccaga ggggaatcat caagttctgg
     2281 gatgagtttg gctacctctc tgccaactgg aaccagcccc catccagtga gctgcgttac
     2341 aaacgccgga gagctatgga aatccccacc accatccagt gcgatttgtg tctgaaatgg
     2401 agaaccctcc ccttccagct gagttctgtg gaaaaagatt accctgacac ctgggtttgc
     2461 tccatgaacc ctgatcctga acaggaccgg tgtgaggctt ctgaacaaaa gcagaaggtt
     2521 cccctgggaa cattcagaaa ggacatgaag acgcaggaag agaagcagaa acaactgaca
     2581 gagaaaattc gccagcagca ggagaagctg gaggcccttc agaaaaccac acccatccgc
     2641 tcccaagcag acctgaagaa attgcccttg gaagtgacca ccagaccttc cactgaggaa
     2701 cctgtgcgta gacctcagcg tcctcggtcg ccccctttac ctgctgtgat caggaacgcc
     2761 cccagcagac ccccttcttt gccaactcct agaccagcca gccagccccg aaaggctcct
     2821 gtcatcagca gtaccccaaa gctccctgct ttggcagccc gggaggaggc cagcacatct
     2881 aggctgctcc agccacctga ggcaccccga aagcctgcca acactctcgt caagactgca
     2941 tcccgacctg cccctctggt gcagcaactg tcaccatctt tactgcccaa ctccaagagc
     3001 cctcgggagg ttccttctcc caaagtcatc aagactccag tggtgaagaa gacagagtca
     3061 cccatcaaac tctccccggc tacccctagt cggaagcgga gtgtcgcagt ttctgatgag
     3121 gaagaagttg aggaggaagc tgagaggagg aaggagaggt gcaagcgggg cagatttgtt
     3181 gtgaaggagg aaaagaagga ctcgaatgag ctctcagaca gtgctgggga agaggactcg
     3241 gctgacctca agagagctca gaaagataaa gggctgcacg tggaggtgcg tgtgaacagg
     3301 gagtggtaca cgggccgtgt cacagccgtg gaggtgggca agcatgtggt gcggtggaag
     3361 gtgaagtttg actacgtgcc cacagacacg acaccaagag accgctgggt ggagaaaggc
     3421 agtgaggatg tgcggctgat gaaaccccct tctccggaac atcagagcct tgatacacaa
     3481 caggagggcg gggaggagga ggtgggccct gtggcccagc aggccatagc tgtcgcagag
     3541 ccctccactt ccgaatgcct ccgcattgag cctgacacca ctgccctgag caccaatcac
     3601 gagaccatcg acctgcttgt ccagatcctc cggaattgtt tacggtactt cctgcctcca
     3661 agtttcccca tctccaagaa gcagctgagt gctatgaatt cagatgagct aatatctttt
     3721 cctctgaagg agtacttcaa gcaatatgaa gtagggctcc aaaacctgtg caattcctac
     3781 cagagccgtg ctgactcccg ggccaaggcc tccgaggaaa gcctgcgcac ctccgagagg
     3841 aagctccgcg agacggagga gaagctgcag aagctgagga ccaacatcgt ggcactcctg
     3901 caaaaggtgc aggaggacat agacatcaac acagatgatg agctggacgc ctacattgag
     3961 gacctcatca ccaaggggga ctgaaggcag gagagagagc agctcccctg cccacctgcc
     4021 cctcaaccct gtagctgcag ggggagggga cttcattcat gggttggtgg tcgcaccttg
     4081 gtttgactta cacgggacat ttgtgttttt ggaggaaaag ataccctgat tctttgaatc
     4141 ttccttaagt ttataaatat ttatttttta aaagaagatg ctgtgcctgt gagaccatac
     4201 tttttttttt tttttttttt tttttttttt ttttttggtg actgcaaagg acagagaacc
     4261 tttccacttt ggccatactg ggttgctaag ccggagccat ttcagctcct ggctcctcaa
     4321 gataacggcg agtccagtgc catcttggag aagctccagg ggcagggctg acttttctcc
     4381 tacaggagga acaatgtggg gatctgaggg atgggaggga gacttccccc tagagtggtg
     4441 gtcctgctgg gggctcatat ccagggaccc aaaagggggg ctgtgtagga ggttccacat
     4501 tggaggggct ctctctctcg cagctgtcag agttggtcct ggctgtggcg tccaaacagc
     4561 ttgagggaaa aagatcctgt ctaaccacct catctactac tcaagttctt tctgaaggag
     4621 ggatttcttc agttaaccat ggacagtgag gtttctcacc acagtaactt gagtccaggt
     4681 tgagggggag acagatctgt ggtaaatctc tgacttgggc agcacactga gtgtggaacc
     4741 ccacaggact ccttagggaa ggagcttgtg tgtgaaagaa cccctggggc tgagctggtg
     4801 acctccatgt gtgggtgcag cagggccttg gatggtgcca attgatctgg acagcctgtt
     4861 gatgcttttc tacttccacc cttcggcctg gccccactga gccccatcaa ggtgcctgaa
     4921 gagggggcca gtgagatccc gtggccacag ggactccaga ggcatctctg caggaagcac
     4981 accatgcctt ccctccatgt tccatcacgg cgccacaatc tgtgtccctt aacttctcag
     5041 ggtcaaagac aaaggcaagc gttgctgaat tttctcttta atggccattg gaagagtctg
     5101 gttcagtttt tcccaactct cttcccactc gtatttgggg cctctgggtt ttctgaaggc
     5161 acaaggactg tgactttgta ccactaacct gtggttcaaa cctgggtgtg tttctggcat
     5221 ctccctaacc cagatcagca atggccaccc tgctcctctg aggtcagcag aagactggga
     5281 agcagaggtg agggatgcag gccacactgg aatgggaagt cttttcccca ctggatgtgc
     5341 ctgtctggtg ggttttggac cttcccagac tacatctcta ggagaggcct gtttggagta
     5401 gtacactgag agaccctggc ctcttctgct ggaagactgt ccaagtcttg gggtttcttg
     5461 agctggtgat tcctctgcca tcctgctctc tctcttcatc tcaggcagca tggggtccac
     5521 ttttgtcccc aaacctaatg ttttaatcca aatgcaaatt ggttccacat ttttactgga
     5581 gggtaatcag tttttaaaat tcacacacat gtaatcgaaa cgcaatacta taaagttcta
     5641 ctggtgagac tcctgaa
//
