LOCUS       NM_032355               2025 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens MON1 homolog A, secretory trafficking associated
            (MON1A), transcript variant 1, mRNA.
ACCESSION   NM_032355
VERSION     NM_032355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Vaites,L.P., Paulo,J.A., Huttlin,E.L. and Harper,J.W.
  TITLE     Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers
            Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in
            Macroautophagic and Selective Autophagic Flux
  JOURNAL   Mol Cell Biol 38 (1), e00392-17 (2017)
   PUBMED   29038162
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Gerondopoulos,A., Langemeyer,L., Liang,J.R., Linford,A. and
            Barr,F.A.
  TITLE     BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine
            nucleotide exchange factor
  JOURNAL   Curr Biol 22 (22), 2135-2139 (2012)
   PUBMED   23084991
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Bagley,D.C., Paradkar,P.N., Kaplan,J. and Ward,D.M.
  TITLE     Mon1a protein acts in trafficking through the secretory apparatus
  JOURNAL   J Biol Chem 287 (30), 25577-25588 (2012)
   PUBMED   22665492
  REMARK    GeneRIF: a role for Mon1a in anterograde trafficking through the
            secretory apparatus.
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Kinchen,J.M. and Ravichandran,K.S.
  TITLE     Identification of two evolutionarily conserved genes regulating
            processing of engulfed apoptotic cells
  JOURNAL   Nature 464 (7289), 778-782 (2010)
   PUBMED   20305638
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105935.2.
            
            On Mar 31, 2021 this sequence version replaced NM_032355.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006299.2, AK074404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296473.8/ ENSP00000296473.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC105935.2         73401-73603
            204-343             AC105935.2         89853-89992
            344-829             AC105935.2         91201-91686
            830-1595            AC105935.2         92328-93093
            1596-1743           AC105935.2         93812-93959
            1744-2025           AC105935.2         94058-94339
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2025
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /note="MON1 homolog A, secretory trafficking associated"
                     /db_xref="GeneID:84315"
                     /db_xref="HGNC:HGNC:28207"
                     /db_xref="MIM:611464"
     exon            1..203
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..343
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1884
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /note="isoform a is encoded by transcript variant 1;
                     vacuolar fusion protein MON1 homolog A; MON1 secretory
                     trafficking family member A"
                     /codon_start=1
                     /product="vacuolar fusion protein MON1 homolog A isoform
                     a"
                     /protein_id="NP_115731.3"
                     /db_xref="CCDS:CCDS2808.3"
                     /db_xref="GeneID:84315"
                     /db_xref="HGNC:HGNC:28207"
                     /db_xref="MIM:611464"
                     /translation="MATDMQRKRSSECLDGTLTPSDGQSMERAESPTPGMAQGMEPGA
                     GQEGAMFVHARSYEDLTESEDGAASGDSHKEGTRGPPPLPTDMRQISQDFSELSTQLT
                     GVARDLQEEMLPGSSEDWLEPPGAVGRPATEPPREGTTEGDEEDATEAWRLHQKHVFV
                     LSEAGKPVYSRYGSEEALSSTMGVMVALVSFLEADKNAIRSIHADGYKVVFVRRSPLV
                     LVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITD
                     NLLQLMARDPSFLMGAARCLPLAAAVRDTVSASLQQARARSLVFSILLARNQLVALVR
                     RKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNAAGFFHAHISYLEPDTDLC
                     LLLVSTDREDFFAVSDCRRRFQERLRKRGAHLALREALRTPYYSVAQVGIPDLRHFLY
                     KSKSSGLFTSPEIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLA
                     WVTGAFELYMCYSPLGTKASAVSAIHKLMRWIRKEEDRLFILTPLTY"
     exon            344..829
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1595
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1743
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2025
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /note="hexamer: ATTAAA"
     polyA_site      2025
                     /gene="MON1A"
                     /gene_synonym="SAND1"
                     /note="major polyA site"
ORIGIN      
        1 atcttcctgc accggcggcc gggtgagggc ggtgggaggg agcggtgcct gcgctgtggc
       61 catgtctgtg tacgcagggg gccggggccc cgcgaagctg tgccctcagg ccggccccgg
      121 ccggacaccc ttacccctcc atgggtccgg cagagggcag tgaccggcac cttctgtgcg
      181 tcctggactc ctctgagaaa caggagagct caaaggatgg ctactgacat gcagaggaag
      241 agaagcagcg aatgccttga tggcacattg actccttctg atggacagag tatggagaga
      301 gctgagagcc ccacaccagg aatggcccag ggaatggagc caggtgcggg ccaggagggt
      361 gccatgttcg tccatgcccg ttcctacgag gacctgactg agtcagagga tggggcagct
      421 tctggggaca gccacaagga gggtaccagg ggtcccccgc cgctgcctac agacatgcgc
      481 cagatcagcc aggactttag cgagctaagc acccagctga cgggtgtggc ccgggacctg
      541 caggaggaga tgctgccagg aagctctgag gattggctgg aacccccagg ggcagttggg
      601 cgaccagcca cagagccccc cagggagggc acaaccgagg gggatgagga ggatgccacg
      661 gaggcatggc gcctgcacca gaagcatgtc tttgtgctga gtgaggcagg gaagcctgtg
      721 tactcccgct atgggtctga ggaggcactt tccagcacta tgggtgttat ggtggccctg
      781 gtgtccttcc tggaggcaga caagaacgcc atccgctcca tccatgcaga tggctacaag
      841 gtagtattcg tgcgccggag cccgctggtg ctagtggcgg tggctcgtac gcggcagtcg
      901 gcacaagagc tggcgcagga gctgctctac atctactacc agatcctaag ccttcttacc
      961 ggtgcgcagc tgagccacat cttccagcag aagcagaact atgatttgcg gcgcctactc
     1021 tcgggctcag agcgcatcac cgacaacctg ctgcagctca tggcacgaga ccccagcttc
     1081 ctgatggggg cggcacggtg cctgcccctg gcggcggccg tgcgcgacac tgtgagcgcc
     1141 agcctgcagc aggcgcgtgc gcgcagcctg gtcttctcca tcctgctggc ccgcaaccag
     1201 ctcgtggcac tcgtgcgccg aaaggaccaa tttctgcacc ccatcgacct gcacctgctc
     1261 ttcaacctca ttagttcctc ctcgtccttt cgcgagggcg aggcctggac gcccgtgtgc
     1321 ctgcccaaat tcaacgcagc cggcttcttc cacgcacaca tctcttacct agagcctgac
     1381 actgacctct gcctgctgct tgtctccact gaccgtgagg acttctttgc agtctctgac
     1441 tgccgccgcc gcttccagga gcgccttcgc aagcgcggag cccacctggc cctgcgagag
     1501 gcactgcgca caccctacta cagcgttgcc caagtgggca tccctgacct gcgtcacttc
     1561 ctctataagt caaagagctc gggactcttc accagccctg agattgaggc cccatacacc
     1621 agtgaagagg agcaggagcg gctgctgggc ctctaccagt acttgcacag tcgtgcccac
     1681 aatgcctctc gcccactcaa gaccatttac tacacgggcc ccaacgagaa cctcctggcc
     1741 tgggtgacag gcgcctttga gctctacatg tgttacagcc ccctggggac caaggcgtca
     1801 gccgtcagtg ccatccataa gctgatgcgc tggatccgca aagaggaaga ccgcctcttc
     1861 attctcacgc ccctcaccta ttgatgggaa tgtgtgcggg ctcagccttc ctggacacac
     1921 taggtgtggg aagccatagg agcctccaga tgggggctgg cctctcttgc ccagccagcg
     1981 ggcagggact gtgggttggt gaatgcatta aagtgctttg gggaa
//
