LOCUS       NM_201403               2738 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens MOB kinase activator 3C (MOB3C), transcript variant 2,
            mRNA.
ACCESSION   NM_201403
VERSION     NM_201403.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Elkholi,I.E., Boulais,J., Thibault,M.P., Phan,H.D., Robert,A.,
            Lai,L.B., Faubert,D., Smith,M.J., Gopalan,V. and Cote,J.F.
  TITLE     Mapping the MOB proteins' proximity network reveals a unique
            interaction between human MOB3C and the RNase P complex
  JOURNAL   J Biol Chem 299 (9), 105123 (2023)
   PUBMED   37536630
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136373.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 14, 2021 this sequence version replaced NM_201403.2.
            
            Summary: The protein encoded by this gene is similar to the yeast
            Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential
            for spindle pole body duplication and mitotic checkpoint
            regulation. Alternatively spliced transcript variants encoding
            distinct isoforms have been observed. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) uses an alternate 5' UTR exon,
            compared to variant 1, that results in the use of a downstream
            start codon. The encoded isoform (2) has a shorter N-terminus, as
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.1050.1,
                                           SRR14038193.807970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2155770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319928.9/ ENSP00000315113.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL136373.21        89518-89618         c
            102-569             AL136373.21        85711-86178         c
            570-772             AL136373.21        82809-83011         c
            773-2738            AL136373.21        80526-82491         c
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2738
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /note="MOB kinase activator 3C"
                     /db_xref="GeneID:148932"
                     /db_xref="HGNC:HGNC:29800"
                     /db_xref="MIM:620804"
     exon            1..101
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /inference="alignment:Splign:2.1.0"
     exon            102..569
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..802
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /note="mob1 homolog 2C; MOB1, Mps One Binder kinase
                     activator-like 2C"
                     /codon_start=1
                     /product="MOB kinase activator 3C"
                     /protein_id="NP_958805.1"
                     /db_xref="CCDS:CCDS540.1"
                     /db_xref="GeneID:148932"
                     /db_xref="HGNC:HGNC:29800"
                     /db_xref="MIM:620804"
                     /translation="MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDL
                     RSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQD
                     ERQYRRPAKLSAPRYMALLMDWIEGLINDEEVFPTRVGVPFPKNFQQVCTKILTRLFR
                     VFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH"
     exon            570..772
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /inference="alignment:Splign:2.1.0"
     exon            773..2738
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /note="hexamer: AATAAA"
     polyA_site      2738
                     /gene="MOB3C"
                     /gene_synonym="MOB1E; MOBKL2C"
                     /note="major polyA site"
ORIGIN      
        1 agacggacag gctgacagga gagagaacag gcactgcggg acctgcagga gaaaggcgat
       61 cctgtggctg ggaatgtgac cccacggcca gaagaggacc cggtatcctc aggtccgagc
      121 ccctggacag cagccccagg cccagctggc catggccctg tgcctgaagc aggtgttcgc
      181 caaggacaag acgttccggc cgcggaagcg ctttgagccg ggcacacagc gctttgagct
      241 gtacaagaag gcacaggcct ctctcaagtc gggcctggac ctgcgcagtg tggtgaggct
      301 accacccggg gagaacatcg acgactggat cgccgtgcac gtggtggact tcttcaaccg
      361 catcaacctc atctacggca ctatggcgga gcgctgcagt gagaccagct gcccggtcat
      421 ggccggcggg ccccgctacg agtaccgctg gcaggacgag cgccagtacc ggcggcccgc
      481 caagctctct gcgccgcgct atatggcatt gctcatggac tggatcgaag gcctcatcaa
      541 cgacgaagag gtctttccca cgcgtgttgg agttcccttc cctaagaact tccagcaggt
      601 ctgcaccaag atcctgaccc gcctcttccg agtctttgtc catgtctaca tccaccactt
      661 cgatagcatc ctcagcatgg gggcagaggc gcacgtcaac acctgctaca agcacttcta
      721 ctacttcatc cgcgagttca gtctggtgga ccagcgggag ctggagccac tgagggagat
      781 gacagagcgg atctgccact gagcccaggt ctggactttt ttggccatca gatggacgat
      841 ctgaacatag ggtggctggc agaggggacc cccaggagcc tgaaggaatc tgaaggcact
      901 ggaatcactc cacacaccca aagcctctgg acttctggtt ctcaggagtc tgcctacctg
      961 tcgccctgac cgcttgtgga tggagaaggg gagagcatct aggcaggcaa acagaaggga
     1021 agtggagtta aacctctggc atgaagtctg ggagtagggt aggctagggg gtttcttcta
     1081 tgacacttga cccttccatg ctggttccca agcctattgg aggaatgtgg gtgtggccga
     1141 ggtgatggca agaaaggtgc aagaaagtga gcagtctgcc tgtgagtgag cacagatgcc
     1201 ggggtgtgtg tgtgtgtgtg tgattttcac tgtggggtgt gtctgtgaga gctagctgcc
     1261 ttacccctcc ttggcacata gtaggccttc cataaatgtt ggatggatgg ataaatagat
     1321 tgggaccatc agaccatggg accatcagac catgaccact gtaggagtga tgacagctca
     1381 gcgtccccac tcagtgtatc tgaccatgtg tgtaagtgca caaaaatgtg gttgtagatg
     1441 ttgctctaca ttcaaacctt ccaggctaca ctcttccatc agcatgagtc ctggagagct
     1501 gggggaacgt aggaagagga gccttgcctt gagttcctaa accgacccac tgcagacaca
     1561 ggctctgatt ctcttaccca gagatgccca tgagctgaca ttttactcat ccctctgcct
     1621 ccaagaaggc ctgtattata cgtgtcctcc tgggggttgg agatgatccc tcaagtacac
     1681 aaaggtcccc tggcccttca tctgggaatc atatactcca ctctagctcc cagaatctac
     1741 agacctggct cctcggatct gaagcccagc acaaaataat ctccccgtcc aaggagcttg
     1801 tggaacttga attgggaact ttggagtctt gtctcccatc ccagcacatt gaggatgtag
     1861 ttggtgaatg gactcttcca ggcatggaga tcctccatcc taaaagtacc tgcctccttc
     1921 ccagccatcc ctgacacatt ccagccagtt ggatctcaca gcacagctat ccacagggag
     1981 actgggatgt tcacgcagca ctccattact cagtacctcc atacccagcc ctatacgcag
     2041 acccacaggt ggggaaactg aggcaggaac agggttctgc cctcccagag cctccactct
     2101 gggatgccag aatggaaagc cagagggaac ctgagaatca tccagtctta ctgtctcaat
     2161 gtacatacgg ggaaactgaa gccaggagaa gaagagggag aaactgtcca gggcctcaca
     2221 gggaggcatt catggagctg gagaaaccag ggatcctgac cgcagggccc atcaattgct
     2281 acatagagat acacatggaa agagggttta acagaccctc tctaggacac aactgtttct
     2341 gctttgagca ataatttcta acctgaggcc aacatgtccc actgcccctt gggttggctg
     2401 gggttgtttc ctgagccaag catccaatat catgccccac tcaatggcct agaagctgcc
     2461 tgtactttgg ggaaacagat ggagctcttg ggcccagcca gctgggcctg ggacttctgc
     2521 ctctgccgcc tccagagtgg cctggcagct ttgccagagg ctgtggagcg agggtagtag
     2581 gagcttttcc cagagtgctg tgacttgcat gatggattct aggctgtggc aagggctgat
     2641 ttctgggata gggggagggt tggaaaattt atttttatga aacagaggga agactttatt
     2701 gttgttattt ttggtaaaat aaaaggcaaa ctaaagca
//
