LOCUS       NM_014226               1909 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MOK protein kinase (MOK), transcript variant 1, mRNA.
ACCESSION   NM_014226
VERSION     NM_014226.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1909)
  AUTHORS   Ramya,R., Coral,K. and Bharathidevi,S.R.
  TITLE     RAGE silencing deters CML-AGE induced inflammation and TLR4
            expression in endothelial cells
  JOURNAL   Exp Eye Res 206, 108519 (2021)
   PUBMED   33639133
  REMARK    GeneRIF: RAGE silencing deters CML-AGE induced inflammation and
            TLR4 expression in endothelial cells.
REFERENCE   2  (bases 1 to 1909)
  AUTHORS   Qian,J., Chen,Q., Yao,D.M., Yang,L., Yang,J., Wen,X.M., Zhang,Y.Y.,
            Chai,H.Y., Ma,J.C., Deng,Z.Q. and Lin,J.
  TITLE     MOK overexpression is associated with promoter hypomethylation in
            patients with acute myeloid leukemia
  JOURNAL   Int J Clin Exp Pathol 8 (1), 127-136 (2015)
   PUBMED   25755699
  REMARK    GeneRIF: our results suggest MOK promoter hypomethylation is a
            common event and contributes to MOK overexpression in acute myeloid
            leukemia
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1909)
  AUTHORS   Vanita,V.
  TITLE     Association of RAGE (p.Gly82Ser) and MnSOD (p.Val16Ala)
            polymorphisms with diabetic retinopathy in T2DM patients from north
            India
  JOURNAL   Diabetes Res Clin Pract 104 (1), 155-162 (2014)
   PUBMED   24529564
  REMARK    GeneRIF: The findings indicate a statistically significant
            association of p.Gly82Ser polymorphism in RAGE with DR in T2DM
            patients.
REFERENCE   4  (bases 1 to 1909)
  AUTHORS   Chen,T., Wu,D., Moskaluk,C.A. and Fu,Z.
  TITLE     Distinct expression patterns of ICK/MAK/MOK protein kinases in the
            intestine implicate functional diversity
  JOURNAL   PLoS One 8 (11), e79359 (2013)
   PUBMED   24244486
  REMARK    GeneRIF: the expressions of ICK/MAK/MOK proteins in the intestinal
            tract can be differentially and dynamically regulated, implicating
            a significant functional diversity within this group of protein
            kinases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1909)
  AUTHORS   Uesaka,T. and Kageyama,N.
  TITLE     Cdx2 homeodomain protein regulates the expression of MOK, a member
            of the mitogen-activated protein kinase superfamily, in the
            intestinal epithelial cells
  JOURNAL   FEBS Lett 573 (1-3), 147-154 (2004)
   PUBMED   15327990
  REMARK    GeneRIF: identification of MOK, a member of the mitogen-activated
            protein kinase superfamily, as one of the genes induced by a
            caudal-related homeobox transcription factor, Cdx2
REFERENCE   6  (bases 1 to 1909)
  AUTHORS   Eichmuller,S., Usener,D., Jochim,A. and Schadendorf,D.
  TITLE     mRNA expression of tumor-associated antigens in melanoma tissues
            and cell lines
  JOURNAL   Exp Dermatol 11 (4), 292-301 (2002)
   PUBMED   12190937
REFERENCE   7  (bases 1 to 1909)
  AUTHORS   Gotte,K., Usener,D., Riedel,F., Hormann,K., Schadendorf,D. and
            Eichmuller,S.
  TITLE     Tumor-associated antigens as possible targets for immune therapy in
            head and neck cancer: comparative mRNA expression analysis of RAGE
            and GAGE genes
  JOURNAL   Acta Otolaryngol 122 (5), 546-552 (2002)
   PUBMED   12206267
REFERENCE   8  (bases 1 to 1909)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 1909)
  AUTHORS   Miyata,Y., Akashi,M. and Nishida,E.
  TITLE     Molecular cloning and characterization of a novel member of the MAP
            kinase superfamily
  JOURNAL   Genes Cells 4 (5), 299-309 (1999)
   PUBMED   10421840
REFERENCE   10 (bases 1 to 1909)
  AUTHORS   Gaugler,B., Brouwenstijn,N., Vantomme,V., Szikora,J.P., Van der
            Spek,C.W., Patard,J.J., Boon,T., Schrier,P. and Van den Eynde,B.J.
  TITLE     A new gene coding for an antigen recognized by autologous cytolytic
            T lymphocytes on a human renal carcinoma
  JOURNAL   Immunogenetics 44 (5), 323-330 (1996)
   PUBMED   8781117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB037795.1, AB022694.1 and
            DB517173.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014226.2.
            
            Summary: This gene belongs to the MAP kinase superfamily. The gene
            was found to be regulated by caudal type transcription factor 2
            (Cdx2) protein. The encoded protein, which is localized to
            epithelial cells in the intestinal crypt, may play a role in growth
            arrest and differentiation of cells of upper crypt and lower villus
            regions. Multiple alternatively spliced transcript variants
            encoding different isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022694.1, SRR1660807.5175.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361847.7/ ENSP00000355304.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               DB037795.1         37-180
            145-1904            AB022694.1         175-1934
            1905-1909           DB517173.1         164-168
FEATURES             Location/Qualifiers
     source          1..1909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.31"
     gene            1..1909
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /note="MOK protein kinase"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
     exon            1..203
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1456
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAPK/MAK/MRK overlapping kinase; renal tumor antigen 1;
                     renal cell carcinoma antigen"
                     /codon_start=1
                     /product="MAPK/MAK/MRK overlapping kinase isoform 1"
                     /protein_id="NP_055041.1"
                     /db_xref="CCDS:CCDS9971.1"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
                     /translation="MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQ
                     VNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSE
                     KKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTE
                     YISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVI
                     GTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAA
                     HQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQE
                     EDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPAS
                     KKTDPQKDLKPAPQQCRLPTIVRKGGR"
     exon            204..318
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            319..408
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            409..479
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            480..558
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            559..607
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            608..786
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            787..888
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1062
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1177
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1378
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1909
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /note="hexamer: ATTAAA"
     polyA_site      1909
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /note="major polyA site"
ORIGIN      
        1 agggcctgac ggttgctagg gtgacaggga cacaacatgg cggcgggatc tctaacgctc
       61 tccttcgagg gaccaccacg gagatcctag tgcgggaccc cgcctcaggg aagtggaaag
      121 cagggggaca accttcctgc ttctttcttt tccgtccagt gtcggcaagg ggttgtcacc
      181 ggcttccgca tccaagatga agaactataa agcaattggc aaaataggag agggaacgtt
      241 ttctgaagtt atgaagatgc aaagcctgag agatggaaac tactatgcat gtaaacaaat
      301 gaagcagcgc tttgaaagta ttgagcaagt caacaaccta cgagagatcc aagcactgag
      361 gcgcctgaat ccgcacccaa acattcttat gttgcatgaa gtggtttttg acagaaaatc
      421 tggttctctt gcactaatat gtgaacttat ggacatgaat atttatgagc taatacgagg
      481 gagaagatac ccattatcag aaaaaaaaat tatgcactat atgtaccagt tatgtaagtc
      541 cctggatcat attcacagaa atggaatatt tcacagagat gtaaaaccag aaaatatact
      601 aataaagcag gatgtcctga aattagggga ctttggctcc tgccggagtg tctattccaa
      661 gcagccgtac acggaataca tctccacccg ctggtaccgg gccccggagt gtctcctcac
      721 tgatgggttc tacacgtaca agatggacct gtggagcgcc ggctgtgtgt tctacgagat
      781 cgccagtctg cagcccctct ttcctggagt aaatgaactg gaccaaatct caaaaatcca
      841 cgatgtcatc ggcacacccg ctcagaagat cctcaccaag ttcaaacagt cgagagctat
      901 gaattttgat tttcctttta aaaagggatc aggaatacct ctactaacaa ccaatttgtc
      961 cccacaatgc ctctccctcc tgcacgcaat ggtggcctat gatcccgatg agagaatcgc
     1021 cgcccaccag gccctgcagc acccctactt ccaagaacag aggaaaacag agaagcgggc
     1081 tctgggcagc cacagaaaag ctggctttcc ggagcaccct gtggcaccgg aaccactcag
     1141 taacagctgc cagatttcca aggagggcag aaagcagaaa cagtccctaa agcaagagga
     1201 ggaccgtccc aagagacgag gaccggccta tgtcatggaa ctgcccaaac taaagctttc
     1261 gggagtggtc agactgtcgt cttactccag ccccacgctg cagtccgtgc ttggatctgg
     1321 aacaaatgga agagtgccgg tgctgagacc cttgaagtgc atccctgcga gcaagaagac
     1381 agatccgcag aaggacctta agcctgcccc gcagcagtgt cgcctgccca ccatagtgcg
     1441 gaaaggcgga agataactga gcagcaccgt cgtctcgact tcggaggcaa caccaagccc
     1501 gaccgggcca ggcctgggtg atctgctgct gagacgccac ggagggctgg ggatgcgcct
     1561 gcgtccgttt cgcgctggcc ggggctctgg gtgctgccct gcgccctgcc gcacccgcgg
     1621 cccgcgcagc tgcctaggat gttctgggct aatatacttg taaaaccacc gcattctagg
     1681 gttttctttc attttcgtta agaatttggg gcaggaaata ctttgtaact ttgtatatga
     1741 atcaaaacaa acgagcaggc atttctgtga tgtgttgggc gtggttggaa ggtgggttct
     1801 gcgtgtccct tcccagcgct gctggtcagt cgtggagcgc catcatgtct taccagtgac
     1861 gctgctgaca cccctgactt ttattaaaga ataagctgtc gttacagta
//
