LOCUS       NM_015387               3752 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MOB family member 4, phocein (MOB4), transcript
            variant 1, mRNA.
ACCESSION   NM_015387
VERSION     NM_015387.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3752)
  AUTHORS   Santos,I.B., Wainman,A., Garrido-Maraver,J., Pires,V.,
            Riparbelli,M.G., Kovacs,L., Callaini,G., Glover,D.M. and
            Tavares,A.A.
  TITLE     Mob4 is essential for spermatogenesis in Drosophila melanogaster
  JOURNAL   Genetics 224 (4) (2023)
   PUBMED   37259670
  REMARK    GeneRIF: Mob4 is essential for spermatogenesis in Drosophila
            melanogaster.
REFERENCE   2  (bases 1 to 3752)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3752)
  AUTHORS   Jeong,B.C., Bae,S.J., Ni,L., Zhang,X., Bai,X.C. and Luo,X.
  TITLE     Cryo-EM structure of the Hippo signaling integrator human STRIPAK
  JOURNAL   Nat Struct Mol Biol 28 (3), 290-299 (2021)
   PUBMED   33633399
REFERENCE   4  (bases 1 to 3752)
  AUTHORS   Chen,M., Zhang,H., Shi,Z., Li,Y., Zhang,X., Gao,Z., Zhou,L., Ma,J.,
            Xu,Q., Guan,J., Cheng,Y., Jiao,S. and Zhou,Z.
  TITLE     The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the
            Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic
            cancer
  JOURNAL   J Biol Chem 293 (37), 14455-14469 (2018)
   PUBMED   30072378
  REMARK    GeneRIF: Because of divergent evolution of key interface residues,
            MST4 and MOB4 could disrupt assembly of the MST1-MOB1 complex
            through alternative pairing and thereby increased YAP activity.
            Collectively, these findings identify the MST4-MOB4 complex as a
            noncanonical regulator of the Hippo-YAP pathway with an oncogenic
            role in PC
REFERENCE   5  (bases 1 to 3752)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3752)
  AUTHORS   Hirabayashi,S., Nakagawa,K., Sumita,K., Hidaka,S., Kawai,T.,
            Ikeda,M., Kawata,A., Ohno,K. and Hata,Y.
  TITLE     Threonine 74 of MOB1 is a putative key phosphorylation site by MST2
            to form the scaffold to activate nuclear Dbf2-related kinase 1
  JOURNAL   Oncogene 27 (31), 4281-4292 (2008)
   PUBMED   18362890
  REMARK    GeneRIF: phosphorylation of MOB1 at Thr74 by MST2 is essential to
            make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1
REFERENCE   7  (bases 1 to 3752)
  AUTHORS   Bailly,Y.J. and Castets,F.
  TITLE     Phocein: A potential actor in vesicular trafficking at Purkinje
            cell dendritic spines
  JOURNAL   Cerebellum 6 (4), 344-352 (2007)
   PUBMED   17853115
  REMARK    Review article
REFERENCE   8  (bases 1 to 3752)
  AUTHORS   Baillat,G., Gaillard,S., Castets,F. and Monneron,A.
  TITLE     Interactions of phocein with nucleoside-diphosphate kinase, Eps15,
            and Dynamin I
  JOURNAL   J Biol Chem 277 (21), 18961-18966 (2002)
   PUBMED   11872741
REFERENCE   9  (bases 1 to 3752)
  AUTHORS   Moreno,C.S., Lane,W.S. and Pallas,D.C.
  TITLE     A mammalian homolog of yeast MOB1 is both a member and a putative
            substrate of striatin family-protein phosphatase 2A complexes
  JOURNAL   J Biol Chem 276 (26), 24253-24260 (2001)
   PUBMED   11319234
REFERENCE   10 (bases 1 to 3752)
  AUTHORS   Baillat,G., Moqrich,A., Castets,F., Baude,A., Bailly,Y.,
            Benmerah,A. and Monneron,A.
  TITLE     Molecular cloning and characterization of phocein, a protein found
            from the Golgi complex to dendritic spines
  JOURNAL   Mol Biol Cell 12 (3), 663-673 (2001)
   PUBMED   11251078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005237.1, AC020550.4 and
            CR736874.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015387.4.
            
            Summary: This gene was identified based on its similarity with the
            mouse counterpart. Studies of the mouse counterpart suggest that
            the expression of this gene may be regulated during oocyte
            maturation and preimplantation following zygotic gene activation.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been observed. Naturally occurring read-through
            transcription occurs between this locus and the neighboring locus
            HSPE1.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.111800.1,
                                           SRR1803614.81834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323303.9/ ENSP00000315702.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-960               BC005237.1         24-983
            961-3745            AC020550.4         112878-115662       c
            3746-3752           CR736874.1         14-20               c
FEATURES             Location/Qualifiers
     source          1..3752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..3752
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="MOB family member 4, phocein"
                     /db_xref="GeneID:25843"
                     /db_xref="HGNC:HGNC:17261"
                     /db_xref="MIM:609361"
     exon            1..81
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..699
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     preimplantation protein 3; Mps One Binder kinase
                     activator-like 3; class II mMOB1; mob1 homolog 3; MOB1,
                     Mps One Binder kinase activator-like 3; phocein, Mob-like
                     protein; mob-like protein phocein"
                     /codon_start=1
                     /product="MOB-like protein phocein isoform 1"
                     /protein_id="NP_056202.2"
                     /db_xref="CCDS:CCDS2321.1"
                     /db_xref="GeneID:25843"
                     /db_xref="HGNC:HGNC:17261"
                     /db_xref="MIM:609361"
                     /translation="MVMAEGTAVLRRNRPGTKAQDFYNWPDESFDEMDSTLAVQQYIQ
                     QNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTA
                     TEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVC
                     RRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNS
                     VSGESEA"
     exon            82..144
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..245
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     exon            246..288
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..375
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     exon            376..455
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..567
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..3752
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      940..945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="hexamer: AATAAA"
     polyA_site      966
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="major polyA site"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="hexamer: CATAAA"
     polyA_site      2670
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="major polyA site"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="hexamer: CATAAA"
     polyA_site      2844
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
     regulatory      3732..3737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
                     /note="hexamer: AGTAAA"
     polyA_site      3752
                     /gene="MOB4"
                     /gene_synonym="2C4D; CGI-95; MOB1; MOB3; MOBKL3; PHOCN;
                     PREI3"
ORIGIN      
        1 agccgcctag acgctggcac tatggtcatg gcggagggga cggcagtgct gaggcggaac
       61 aggccgggca ccaaggcgca ggatttctat aattggcctg atgaatcctt tgatgaaatg
      121 gacagtacac tagctgttca acagtatatt caacagaaca taagagcaga ttgctccaat
      181 attgacaaaa ttcttgaacc acctgaaggc caagatgaag gtgtgtggaa gtatgaacat
      241 ttaaggcagt tctgccttga gctaaatgga cttgctgtca aacttcagag tgaatgccat
      301 ccagatactt gcactcaaat gacagcaact gaacaatgga tttttctttg tgcagctcat
      361 aaaactccaa aagagtgtcc tgctatagac tatactagac acacacttga tggtgctgca
      421 tgtcttctga atagcaataa atattttccc agcagggtta gcataaagga atcatctgta
      481 gcgaaactag gatcagtatg ccgtaggatt tacagaatat tttcacatgc ttattttcat
      541 catcggcaga tatttgatga atatgaaaat gaaacatttt tgtgtcatcg gtttactaag
      601 tttgtgatga aatacaattt gatgtccaag gataacctga ttgtaccaat tttagaagag
      661 gaagtacaga attcagtttc tggggaaagt gaagcatgaa gggaatcata ggaaaaatgt
      721 actgatcata taattaacat tatgtactgt atatatcatt ttagacacat caatcatgta
      781 tccatattat agcttctttg tttagtatag gtttttgtat gctgggtttg ccttttaaaa
      841 tgggaaatac tttttaagtt attcataagc tgtatattca ccagtgtggc actcatggtt
      901 tttaaataag attagtatta tctgtttata atgcctgtta ataaaagaat ttacagtttg
      961 gtaaaattgc tgctaaacaa tcattggatc acaatcctca tcagacaaac ccatctgtaa
     1021 aaaaaatgag ggagagcttg aggtttcaca caagccattt actaaagagg tagaaatgtt
     1081 ttctattggt tttaccttga gtttagatat cctaaaaaat tctgtagtac gtagttttgt
     1141 cttacctgtt aactttcccc aattgagata aaagtgtttt aaaattctgt ttatagtttt
     1201 tgatatgcat atataattat gtgtatatct aaatacaaat gcaaatgaag cattagtaat
     1261 acttaaataa ttttactgtg ctacataaag tataacatac ttggaaagga tttaccgttc
     1321 tgcaacaacg gactggtaca tacaggatga tcacaatggt aaggcacata aattattttc
     1381 ccactggaaa cctgccctgt ccaccccttc tcatttccct taaccttatc ttcaaactac
     1441 tttagctgag aagcttttca ccagactgag ttagtggtgg cttataccta tttatatttg
     1501 tattaattgc ttacagatta tacctcatat tagcaattac attacactac aagaaaatgt
     1561 atttgcatag gctcttgctt atctttgttt tgcaaaattg ttctacttag aaaacagtcc
     1621 ttaaaatagt ttgactcttc ctgttagtaa tatattaatc tttcatttaa ccagctaggc
     1681 agcattaaat agaattgaag aaataccata gtatttattt tacaccccct ctcccacgaa
     1741 gtttatgttt ggattacatg cacgtgtgag attatttgca ataattcata ggttccaagg
     1801 gtgttgatga atagtcatac atttttttgg actttgttat aattcattgt ggtaagaatg
     1861 attgaaatgc agatttaaca atcttataat ctattgaatg ccatttttga taaagcactg
     1921 gaggtcttat tgccaaactg attgtaatga ggcagtaagg gtgaaaacat tgtacatgtt
     1981 gtgaagaaag tatttaaatc caacttttga acagatttaa caaacatgag gaactttttt
     2041 atttagaagg ataattttga agatgaaaat gtattcatct taattgtttt ttcaaattta
     2101 agggaataat ttataccatc ttttcagaca agaatgtaca gcaaaaataa ggggaacagt
     2161 agtatactga gagtgtgtgt atgtatagtg tatgcctttc caagcttgcc agtctttttg
     2221 gctttgaaca ctgcccatca gctacagtca ttactgttcc ccaacccaca actatctttt
     2281 aagaagtctt agttcacagt gaaaggaatg atgactttga aattatggat ttatattaat
     2341 ggcactataa accaatggta atggtaattt ttaaacttgc taaatattga gaaactaaac
     2401 tactaagtta ataaattata tatagcagtg tagctgttct ctctagatgg tgtctcacaa
     2461 tggatttctg ttgcttgact attttcttag tgaatattta tactaaggta gtgactgaga
     2521 tttggtgatc tggctgagta ttttgaaaca cattttgaat aatatggctt agtgttaacg
     2581 gggacttaaa tatgattttt ttttcttact catttcacct tccctgtact gtatgtttgg
     2641 aattgatcat aaaacatctc caaaagaaaa taatcagttt gtagtcttgc ttttgtattc
     2701 atgttgataa tcttactaat tgtgaagttg attcactact atactaggta agacctaagt
     2761 gaaacagttc ctgtttttcc ttaatactgt tttcagaatt ttgaaaatgt acttatatat
     2821 acataaatac tactaaaaaa ttaatgagcc tggcaaacca ttgatttata aaagtaagtg
     2881 ttctaagagg ggaacaagac agttctgtgt gataaggaag ttaggctcca ctttttgttt
     2941 gaattaccct atgtatatcc gaaggtaaac ttaggctttt ctttccaaaa gatcgtatag
     3001 tcaattcatt ctttttctcc tatcacatct gggaaagtag ctaactttta actatttatg
     3061 ttcccataag taacccttct tttgtgtgta tacatttcct tttctctgac ttgagatgtc
     3121 aaatttggat ttctagaaca gtttctcagt taaattcttg atgacttaac aacttttact
     3181 atcagaatac aattagaaat ccttggtcag gcacaggggc tcacgcctgt aatcccagca
     3241 ctttgggaag ccaaggcaga cagatcacct gaggtcagga gttcgagacc agcctgacca
     3301 acatggagaa accctgtctc tactaaaaat acaaaaatta gccgggcgtg gtgctactcg
     3361 tgaggctgag gcaggagaat cgcttgaacc cgggaggtgg aggttgcggt gagctgagat
     3421 cgtgccattg cactccagcc tgggtaacga gcaaaactcc gtctcaaaaa ctccgtctca
     3481 aaaaaaaaaa atccttgatt acattgttag taaggactgt gttacgatta taaacacatt
     3541 tattggttga tgtcaaattc actgtaatag tagaactaag ttttttatgt gagtactttg
     3601 ccctactgtc tatatgatga catctttttt gagcagctaa attttaaatt gtatatactt
     3661 tattttgtga atccttgttg aatgtgctaa aggtttcttt gtgtagttct tccatgctat
     3721 gcgaatattt tagtaaaagt agttgatttt ta
//
