LOCUS       NM_025098               2723 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens monoacylglycerol O-acyltransferase 2 (MOGAT2), mRNA.
ACCESSION   NM_025098
VERSION     NM_025098.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Fu,D., Zhang,B., Fan,W., Zeng,F., Feng,J. and Wang,X.
  TITLE     Fatty acid metabolism prognostic signature predicts tumor immune
            microenvironment and immunotherapy, and identifies tumorigenic role
            of MOGAT2 in lung adenocarcinoma
  JOURNAL   Front Immunol 15, 1456719 (2024)
   PUBMED   39478862
  REMARK    GeneRIF: Fatty acid metabolism prognostic signature predicts tumor
            immune microenvironment and immunotherapy, and identifies
            tumorigenic role of MOGAT2 in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Ma,Z., Onorato,J.M., Chen,L., Nelson,D.W., Yen,C.E. and Cheng,D.
  TITLE     Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid
            acyltransferases
  JOURNAL   J Lipid Res 58 (6), 1091-1099 (2017)
   PUBMED   28420705
REFERENCE   3  (bases 1 to 2723)
  AUTHORS   Qi,J., Lang,W., Connelly,M.A., Du,F., Liang,Y., Caldwell,G.W.,
            Martin,T., Hansen,M.K., Kuo,G.H., Gaul,M.D., Pocai,A. and Lee,S.
  TITLE     Metabolic tracing of monoacylglycerol acyltransferase-2 activity in
            vitro and in vivo
  JOURNAL   Anal Biochem 524, 68-75 (2017)
   PUBMED   27665677
  REMARK    GeneRIF: The use of 1-oleoyl-glycerol-d5 and (U13)C-TG oil followed
            by LC/ESI/MS/MS detection of stable-isotopic labeled DAG, TG, or
            glycerol provides a wide range of applications to study
            pathophysiological regulation of the monoacylglycerol pathway and
            MGAT2 activity.
REFERENCE   4  (bases 1 to 2723)
  AUTHORS   Brandt,C., McFie,P.J. and Stone,S.J.
  TITLE     Diacylglycerol acyltransferase-2 and monoacylglycerol
            acyltransferase-2 are ubiquitinated proteins that are degraded by
            the 26S proteasome
  JOURNAL   Biochem J 473 (20), 3621-3637 (2016)
   PUBMED   27531967
  REMARK    GeneRIF: Diacylglycerol acyltransferase-2 and monoacylglycerol
            acyltransferase-2 are ubiquitinated proteins that are degraded by
            the 26S proteasome
REFERENCE   5  (bases 1 to 2723)
  AUTHORS   Brandt,C., McFie,P.J. and Stone,S.J.
  TITLE     Biochemical characterization of human acyl coenzyme A:
            2-monoacylglycerol acyltransferase-3 (MGAT3)
  JOURNAL   Biochem Biophys Res Commun 475 (3), 264-270 (2016)
   PUBMED   27184406
REFERENCE   6  (bases 1 to 2723)
  AUTHORS   Cao,J., Hawkins,E., Brozinick,J., Liu,X., Zhang,H., Burn,P. and
            Shi,Y.
  TITLE     A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2
            in dietary fat absorption implicated by tissue distribution,
            subcellular localization, and up-regulation by high fat diet
  JOURNAL   J Biol Chem 279 (18), 18878-18886 (2004)
   PUBMED   14966132
REFERENCE   7  (bases 1 to 2723)
  AUTHORS   Lockwood,J.F., Cao,J., Burn,P. and Shi,Y.
  TITLE     Human intestinal monoacylglycerol acyltransferase: differential
            features in tissue expression and activity
  JOURNAL   Am J Physiol Endocrinol Metab 285 (5), E927-E937 (2003)
   PUBMED   12824082
REFERENCE   8  (bases 1 to 2723)
  AUTHORS   Yen,C.L. and Farese,R.V. Jr.
  TITLE     MGAT2, a monoacylglycerol acyltransferase expressed in the small
            intestine
  JOURNAL   J Biol Chem 278 (20), 18532-18537 (2003)
   PUBMED   12621063
  REMARK    GeneRIF: MGAT2 is a monoacylglycerol acyltransferase expressed in
            the small intestine
REFERENCE   9  (bases 1 to 2723)
  AUTHORS   Cao,J., Lockwood,J., Burn,P. and Shi,Y.
  TITLE     Cloning and functional characterization of a mouse intestinal
            acyl-CoA:monoacylglycerol acyltransferase, MGAT2
  JOURNAL   J Biol Chem 278 (16), 13860-13866 (2003)
   PUBMED   12576479
  REMARK    GeneRIF: MGAT2 may play an important role in dietary fat absorption
REFERENCE   10 (bases 1 to 2723)
  AUTHORS   Winter,A., van Eckeveld,M., Bininda-Emonds,O.R., Habermann,F.A. and
            Fries,R.
  TITLE     Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos
            taurus) and other mammals
  JOURNAL   Cytogenet Genome Res 102 (1-4), 42-47 (2003)
   PUBMED   14970677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA922421.1, AK291998.1 and
            AK000245.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025098.3.
            
            Summary: The protein encoded by this gene is an enzyme that
            catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol
            and fatty acyl-CoA. The encoded protein is important in the uptake
            of dietary fat by the small intestine. This protein forms a complex
            with diacylglycerol O-acyltransferase 2 in the endoplasmic
            reticulum, and this complex catalyzes the synthesis of
            triacylglycerol. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291998.1, BC103876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000198801.10/ ENSP00000198801.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA922421.1         21-25
            6-1366              AK291998.1         1-1361
            1367-2723           AK000245.1         595-1951
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..2723
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /note="monoacylglycerol O-acyltransferase 2"
                     /db_xref="GeneID:80168"
                     /db_xref="HGNC:HGNC:23248"
                     /db_xref="MIM:610270"
     exon            1..142
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1056
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.22"
                     /note="acyl-CoA:monoacylglycerol acyltransferase 2;
                     diacylglycerol O-acyltransferase candidate 5;
                     diacylglycerol acyltransferase 2-like protein 5"
                     /codon_start=1
                     /product="2-acylglycerol O-acyltransferase 2"
                     /protein_id="NP_079374.2"
                     /db_xref="CCDS:CCDS8240.1"
                     /db_xref="GeneID:80168"
                     /db_xref="HGNC:HGNC:23248"
                     /db_xref="MIM:610270"
                     /translation="MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFT
                     RFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRN
                     YIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGL
                     VTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGA
                     PLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPY
                     RRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
                     "
     exon            143..321
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..526
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..701
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..901
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..2723
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2703..2708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /note="hexamer: AATAAA"
     polyA_site      2723
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /note="major polyA site"
ORIGIN      
        1 agaccacagc agagctcaca gaacctgcgg gagccaggct gacccgccag catggtagag
       61 ttcgcgccct tgtttatgcc gtgggagcgc aggctgcaga cacttgctgt cctacagttt
      121 gtcttctcct tcttggcact ggccgagatc tgcactgtgg gcttcatagc cctcctgttt
      181 acaagattct ggctcctcac tgtcctgtat gcggcctggt ggtatctgga ccgagacaag
      241 ccacggcagg ggggccggca catccaggcc atcaggtgct ggactatatg gaagtacatg
      301 aaggactatt tccccatctc gctggtcaag actgctgagc tggacccctc tcggaactac
      361 attgcgggct tccaccccca tggagtcctg gcagtcggag cctttgccaa cctgtgcact
      421 gagagcacag gcttctcttc gatcttcccc ggtatccgcc cccatctgat gatgctgacc
      481 ttgtggttcc gggccccctt cttcagagat tacatcatgt ctgcagggtt ggtcacatca
      541 gaaaaggaga gtgctgctca cattctgaac aggaagggtg gcggaaactt gctgggcatc
      601 attgtagggg gtgcccagga ggccctggat gccaggcctg gatccttcac gctgttactg
      661 cggaaccgaa agggcttcgt caggctcgcc ctgacacacg gggcacccct ggtgccaatc
      721 ttctccttcg gggagaatga cctatttgac cagattccca actcttctgg ctcctggtta
      781 cgctatatcc agaatcggtt gcagaagatc atgggcatct ccctcccact ctttcatggc
      841 cgtggtgtct tccagtacag ctttggttta ataccctacc gccggcccat caccactgtg
      901 gtggggaagc ccatcgaggt acagaagacg ctgcatccct cggaggagga ggtgaaccag
      961 ctgcaccagc gttatatcaa agagctgtgc aacctcttcg aggcccacaa acttaagttc
     1021 aacatccctg ctgaccagca cttggagttc tgctgagccc aaagggcagg gccaacatta
     1081 gggagcccag caggaggtgc tgtgctgaga agacttcctg gaggtgtttg ttgaacatat
     1141 ctgcagagcc ttcccagact cctgcaaatc caacccatat caggctgtaa gtcagagcag
     1201 gcaatgcaga agaggagacc agaccaaggg gtcagctggg gctaggacag tgagggctgc
     1261 tagaggggct gggcctctct ttgcacatgg acactgggcc cctctctata ttgagtggtc
     1321 tgttaacatt cattggtggc tgattccaaa agatgagagc caaagctgca cggactcgag
     1381 tcctaggctg cacacctcac aagcatctct tctactgcat tctgttggtc gaagcaagtc
     1441 acaacccagc agattcaagg agtaaggaat aggatccccc tctggatggg aggagcagca
     1501 atgtcatatt acaaaagggt gtggacacat gcagggattc ttactgccgt ctttgcaaac
     1561 aatccaccaa aacttaaaaa ctaaaagcct gaagcacaag cactctccac cccaggcaca
     1621 cacaccctgg aattccctgt gtgaccatgg taccaccact gtgtgtcccg aggatcccag
     1681 ctcagctttg catcgctgcc ctatctccct ctcgctctcc cctgttgatc cctcatgcac
     1741 agccacagcg agctgtctaa aacacaaagc tgaccgcgcc atttcctact cagcatcctt
     1801 ccatgaccct ccattgctcc taggataggg tttggaccag tctgaatcca gaggatcagg
     1861 atccagcagg aaccagagga taatttgagg agggtttaaa aaggaaccat tttttgaggt
     1921 gtgtgcactg tttccaccct gaggcctgga aggatgaatg gaagcagcag ttcctgaacc
     1981 aggaagactc atgtgtgggg gccattgctg gtcaaggggc acgaacaggt ctggtgaccc
     2041 tgcaagggag gagccaggag caagcattcc cacttcacct tcctccattc agtctgctgc
     2101 caagttcccc actgcctgag cccaactaga agctggaggg aaggagggcc tgtggctgca
     2161 gtccaggcat gtaggcctcc tgggaaaggg agaatggcaa agacaggcag agtggatctg
     2221 gaggggtcaa cggaagacgg aacatgtcca cttccaggcc cgagcttctc agcctgccgt
     2281 ttgccactct ccagcatctg gcccagcctg tccatcctca tctctcttcc tcccttactc
     2341 cgtgctccca tcactcggaa ccatttgcat ttctttgtct cagctatatt gtctcacctc
     2401 tgagtttttg cccatgatgt tggatgccat ggaatgccat atcctcccca ttatctcccc
     2461 cttgtctgga taattcctac tcatcctaca atactgattt tatctgtgca aagaagtctt
     2521 ccccagtgcc tctggttgac aggggtttcc tctggcttct ccagactttc tgttcctcca
     2581 ccacagccct tagcaccctg gggaggaggt gttgctgtcc aggtaaatgc tgcgccaatg
     2641 cccctgcctc tagtgcactc cctccagcct acccacaaac aggacctgca tcctgtctca
     2701 caaataaaac tgaactcttg aaa
//
