LOCUS       NM_017947               6182 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.
ACCESSION   NM_017947
VERSION     NM_017947.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6182)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6182)
  AUTHORS   Rontani,P., Perche,O., Greetham,L., Jullien,N., Gepner,B.,
            Feron,F., Nivet,E. and Erard-Garcia,M.
  TITLE     Impaired expression of the COSMOC/MOCOS gene unit in ASD patient
            stem cells
  JOURNAL   Mol Psychiatry 26 (5), 1606-1618 (2021)
   PUBMED   32327736
  REMARK    GeneRIF: Impaired expression of the COSMOC/MOCOS gene unit in ASD
            patient stem cells.
REFERENCE   3  (bases 1 to 6182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6182)
  AUTHORS   Taheri,M., Noroozi,R., Aghaei,K., Omrani,M.D. and Ghafouri-Fard,S.
  TITLE     The rs594445 in MOCOS gene is associated with risk of autism
            spectrum disorder
  JOURNAL   Metab Brain Dis 35 (3), 497-501 (2020)
   PUBMED   31900757
  REMARK    GeneRIF: The rs594445 in MOCOS gene is associated with risk of
            autism spectrum disorder.
REFERENCE   5  (bases 1 to 6182)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 6182)
  AUTHORS   Peretz,H., Naamati,M.S., Levartovsky,D., Lagziel,A., Shani,E.,
            Horn,I., Shalev,H. and Landau,D.
  TITLE     Identification and characterization of the first mutation
            (Arg776Cys) in the C-terminal domain of the Human Molybdenum
            Cofactor Sulfurase (HMCS) associated with type II classical
            xanthinuria
  JOURNAL   Mol Genet Metab 91 (1), 23-29 (2007)
   PUBMED   17368066
  REMARK    GeneRIF: Two mutations, both in the N-terminal domain of the Human
            Molybdenum Cofactor Sulfurase (HMCS), were reported in patients
            with type II xanthinuria.
REFERENCE   7  (bases 1 to 6182)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 6182)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 6182)
  AUTHORS   Yamamoto,T., Moriwaki,Y., Takahashi,S., Tsutsumi,Z., Tuneyoshi,K.,
            Matsui,K., Cheng,J. and Hada,T.
  TITLE     Identification of a new point mutation in the human molybdenum
            cofactor sulferase gene that is responsible for xanthinuria type II
  JOURNAL   Metabolism 52 (11), 1501-1504 (2003)
   PUBMED   14624414
REFERENCE   10 (bases 1 to 6182)
  AUTHORS   Ichida,K., Matsumura,T., Sakuma,R., Hosoya,T. and Nishino,T.
  TITLE     Mutation of human molybdenum cofactor sulfurase gene is responsible
            for classical xanthinuria type II
  JOURNAL   Biochem Biophys Res Commun 282 (5), 1194-1200 (2001)
   PUBMED   11302742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023043.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017947.3.
            
            Summary: This gene encodes an enzyme that sulfurates the molybdenum
            cofactor which is required for activation of the xanthine
            dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH
            catalyzes the conversion of hypoxanthine to uric acid via xanthine,
            as well as the conversion of allopurinol to oxypurinol, and
            pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene
            cause the metabolic disorder classical xanthinuria type II which is
            characterized by the loss of XDH/XO and AO enzyme activity,
            decreased levels of uric acid in the urine, increased levels of
            xanthine and hypoxanthine in the serum and urine, formation of
            xanthine stones in the urinary tract, and myositis due to tissue
            deposition of xanthine. [provided by RefSeq, Apr 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000740.1, AK222886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261326.6/ ENSP00000261326.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC023043.8         27584-27768
            186-275             AC023043.8         35344-35433
            276-342             AC023043.8         38777-38843
            343-984             AC023043.8         39770-40411
            985-1061            AC023043.8         43200-43276
            1062-1261           AC023043.8         45164-45363
            1262-1378           AC023043.8         53453-53569
            1379-1840           AC023043.8         55603-56064
            1841-2003           AC023043.8         60142-60304
            2004-2082           AC023043.8         89009-89087
            2083-2207           AC023043.8         91246-91370
            2208-2313           AC023043.8         97055-97160
            2314-2452           AC023043.8         100124-100262
            2453-2557           AC023043.8         106836-106940
            2558-6182           AC023043.8         108620-112244
FEATURES             Location/Qualifiers
     source          1..6182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..6182
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /note="molybdenum cofactor sulfurase"
                     /db_xref="GeneID:55034"
                     /db_xref="HGNC:HGNC:18234"
                     /db_xref="MIM:613274"
     exon            1..185
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2710
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /EC_number="2.8.1.9"
                     /note="human molybdenum cofactor sulfurase"
                     /codon_start=1
                     /product="molybdenum cofactor sulfurase"
                     /protein_id="NP_060417.4"
                     /db_xref="CCDS:CCDS11919.1"
                     /db_xref="GeneID:55034"
                     /db_xref="HGNC:HGNC:18234"
                     /db_xref="MIM:613274"
                     /translation="MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFS
                     RLAGTVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRIL
                     AHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRN
                     VTMAINVISTPVRPEDLWSAEERSASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEE
                     VKSGRLHPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALL
                     VHNRAAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDT
                     LERLTGGMENIKQHTFTLAQYTYVALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINF
                     NVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHFQAGHVC
                     GDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGET
                     GAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPT
                     PSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGV
                     CLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVS
                     TYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYL
                     LINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIG
                     SLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPC
                     FLSVGSQVLPVLKENVEGHDLPASEKHQDVTS"
     exon            186..275
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            276..342
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            343..984
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1061
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1261
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1378
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1840
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2003
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2082
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2207
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2313
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2452
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2557
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..6182
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5381..5386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /note="hexamer: AATATA"
     polyA_site      5402
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /note="major polyA site"
     regulatory      6159..6164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /note="hexamer: ATTAAA"
     polyA_site      6182
                     /gene="MOCOS"
                     /gene_synonym="HMCS; MCS; MOS"
                     /note="major polyA site"
ORIGIN      
        1 gcacttcccg ggcccggccg gcctggatgg actagccggg gccatggccg gcgcggcggc
       61 ggagtcaggg cgggagctgt ggaccttcgc gggttcccgg gacccgagcg caccgcggct
      121 agcctacggc tacggcccgg gcagcctgcg cgagctgcgg gcgcgcgagt tcagccgcct
      181 ggcaggaact gtctatcttg accatgcagg tgccaccttg ttctcccaga gccagctcga
      241 aagcttcact agtgatctca tggaaaacac ttatggtaat cctcacagcc agaacatcag
      301 cagcaagctc acccatgaca ctgtggagca ggtgcgctac agaatcctgg cgcacttcca
      361 caccaccgca gaagactaca ctgtgatctt cactgccggg agcacggctg ctctcaaact
      421 ggtggcagag gcctttccat gggtgtccca gggcccagag agcagtggga gtcgcttctg
      481 ttacctcacc gacagccaca cctccgtagt gggtatgcgg aacgtgacca tggctataaa
      541 tgtcatatcc accccggtca ggccagagga cctgtggtct gcagaggaac gtagtgcttc
      601 agccagcaac ccagactgcc agctgccgca tctcttctgc tacccagctc agagtaactt
      661 ttctggagtc agataccccc tgtcctggat agaagaggtc aagtctgggc ggttgcaccc
      721 tgtgagcacg cctgggaagt ggtttgtgct gctggatgca gcctcctacg tgagcacctc
      781 gcctttggac ctgtcagctc accaggccga ctttgtcccc atctccttct ataagatctt
      841 cgggtttcct acaggcctgg gcgctctgct ggtccataat cgtgcggctc ctctactgag
      901 gaagacctac tttggaggag ggacagcctc tgcgtaccta gcaggagaag acttctacat
      961 cccgaggcag tcggtagctc agaggtttga agatggcacc atctcattcc ttgatgttat
     1021 cgcgctaaaa catggatttg acaccctaga gcgcctcaca ggtggaatgg agaatataaa
     1081 gcagcacacc ttcaccttgg ctcagtatac ctacgtggcc ctgtcctctc tccagtaccc
     1141 caatggagcc cctgtggtgc ggatttacag cgattctgag ttcagcagcc ctgaggttca
     1201 gggcccaatc atcaatttta atgtgctgga tgacaaaggg aacatcattg gttactccca
     1261 ggtggacaaa atggccagtc tttacaacat ccacctgcga actggctgct tctgtaacac
     1321 tggggcctgc cagaggcacc tgggcataag caacgagatg gtcaggaagc attttcaggc
     1381 tggtcatgtc tgtggggaca atatggacct catagatggg cagcccacag gatctgtgag
     1441 gatttcattt ggatacatgt cgacgctgga tgatgtccag gcctttctta ggttcatcat
     1501 agacactcgc ctgcactcat caggggactg gcctgtccct caggcccatg ctgacaccgg
     1561 ggagactgga gccccatcag cagacagcca ggctgatgtt atacctgctg tcatgggcag
     1621 acgtagcctc tcgcctcagg aagatgccct cacaggctcc agggtttgga acaactcgtc
     1681 tactgtgaat gctgtgcctg tggccccacc tgtgtgtgat gtcgccagaa cccagccgac
     1741 tccttcagag aaagctgcag gagtcctgga gggggccctt gggccacatg ttgtcactaa
     1801 cctttatctc tatccaatca aatcctgtgc tgcatttgag gtgaccaggt ggcctgtagg
     1861 aaaccaaggg ctgctatatg accggagctg gatggttgtg aatcacaatg gtgtttgcct
     1921 gagtcagaag caggaacccc ggctctgcct gatccagccc ttcatcgact tgcggcaaag
     1981 gatcatggtc atcaaagcca aagggatgga gcctatagag gtgcctcttg aggaaaatag
     2041 tgaacggact cagattcgcc aaagcagggt ctgtgctgac agagtaagta cttatgattg
     2101 tggagaaaaa atttcaagct ggttgtcaac attttttggc cgtccttgtc atttgatcaa
     2161 acaaagttca aactctcaaa ggaatgcaaa gaagaaacat ggaaaagatc aacttcctgg
     2221 tacaatggcc accctttctc tggtgaatga ggcacagtat ctgctgatca acacatccag
     2281 tattttggaa cttcaccggc aactaaacac cagtgatgag aatggaaagg aggaattatt
     2341 ctcactgaag gatctcagct tgcgttttcg tgccaatatt attatcaatg gaaaaagggc
     2401 ttttgaagaa gagaaatggg atgagatttc aattggctct ttgcgtttcc aggttttggg
     2461 gccttgtcac agatgccaga tgatttgcat cgaccagcaa actgggcaac gaaaccagca
     2521 tgttttccaa aaactttctg agagtcgtga aacaaaggtg aactttggca tgtacctgat
     2581 gcatgcatca ttggatttat cctccccatg tttcctgtct gtaggatctc aggtgctccc
     2641 tgtgttgaaa gagaatgtgg aaggtcatga tttacctgca tctgagaaac accaggatgt
     2701 tacctcctaa aaaaaatttt tagcataaag tttctctttt acagtgatct ctattattgt
     2761 taagatctgc aacttggttc agtagaactt gatgttttga ataaggagag ctctttttct
     2821 ttagaggcag ggaatgctct cacctgcttc cttctgcctt tgacttctca ccctgcaaat
     2881 ttgcactggc tgtgctcagg agagcacttc tgaggcctca ggaacgaatg ctgcacccac
     2941 atccagtgag gctcctgtag gtatttgaag tataatcact tgtaatcaga tgaaattttt
     3001 aatgaagttc actgggaaga ttgaacttac tgcgggtccc tattttgcca ttttctcaca
     3061 ttgttacttt gtttttagag agcatctttg gatctctcca acccgtttgt agtgaggaag
     3121 ggagtctatg cccagtgatc ctgggtatga gaaggtgctc ctctcctccc atgtacatga
     3181 tggtgtgggt ttatgctcag gggcccagag ggtaacttgt gaccacattc cttgagggga
     3241 gtttctacca gaatatttat attctgagca aaggcacagg ccagcaattc ctttcctgtt
     3301 gcttcccatc cctggcctcc gtcctcatcc cccactgagt tgatgcactg aggatggctc
     3361 acgagcctga agttacactc agtgatggct gtgcttatgc aggttgtcat cctcccctcc
     3421 acaagcccac aggatggtgt tggtccatca cccgagagcc tccaaatcct atcgagggag
     3481 gaactttggc attcaggaat cctgtctgta tcatctttga ccactgctcc tgcagcctcc
     3541 agatgaaaat gtccagtgag gaaatctcat tctctaatga agttacccat cccgctgagt
     3601 ttctaagaag tttctccctg tgcggagctt gtgtgtgcct tatctgcttc tgcatgactt
     3661 ccagcctggg gtcttaccct gtcctctgga gcaatgcaga gtgagtacat ccactccaca
     3721 ttcattctgc tggcgtcctt ctgaagcctg ctgtccatgt gtgaacccag tcccttcatc
     3781 atcttccccc tggatggttg tatttttcca gtcacttctc ccccaaatgt ctgcctgctg
     3841 cagcccactg catcttttga aagcctgtgc caccccatct ctcctgctgc tcagttggag
     3901 agcaggctcc aggctcaggc ttccctaatg tatctgttca gagcctgtgg gattcagggt
     3961 cagtttgttt cattatcaca tttgtaggac tttgtgttgt tcccagcact aggtgagatt
     4021 tgaaagatga ggtgtgctct gttctcaagg attgttgaga tggagcctaa tgattgcaca
     4081 ctcacgtgct gtgaagagtt aagggtaaaa agtacaactc tgactctggt tcctgagatc
     4141 accgaaagaa gaggcaaatg aagttaggtg gggtggggtg gggtttattg ttttgaactg
     4201 tttattaaaa acgcaacctc ttcaaagact cagcactgcc acatcatatg agtggacttg
     4261 tcctcatcag ctaactgata ggagaacaat gccctaaagt aatggattta tccacctact
     4321 caggccagtt tcatgcagga gggaactttc cagatggcac attgccccat ttccaagacc
     4381 ttccgctgac aaatgcatca tattaattat gatggaaaac aagtaagaag gcatgctcta
     4441 caaaaattag gtcacttgcc caggtgcggt ggctcacacc tgtaattcca gcactttggg
     4501 aggctgacgt gggcagatca tgaggtcagg agatcgagac catcctggct aacacggtga
     4561 aaccccgtct ctactaaaat acaaaaaatt agctgggcat ggtggcatgc acctgtagtc
     4621 ccagctactt gggaggctga ggcaggggaa tcgcttgaac ccgggaggcg gaggttgcag
     4681 tgagccgaga tcatgccact gcacaccggc ctggtgacag agcaagactc catctcaaaa
     4741 aaaaaaaaaa aaaaattagg tcacttttgt catcaagaat atgtttttct tatccacgtc
     4801 tatgtcacct tttgcagtag atactttcat gactgatttc aggctttttg tttttttgag
     4861 acagggtctc actctgtcac ccaggctgga gtgcagtggc atgatcacag atcattgcag
     4921 ccttgacctc ttgggctcaa gcgattcccc tgcctcagcc tcccaagtag ctgggactac
     4981 aggcacacat caccacatcc agctaatttt ttttttcttt tttttctttt tggtagagat
     5041 ggcatctcac tttgttgccc aggctagttt tgaattcctg ggctcaagcc atcctcccgc
     5101 cacagcctcc caaagttctg ggattacaag tgtgagccac tgtgcccagc ttttgatttc
     5161 agacatttta atgcagatcc tctcctttac agcactatta tttggttatc tacttataat
     5221 tactgattta acattgatct gttttcacta gactgtaagc tccatgagga caagtcctgt
     5281 gccagtatat ctctagtgtc agcagacaat actcaaaatt tgttgacaga ctatttaaag
     5341 ctgcccctat ttttatcatt aattgattga atattaatta aatatatttt attaatttaa
     5401 aatgaatttt aaatgcattt tttctttagt gtctaccttc aatatttctt gtatgaagtt
     5461 tcagctaaaa atgtactttg tgtatctgta gagtggcttc atattcagag tttatggaca
     5521 tttatgattt tatgtcccct ccttggttct tatctcctgg agttcagcct tatgtgcttc
     5581 tcaaagtgta taacaaaatc aaagacaatg tcatgtccct tgaatttaat tctaacacca
     5641 aaccttggtg ttagagtcac aaaaagtcct tttttaaaaa aacttggtga gaacagacaa
     5701 taacttgtct ttctgggcat tcgcgtcatg gtccttttag ccagaagaga ggttttcttt
     5761 tgcatagttt ggtgagcatc aagaatcctt taaggagggt ggcggtgctg acttctcccc
     5821 attgagagtc agcctcatcc cctcctcagc cttgtggatg gagaagaaca ggcagtgata
     5881 tacattttct gctgttgaaa gatgtccgct tatccttctc tttcagtgaa aagttgcttt
     5941 tttattcaat atgtactgaa caggttctag agtttcagaa acaaaagaaa cagaaccaac
     6001 atttatagat ctcactatag aggcatcact aattggggaa agacagacta ggtaatagtc
     6061 agatgtgata tagtatgttt aagctatagg atggcaggtg catgagtgtt ggttgtatta
     6121 ttctttattt ttttgtatga cttatgatat tcatgataat taaaacgttt tggaacaatt
     6181 ca
//
