LOCUS       NM_014940               5813 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MON1 homolog B, secretory trafficking associated
            (MON1B), transcript variant 1, mRNA.
ACCESSION   NM_014940
VERSION     NM_014940.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5813)
  AUTHORS   Vaites,L.P., Paulo,J.A., Huttlin,E.L. and Harper,J.W.
  TITLE     Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers
            Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in
            Macroautophagic and Selective Autophagic Flux
  JOURNAL   Mol Cell Biol 38 (1), e00392-17 (2017)
   PUBMED   29038162
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5813)
  AUTHORS   Shao,X., Liu,Y., Yu,Q., Ding,Z., Qian,W., Zhang,L., Zhang,J.,
            Jiang,N., Gui,L., Xu,Z., Hong,Y., Ma,Y., Wei,Y., Liu,X., Jiang,C.,
            Zhu,M., Li,H. and Li,H.
  TITLE     Numb regulates vesicular docking for homotypic fusion of early
            endosomes via membrane recruitment of Mon1b
  JOURNAL   Cell Res 26 (5), 593-612 (2016)
   PUBMED   26987402
  REMARK    GeneRIF: Numb binds to another docking regulator, Mon1b, and is
            required for the recruitment of cytosolic Mon1b to the early
            endosomes membrane.
REFERENCE   3  (bases 1 to 5813)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Haralambieva,I.H., Lambert,N.D.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide SNP associations with rubella-specific cytokine
            responses in measles-mumps-rubella vaccine recipients
  JOURNAL   Immunogenetics 66 (7-8), 493-499 (2014)
   PUBMED   24811271
REFERENCE   4  (bases 1 to 5813)
  AUTHORS   Wu,W., Yu,X., Li,W., Guo,L., Liu,L., Wang,L. and Li,Q.
  TITLE     HSV-1 stimulation-related protein HSRG1 inhibits viral gene
            transcriptional elongation by interacting with Cyclin T2
  JOURNAL   Sci China Life Sci 54 (4), 359-365 (2011)
   PUBMED   21509660
REFERENCE   5  (bases 1 to 5813)
  AUTHORS   Poteryaev,D., Datta,S., Ackema,K., Zerial,M. and Spang,A.
  TITLE     Identification of the switch in early-to-late endosome transition
  JOURNAL   Cell 141 (3), 497-508 (2010)
   PUBMED   20434987
REFERENCE   6  (bases 1 to 5813)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5813)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5813)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5813)
  AUTHORS   Guo,H.X., Cun,W., Liu,L.D., Dong,S.Z., Wang,L.C., Dong,C.H. and
            Li,Q.H.
  TITLE     Protein encoded by HSV-1 stimulation-related gene 1 (HSRG1)
            interacts with and inhibits SV40 large T antigen
  JOURNAL   Cell Prolif 39 (6), 507-518 (2006)
   PUBMED   17109635
  REMARK    GeneRIF: HSRG1 interacts with SV40 large T antigen (LT) in yeast
            two-hybrid assay
REFERENCE   10 (bases 1 to 5813)
  AUTHORS   Dong,S., Dong,C., Liu,L., Che,Y., Sun,M., Hu,F., Li,J. and Li,Q.
  TITLE     Identification of a novel human sand family protein in human
            fibroblasts induced by herpes simplex virus 1 binding
  JOURNAL   Acta Virol 47 (1), 27-32 (2003)
   PUBMED   12828340
  REMARK    GeneRIF: Identification of HSV-1 stimulation-related gene 1, a
            novel sand family protein, induced by herpes simplex virus 1
            binding. (HSV-1 stimulation-related gene 1 (HSRG1)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009139.8.
            
            On May 17, 2019 this sequence version replaced NM_014940.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020679.1, SRR1660807.153909.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248248.8/ ENSP00000248248.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC009139.8         46030-46098
            70-227              AC009139.8         46316-46473
            228-554             AC009139.8         48291-48617
            555-1374            AC009139.8         49175-49994
            1375-1522           AC009139.8         50375-50522
            1523-5813           AC009139.8         52948-57238
FEATURES             Location/Qualifiers
     source          1..5813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..5813
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /note="MON1 homolog B, secretory trafficking associated"
                     /db_xref="GeneID:22879"
                     /db_xref="HGNC:HGNC:25020"
                     /db_xref="MIM:608954"
     exon            1..69
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..227
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1723
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vacuolar fusion protein MON1 homolog B; HSV-I
                     stimulating-related protein; HSV-1 stimulation-related
                     gene 1 protein; MON1 secretory trafficking family member
                     B"
                     /codon_start=1
                     /product="vacuolar fusion protein MON1 homolog B isoform
                     1"
                     /protein_id="NP_055755.1"
                     /db_xref="CCDS:CCDS10925.1"
                     /db_xref="GeneID:22879"
                     /db_xref="HGNC:HGNC:25020"
                     /db_xref="MIM:608954"
                     /translation="MEVGGDTAAPAPGGAEDLEDTQFPSEEAREGGGVHAVPPDPEDE
                     GLEETGSKDKDQPPSPSPPPQSEALSSTSRLWSPAAPENSPTCSPESSSGGQGGDPSD
                     EEWRSQRKHVFVLSEAGKPIYSRYGSVEALSATMGVMTALVSFVQSAGDAIRAIYAED
                     HKLVFLQQGPLLLVAMSRTSQSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDL
                     RRLLAGSERTLDRLLDSMEQDPGALLLGAVRCVPLARPLRDALGALLRRCTAPGLALS
                     VLAVGGRLITAAQERNVLAECRLDPADLQLLLDWVGAPAFAAGEAWAPVCLPRFNPDG
                     FFYAYVARLDAMPVCLLLLGTQREAFHAMAACRRLVEDGMHALGAMRALGEAASFSNA
                     SSASAPAYSVQAVGAPGLRHFLYKPLDIPDHHRQLPQFTSPELEAPYSREEERQRLSD
                     LYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAGAILVVTKL
                     LRWVKKEEDRLFIRYPPKYSTPPATSTDQAAHNGLFTGL"
     exon            228..554
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1374
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1522
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..5813
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5794..5799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /note="hexamer: AATAAA"
     polyA_site      5813
                     /gene="MON1B"
                     /gene_synonym="HSRG1; SAND2; SRG1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgtgatg ccaccgccgc tacggggaag taatggtatc cggccaattg agattcggag
       61 ttaaaacagg gatgtgcaga tggaggtcgg aggagacact gctgccccgg cccccggggg
      121 cgcggaggac ttggaggaca cgcagttccc cagtgaggaa gctagagaag gtggaggggt
      181 tcacgcggtc ccgccggatc ccgaagacga gggcctggag gaaacaggat ccaaggacaa
      241 ggaccagcca cccagcccat caccaccgcc ccagtcagag gccctgtcaa gcacctctcg
      301 gctctggagt cctgcagccc ctgagaatag tcccacatgt agccctgaga gtagctctgg
      361 aggccagggc ggggacccca gtgatgagga gtggcgcagc cagcggaagc atgtgtttgt
      421 gctgagtgag gctggcaagc ccatctactc gcggtatggt agtgtggagg cgctgtcggc
      481 taccatgggt gtaatgaccg ccctggtgtc ctttgtgcag agtgcgggag atgccatccg
      541 tgccatctac gctgaggacc acaagctggt gttcctacaa cagggcccac tgttgctcgt
      601 ggccatgtca cggacttctc agtcagcagc ccagctgcgg ggggagctgc tagctgtgca
      661 cgcacagatc gtgagcacac ttacacgtgc aagtgtcgcc cgcatcttcg cacacaagca
      721 gaactatgac ctccgccgcc tgctggctgg ttcagagcgc acactggacc gacttctgga
      781 cagtatggag caggacccag gagccctgct cctgggtgcc gtgcgctgtg tgccccttgc
      841 ccgcccgctg cgagacgcac taggtgcgct cctccgacgt tgcacagcgc ctggcctggc
      901 gctgtcagtg ctggcagtag gcggtcgact tataacagca gcccaggagc gaaatgtgct
      961 ggccgagtgc cggctggacc cagctgacct gcagttgctg ctcgactggg tgggtgcacc
     1021 agcctttgcg gcgggtgagg cttgggcacc tgtgtgcctg ccccgcttca accctgatgg
     1081 ttttttctac gcctacgtgg cccgcctgga tgctatgcct gtctgcctgc tgctgcttgg
     1141 cacccaacgt gaagccttcc atgccatggc cgcctgccgg cgcctggttg aagatgggat
     1201 gcatgccctt ggtgccatgc gtgcccttgg ggaggctgcc agcttctcta atgcctcatc
     1261 agccagtgct cctgcctaca gcgtgcaggc tgtcggggcg ccgggcctcc ggcacttcct
     1321 gtataagccg ctggacatcc ctgaccacca ccgccaactg ccccagttta ccagccctga
     1381 gctagaggcc ccctacagca gagaggagga gcggcagcgg ctgtcggacc tgtaccaccg
     1441 cctgcatgct cgtctccaca gcacctcccg acccctgcgc ctcatttacc acgtggctga
     1501 gaaggagaca ctactggcct gggtgacctc caaattcgag ctctatacct gcctcagccc
     1561 tctggtgacc aaggcaggtg caatcttggt agtgaccaaa ctcctgcgct gggtgaagaa
     1621 agaggaggac cggctcttca ttcgttaccc acccaagtac tccacaccac cagccacctc
     1681 tacggaccaa gctgcccata atggcttgtt cactggactc tgatagttgg agctcccaga
     1741 ccaggcagtg ctgggagcaa ccacctttgt tttttacctt ctgtctaccc tggaaatgtg
     1801 tgtgggggtg tgtctgtggc cagtcattgt ctccctaagc aatggggcaa ggtctgaggg
     1861 cccaccgatg agagagatgg tggcagccgc caggcgagca ggctgctttc cctgcccagt
     1921 catgcacctc cccctctggg gaaatcctta ggcctccctc tcccttccct ctgtctcatc
     1981 tcctccactt ggatgatgct ctagcctctg tcagggactg tcccctccaa acttgcttcc
     2041 gtggtctgcc tcctagttga atctcagccc tgagtgtcca gatctggcca aggtgtctag
     2101 ggtggcccac gggggtgctg gaattggcac ttcagggcca ggctatgctt gggactggcc
     2161 tgagggtatt ttaaagaaaa aaactacata aaaggcctaa aagtaagacc cacaaggata
     2221 ttcctttgcc cttcttgtac ttttttcatc tttaccctgc cagaaatgac ccgccctcaa
     2281 tgctggctgc tgctaacatt aatgagaagg tggccttcag tgtccacctg tggaacccag
     2341 gacacagcac ctgactgcac acagtggctg aaatccagca tttttacata ggagatgcac
     2401 ttagcctcta agcctcgttt tactcatctg tgaaacagag ataagtaacc ctctctcatg
     2461 aactctttga tgaggatttg taaacgaaaa cagactcgaa ctattgtgta ccaccacata
     2521 gcacatgcac gtctgtccca gactttgaca acctgcacaa gacaagcagc ctaaagcagg
     2581 agagacctcc ctagggtttt gtgtgtgtgc acactaccct cactccccaa ctggccatta
     2641 ccctagttct gcccttgttt gtggagttac agcctcaagg ttgtagcatg tgtgctggca
     2701 atcagggccg cagtgtgttc tgcgcctgcc cagagctgac tcctgattta accgctggcg
     2761 taaccgcggg ttgcacgcat gcgtgctgaa aagcctttca ccctcacgtg gtttcttttt
     2821 taaccagtca tcaagcgagg ctcgcgcgca ggccccgcgt tggaaaatgg cggggaagct
     2881 gaaacctctg aatgtggagg cgccagaagc tactgaggag gctgaaggta gtgagggcaa
     2941 gtgggctgca ctcctttctc tccaaccagg gcagaaagga gggaggattc gtcccattac
     3001 aataatgaaa taatgatatt ctaatttttt taaataaaat gttaagcctt ttgttattga
     3061 agaaaaacaa ttttttaacc gttcagcaca gtggagataa attaacaggc atattcttat
     3121 caccgagatt aacttttgtc aactgtagtg tatacgttgt tgaaagtaaa caacatgtag
     3181 ttcagtacga aagtcttcaa acaaaagtgg ggcggtgggg atgttctcat aacaatcacc
     3241 gtgctgcagc caccccttat taacagtaat tcccagtgtc gccatttcac acctaacaca
     3301 tatgacactt tgatggactc ttaaacctcc taatcgaaca tggcctcccc cacagcctct
     3361 tttctccagg gtattgactt gaatgacagg caaaggaggg tggaggggtg tcggcctaga
     3421 cactattgga aattgtattc catccaaaag aaaaaaaaat ctcaggccgg gcacggaggc
     3481 tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cggatcacga ggttaggagt
     3541 tcgaggccag cctgaccaac atggtgaaac accatctcta ctaaaaaact atatatacat
     3601 atacatatgt gtgtatgtgt atttatatgt atgtatgtat gtgtgtgtat atatatatat
     3661 atgtatatgt gtatatatat atatatgtgt atatatatat atatatacac acactaatca
     3721 gccgggcgcg gtggtgtggg cctgtaatcg cagctactca ggaagctgag gcaggagaat
     3781 cacttgaacc cgagaggcgg aggttgcagt gagccgagat catgtcactg cactccagcc
     3841 tgggtgacag agtgagactc cgtctcaaaa gaaaaaaaat tctcccttgg ccgggcttgg
     3901 tggcttatgc ctgtaatccc agcactttgg aaggccgagg cgggtgggtc acctgaggtc
     3961 aggagtttga gaccagcctg gccagcatgg cgaaacctcg tctctactaa aaatacaaaa
     4021 attgtccggg tgtggtggcg ggcgcctgta gtcccagcta ctggggaggc tgaggcaggg
     4081 gaattgcttg aacccgggag gcagaggtta tcgtgagctg acattgcgcc actgcactcc
     4141 agcgcggaag acagagtgag caaaaaaaaa aaaaaaaaaa gaaaaaacaa aaagaaaaaa
     4201 atctcccaag gcagtcatgc atttgtatgc cactagcatt tttttgttat agaaatattc
     4261 aaagtgtacc aacgtagaga aaatagcttt aaacaaagcc catgtgtacc tatcagtatg
     4321 ctttaactgt tgtcaccttt ctgccccact tttatctatc tcgaacaccc ctttctgcac
     4381 actctttaaa ccactgtatt aacaaacaca ttagactgca tcctgccaga cctacccata
     4441 cagacatcaa agtaatgatt attgcttatt gcctgaccta ggatgtgagc tccatgagaa
     4501 cagagactgt ttacctctcg ctcccctgca cctaaaacaa tgcctgcttg gtgtaaagta
     4561 agtgctcagt aattttttaa tgtgtgacca atgaaataac ttcaagagca gagagctctt
     4621 ttagattaga ggcacatact aagtgccagc attcaacaaa agacagacgg aaataagaca
     4681 gatgcaaata gatctcattt attaactgtg taatgcagct gccactgcaa ttaaaaaaaa
     4741 aattttagta tcaacctttc aaattcctca aaattaaagt tatgactaac ttcaccagca
     4801 aaggaaaaat tgaaggatgt atcaagttgc catttctagc ccatcaaatc ggctttataa
     4861 agggaagcat agtatctggt attgacgacc ttgtagagaa acaggccttt tcctgcctca
     4921 gggaagagag ctgactcaaa gtaaaggctt tgctagaggc agtcggcaga gtatttttag
     4981 catctaaaat gctcttccac ttcggcagtg accatgcgat gtaatcaaag gagaatacgt
     5041 aagtgtatgg accaggaatg gtcactggag tgttgatgta ggcacaacac aagaagtagt
     5101 cacagaaatt gctaagtcta ggtttatgtg tgcatgctgt ggagtgtctc tgtggtggat
     5161 ttctttttaa gaggcagaaa aaaattctaa tttaaatgta ttaaattata agttctaatt
     5221 taaatgtatt aaaattaaat tataagttga taggattatt attgacacac aaggagctcc
     5281 aaaagagatc gtatttttat tagagacaag ccagttggga ttgaaacaaa aatggagggg
     5341 ggtatagccc tgtgtatgtt gcacagaaaa agtatctgaa tgataaaggc ctaagtgata
     5401 actctggaca aggaatttgg attttgggag tagtgcagag gtagaggcat ttttgtgatt
     5461 tattgttcta ttttttcttc tagaaaaatg taagtagtca tatataattt taaaatataa
     5521 aggagaagag gcaaaatgtt gaatggcacc tgaggatcct atattcatat tggatcagta
     5581 ttaacatcca ggttttgatt gttgtactat ggttacctgg tagattccct ttgtatatag
     5641 gaaatagaca ctggaatagt aaggagtagt gggtcaagat gtctgcaact tattgttcag
     5701 aatcactcac aaatgggaaa tctgatataa ggacaaaatg ggagcactgt ggcctatttt
     5761 tacaactttt gtgtacatct gcaattgttt caaaataaaa tgtttaaaag ggt
//
