LOCUS       NM_015026              13263 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MON2 homolog, regulator of endosome-to-Golgi
            trafficking (MON2), transcript variant 1, mRNA.
ACCESSION   NM_015026 XM_051091
VERSION     NM_015026.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13263)
  AUTHORS   Li,P., Wu,Q., Yang,X.R. and Sun,T.
  TITLE     MicroRNA-133a-5p inhibiting metastatic capacity of renal clear cell
            carcinoma through regulating MON2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 5988-5995 (2020)
   PUBMED   32572912
  REMARK    GeneRIF: MicroRNA-133a-5p inhibiting metastatic capacity of renal
            clear cell carcinoma through regulating MON2.
REFERENCE   2  (bases 1 to 13263)
  AUTHORS   McGough,I.J., de Groot,R.E.A., Jellett,A.P., Betist,M.C.,
            Varandas,K.C., Danson,C.M., Heesom,K.J., Korswagen,H.C. and
            Cullen,P.J.
  TITLE     SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A
            complex to mediate Wntless sorting and Wnt secretion
  JOURNAL   Nat Commun 9 (1), 3737 (2018)
   PUBMED   30213940
  REMARK    GeneRIF: an evolutionary conserved MON2:DOPEY2:ATP9A complex is
            required for SNX3 retromer mediation of Wntless sorting and Wnt
            secretion
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13263)
  AUTHORS   Mahajan,D., Boh,B.K., Zhou,Y., Chen,L., Cornvik,T.C., Hong,W. and
            Lu,L.
  TITLE     Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but
            possesses no guanine nucleotide exchange activity toward Arl1
            GTPase
  JOURNAL   Sci Rep 3, 3362 (2013)
   PUBMED   24285343
  REMARK    GeneRIF: Mon2 is involved in endosome-to-Golgi trafficking as its
            depletion accelerated the delivery of furin and CI-M6PR to Golgi
            after endocytosis.
            Erratum:[Sci Rep. 2016 Sep 22;6:33619. doi: 10.1038/srep33619..
            PMID: 27654351]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13263)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   5  (bases 1 to 13263)
  AUTHORS   Tomita,Y., Noda,T., Fujii,K., Watanabe,T., Morikawa,Y. and
            Kawaoka,Y.
  TITLE     The cellular factors Vps18 and Mon2 are required for efficient
            production of infectious HIV-1 particles
  JOURNAL   J Virol 85 (11), 5618-5627 (2011)
   PUBMED   21450827
  REMARK    GeneRIF: Depletion of hVps18 or hMon2 reduced the efficient
            production of infectious HIV-1 virions in human cells.
REFERENCE   6  (bases 1 to 13263)
  AUTHORS   Singer-Kruger,B., Lasic,M., Burger,A.M., Hausser,A., Pipkorn,R. and
            Wang,Y.
  TITLE     Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate
            their subcellular distribution
  JOURNAL   EMBO J 27 (10), 1423-1435 (2008)
   PUBMED   18418388
  REMARK    GeneRIF: Ysl2p represents an essential, evolutionarily conserved
            member of a network controlling direct binding and membrane docking
            of Ggas.
REFERENCE   7  (bases 1 to 13263)
  AUTHORS   Gillingham,A.K., Whyte,J.R., Panic,B. and Munro,S.
  TITLE     Mon2, a relative of large Arf exchange factors, recruits Dop1 to
            the Golgi apparatus
  JOURNAL   J Biol Chem 281 (4), 2273-2280 (2006)
   PUBMED   16301316
REFERENCE   8  (bases 1 to 13263)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA125763.1, AB017814.1, AL834320.1 and AC026115.27.
            
            On Nov 23, 2018 this sequence version replaced NM_015026.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.120847.1,
                                           SRR1803616.219310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393630.8/ ENSP00000377250.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               DA125763.1         10-277
            269-1962            AB017814.1         3-1696
            1963-8397           AL834320.1         930-7364
            8398-10370          AC026115.27        93005-94977
            10371-13263         AC026115.27        94978-97870
FEATURES             Location/Qualifiers
     source          1..13263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..13263
                     /gene="MON2"
                     /note="MON2 homolog, regulator of endosome-to-Golgi
                     trafficking"
                     /db_xref="GeneID:23041"
                     /db_xref="HGNC:HGNC:29177"
                     /db_xref="MIM:616822"
     exon            1..493
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..5536
                     /gene="MON2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein MON2 homolog; MON2 regulator of endosome-to-Golgi
                     trafficking"
                     /codon_start=1
                     /product="protein MON2 homolog isoform 1"
                     /protein_id="NP_055841.2"
                     /db_xref="CCDS:CCDS31849.1"
                     /db_xref="GeneID:23041"
                     /db_xref="HGNC:HGNC:29177"
                     /db_xref="MIM:616822"
                     /translation="MSGTSSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGII
                     KVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSET
                     AAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNI
                     TNNTAAATVRQVVTVVFERMVAEDERHRDIIEQPVLVQGNSNRRSVSTLKPCAKDAYM
                     LFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVC
                     PLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEI
                     FLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIVNA
                     LGSFIQSLFLVPPTGNPATSNQAGNNNLGGSVSAPANSGMVGIGGGVTLLPAFEYRGT
                     WIPILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITSMIEGELG
                     ELETECQTTTEEGSSPTQSTEQQDLQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALS
                     LLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNT
                     TTAATLSNKSYSVQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRT
                     LLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVM
                     TDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKL
                     LETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLS
                     QNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIR
                     NDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLL
                     WNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLG
                     ELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADK
                     EKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVL
                     LDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPVVNVPVPVLIGPISG
                     MSRPFVRTDSIGEKLGRYSSSEPPIVTDELEDLNLWWAAWNTWYRIGSESTKPPITFD
                     KLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHSAISVPISSDASPFIL
                     PSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYG
                     QLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVL
                     QNIIKTLRVPLSLKYSCPSESTWKLAVSSLLRVLSIGLPVARQHASSGKFDSMWPELA
                     NTFEDFLFTKSIPPDNLSIQEFQRNENIDVEVVQLISNEILPYANFIPKEFVGQIMTM
                     LNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSV
                     LLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNT
                     WAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPASRVQNGES"
     exon            494..557
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..685
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..817
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..947
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1045
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1171
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1366
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1491
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1628
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1782
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2015
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2097
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2282
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2395
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2500
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2581
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2655
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2746
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2848
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2959
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3135
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3298
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3592
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3791
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..4414
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4558
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            4559..4576
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4705
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4896
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..4957
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5081
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5289
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            5290..5372
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     exon            5373..13263
                     /gene="MON2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6040..6045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON2"
                     /note="hexamer: AATAAA"
     polyA_site      6065
                     /gene="MON2"
                     /note="major polyA site"
     polyA_site      6944
                     /gene="MON2"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON2"
                     /note="hexamer: AATAAA"
     polyA_site      8397
                     /gene="MON2"
     regulatory      9517..9522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON2"
                     /note="hexamer: ATTAAA"
     polyA_site      9541
                     /gene="MON2"
     regulatory      10350..10355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON2"
                     /note="hexamer: AATAAA"
     polyA_site      10373
                     /gene="MON2"
     regulatory      13241..13246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON2"
                     /note="hexamer: ATTAAA"
     polyA_site      13263
                     /gene="MON2"
ORIGIN      
        1 gactcggcta atggcgtcgg cgagtcttag gggcctgggg agctggcgct gaagcttctt
       61 gccaggttgg ctggtgacac ccggtgtggc tgggccccgc ggcagcggag ggacctgccc
      121 gccttgtggg tttctcggcc agagtcggcg gagcctagcg ggacggtgcg actgcggggg
      181 gcgcctccga gaaaagccag aggtgttgcg gggaagctgc tgggggacgc tcgagcaggc
      241 tccgggttcg cagcccaggg cccaagaagc gggctgctga aggaccagag acaccgggag
      301 ggagctgcct gtggccctaa ggagctgacc gtgccagagc ttgtttgtac ctctcggaaa
      361 ttggctggga ccttggagga tcatgtccgg caccagcagc cccgaggcgg tgaagaagct
      421 gctggagaat atgcagagcg acttgcgcgc cttgtcactg gagtgcaaga agaaattccc
      481 acctgtcaaa gaggctgctg aatcaggaat aataaaagtt aaaacaattg ctgcacgaaa
      541 cactgaaatt ttggcagcac tgaaagagaa cagctcagag gttgtacagc cttttttaat
      601 gggttgtgga accaaggaac cgaagatcac tcagctatgt ttggctgcta ttcagagact
      661 catgtcacat gaagtcgtgt ctgagactgc agctggaaat ataattaaca tgctttggca
      721 gctaatggag aatagtcttg aagaacttaa gctacttcaa acagttcttg ttcttttaac
      781 aaccaataca gtagttcatg atgaggcact ttctaaggca atcgttcttt gttttcgact
      841 acacttcaca aaagataata ttacaaataa tacagctgct gctacagtgc gacaagttgt
      901 tactgttgtt tttgagagga tggttgctga agatgaacga cacagagata ttatagaaca
      961 accagtactg gtacaaggaa atagtaacag aagatctgtc agtaccctca aaccttgtgc
     1021 taaagatgca tatatgcttt tccaggatct ttgtcagttg gttaatgctg atgctcctta
     1081 ttggctagtg ggcatgacag aaatgactcg gacgtttggc ctcgaattac ttgagtcagt
     1141 cctcaatgat tttccgcagg tctttttaca acaccaagaa tttagtttcc tcctcaaaga
     1201 aagggtatgt cctcttgtga taaagctctt ttctccaaat ataaagttca gacaaggttc
     1261 cagcacctca tcttctccag caccagttga aaaaccatat tttcctatct gcatgcgttt
     1321 gctgagagta gtatctgttc tgattaagca gttttacagt cttttggtaa ctgaatgtga
     1381 gatatttctg tcacttctgg tgaaatttct ggatgcagat aaaccacagt ggctacgagc
     1441 tgttgcggtg gaatcaatac acagattctg tgtgcagcct caactattaa ggtcattttg
     1501 tcagtcctat gatatgaaac agcattctac caaggttttt cgtgatattg taaatgcact
     1561 gggatctttt atacagtcct tgtttcttgt cccccctact ggaaatcctg caacaagcaa
     1621 ccaagctgga aacaataatt taggtggctc agtctcagca ccagctaact caggaatggt
     1681 ggggattggt ggaggtgtta ctttgctacc agcatttgaa tataggggaa cctggatacc
     1741 tattctgaca atcacagttc aaggcagtgc taaagccacc tacttagaaa tgttggacaa
     1801 agttgagcct ccaactatac ctgaaggtta cgccatgtct gtggcattcc attgtttgct
     1861 agaccttgtt cgtggaatca caagtatgat tgaaggagag ctaggagagc ttgaaacaga
     1921 atgtcaaacc accactgaag aaggttcttc accaacacag tcgacagaac agcaggattt
     1981 acagtcaaca tcagaccaaa tggataagga aattgttagt agggctgttt gggaagaaat
     2041 ggtgaatgcc tgctggtgtg gtcttcttgc tgcactctca ctccttcttg atgccagcac
     2101 agatgaagct gccactgaga atattttaaa agctgaactg actatggctg ctctttgtgg
     2161 aagactgggc cttgtaactt caagagatgc ctttataact gcaatatgca aaggttccct
     2221 gcctccccat tatgctctta ctgtattgaa taccaccact gcagctacac tttccaacaa
     2281 atcatattcc gttcagggcc aaagtgttat gatgataagt ccatcaagtg aatctcacca
     2341 acaagttgtg gcagtgggtc aacctttagc agtccagcct caagggacag taatgctgac
     2401 ttccaaaaat atccagtgta tgaggacttt acttaacttg gcgcattgcc atggggctgt
     2461 tcttggaaca tcatggcaac ttgtcttggc aactcttcag catcttgtgt ggattctggg
     2521 attaaagcct agtagtggcg gtgccttgaa acctgggaga gctgtagaag gacccagtac
     2581 agttctaaca acagcagtga tgacagattt accagtgatt tccaatatac tttcaagatt
     2641 gtttgaaagc tcacagtatc ttgatgatgt atcactgcat catttaataa atgcactttg
     2701 ctccttgtct ctagaagcaa tggatatggc ctatggaaat aataaggaac catctctttt
     2761 tgctgttgcc aaattgttag aaactggttt agttaatatg caccgaatag aaattctgtg
     2821 gagacctctg actggccatc tacttgaggt ctgccagcat ccaaactctc gaatgagaga
     2881 atggggagca gaagctttaa cttctcttat taaagcagga ttaacattta accatgatcc
     2941 tccactctca caaaaccaga ggctgcagtt gcttttattg aacccgttaa aggagatgtc
     3001 caatattaat catccagata ttcgactcaa gcagttagaa tgcgtgttgc agattctgca
     3061 gagtcaggga gacagtcttg ggcctggatg gccattagtg cttggagtca tgggagcaat
     3121 cagaaatgat caaggagaat ccttgatacg aactgcattc cagtgtcttc agttggttgt
     3181 gacagatttt ctaccaacaa tgccttgtac ttgcctgcaa atagttgtag atgttgcagg
     3241 tagctttggc ctccataacc aagaactcaa tattagttta acttcaatag gtttattgtg
     3301 gaatatttca gattattttt tccaaagagg ggaaactatt gaaaaagaac taaataagga
     3361 agaggcagca cagcaaaagc aggcagaaga gaaaggagtt gttttaaatc ggccattcca
     3421 ccctgcaccg ccatttgatt gcttgtggtt atgtctttat gcaaaattgg gtgaactatg
     3481 tgtggatccc cgtcctgctg tcaggaagag tgcagggcaa actctgtttt ctacaattgg
     3541 tgcgcatgga actttattac agcattcaac ctggcacact gttatctgga aggtactctt
     3601 tcatctactg gacagagttc gagagtcctc taccactgca gacaaagaaa agattgagtc
     3661 tggaggtggc aatattctca ttcatcattc aagggacacc gccgagaagc aatgggctga
     3721 gacgtgggta ttaacattgg ctggagtagc aaggatcttc aacactagaa gatatttgct
     3781 gcagccttta ggagattttt caagagcttg ggatgttctt cttgaccata tacagtcagc
     3841 agcactcagc aaaaacaatg aagtatctct ggctgctctg aaaagcttcc aggaaatttt
     3901 acagattgtg tcccctgtca gagactcaga taagcctgag acaccacctg tagttaatgt
     3961 acctgtgcct gttcttatag ggcccatatc aggcatgagc aggccatttg taagaacaga
     4021 ttccattgga gaaaaactag gaagatatag tagctctgag ccacccattg ttactgatga
     4081 gcttgaagat ttgaatctat ggtgggctgc gtggaatacc tggtatagaa ttggatctga
     4141 aagtactaag cctcctatta cttttgataa actaactttt attcctagcc agccttttct
     4201 tacagcttta attcagatat ttccagctct ctaccaacac ataaaaactg gtttcaatat
     4261 ggatgacttg caaaagttgg gagtcatatt gcacagtgct atttcagtcc caataagttc
     4321 agatgcatcc ccttttattc ttccatctta taccgaagca gttttgacaa gtttacagga
     4381 agctgtactt acagctttag atgttctcca aaaggccatt tgtgtaggac cagaaaacat
     4441 gcagataatg tatccagcta tatttgacca gttgttggca tttgtagaat tttcctgtaa
     4501 acctccacag tatggacagc tggaaacaaa gcacattgca aatgcaaaat ataatcagat
     4561 ccaactattt gcaccggcgg aatgggtagc cttgaattat gtgccgtttg ctgaaaggtc
     4621 tttagaagta gttgtggatt tataccaaaa aacagcgtgt cacaaagcag tggtgaatga
     4681 gaaagtgctc cagaatatta ttaagactct tagggttcct ctcagtttga agtattcctg
     4741 cccttctgaa agcacatgga aactagcagt atcctctctc ctcagagttc tttctattgg
     4801 gctacctgtt gcccggcagc atgcttcttc tggaaaattt gacagtatgt ggccagaact
     4861 agccaatact tttgaagatt ttctctttac taaaagcata cctccagata atctctctat
     4921 tcaagagttt caaagaaatg aaaatattga tgtcgaggta gttcaactta tcagcaatga
     4981 gatactacct tatgccaatt ttattcctaa ggaatttgtt ggtcaaataa tgacaatgct
     5041 taacaagggc tcaatacatt ctcagtcatc ttcatttaca gaagcagaga ttgatattcg
     5101 tttgagagag gaattttcta aaatgtgttt tgaaacatta ctccagtttt ccttcagtaa
     5161 taaagtcaca acacctcaag aaggctacat ctcacgaatg gcactctcag tgcttttaaa
     5221 gaggtcccaa gatgtactac atcgctatat agaggatgaa agattaagtg gtaaatgccc
     5281 tcttccaagg caacaagtaa cagaaattat atttgtttta aaagcagtca gtactcttat
     5341 tgattcactt aagaaaactc agcctgagaa tgttgatgga aatacctggg cacaagtaat
     5401 tgccttatac ccaactttag tagaatgcat cacctgttct tcttcagaag tctgttctgc
     5461 acttaaagag gcactagttc cttttaagga tttcatgcag ccaccagcat ccagagttca
     5521 aaatggagaa tcttgaccgg ctacaatata tttgaaagca ggaagatagt ctaaaaaatg
     5581 tttgctccta attgagtctt ctgtgagaag gacatttctt actgcagata attcttggca
     5641 gctgttgttg gcctccttta aattctactt acctgagttc agtaattcat attacaggct
     5701 tgcacatcaa caaaggctcc tgaatgaaca gcagtgtaag gctttaataa attaaactga
     5761 tgggagggat aattaacact acagtataca tgctaccata tctccagttg gtgatttaaa
     5821 gtgagcttat gtacagtttg tggtgtatgt gttaatgatg tactttttaa aaagaaagaa
     5881 gagatatttc aattcagtca gatttattag tctggtgttt ttgcaccctt tttcaagtac
     5941 aaaatcgtac tagaatttta tgcaagatgg tactgtaaca ttccatatta tctataacca
     6001 gcctttgtta acaaagggaa ctgatatact tgtgtgtata ataaatggta cagttctgta
     6061 taaaatagtg catttattta aattttaaaa gtattgataa tgttaaatgc ttaaagctct
     6121 atttattatt aatacaaaat tgtttgctta catttttact tataatttgc cttcatatgt
     6181 ggcggataag ctcaccatat gatcatgcag ttagcttcat gcttatttta aatgtattat
     6241 tagtgaccat taaacatctg accagtaagg tcatgtgaac acagcagcaa atagtttatg
     6301 atttgctgat tttggagctt tgaaatatag gttcttaata cattgataca tattgtagca
     6361 ctatgacttc atcatacctc atttctttaa acagctctcc aagctttcac tgaagtctgt
     6421 ctgtttttta tattggctgt ctggatttta aagacttttc atattttata tttctactga
     6481 ttttgtttcc cctaacaaca tttgtcactg tctttgaatt atgacccagg caagatgatt
     6541 tcagattttc taaaatcttg cctgtgaggt tttgttcata tcagtgcttc attttgtaat
     6601 gtcttctcaa gaaaaatacc tatgttaact cacaagtata aaatatgtgt gtattataaa
     6661 acaatgaaaa gtgtattttt ggagatagtc aagcatttag aagtgcagtg aacttgctgt
     6721 cacggagtaa aatgctaatt atgtttcact ttcctagcct agtgaaaaag aaaagtgctc
     6781 ttgagtacaa taccttaatt atttcttaaa atactgactt tgacctagct cactgtattt
     6841 tttatttaat ggattatgga ttacagtatt tttcttctga gttaaatttt cataatttat
     6901 gtgaagacac aaagatgttt aaaacaatga ttattcataa gaaatcatga tggtctcagt
     6961 attattttag tgtattggaa ggtctttgat cttaatagaa tttataaatt tcagcttctc
     7021 cagaataatc ataaaactgc aaaaagatat tataattgag tcatgattga gatacagttt
     7081 tgaggctatt ataattgtat aattatttaa tttgcattat ctgtaaaatg tagtaaggtc
     7141 tttgagggga tattttttat ttacatgaat tactgaattt ctattttatt atttcaccta
     7201 aaattaaggt aaaatatggc atttcataag ttctgctttc agcattttcc ttaaagttgt
     7261 aaaaaatcaa gctatgtact tattttctat atttgggtgt gttaaattga ggattagaaa
     7321 aatccacata atcactgata aagcattgaa acagaataac ccaagggtag tgtaccgatt
     7381 cagtaacatg ttaaaaatat tgctatgcat ttattcaaag gaaaatggtc tgttcttgag
     7441 aaataaaaga tcagttgcaa ttaggataat taaatagtta aatatgagtc aagtgtatgc
     7501 aatatacatt tatatgaacc aaagcttgct ttatcaggac catgccctac agttcaaaac
     7561 ataaacatag tgaatgtgtt aatatcatat aataaggtaa taaatgccag tcttagtgtg
     7621 aagcaagtgg gtggccccct tggtagtata attggacagg attttcctcc agaatatttc
     7681 ctgtcaccct ccaagagtca ctacagtaat tgattgctgg catggaacac attgcccttg
     7741 tcttgttagt atgaattggg ttctccagtg actagaagaa ctggggtgtg tgaaagtatt
     7801 cgatgccagg agattcaaaa aggaagctct caaagataag atcattttat ggcacaattg
     7861 agtctataac cagcccttta agcagtagta aaaatgtcct ttgtcatact tactagaaat
     7921 actatgagtt tttttttttt ttttcatttg agacggagtc tcgctctgtc acccaggctg
     7981 gaatgcagtg gcacgatctt ggctcactgc aacctctgct tcccgggttc aagcagtttc
     8041 ctgcttcaga cttccaagta gctgggatta cagacatgcc accatgccag gctaattttt
     8101 ttaatatttt tagtagagat ggggtttcac cattttggcc attctagtct tgaactcctg
     8161 acctcaggtg atctgcccgc cttggcctcc caaagtgctg acattacagg cctgagccac
     8221 tgcgcccagc caataccatg agttttaagc ctcacatcgt cacttgctgt cactgccagt
     8281 gcctgtttta ttcatattgc tggacaacag acatatgcca ccaattgtat gattaataaa
     8341 gtctttttct ggccattttg tccattataa aggaaataaa ctaattgtta acttgcatag
     8401 attacttctt agtttcctat gctaccacca ctgccaaggg agaaaaaaat acatcatttt
     8461 gtaatgtctt tagtatttct ttataactag tgttaaggtt ttgttaattt tattgtatac
     8521 atttgtaaca tttattagga gccttttagg ttccaaaaca aacaaaaggc ataaaaaagt
     8581 ctagcttaga accacttttc acttgctttc atttttaatt ttattcactt aacagctaac
     8641 atctttcttg tttcttgttt tttccattat atggttatcg attcaactct tgctatattc
     8701 cttaaatttg tatgtatcat cagaagaaag agatgaacaa tttagtgtag atattttatt
     8761 ctggagaata atattcaatt aaattatttc tacagcaggc cagtaacaac tagattattt
     8821 gtcctttctc agtataattt taaagagcat tttgttttat tgtcacaatt tggtaccact
     8881 agtcccaggt aaccattggg ccaaaggatc agttgagaaa cagttaagga tgaattagca
     8941 taagttatgg aacagtgtta gaaaacaact caaaagtata ttctttatta atgaggtggt
     9001 cattattaca tttgtgtcaa tgaagggcag tgtagttatt ttaaaatgac taatattttc
     9061 tccccaaata cagaataatt cagatgggca accaagtttt caagagactg ctgtaggtga
     9121 agtctgtcta gccaaggcag aacacttaca ggagtcccta actgtgccac ccttggaatg
     9181 ggttagtgta caggctcaga atattgtgga ttacagtttt tcagagaaaa ctaccacaga
     9241 tgtagacaaa aatgatctct gaaagcattg ccagcagcca ggtatgttcc ttagatttcc
     9301 acttaggttt ggcattttgg cagataagct aatcttgtat aaagcatcac attttactat
     9361 gcttagtgtt cctgggttgt atttatctac attattagag ggaattttta ttttaaaaaa
     9421 attgtcattc atgagaagaa tgggagttca tgccacatag tattttacca atttatataa
     9481 agtgggaaaa gtctttaata cttcatgatc acttgaatta aagtttttgt atctctggaa
     9541 agtagaatag tgctttcatt tgaatgaaaa gtgtttatag attcagaaag agagatgata
     9601 tctttgtatc ttgatttata tacagaccat ttcagaggaa gttaaatgtc ttacaaatcc
     9661 aatactttct aatgctctaa cagtgttggc tatttaaaag aacatgtggc aagttctata
     9721 tgaatattct tggtcatctc gactaattct gaggcaatga tggacagaga tgctacttct
     9781 tatttaactc taggcatgtt gacttttcaa agcggtttcc ttatttctaa acagagatga
     9841 tgatcaatga gttactaatt ctttagagga aaaaatgcat aatttgagtg tggagttgat
     9901 tttaatgaca gggtaattca agttgtttga taaatttatt actatattgt aagagagatc
     9961 tttgaccatt tttcttcctt tttcttggac atcactttct tccctcccct tctctctttt
    10021 atgtttttat ccttgttaaa ttttatgttt acgttaccat ctttcttata ctttcccctg
    10081 atttttctct tttaattcct ctttcattct ctgcctcttc tctttcagct ctttctctaa
    10141 ttgtgcctat tccttgttca taagaagtgg agctgttagt ggtagaacca ctgctcatgg
    10201 ttctaccact acaaagtgga aagtagaaat actttgcact ttggccactg ttgcgttttt
    10261 gccaaggtaa agttcccctg ccattttgaa atagctgaac aagttaaagt aatatgttcc
    10321 aaaaactgga agtgccataa aaaactaaaa ataaaaaaaa attgtgacta taactcctac
    10381 tgtctttatg aatacacggg attcagcagc caagatgctc acaaaatggg attgctataa
    10441 atatgatgga ttcagcacct aaatttggaa taatcatgtc ttttctgtta tgtgggtaga
    10501 gagattatat atcttttctc aaagtaaagt atttaaaacc tgtttaaatg agggttttgg
    10561 ctggcgtggt ggcccacacc tgtaatccca gcactttggg aagccaaggt gggagtatca
    10621 cttgaggcca ggagtttgag actagcctag acaacatagc aagatcctat ctctagttca
    10681 aaaaaatatt tttaattagg gttttggttt tttatgattt tggggggtgg gggagatatt
    10741 tgtttttttg aggcagacgt ttaaactttt agatttatcc catcttaata ttgatttata
    10801 ttgacactgc ctacttacaa gaataatttg aggcagcata ttgcccatgt atttcaacta
    10861 ttttcatttt tctgttgcaa agcagtcttt gatggaagac ccggaatctt atagttctca
    10921 tatctgagtc tttctggagt gtatttggtg tctgtgtgat tggttcaccc agaggtcacc
    10981 cagaggtcaa ttgaaacctt cctaattgta ctatggtatt gattctatcc cctcaagtat
    11041 gaaaaaatta aattttcaga ccattttcag ttgctgcgaa tgtagttaca ctaagtttta
    11101 ttttaaacta aaattcaata aacagtgcag ccagggaaga tctgctaaac catgccgtta
    11161 tttggaaaat cattgcaata tattaacaac tgcttccttc tatgatgttt actagatgga
    11221 gaaaaatact ccatacctat attgcaattt tatttttatc tagaaaaaga aaatattagg
    11281 cttcagaccc aactgtgcaa atttcatttg ctttccatct cttactacta cctctgtgtc
    11341 ataatttaac acgtaacata caactcctgt ctcttaaggc agctaccata tggtgtttat
    11401 gtcagactgg atatatttat ctaattttgt gaaattattt tttagttccc aacacaattc
    11461 ttgaaagtaa taccactgtt gttactcttt ctccttacaa tttttatgtt gttgagatgt
    11521 atcagttatg tattataatc atgaaattgt attggcctca aacccaaatt ttctttgtag
    11581 tctaggatag atttttcatg aaagctatat agttataact gtgattgtac agattgttta
    11641 tttgttttac agctaacatt aagcatgatt ccaggttttt aattatgttc cagcaacact
    11701 agtgtttctt tataacttaa aatcataacc actttgataa tttacctttg gatctgacca
    11761 gtgattcatt tttttcttga atatactttg tgtttgcttt ctcatccccg ttaagtctga
    11821 aacattattg acaccccaca tcacttactc tgtttaaaga ctttacgagt agtgagtcac
    11881 atgtttagga tgatcacttt gggaaaaaaa aaattataga gtaaagggga aatgttcttg
    11941 agagctttat taaaaccatt aatatataaa atgaaaaaat aataaacaga agacacgaag
    12001 tgtctctcaa tagtttagaa agaaagattt ggaactttaa gtaaaaatgc taggtcaagt
    12061 aaaaatcctg atgtagatta gattatctta atcttatgag catttttttt taatttggtg
    12121 aagctgtttt gaaactgcct gtccatatca atgccagact atctctctac ctctcaaaga
    12181 aaataatttg cattaaaatt cctttttttg ttatgtaatg aaagtataaa acaagaattt
    12241 gtacgttact cagtgtgtac tgcagtcaga tatagttaaa ataatttttc tgatgcgtaa
    12301 ttttaaccac catttctgga gtacctagta tgtgcaggcc aaggctttgc ctatattatt
    12361 ccctttaatc ctcaaagtag ccttgcaaag aagttatttt cattttacag aagagtcaag
    12421 gattaggggg ttgaagtgag ctgcctagag tcacatacct aaagtccagg tggatcacta
    12481 tgtcttgctt tttcaaaagc agttctttct actacagtac aatagtttca tgttttacag
    12541 tccattaaaa tccaagactt ataaaataaa ctaaaaatac tcttgaggca attactattt
    12601 ctatgatggg cactgggaca aatatacttg aacataacaa agaactaaaa atactgtgaa
    12661 aaaaagattt gtcttaacga tgaccttgaa agttgcattg ggtttttatt attggtccag
    12721 gtttaaaaca ttttatctat ttaaaacata tgttgtgtgt tttaagaagt tatgttataa
    12781 ataacagcat tgtggttaag agcccagagt ctggggccag gcttcttaga tgcaaatccc
    12841 aactctgtta ttttactaaa tgtgtgacct tgggcaagtt aattaacctg ttttggtgtc
    12901 ctcctctgtg aaatggagtt aatcgtggta tttaacagaa ttcaaaatgt agtgtgttct
    12961 aaagcgctgt gcctggagca tcatcaccac taggtggtta gggaagtaaa acacatttgg
    13021 cacacatcat tcaagaatgg ccagaaaatc catgtcttcc cacaataggg accaattttt
    13081 tgcctttcac cagacaacca ctgaatgtta agaatctact gtgtgctaat aactgtgtcc
    13141 ttgctgtatg acagaagcta tttggagcgc tctcaagtgc ttattacagc tagtcaagga
    13201 aaccgcatat ataaaataat actggataca agactataca attaaatact ggtgtatcac
    13261 taa
//
