LOCUS       NM_178176               2147 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens monoacylglycerol O-acyltransferase 3 (MOGAT3),
            transcript variant 1, mRNA.
ACCESSION   NM_178176
VERSION     NM_178176.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Ma,Z., Onorato,J.M., Chen,L., Nelson,D.W., Yen,C.E. and Cheng,D.
  TITLE     Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid
            acyltransferases
  JOURNAL   J Lipid Res 58 (6), 1091-1099 (2017)
   PUBMED   28420705
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Brandt,C., McFie,P.J. and Stone,S.J.
  TITLE     Biochemical characterization of human acyl coenzyme A:
            2-monoacylglycerol acyltransferase-3 (MGAT3)
  JOURNAL   Biochem Biophys Res Commun 475 (3), 264-270 (2016)
   PUBMED   27184406
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Cheng,D., Nelson,T.C., Chen,J., Walker,S.G., Wardwell-Swanson,J.,
            Meegalla,R., Taub,R., Billheimer,J.T., Ramaker,M. and Feder,J.N.
  TITLE     Identification of acyl coenzyme A:monoacylglycerol acyltransferase
            3, an intestinal specific enzyme implicated in dietary fat
            absorption
  JOURNAL   J Biol Chem 278 (16), 13611-13614 (2003)
   PUBMED   12618427
  REMARK    GeneRIF: MGAT3 encodes a approximately 36-kDa transmembrane protein
            that is highly homologous to MGAT1 and -2 and is expressed in the
            human gastrointestinal tract with the highest level found in the
            ileum
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   Winter,A., van Eckeveld,M., Bininda-Emonds,O.R., Habermann,F.A. and
            Fries,R.
  TITLE     Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos
            taurus) and other mammals
  JOURNAL   Cytogenet Genome Res 102 (1-4), 42-47 (2003)
   PUBMED   14970677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004876.2, AY229854.1 and BE042458.1.
            
            On Nov 24, 2018 this sequence version replaced NM_178176.3.
            
            Summary: Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC
            2.3.1.22) catalyzes the synthesis of diacylglycerol from
            2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed
            12618427]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY229854.1, AY358200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223114.9/ ENSP00000223114.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC004876.2         97057-97071         c
            16-1319             AY229854.1         1-1304
            1320-1351           BE042458.1         257-288             c
            1352-1425           AY229854.1         1337-1410
            1426-2147           AC004876.2         91042-91763         c
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2147
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /note="monoacylglycerol O-acyltransferase 3"
                     /db_xref="GeneID:346606"
                     /db_xref="HGNC:HGNC:23249"
                     /db_xref="MIM:610184"
     exon            1..291
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1208
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.22"
                     /note="isoform a is encoded by transcript variant 1; acyl
                     coenzyme A:monoacylglycerol acyltransferase 3;
                     2-acylglycerol O-acyltransferase 3;
                     acyl-CoA:monoacylglycerol acyltransferase 3;
                     diacylglycerol O-acyltransferase candidate 7;
                     diacylglycerol acyltransferase 2-like protein 7"
                     /codon_start=1
                     /product="2-acylglycerol O-acyltransferase 3 isoform a"
                     /protein_id="NP_835470.1"
                     /db_xref="CCDS:CCDS5714.1"
                     /db_xref="GeneID:346606"
                     /db_xref="HGNC:HGNC:23249"
                     /db_xref="MIM:610184"
                     /translation="MGVATTLQPPTTSKTLQKQHLEAVGAYQYVLTFLFMGPFFSLLV
                     FVLLFTSLWPFSVFYLVWLYVDWDTPNQGGRRSEWIRNRAIWRQLRDYYPVKLVKTAE
                     LPPDRNYVLGAHPHGIMCTGFLCNFSTESNGFSQLFPGLRPWLAVLAGLFYLPVYRDY
                     IMSFGLCPVSRQSLDFILSQPQLGQAVVIMVGGAHEALYSVPGEHCLTLQKRKGFVRL
                     ALRHGASLVPVYSFGENDIFRLKAFATGSWQHWCQLTFKKLMGFSPCIFWGRGLFSAT
                     SWGLLPFAVPITTVVGRPIPVPQRLHPTEEEVNHYHALYMTALEQLFEEHKESCGVPA
                     STCLTFI"
     exon            292..399
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..470
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..675
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..850
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1053
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..2147
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /note="hexamer: AATAAA"
     polyA_site      1307
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /note="major polyA site"
     regulatory      2125..2130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /note="hexamer: AATAAA"
     polyA_site      2147
                     /gene="MOGAT3"
                     /gene_synonym="DC7; DGAT2L2; MGAT3"
                     /note="major polyA site"
ORIGIN      
        1 atccaaagat ctccccactc acacacctac ggacacacgc tactctggga ggtgatttgc
       61 gacttagcca ggcccccaaa gctgggctcc tgtagggaga aagtctgccc aggtccacat
      121 ccaagccttc atcgtttgtc ctccgggttc tgggatcctg ctggaagagg ggagcttctg
      181 caatgggagt tgccacaacc ctgcagcccc caaccacttc caaaaccttg cagaagcagc
      241 atctagaagc agtgggcgcc taccaatatg tgctcacttt cctcttcatg ggccctttct
      301 tctcccttct tgtctttgtc ctcctcttca cgtcactctg gcccttctct gttttttact
      361 tggtgtggct ctatgtggac tgggacacac ccaaccaagg tggaaggcgt tcggagtgga
      421 taaggaaccg ggcaatttgg agacaactaa gggattatta tcctgtcaag ctggtgaaaa
      481 cagcagagct gcccccggat cggaactacg tgctgggcgc ccaccctcat gggatcatgt
      541 gtacaggctt cctctgtaat ttctccaccg agagcaatgg cttctcccag ctcttcccgg
      601 ggctccggcc ctggttagcc gtgctggctg gcctcttcta cctcccggtc tatcgcgact
      661 acatcatgtc ctttggactc tgtccggtga gccgccagag cctggacttc atcctgtccc
      721 agccccagct cgggcaggcc gtggtcatca tggtgggggg tgcgcacgag gccctgtatt
      781 cagtccccgg ggagcactgc cttacgctcc agaagcgcaa aggcttcgtg cgcctggcgc
      841 tgaggcacgg ggcgtccctg gtgcccgtgt actcctttgg ggagaatgac atctttagac
      901 ttaaggcttt tgccacaggc tcctggcagc attggtgcca gctcaccttc aagaagctca
      961 tgggcttctc tccttgcatc ttctggggtc gcggtctctt ctcagccacc tcctggggcc
     1021 tgctgccctt tgctgtgccc atcaccactg tggtgggccg ccccatcccc gtcccccagc
     1081 gcctccaccc caccgaggag gaagtcaatc actatcacgc cctctacatg acggccctgg
     1141 agcagctctt cgaggagcac aaggaaagct gtggggtccc cgcttccacc tgcctcacct
     1201 tcatctaggc ctggccgcgg cctttcgctg agcccctgag cccaaggcac tgagacctcc
     1261 acccactgtg gactccatgc ctccaataaa aggtagttct gggcccagcg cagtgcctca
     1321 tgcctgtaat cccagcactt tgggaggcca aggtgggagg atcgtttgag cccaggagtt
     1381 gaagaccagc ctgggcaaca cagtgagact tcatttctac aaaaattaaa aaataatgtt
     1441 gttaattagc cgggcatggt ggcatgtgcc tgtaatccca gctatttggg aggctgaggc
     1501 aggagacttg cttaaaccca ggaggcggag gttgcagtga gctgagatca caccacagta
     1561 ctccagcctg ggcaacacag cgagactcaa tctcaaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 gactgttaaa gctgtagtag gctgggcgtg gtggctcatg cccataatcc caacactttg
     1681 ggaagccgag gcaggtggat caactgaggt caggagttca agaccagcct ggccaaaatg
     1741 gcaaaacccc ctctctacta aaactacaaa aattagccgg gcatggtggc tcatgcctat
     1801 aatcccagct actccggagg ctgaggcagg agaatcgctt gaacccagga ggcagaggtt
     1861 gcagtgagcc gagatcacac cactgcactc cagtctgggc aacagagcga gattccatct
     1921 caaaaaaaaa aaaatgttgt taaagctata atcgttctgg aagtgaacat ggccaggcat
     1981 gacctgcccc catcctgatg tgctacaaag ctgctgcctt agattgggta tcaggaccct
     2041 gaactgtcct cccagtgaga gttcagtctg tggcatgacc ttggacaagc ctcttccttt
     2101 tgcctgttta cttctttgtc tgtaaataaa ggcatctgct tagcaaa
//
