LOCUS       NM_206809               2042 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens myelin oligodendrocyte glycoprotein (MOG), transcript
            variant alpha1, mRNA.
ACCESSION   NM_206809
VERSION     NM_206809.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Cho,E.B., Min,J.H., Waters,P., Jeon,M., Ju,E.S., Kim,H.J.,
            Kim,S.H., Shin,H.Y., Kang,S.Y., Lim,Y.M., Oh,S.Y., Lee,H.L.,
            Sohn,E., Lee,S.S., Oh,J., Kim,S., Huh,S.Y., Cho,J.Y., Seok,J.M.,
            Kim,B.J. and Kim,B.J.
  TITLE     Differentiated pattern of complement system activation between
            MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis
            optica spectrum disorder
  JOURNAL   Front Immunol 15, 1320094 (2024)
   PUBMED   38576611
  REMARK    GeneRIF: Differentiated pattern of complement system activation
            between MOG-IgG-associated disease and AQP4-IgG-positive
            neuromyelitis optica spectrum disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Boyle,L.H., Traherne,J.A., Plotnek,G., Ward,R. and Trowsdale,J.
  TITLE     Splice variation in the cytoplasmic domains of myelin
            oligodendrocyte glycoprotein affects its cellular localisation and
            transport
  JOURNAL   J Neurochem 102 (6), 1853-1862 (2007)
   PUBMED   17573820
  REMARK    GeneRIF: Our findings highlight myelin oligodendrocyte glycoprotein
            splicing as a factor that could be critical to the phenotypic
            expression of multiple sclerosis.
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Allamargot,C. and Gardinier,M.V.
  TITLE     Alternative isoforms of myelin/oligodendrocyte glycoprotein with
            variable cytoplasmic domains are expressed in human brain
  JOURNAL   J Neurochem 101 (2), 298-312 (2007)
   PUBMED   17402967
  REMARK    GeneRIF: This study represents the first evidence of alternative
            translation products from the MOG gene. To date, it is believed
            that alternative splicing of MOG is limited to primates.
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Delarasse,C., Della Gaspera,B., Lu,C.W., Lachapelle,F., Gelot,A.,
            Rodriguez,D., Dautigny,A., Genain,C. and Pham-Dinh,D.
  TITLE     Complex alternative splicing of the myelin oligodendrocyte
            glycoprotein gene is unique to human and non-human primates
  JOURNAL   J Neurochem 98 (6), 1707-1717 (2006)
   PUBMED   16903876
  REMARK    GeneRIF: In human brain the splice variants of MOG appear at a late
            stage compared to the major isoform, coincidental with myelination
            and myelin maturation, unlike other myelin proteins.
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Ballenthin,P.A. and Gardinier,M.V.
  TITLE     Myelin/oligodendrocyte glycoprotein is alternatively spliced in
            humans but not mice
  JOURNAL   J Neurosci Res 46 (2), 271-281 (1996)
   PUBMED   8915905
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Pham-Dinh,D., Della Gaspera,B., Kerlero de Rosbo,N. and Dautigny,A.
  TITLE     Structure of the human myelin/oligodendrocyte glycoprotein gene and
            multiple alternative spliced isoforms
  JOURNAL   Genomics 29 (2), 345-352 (1995)
   PUBMED   8666381
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Roth,M.P., Malfroy,L., Offer,C., Sevin,J., Enault,G., Borot,N.,
            Pontarotti,P. and Coppin,H.
  TITLE     The human myelin oligodendrocyte glycoprotein (MOG) gene: complete
            nucleotide sequence and structural characterization
  JOURNAL   Genomics 28 (2), 241-250 (1995)
   PUBMED   8530032
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Hilton,A.A., Slavin,A.J., Hilton,D.J. and Bernard,C.C.
  TITLE     Characterization of cDNA and genomic clones encoding human myelin
            oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 65 (1), 309-318 (1995)
   PUBMED   7790876
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Pham-Dinh,D., Allinquant,B., Ruberg,M., Della Gaspera,B.,
            Nussbaum,J.L. and Dautigny,A.
  TITLE     Characterization and expression of the cDNA coding for the human
            myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 63 (6), 2353-2356 (1994)
   PUBMED   7964757
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Pham-Dinh,D., Mattei,M.G., Nussbaum,J.L., Roussel,G.,
            Pontarotti,P., Roeckel,N., Mather,I.H., Artzt,K., Lindahl,K.F. and
            Dautigny,A.
  TITLE     Myelin/oligodendrocyte glycoprotein is a member of a subset of the
            immunoglobulin superfamily encoded within the major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 7990-7994 (1993)
   PUBMED   8367453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA139582.1, X74511.1,
            DA140757.1, U64564.1 and AL119259.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_206809.3.
            
            Summary: The product of this gene is a membrane protein expressed
            on the oligodendrocyte cell surface and the outermost surface of
            myelin sheaths. Due to this localization, it is a primary target
            antigen involved in immune-mediated demyelination. This protein may
            be involved in completion and maintenance of the myelin sheath and
            in cell-cell communication. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (alpha1) contains an additional
            segment in the coding region compared to variant beta1. Alpha type
            variants use an alternative splice site at the 3' end, compared to
            variant beta1. The resulting isoform (alpha1), also known as
            isoform 2, contains a shorter and distinct C-terminus compared to
            isoform beta1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.7542.1, U64564.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376917.8/ ENSP00000366115.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               DA139582.1         103-235
            134-637             X74511.1           16-519
            638-654             DA140757.1         599-615
            655-862             X74511.1           537-744
            863-1695            U64564.1           907-1739
            1696-1968           AL119259.1         517-789
            1969-2042           U64564.1           2012-2085
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..2042
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /note="myelin oligodendrocyte glycoprotein"
                     /db_xref="GeneID:4340"
                     /db_xref="HGNC:HGNC:7197"
                     /db_xref="MIM:159465"
     exon            1..206
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..862
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /note="isoform alpha1 precursor is encoded by transcript
                     variant alpha1; MOG Ig-AluB; MOG alpha-5; MOG AluA; MOG
                     AluB"
                     /codon_start=1
                     /product="myelin-oligodendrocyte glycoprotein isoform
                     alpha1 precursor"
                     /protein_id="NP_996532.2"
                     /db_xref="CCDS:CCDS34370.1"
                     /db_xref="GeneID:4340"
                     /db_xref="HGNC:HGNC:7197"
                     /db_xref="MIM:159465"
                     /translation="MASLSRPSLPSCLCSFLLLLLLQVSSSYAGQFRVIGPRHPIRAL
                     VGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLK
                     DAIGEGKVTLRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKVEDPFYWVSPGVLVLLA
                     VLPVLLLQITVGLIFLCLQYRLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVL
                     GPLVALIICYNWLHRRLAGQFLEELRNPF"
     exon            207..554
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     exon            555..668
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     exon            669..689
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     exon            690..710
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     exon            711..827
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     exon            828..848
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     exon            849..2042
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /note="hexamer: ATTACA"
     polyA_site      1254
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /note="major polyA site"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /note="hexamer: AATACA"
     polyA_site      2042
                     /gene="MOG"
                     /gene_synonym="BTN6; BTNL11; MOGIG2; NRCLP7"
                     /note="major polyA site"
ORIGIN      
        1 agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa
       61 gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat
      121 ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct
      181 cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat
      241 ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc
      301 tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag
      361 aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct
      421 gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga
      481 tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga
      541 attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt
      601 gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag
      661 actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt
      721 tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt
      781 ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga
      841 agagctacga aatcccttct gagtgatgtc acatcttggc aggggtggag gagagcctgg
      901 ttgcccaggg atttgtcctt ggggacatct catccatcaa gttgcacact cactggcatc
      961 tttgctatgg ggacattcca atttgcactt tcaggaacac tctgaattcc aagtagaatt
     1021 gatttccctt cttctgtcat ctaccttttc tcttcatttt cccattttta ttacccttct
     1081 ttccatttct ctctccagtc ttccacctgg aagccctctc tggctaagga caggcaggtg
     1141 cccctctctc catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg
     1201 aactggaggc caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg
     1261 ttgtttcttc caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg
     1321 aagaggaaga gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga
     1381 gtagccccaa cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct
     1441 ccttgtcttg gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc
     1501 ctgctttaga atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt
     1561 cctctcatcc ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac
     1621 tactacttga tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt
     1681 tttggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc
     1741 gaatcacgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac
     1801 taaaaataca aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg
     1861 aggctgaggc aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg
     1921 tgccactgca ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa
     1981 ataaataaat aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca
     2041 ca
//
