LOCUS       NM_014429               3747 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MORC family CW-type zinc finger 1 (MORC1), mRNA.
ACCESSION   NM_014429
VERSION     NM_014429.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3747)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3747)
  AUTHORS   Mundorf,A., Schmitz,J., Hunten,K., Fraenz,C., Schluter,C., Genc,E.,
            Ocklenburg,S. and Freund,N.
  TITLE     MORC1 methylation and BDI are associated with microstructural
            features of the hippocampus and medial prefrontal cortex
  JOURNAL   J Affect Disord 282, 91-97 (2021)
   PUBMED   33401128
  REMARK    GeneRIF: MORC1 methylation and BDI are associated with
            microstructural features of the hippocampus and medial prefrontal
            cortex.
REFERENCE   3  (bases 1 to 3747)
  AUTHORS   Thomas,M., Coope,A., Falkenberg,C., Dunlop,B.W., Czamara,D.,
            Provencal,N., Craighead,W.E., Mayberg,H.S., Nemeroff,C.B.,
            Binder,E.B. and Nieratschker,V.
  TITLE     Investigation of MORC1 DNA methylation as biomarker of early life
            stress and depressive symptoms
  JOURNAL   J Psychiatr Res 120, 154-162 (2020)
   PUBMED   31683097
  REMARK    GeneRIF: Investigation of MORC1 DNA methylation as biomarker of
            early life stress and depressive symptoms.
REFERENCE   4  (bases 1 to 3747)
  AUTHORS   Mundorf,A., Schmitz,J., Gunturkun,O., Freund,N. and Ocklenburg,S.
  TITLE     Methylation of MORC1: A possible biomarker for depression?
  JOURNAL   J Psychiatr Res 103, 208-211 (2018)
   PUBMED   29890506
  REMARK    GeneRIF: The results of this study showed that DNA methylation in
            the MORC1 promoter region significantly correlates with the Beck
            Depression Inventory score in the examined non-clinical population.
REFERENCE   5  (bases 1 to 3747)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3747)
  AUTHORS   Nieratschker,V., Massart,R., Gilles,M., Luoni,A., Suderman,M.J.,
            Krumm,B., Meier,S., Witt,S.H., Nothen,M.M., Suomi,S.J., Peus,V.,
            Scharnholz,B., Dukal,H., Hohmeyer,C., Wolf,I.A., Cirulli,F.,
            Gass,P., Sutterlin,M.W., Filsinger,B., Laucht,M., Riva,M.A.,
            Rietschel,M., Deuschle,M. and Szyf,M.
  TITLE     MORC1 exhibits cross-species differential methylation in
            association with early life stress as well as genome-wide
            association with MDD
  JOURNAL   Transl Psychiatry 4 (8), e429 (2014)
   PUBMED   25158004
  REMARK    GeneRIF: MORC1 is thus the first identified epigenetic marker of
            ELS to be present in blood cell progenitors at birth and in the
            brain in adulthood.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3747)
  AUTHORS   Figueiredo,J.C., Hsu,L., Hutter,C.M., Lin,Y., Campbell,P.T.,
            Baron,J.A., Berndt,S.I., Jiao,S., Casey,G., Fortini,B., Chan,A.T.,
            Cotterchio,M., Lemire,M., Gallinger,S., Harrison,T.A., Le
            Marchand,L., Newcomb,P.A., Slattery,M.L., Caan,B.J., Carlson,C.S.,
            Zanke,B.W., Rosse,S.A., Brenner,H., Giovannucci,E.L., Wu,K.,
            Chang-Claude,J., Chanock,S.J., Curtis,K.R., Duggan,D., Gong,J.,
            Haile,R.W., Hayes,R.B., Hoffmeister,M., Hopper,J.L., Jenkins,M.A.,
            Kolonel,L.N., Qu,C., Rudolph,A., Schoen,R.E., Schumacher,F.R.,
            Seminara,D., Stelling,D.L., Thibodeau,S.N., Thornquist,M.,
            Warnick,G.S., Henderson,B.E., Ulrich,C.M., Gauderman,W.J.,
            Potter,J.D., White,E. and Peters,U.
  CONSRTM   CCFR; GECCO
  TITLE     Genome-wide diet-gene interaction analyses for risk of colorectal
            cancer
  JOURNAL   PLoS Genet 10 (4), e1004228 (2014)
   PUBMED   24743840
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3747)
  AUTHORS   Zheng,J.S., Arnett,D.K., Lee,Y.C., Shen,J., Parnell,L.D.,
            Smith,C.E., Richardson,K., Li,D., Borecki,I.B., Ordovas,J.M. and
            Lai,C.Q.
  TITLE     Genome-wide contribution of genotype by environment interaction to
            variation of diabetes-related traits
  JOURNAL   PLoS One 8 (10), e77442 (2013)
   PUBMED   24204828
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3747)
  AUTHORS   Inoue,N., Wei,F., Seldin,M.F., Zinn,A.R. and Watson,M.L.
  TITLE     Assignment of microrchidia (Morc) to mouse chromosome 16 by
            interspecific backcross linkage analysis and human chromosome 3q13
            using somatic cell hybrids and in situ hybridization
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 123-125 (2000)
   PUBMED   11060461
REFERENCE   10 (bases 1 to 3747)
  AUTHORS   Inoue,N., Hess,K.D., Moreadith,R.W., Richardson,L.L., Handel,M.A.,
            Watson,M.L. and Zinn,A.R.
  TITLE     New gene family defined by MORC, a nuclear protein required for
            mouse spermatogenesis
  JOURNAL   Hum Mol Genet 8 (7), 1201-1207 (1999)
   PUBMED   10369865
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112138.3, BC050307.1 and
            AC016948.4.
            
            On May 17, 2019 this sequence version replaced NM_014429.3.
            
            Summary: This gene encodes the human homolog of mouse morc and like
            the mouse protein it is testis-specific. Mouse studies support a
            testis-specific function since only male knockout mice are
            infertile; infertility is the only apparent defect. These studies
            further support a role for this protein early in spermatogenesis,
            possibly by affecting entry into apoptosis because testis from
            knockout mice show greatly increased numbers of apoptotic cells.
            [provided by RefSeq, Jan 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050307.1, AF084946.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232603.10/ ENSP00000232603.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC112138.3         124176-124224       c
            50-1482             BC050307.1         1-1433
            1483-1525           AC016948.4         118827-118869       c
            1526-3747           BC050307.1         1477-3698
FEATURES             Location/Qualifiers
     source          1..3747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..3747
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /note="MORC family CW-type zinc finger 1"
                     /db_xref="GeneID:27136"
                     /db_xref="HGNC:HGNC:7198"
                     /db_xref="MIM:603205"
     exon            1..140
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..3030
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /note="microrchidia, mouse, homolog of; cancer/testis
                     antigen 33"
                     /codon_start=1
                     /product="MORC family CW-type zinc finger protein 1"
                     /protein_id="NP_055244.3"
                     /db_xref="CCDS:CCDS2955.1"
                     /db_xref="GeneID:27136"
                     /db_xref="HGNC:HGNC:7198"
                     /db_xref="MIM:603205"
                     /translation="MDDRYPALQRAQLRLDFIHANSTTHSFLFGALAELLDNARDAGA
                     ERLDVFSVDNEKLQGGFMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFIGQYGNG
                     LKSGSMRIGKDFILFTKKEETMTCVFFSQTFCEEESLSEVVVPMPSWLIRTRESVTDD
                     PQKFAMELSIIYKYSPFKTEAELMQQFDVIYGKCGTLLVIYNLKLLLNGEPELDVKTD
                     KEDILMAGALEDFPARWSFRAYTSVLYFNPWMRIFIQAKRVKTKHLCYCLYRPRKYLY
                     VTSSFKGAFKDEVKKAEEAVKIAESILKEAQIKVNQCDRTSLSSAKDVLQRALEDVEA
                     KQKNLKEKQRELKTARTLSLFYGVNVENRSQAGMFIYSNNRLIKMHEKVGSQLKLKSL
                     LGAGVVGIVNIPLEVMEPSHNKQEFLNVQEYNHLLKVMGQYLVQYCKDTGINNRNLTL
                     FCNEFGYQNDIDVEKPLNSFQYQRRQAMGIPFIIQCDLCLKWRVLPSSTNYQEKEFFD
                     IWICANNPNRLENSCHQVECLPSIPLGTMSTISPSKNEKEKQLRESVIKYQNRLAEQQ
                     PQPQFIPVDEITVTSTCLTSAHKENTKTQKIRLLGDDLKHESLSSFELSASRRGQKRN
                     IEETDSDVEYISETKIMKKSMEEKMNSQQQRIPVALPENVKLAERSQRSQIANITTVW
                     RAQPTEGCLKNAQAASWEMKRKQSLNFVEECKVLTEDENTSDSDIILVSDKSNTDVSL
                     KQEKKEIPLLNQEKQELCNDVLAMKRSSSLPSWKSLLNVPMEDVNLSSGHIARVSVSG
                     SCKVASSPASSQSTPVKETVRKLKSKLREILLYFFPEHQLPSELEEPALSCELEQCPE
                     QMNKKLKMCFNQIQNTYMVQYEKKIKRKLQSIIYDSNTRGIHNEISLGQCENKRKISE
                     DKLKNLRIKLALLLQKLQLGGPEGDLEQTDTYLEALLKEDNLLFQNNLNKVTIDARHR
                     LPLEKNEKTSEN"
     exon            141..194
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            195..229
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            230..298
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            299..389
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            390..498
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            499..658
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            659..764
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            765..890
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            891..970
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1041
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1106
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1250
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1405
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1534
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1640
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1779
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1842
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2088
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2160
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2262
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2332
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2399
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2552
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2625
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2679
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2874
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3747
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3728..3733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /note="hexamer: AGTAAA"
     polyA_site      3747
                     /gene="MORC1"
                     /gene_synonym="CT33; MORC; ZCW6"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgggc gcaggcgaac ggctgccggt caggtgtcct tgtccccttg agttgcgcgg
       61 gtcgtgttcg agggcatgga cgacaggtac cctgcgcttc agcgggccca gctgcgtctg
      121 gatttcatcc acgccaactc caccactcac agtttccttt ttggagcact ggctgaattg
      181 ctggacaatg caagagatgc aggggctgaa agacttgatg tcttttcagt ggataatgaa
      241 aaactgcagg ggggattcat gttgtgtttc ctggatgatg gatgtggcat gagccctgag
      301 gaagcttcag acatcattta ctttggacga tccaaaaaac ggctgtcaac cttgaagttc
      361 atagggcaat acggcaatgg tcttaaaagt gggtccatga gaattggaaa agactttatt
      421 ctttttacga agaaggaaga aacgatgacc tgtgtgtttt tttctcagac attctgtgaa
      481 gaagaaagtc ttagtgaggt tgtagttcca atgccctcat ggttaataag aaccagagaa
      541 tctgtcacag atgatcccca gaaatttgca atggaattat ctataattta taaatactcc
      601 ccatttaaaa ctgaagcaga attgatgcag cagtttgatg tgatctatgg aaaatgtggt
      661 actttgctgg ttatttataa cttgaagctt ctgcttaatg gagaaccaga gttggatgtt
      721 aaaactgaca aagaagatat actgatggct ggagctctgg aggatttccc agcgaggtgg
      781 tcattcagag cctacacatc tgttctgtat tttaacccat ggatgagaat attcattcaa
      841 gccaagagag ttaaaactaa acatctttgc tattgcctct acagacccag aaagtatctt
      901 tatgtcacat cttcttttaa aggagcattt aaagatgaag ttaaaaaggc agaagaagca
      961 gtaaagattg ctgaatccat attgaaagaa gcacaaatca aagtaaacca gtgtgacaga
     1021 acctctttat cttctgccaa ggatgtatta cagagagctt tggaagatgt agaagcaaag
     1081 caaaagaatc ttaaagagaa acaaagagaa ttaaaaacag caagaacgct ctccctgttc
     1141 tatggagtga acgtagaaaa ccgaagccaa gctggaatgt tcatttacag taataaccgt
     1201 ttgatcaaaa tgcatgaaaa agtgggctca cagttgaaac tgaagtcctt acttggcgca
     1261 ggcgtggttg gaattgttaa tatacccttg gaggtcatgg aaccatccca taataaacag
     1321 gaatttctca atgtccaaga gtataatcat ctactaaaag tcatgggaca gtacttggtc
     1381 cagtactgta aggacaccgg catcaataat agaaatttaa cattgttttg caatgaattt
     1441 ggataccaga atgacatcga tgtggagaaa cctttaaatt cttttcaata tcaaagaaga
     1501 caagccatgg gtatcccatt catcatacaa tgtgatcttt gtcttaaatg gagagtcttg
     1561 ccttcctcta ctaattatca ggaaaaagaa ttttttgaca tttggatttg tgctaataat
     1621 cccaaccgct tggaaaacag ttgtcatcag gtagaatgtc taccttccat cccactgggc
     1681 accatgagca caatatcacc atcaaaaaat gagaaagaga agcaacttag agagtcggtc
     1741 ataaagtatc aaaatagact ggcagaacag cagccacagc ctcaatttat accagtggac
     1801 gaaatcactg tcacttccac ctgcctaact tcagcacata aggaaaatac caaaacccag
     1861 aaaatcaggc ttttgggcga tgacttgaag catgaatctc tttcatcctt tgagctttca
     1921 gcgagccgta gaggacagaa aagaaacata gaagagacag actctgatgt agagtatatt
     1981 tcagaaacaa aaattatgaa aaagtctatg gaggagaaaa tgaactctca acagcagaga
     2041 attccagtag ctctgccaga aaatgtcaaa ctagctgaga gatcccagag aagtcagatt
     2101 gctaatatta ccactgtctg gagagctcaa ccaactgaag ggtgcctgaa gaatgcccag
     2161 gccgcttctt gggaaatgaa aaggaagcag agtctgaact ttgtagagga atgtaaggta
     2221 ttgactgaag atgagaacac gagtgattca gatataatcc tggtttcaga taaaagcaac
     2281 actgatgttt cattgaaaca agaaaaaaag gaaattcctc ttttaaacca agaaaaacag
     2341 gagctgtgca atgatgttct agcaatgaaa agaagctctt cattacctag ctggaaaagc
     2401 ttgctcaatg tgccgatgga agatgtgaat ctaagttctg gacacatagc cagagtttct
     2461 gtgagtggca gttgtaaagt tgcttcttcg ccagcgtctt ctcaaagcac acctgtcaag
     2521 gaaacagtga gaaaactgaa gtctaagtta agggagattc ttctgtattt ttttcctgag
     2581 catcagctac catcagaatt ggaagaacct gcattaagtt gtgagctgga gcagtgccca
     2641 gagcagatga acaaaaagct gaaaatgtgt ttcaaccaga tacagaatac ttacatggtc
     2701 caatatgaaa aaaaaataaa gaggaaattg cagtccatta tctatgattc aaatacaaga
     2761 ggaatacata atgaaatctc tctggggcaa tgtgaaaata aaagaaaaat ctctgaggat
     2821 aagctgaaga atcttcgtat aaaactggca ctattgttgc agaaactcca actgggtggt
     2881 ccagaaggtg acctggagca gactgacact tatttagaag ctttgcttaa agaagataat
     2941 cttctcttcc agaacaattt aaataaagta actatagatg caagacatag actcccttta
     3001 gaaaaaaatg aaaagacttc ggaaaattaa gtcagagatg gtattacctt ttaaaaaatg
     3061 ctaataagaa aattggaaga ttcttttaaa aatttttctt ttttgttgtt gttactgtaa
     3121 agtctattct gtttaacaat aagaaataag aaataatttt tttcaaataa gaaaattgtg
     3181 tactctagaa atggagaccg atttacaatt tatgtattcc ctaatccaat tatctaaatc
     3241 ttccttttct ttcagaaata ttaataatat ctagagttct ctaattttca tgtgagctac
     3301 tgaaaaaaat gaaaatgtca ctcaagctta acttttgtta ttccttaaaa gattgttatt
     3361 gtaattttgt tattccttaa aaacatttaa aagcagattt tttcaaaatc gatatgtgaa
     3421 ggactacaga atcacctcct cttgaagata ttgaaaaaga aagacattat gccctttctc
     3481 cactatagcc aacactcagt caagcagaaa atacaaatcc ccccaaaact ttgagacata
     3541 gcttatataa ttttattatt tagtcatagt aaaagaataa atctcctaag cataatatgt
     3601 atacatatta cacatatgta aaaattgttg ttttacattt acatatacgt aaagaagtat
     3661 gtttttacac ttttcttgat aagtgttttt tttttgttta gaaatgtctg aaactttaga
     3721 caaaaacagt aaaacattta atattca
//
