LOCUS       NM_130807               3387 bp    mRNA    linear   PRI 22-AUG-2024
DEFINITION  Homo sapiens MOB kinase activator 3A (MOB3A), mRNA.
ACCESSION   NM_130807
VERSION     NM_130807.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Dutchak,K., Garnett,S., Nicoll,M., de Bruyns,A. and Dankort,D.
  TITLE     MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging
            the Hippo Pathway
  JOURNAL   Mol Cancer Res 20 (5), 770-781 (2022)
   PUBMED   35046109
  REMARK    GeneRIF: MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by
            Engaging the Hippo Pathway.
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005328.1, AK095471.1, AK094732.1 and BC015049.1.
            
            On Nov 23, 2018 this sequence version replaced NM_130807.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832474.1, SRR3476690.921095.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357066.8/ ENSP00000349575.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC005328.1         28125-28180         c
            57-2281             AK095471.1         1-2225
            2282-2686           AK094732.1         1327-1731
            2687-3387           BC015049.1         2520-3220
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3387
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /note="MOB kinase activator 3A"
                     /db_xref="GeneID:126308"
                     /db_xref="HGNC:HGNC:29802"
                     /db_xref="MIM:620929"
     exon            1..101
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /inference="alignment:Splign:2.1.0"
     exon            102..255
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /inference="alignment:Splign:2.1.0"
     exon            256..795
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1028
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /note="MOB LAK; mps one binder kinase activator-like 2A;
                     mob1 homolog 2A; MOB1, Mps One Binder kinase
                     activator-like 2A"
                     /codon_start=1
                     /product="MOB kinase activator 3A"
                     /protein_id="NP_570719.1"
                     /db_xref="CCDS:CCDS12081.1"
                     /db_xref="GeneID:126308"
                     /db_xref="HGNC:HGNC:29802"
                     /db_xref="MIM:620929"
                     /translation="MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLD
                     LRLAVQLPPGEDLNDWVAVHVVDFFNRVNLIYGTISDGCTEQSCPVMSGGPKYEYRWQ
                     DEHKFRKPTALSAPRYMDLLMDWIEAQINNEDLFPTNVGTPFPKNFLQTVRKILSRLF
                     RVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVKEFGLIDTKELEPLKEMTARMCH"
     exon            796..998
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /inference="alignment:Splign:2.1.0"
     exon            999..3387
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3360..3365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /note="hexamer: AATAAA"
     polyA_site      3387
                     /gene="MOB3A"
                     /gene_synonym="MOB-LAK; MOB1C; MOBKL2A; moblak"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccctcc gcggcggctg cgaggcggtg cggcggctga ggcggccgag gcggccagtt
       61 gggtaccggg aggggcgaag gcgggcggca gaggcgatca gaagtttcca agggtcactt
      121 gtgtctcgtc cgtgggaaga ccgggggagc ccagaaggcc ttggtgtgga attctgagag
      181 ctgattcctg ccttgtcttc tccactgttc ctggaggaat ccgagaagag cagagcggag
      241 ggagccccag acacggtccg cgggagagct gtggggcttg gtgagtgttt cgtggcctct
      301 cgggttggtc agcaccccca gccagctggc ccaggacccc tctacagaag tccaggagag
      361 caggcgtcac caagatgtcc aaccccttcc tgaagcaagt cttcaacaag gacaagacat
      421 tccgccccaa gcgcaagttt gagccaggca cccagcgctt cgagctgcac aagaaggcgc
      481 aggcgtcgct gaacgccggg ctggacctgc ggctggccgt gcagttgccc ccgggcgagg
      541 acctgaacga ctgggtggct gttcacgtgg tggacttctt taaccgcgtc aacctcatct
      601 acggcaccat cagcgacggc tgcacggagc agtcctgccc cgtcatgtcg gggggcccca
      661 agtatgagta ccgctggcag gatgagcata agttccggaa gcccacggca ctctccgcgc
      721 ccaggtacat ggacctgctg atggactgga tcgaggcgca gatcaacaac gaggacctct
      781 tccccaccaa cgttggcact ccgtttccca agaacttcct gcagacggtg cggaagatcc
      841 tgtcgcggct gttccgcgtg ttcgtgcacg tctacatcca ccactttgac cgcatcgcgc
      901 agatgggctc cgaggcccac gtgaacacct gctacaagca cttctactat ttcgtcaagg
      961 agttcggcct catcgacacc aaggagctgg agccactgaa agaaatgacc gcccggatgt
     1021 gccactgaga gccccgcggg tctcccggtg cccgaaccgc cgctggggcc tcggagactt
     1081 ggaggaggac gctctggaac catcatcccg cttctctccg gcctgagcat ctcagggaga
     1141 ccaggggccg agccgctgag caggtgttgg tcctcaggag ctccaacccc ggacggcaga
     1201 tgccttcctc agtctcgagc ctcagtctcc cgtctgggac taaaacgtga actctgtaat
     1261 tctatgtgtt actagcaacc ggaaaagccc actgtgtttt taaaccactt ccactttcca
     1321 ggaggctgga tggcttccag ggtcactcct tgccctgggt ggctcccagg ctcctggaac
     1381 ttctgcctcc acctcgctgg ggagccccca gggctgctgt ggccacagcc ctgcctgggc
     1441 ctgtctctca agggcaccca gcttgctcgg cctcctacat gtctcccgtt ggggaggcaa
     1501 gaggctgagg ggcttccgag cccctgagag cggacatctc ctcccgcagg cctttactcc
     1561 gcactcccca ctggcagccg ctggtgtctc ttcacacaga ggcacaacct ggacccaggc
     1621 agcctctttc ctccctcccc aatctcttcc atttttctac agattttttt ttttttggtc
     1681 atactagaga caggggtctc gctgaactcc tggcctccag tgatcctcca tcctcggcct
     1741 cccaaagtgc tggaatcaca ggggtgagcc accgcaccca gccctctctc ttcctcaatg
     1801 cactctgctt cttccgttct tccgaaacat tcagctgact gtatccaggg cttcctggac
     1861 tcctgggacc ccacgtcctg caccccggct tctgactcat ttcctaaggg cccctttgtg
     1921 tatcataaag ggtttgattt ttatagtcac atttacaacc atcttgagat ttttattttt
     1981 tttgaacgga gtctcccact gtcgcccaga ctggagtcca gtggcacaat ctcggctcac
     2041 tgcatcctcc acctcctggg ttcaagtgat tctcctgctt cagcctccca agtagctggg
     2101 attacaggtg tgcgccacca cgcccaggaa attattgtag ttttagtaga gacaagattt
     2161 caccatgttg gccaggctgg tctcaaactc ctgacttcag gtgatccgcc taccttggcc
     2221 tccaaaagtg ctgggattac aggcatgagc tactgcaccc ggcctaacca ggctggagtg
     2281 cagtggtggg atctcggctc actgcaagct ccgcctccca gattcacgcc attctcctgc
     2341 ctcagcctcc ccagcagctg ggactacagg cacccaccgt cacacccggc taattttttt
     2401 gtattttagt agagacaggg tttcaccgtg ttagccagga tggtcttgat ctcctgacct
     2461 tgtgatccac cagcctcagc ctcccaaagt gctgggatta caggcgtgag ccactgtgcc
     2521 cggccaagaa tttttttatc gataacatag tgagctctct gcctcttcgg aacgatgtcc
     2581 actttgctta tgatcaaccc aagcaggact cttctctccc tggacgcctc tcccctggtc
     2641 tggaatcttc cagttctgcc agaattggcc tttcccagat gctgcaaact tccagttgaa
     2701 cccctttttc tgtgtggccc ctggggctgc gagaccaaaa tccatgagtt ctgtgtaccc
     2761 tagacctttg gaaggtgaga gcagggccct gagaaaaggc agccacctcc tctccctggc
     2821 tgaacccctg ccaccctact cctcaccaga attgtcagtg gcctttcacc acagtggtcc
     2881 ttcctgcctg agccctgcac tgtcccagac cacacagaag tctggtcacc tctgggcgcc
     2941 tgggatggtc accgaagaga agcacgctgt ccccgtctct cctggcttct gccagaaaat
     3001 cgaacaagtg caattaacac actgttactg ccgaagcctg aaactcccag gacttgtcct
     3061 tgatccttcc agaaaccacc aggtccggca cttggagccc cccggagagg gacctcccag
     3121 ccgagccctc aaagaactcc atgaaatcag gaactgcttg atgaaatgta tctccttgta
     3181 cctggaagat gaagcccaaa cacccacacc tctgtctccc ccagggctcg ggatgtctcc
     3241 agcagcccgg ccacgcagct tcccaggtgg gctcggggag gtgggagcag ggaccatctc
     3301 tgtcccctcc accctcactc catccacctc ggagaccacc ctcccccagc cagatacgga
     3361 ataaaactac agacgcagac gtcggaa
//
