LOCUS       NM_001393704             848 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens myelin associated oligodendrocyte basic protein
            (MOBP), transcript variant 8, mRNA.
ACCESSION   NM_001393704
VERSION     NM_001393704.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 848)
  AUTHORS   Siokas,V., Aloizou,A.M., Liampas,I., Bakirtzis,C., Tsouris,Z.,
            Sgantzos,M., Liakos,P., Bogdanos,D.P., Hadjigeorgiou,G.M. and
            Dardiotis,E.
  TITLE     Myelin-associated oligodendrocyte basic protein rs616147
            polymorphism as a risk factor for Parkinson's disease
  JOURNAL   Acta Neurol Scand 145 (2), 223-228 (2022)
   PUBMED   34694630
  REMARK    GeneRIF: Myelin-associated oligodendrocyte basic protein rs616147
            polymorphism as a risk factor for Parkinson's disease.
REFERENCE   2  (bases 1 to 848)
  AUTHORS   Liampas,I., Siokas,V., Aloizou,A.M., Bakirtzis,C., Tsouris,Z.,
            Nousia,A., Nasios,G., Papadimitriou,D., Liakos,P., Bogdanos,D.P.,
            Hadjigeorgiou,G.M. and Dardiotis,E.
  TITLE     MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral
            Sclerosis in a Greek Population: A Case-Control Study
  JOURNAL   Medicina (Kaunas) 57 (12), 1337 (2021)
   PUBMED   34946282
  REMARK    GeneRIF: MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral
            Sclerosis in a Greek Population: A Case-Control Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 848)
  AUTHORS   Bettencourt,C., Miki,Y., Piras,I.S., de Silva,R., Foti,S.C.,
            Talboom,J.S., Revesz,T., Lashley,T., Balazs,R., Vire,E.,
            Warner,T.T., Huentelman,M.J. and Holton,J.L.
  TITLE     MOBP and HIP1 in multiple system atrophy: New alpha-synuclein
            partners in glial cytoplasmic inclusions implicated in the disease
            pathogenesis
  JOURNAL   Neuropathol Appl Neurobiol 47 (5), 640-652 (2021)
   PUBMED   33368549
  REMARK    GeneRIF: MOBP and HIP1 in multiple system atrophy: New
            alpha-synuclein partners in glial cytoplasmic inclusions implicated
            in the disease pathogenesis.
REFERENCE   4  (bases 1 to 848)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 848)
  AUTHORS   Bettencourt,C., Foti,S.C., Miki,Y., Botia,J., Chatterjee,A.,
            Warner,T.T., Revesz,T., Lashley,T., Balazs,R., Vire,E. and
            Holton,J.L.
  TITLE     White matter DNA methylation profiling reveals deregulation of
            HIP1, LMAN2, MOBP, and other loci in multiple system atrophy
  JOURNAL   Acta Neuropathol 139 (1), 135-156 (2020)
   PUBMED   31535203
  REMARK    GeneRIF: White matter DNA methylation profiling reveals
            deregulation of HIP1, LMAN2, MOBP, and other loci in multiple
            system atrophy.
REFERENCE   6  (bases 1 to 848)
  AUTHORS   Mitkus,S.N., Hyde,T.M., Vakkalanka,R., Kolachana,B.,
            Weinberger,D.R., Kleinman,J.E. and Lipska,B.K.
  TITLE     Expression of oligodendrocyte-associated genes in dorsolateral
            prefrontal cortex of patients with schizophrenia
  JOURNAL   Schizophr Res 98 (1-3), 129-138 (2008)
   PUBMED   17964117
  REMARK    GeneRIF: MOBP mRNA levels were increased in the DLPFC white matter
            in patients with a history of substance abuse.
REFERENCE   7  (bases 1 to 848)
  AUTHORS   Albertson,D.N., Pruetz,B., Schmidt,C.J., Kuhn,D.M., Kapatos,G. and
            Bannon,M.J.
  TITLE     Gene expression profile of the nucleus accumbens of human cocaine
            abusers: evidence for dysregulation of myelin
  JOURNAL   J Neurochem 88 (5), 1211-1219 (2004)
   PUBMED   15009677
  REMARK    GeneRIF: Decreased expression of a number of myelin-related genes,
            including myelin basic protein (MBP), proteolipid protein (PLP),
            and myelin-associated oligodendrocyte basic protein (MOBP) was
            noted in nucleus accumbens of cocaine abusers
REFERENCE   8  (bases 1 to 848)
  AUTHORS   Montague,P., Barrie,J.A., Thomson,C.E., Kirkham,D., McCallion,A.S.,
            Davies,R.W., Kennedy,P.G. and Griffths,I.R.
  TITLE     Cytoskeletal and nuclear localization of myelin oligodendrocytic
            basic protein isoforms
  JOURNAL   Eur J Neurosci 10 (4), 1321-1328 (1998)
   PUBMED   9749786
REFERENCE   9  (bases 1 to 848)
  AUTHORS   Yamamoto,Y., Mizuno,R., Nishimura,T., Ogawa,Y., Yoshikawa,H.,
            Fujimura,H., Adachi,E., Kishimoto,T., Yanagihara,T. and Sakoda,S.
  TITLE     Cloning and expression of myelin-associated oligodendrocytic basic
            protein. A novel basic protein constituting the central nervous
            system myelin
  JOURNAL   J Biol Chem 269 (50), 31725-31730 (1994)
   PUBMED   7989345
REFERENCE   10 (bases 1 to 848)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092058.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB471621.2, DA205950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684792.1/ ENSP00000508923.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC092058.3         154512-154572       c
            62-145              AC092058.3         142129-142212       c
            146-355             AC092058.3         119977-120186       c
            356-848             AC092058.3         119225-119717       c
FEATURES             Location/Qualifiers
     source          1..848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..848
                     /gene="MOBP"
                     /note="myelin associated oligodendrocyte basic protein"
                     /db_xref="GeneID:4336"
                     /db_xref="HGNC:HGNC:7189"
                     /db_xref="MIM:600948"
     exon            1..61
                     /gene="MOBP"
                     /inference="alignment:Splign:2.1.0"
     exon            62..145
                     /gene="MOBP"
                     /inference="alignment:Splign:2.1.0"
     exon            146..355
                     /gene="MOBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..701
                     /gene="MOBP"
                     /note="isoform b is encoded by transcript variant 8"
                     /codon_start=1
                     /product="myelin-associated oligodendrocyte basic protein
                     isoform b"
                     /protein_id="NP_001380633.1"
                     /db_xref="CCDS:CCDS2688.1"
                     /db_xref="GeneID:4336"
                     /db_xref="HGNC:HGNC:7189"
                     /db_xref="MIM:600948"
                     /translation="MSQKPAKEGPRLSKNQKYSEHFSIHCCPPFTFLNSKKEIVDRKY
                     SICKSGCFYQKKEEDWICCACQKTRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPR
                     SERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRPRPEVRPPPAKQRPPQKSKQQP
                     RSSPLRGPGASRGGSPVKASRFW"
     exon            356..848
                     /gene="MOBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      827..832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOBP"
                     /note="hexamer: ATTAAA"
     polyA_site      848
                     /gene="MOBP"
                     /note="major polyA site"
ORIGIN      
        1 aaaccctcag ggacctggta tagacgcaga atctgtttca cacaacaact gctatttgaa
       61 ggaaaaaaaa aaaaagaagc aaatgatacc aagacaagct cataacagag atccaatcag
      121 cagatgtgta cggatgaaaa tacagtgaga tgagtcagaa accggccaag gagggtccca
      181 gactctccaa aaaccagaag tactccgaac acttcagcat acactgctgc ccgccgttca
      241 ccttcctcaa ttccaagaag gagatagtgg atcggaaata cagcatctgt aagagcggct
      301 gcttctacca gaagaaagag gaggactgga tctgctgcgc ctgccagaag accagaacca
      361 gccgccgtgc caagtcccct cagaggccca agcaacagcc agctgcgccc cccgcggtgg
      421 tcagagcgcc agccaagcca cggtcccctc cgaggtctga gcgtcagcca cggtcccctc
      481 cgaggtctga gcgtcagcca cggtcccctc cgaggtctga gcgtcagcca cggtcccctc
      541 cgaggtctga gcgtcagcca cgtccccgcc cagaggtccg accaccgcca gccaagcagc
      601 gtccccctca gaagtccaag caacagccgc gcagcagccc cctcagaggg ccaggcgcca
      661 gccgtggggg gtcccccgtc aaagcttcta ggttctggta acaccatctc ttcccttttg
      721 ttccccagcc ctaaggttag tagttgcttc ctgtgtttac taacaccggg ctgtctccat
      781 ggccctcttc agccttatta cccaacctgt gtaatcagct ccctccatta aatcccctct
      841 gtttgaaa
//
